Abnormal ghrelin and pancreatic polypeptide responses in gastroparesis

Digestive Diseases and Sciences

Volumn 51, Issue 8, 2006, Pages 1339-1346

  Gaddipati, Kishore V ^a   Simonian, Hrair P ^a   Kresge, Karen M ^a   Boden, Guenther H ^a   Parkman, Henry P ^a,b  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TEMPLE UNIVERSITY HOSPITAL   (United States)

Author keywords

Diabetes mellitus; Gastroparesis; Vagal function; Vagotomy

Indexed keywords

GHRELIN; PANCREAS POLYPEPTIDE;

ADULT; APPETITE; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; FEMALE; HUMAN; IDIOPATHIC DISEASE; MALE; PRIORITY JOURNAL; PROTEIN CONTENT; SHAM FEEDING; STATISTICAL SIGNIFICANCE; STOMACH PARESIS; VAGUS NERVE DISEASE;

ADULT; APPETITE; BIOLOGICAL MARKERS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FEMALE; GASTRIC EMPTYING; GASTROPARESIS; GROWTH HORMONE; HUMANS; INSULIN; MALE; MIDDLE AGED; PANCREATIC POLYPEPTIDE; PEPTIDE HORMONES; RADIOIMMUNOASSAY; VAGOTOMY; VAGUS NERVE;

EID: 33748187716     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-9022-z     Document Type: Article

References (33)

1. Soykan I, Sivri B, Sarosiek I, Kiernan B, McCallum RW (1998) Demography, clinical characteristics, psychological profiles, treatment and long-term follow-up of patients with gastroparesis. Dig Dis Sci 43:2398-2404
2. Parkman HP, Fisher RS (2003) Disorders of gastric emptying. Yamada Textbook of gastroenterology, 3rd ed
3. Feldman M, Corbett DB, Ramsey EJ, Walsh JH, Richardson CT (1979) Abnormal gastric function in longstanding, insulin-dependent diabetic patients. Gastroenterology 77:12-17
4. Taylor IL, Feldman M, Richardson CT, Walsh JH (1978) Gastric and cephalic stimulation of human pancreatic polypeptide release. Gastroenterology 75:432-437
5. Greydanus MP, Vassallo M, Camilleri M, Nelson DK, Hanson RB, Thomforde GM (1991) Neurohormonal factors in functional dyspepsia: Insights on pathophysiological mechanisms. Gastroenterology 100:1311-1318
6. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
7. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50:1714-1719
8. Date Y, Murakami N, Toshinai K, Matsukura S, Niijima A, Matsuo H, Kangawa K, Nakazato M (2002) The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 123:1120-1128
9. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purnell JQ (2002) Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Eng J Med 346:1623-1630
10. Simonian HP, Kresge KM, Boden GH, Parkman HP (2005) Differential effects of sham feeding and meal ingestion on ghrelin and pancreatic polypeptide levels: Evidence for vagal efferent stimulation mediating ghrelin release. Neurogastroenterol Motil 17:348-354
11. Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka S, Itoh Z, Hosoda H, Kojima M, Kangawa K (2000) Ghrelin stimulated gastric acid secretion and motility in rats. Biochem Biophys 276:905-908
12. Asakawa A, Inui A, Kaga T, Yuzuriha H, et al. (2001) Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120:337-345
13. Trudel L, Tomasetto C, Rio MC, Bouin M, Plourde V, Eberling P, Poitras P (2002) Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. Am J Physiol Gastro Liver Physiol 282:G948-G952
14. Tack J, Depoortere I, Bisschops R, Verbeke K, Janssens J, Peeters T (2004) Influence of ghrelin on gastric emptying and meal-related symptoms in gastroparesis. Gastroenterology 126:A-485 (abstract)
15. Parkman HP, Harris AD, Fisher RS (1996) Influence of age, gender, and menstrual cycle on the normal electrogastrogram. Am J Gastroenterol 91:127-133
16. Parkman HP, Miller Knight LC, Urbain J-L, Maurer AH, Fisher RS (1997) Electrogastrography and gastric emptying scintigraphy are complementary for assessment of dyspepsia. J Clin Gastroenterol 24:214-219
17. Phoenix Pharmaceuticals web site:http://www.phoenixpeptide.com/qcdata/ EIS/EIA protocol0-100.html; accessed May 23, 2002
18. Hosoda H, Doi K, Nagaya N, et al. (2004) Optimum collection and storage conditions for ghrelin measurements. Clinical Chemistry 50:1077-1080
19. Guy RJ, Dawson JL, Garrett JR, Laws JW, Thomas PK, Sharma AK, Watkins PJ (1984) Diabetic gastroparesis from autonomic neuropathy: Surgical considerations and changes in vagus nerve morphology. J Neurol Neurosurg Psychiatry 47:686-691
20. Feldman M, Richardson CT (1986) Role of thought, sight, smell, and taste of food in the cephalic phase of gastric acid secretion in humans. Gastroenterology 90:428-433
21. Konturek SJ, Popiela T, Slowiaczek M, Bielanski W (1987) Gastric acid and pancreatic polypeptide response to modified sham feeding. Effects of truncal and parietal cell vagotomy. Gut 28:280-286
22. Marco J, Hedo JA, Castilo-Olivares J, Villanueva ML (1980) Human pancreatic polypeptide secretion in conditions of exogenous and endogenous hyperglycemia. Diabetologia 19:418-422
23. Lam WF, Masclee AAM, de Boer SY, et al. (1993) Hyperglycemia reduces gastric secretory and plasma pancreatic polypeptide responses to modified sham feeding in humans. Digestion 54:48-53
24. Mizuno Y, Oomura Y (1984) Glucose responding neurons in the nucleus tractus solitarius of the rat: In vitro study. Brain Res 307:109-116
25. Stern RM, Crawford HE, Stewart WR, Vasey MW, Koch KL (1989) Sham feeding. Cephalic-vagal influences on gastric myoelectric activity. Dig Dis Sci 34:521-527
26. Date Y, Kojima M, Hosoda H, Swaaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M (2000) Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141:4255-4261
27. Heath RB, Jones R, Frayn KN, Robertson MD (2004) Vagal stimulation exaggerates the inhibitory ghrelin response to oral fat in humans. J Endocrinol 180:273-281
28. Erdmann J, Lippl F, Schusdziarra V (2003) Differential effect of protein and fat on plasma ghrelin levels in man. Regul Pept 116:101-107
29. Arosio M, Ronchi CL, Beck-Peccoz P, Gebbia C, Giavoli C, Cappiello V, Conte D, Peracchi M (2004) Effects of modified sham feeding on ghrelin levels in healthy human subjects. J Clin Endocrinol Metab 89:5101-5104
30. Williams DL, Grill HJ, Cummings DE, Kaplan JM (2003) Vagotomy dissociates short- and long-term controls of circulating ghrelin. Endocrinology 144:5184-5187
31. Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, Nozoe S-I, Hosoda H, Kangawa K, Matsukura S (2002) Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretions. J Clin Endocrinol Metab 87:240-247
32. Schaller G, Schmidt A, Pleiner J, Woloszczuk W, Wolzt M, Luger A (2003) Plasma ghrelin concentrations are not regulated by glucose or insulin. Diabetes 52:16-20
33. Lee H-M, Wang G, Englander EW, Kojima M, Ghreeley GH (2002) Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion. Endocrinology 143:185-190