Ghrelin stimulates gastric emptying and hunger in normal-weight humans

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 9, 2006, Pages 3296-3302

  Levin, F ^a   Edholm, T ^b   Schmidt, P T ^b   Gryback P ^b   Jacobsson, H ^b   Degerblad, M ^b   Hoybye C ^b   Holst, J J ^c   Rehfeld, J F ^c   Hellstrom P M ^b   Naslund E ^a  

^a DANDERYD HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ; GHRELIN; GLUCAGON LIKE PEPTIDE 1; MOTILIN; PEPTIDE YY; SODIUM CHLORIDE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; GASTROINTESTINAL MOTILITY; GROWTH HORMONE DEFICIENCY; HORMONE RELEASE; HORMONE RESPONSE; HUMAN; HUMAN EXPERIMENT; HUNGER; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH EMPTYING; STOMACH PARESIS;

EID: 33748752142     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-2638     Document Type: Article

References (53)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
2. Tschop M, Smiley DL, Heiman ML 2000 Ghrelin induces adiposity in rodents. Nature 407:908-913
3. Davenport AP, Bonner TI, Foord SM, Harmar AJ, Neubig RR, Pin JP, Spedding M, Kojima M, Kangawa K 2005 International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function. Pharmacol Rev 57:541-546
4. Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M 2000 Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141:4255-4261
5. Bernardis LL, Bellinger LL 1996 The lateral hypothalamic area revisited: ingestive behavior. Neurosci Biobehav Rev 20:189-287
6. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S 2001 A role for ghrelin in the central regulation of feeding. Nature 409:194-198
7. Tschop M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R, Folwaczny C 2001 Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest 24:RC19-RC21
8. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS 2001 A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50:1714-1719
9. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DG, Ghatei MA, Bloom SR 2000 The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141:4325-4328
10. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR 2001 Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86:5992
11. Hansen TK, Dall R, Hosoda H, Kojima M, Kangawa K, Christiansen JS, Jorgensen JO 2002 Weight loss increases circulating levels of ghrelin in human obesity. Clin Endocrinol (Oxf) 56:203-206
12. Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, Nozoe S, Hosoda H, Kangawa K, Matsukura S 2002 Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 87:240-244
13. Cummings DE, Foster-Schubert KE, Overduin J 2005 Ghrelin and energy balance: focus on current controversies. Curr Drug Targets 6:153-169
14. Korbonits M, Grossman AB 2004 Ghrelin: update on a novel hormonal system. Eur J Endocrinol 151(Suppl 1):S67-S70
15. Date Y, Nakazato M, Murakami N, Kojima M, Kangawa K, Matsukura S 2001 Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem Biophys Res Commun 280:904-907
16. Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka S, Itoh Z, Hosoda H, Kojima M, Kangawa K 2000 Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 276:905-908
17. Edholm T, Levin F, Hellstrom PM, Schmidt PT 2004 Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons. Regul Pept 121:25-30
18. Levin F, Edholm T, Ehrström M, Wallin B, Schmidt PT, Kirchgessner AM, Hilsted LM, Hellström PM, Näslund E 2005 Effect of peripherally administered ghrelin on gastric emptying and acid secretion in the rat. Regul Pept 131:59-65
19. Trudel L, Tomasetto C, Rio MC, Bouin M, Plourde V, Eberling P, Poitras P 2002 Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. Am J Physiol Gastrointest Liver Physiol 282:G948-G952
20. Dornonville de la Cour C, Lindström E, Norlen P, Håkanson R 2004 Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells. Regul Pept 120:23-32
21. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, Kasuga M 2001 Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120:337-345
22. Kitazawa T, De Smet B, Verbeke K, Depoortere I, Peeters TL 2005 Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro. Gut 54:1078-1084
23. Moreaux B, Van den Berg J, Thielemans L 2004 Activation of the GHS-receptor accelerates gastric emptying in dogs. Gastroenterology 126(Suppl):A-278
24. Ohno T, Kamiyama Y, Aihara R, Nakabayashi T, Mochiki E, Asao T, Kuwano H 2006 Ghrelin does not stimulate gastrointestinal motility and gastric emptying: an experimental study of conscious dogs. Neurogastroenterol Motil 18:129-135
25. Sepple CP, Read NW 1989 Gastrointestinal correlates of the development of hunger in man. Appetite 13:183-191
26. Murray CD, Martin NM, Patterson M, Taylor S, Ghatei MA, Kamm MA, Johnston C, Bloom SR, Emmanuel AV 2005 Ghrelin enhances gastric emptying in diabetic gastroparesis: a double-blind, placebo-controlled, cross-over study. Gut 54:1693-1698
27. Smith DS, Ferris CD 2003 Current concepts in diabetic gastroparesis. Drugs 63:1339-1358
28. Binn M, Albert C, Gougeon A, Maerki H, Coulie B, Lemoyne M, Rabasa Lhoret R, Tomasetto C, Poitras P 2006 Ghrelin gastrokinetic action in patients with neurogenic gastroparesis. Peptides 27:1603-1606
29. Tack J, Depoortere I, Bisschops R, Verbeke K, Janssens J, Peeters T 2005 Influence of ghrelin on gastric emptying and meal-related symptoms in idiopathic gastroparesis. Aliment Pharmacol Ther 22:847-853
30. Naslund E, Bogefors J, Skogar S, Gryback P, Jacobsson H, Holst JJ, Hellstrom PM 1999 GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. Am J Physiol 277:R910-R916
31. Orskov C, Rabenhoj L, Wettergren A, Kofod H, Holst JJ 1994 Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans. Diabetes 43:535-539
32. Ekman R, Wahlestedt C, Bottcher G, Sundler F, Håkanson R, Panula P 1986 Peptide YY-like immunoreactivity in the central nervous system of the rat. Regul Pept 16:157-168
33. Holst JJ, Bersani M 1991 Assays for peptide products of somatostatin gene expression. Methods Neurosci Neuropeptide Technology 5:3-22
34. Rehfeld JF 1998 Accurate measurement of cholecystokinin in plasma. Clin Chem 44:991-1001
35. Goll R, Nielsen SH, Holst JJ 1996 Regulation of motilin release from isolated perfused pig duodenum. Digestion 57:341-348
36. Heath RB, Jones R, Frayn KN, Robertson MD 2004 Vagal stimulation exaggerates the inhibitory ghrelin response to oral fat in humans. J Endocrinol 180:273-281
37. Camilleri M, Hasler WL, Parkman HP, Quigley EM, Soffer E 1998 Measurement of gastrointestinal motility in the GI laboratory. Gastroenterology 115:747-762
38. Talley NJ 2003 Diabetic gastropathy and prokinetics. Am J Gastroenterol 98:264-271
39. Wegener M, Borsch G, Schaffstein J, Reuter C, Leverkus F 1989 Frequency of idiopathic gastric stasis and intestinal transit disorders in essential dyspepsia. J Clin Gastroenterol 11:163-168
40. Peino R, Baldelli R, Rodriguez-Garcia J, Rodriguez-Segade S, Kojima M, Kangawa K, Arvat E, Ghigo E, Dieguez C, Casanueva FF 2000 Ghrelin-induced growth hormone secretion in humans. Eur J Endocrinol 143:R11-R14
41. Arvat E, Maccario M, Di Vito L, Broglio F, Benso A, Gottero C, Papotti M, Muccioli G, Dieguez C, Casanueva FF, Deghenghi R, Camanni F, Ghigo E 2001 Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. J Clin Endocrinol Metab 86:1169-1174
42. Tack J, Depoortere I, Bisschops R, Delporte C, Coulie B, Meulemans A, Janssens J, Peeters T 2006 Influence of ghrelin on interdigestive gastrointestinal motility in humans. Gut 55:327-333
43. Allen JM, Fitzpatrick ML, Yeats JC, Darcy K, Adrian TE, Bloom SR 1984 Effects of peptide YY and neuropeptide Y on gastric emptying in man. Digestion 30:255-262
44. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, Bhattacharya S, Carpenter R, Grossman AB, Korbonits M 2002 The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 87:2988
45. Dass NB, Munonyara M, Bassil AK, Hervieu GJ, Osbourne S, Corcoran S, Morgan M, Sanger GJ 2003 Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin. Neuroscience 120:443-453
46. Sakata I, Yamazaki M, Inoue K, Hayashi Y, Kangawa K, Sakai T 2003 Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion. Neurosci Lett 342:183-186
47. Hellstrom PM, Geliebter A, Naslund E, Schmidt PT, Yahav EK, Hashim SA, Yeomans MR 2004 Peripheral and central signals in the control of eating in normal, obese and binge-eating human subjects. Br J Nutr 92(Suppl 1):S47-S57
48. Wang G, Lee HM, Englander E, Greeley Jr GH 2002 Ghrelin - not just another stomach hormone. Regul Pept 105:75-81
49. Camina JP, Carreira MC, Micic D, Pombo M, Kelestimur F, Dieguez C, Casanueva FF 2003 Regulation of ghrelin secretion and action. Endocrine 22:5-12
50. Kojima M, Hosoda H, Kangawa K 2004 Ghrelin, a novel growth-hormone- releasing and appetite-stimulating peptide from stomach. Best Pract Res Clin Endocrinol Metab 18:517-530
51. Arvat E, Di Vito L, Broglio F, Papotti M, Muccioli G, Dieguez C, Casanueva FF, Deghenghi R, Camanni F, Ghigo E 2000 Preliminary evidence that ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J Endocrinol Invest 23:493-495
52. Broglio F, Arvat E, Benso A, Gottero C, Muccioli G, Papotti M, van der Lely AJ, Deghenghi R, Ghigo E 2001 Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab 86:5083-5086
53. Carraro G, Albertin G, Abudukerimu A, Aragona F, Nussdorfer GG 2004 Growth hormone secretagogue receptor subtypes 1a and 1b are expressed in human adrenal cortex. Int J Mol Med 13:295-298