Ghrelin-induced stimulation of colonic propulsion is dependent on hypothalamic neuropeptide Y1-and corticotrophin-releasing factor 1 receptor activation

Journal of Neuroendocrinology

Volumn 17, Issue 9, 2005, Pages 570-576

  Tebbe, Johannes J ^a   Mronga, S ^a   Tebbe, C G ^a   Ortmann, E ^a   Arnold, R ^a   Schafert M K H ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Brain gut interaction; Colonic motility; CRF; Ghrelin; Neuropeptide Y

Indexed keywords

ANTISAUVAGINE 30; ASTRESSIN; CORTICOTROPIN RELEASING FACTOR; GHRELIN; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE Y1 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC INNERVATION; AUTONOMIC NERVOUS SYSTEM FUNCTION; COLON MOTILITY; HISTOPATHOLOGY; HORMONAL REGULATION; INTESTINE TRANSIT TIME; MALE; MICROINJECTION; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; THALAMUS MIDLINE NUCLEUS;

ANIMALS; ARGININE; BRAIN; COLON; CORTICOTROPIN-RELEASING HORMONE; GASTROINTESTINAL MOTILITY; HYPOTHALAMUS; MALE; MICROINJECTIONS; NEUROPEPTIDE Y; NEUROPROTECTIVE AGENTS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PEPTIDE FRAGMENTS; PEPTIDE HORMONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STIMULATION, CHEMICAL;

EID: 23944509038     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2005.01340.x     Document Type: Article

References (36)

1. Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M. Ghrelin, a novel growth hormone releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tract of rats and humans. Endocrinology 2000; 141: 4255-4261.
2. Date Y, Nakazato M, Murakami N, Kojima M, Kangawa K, Matsukura S. Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem Biophys Res Commun 2001; 280: 904-907.
3. Fujimiya M, Itoh E, Kihara N, Yamamoto I, Fujimura M, Inui A. Neuropeptide Y induces fasted pattern of duodenal motility via Y2 receptors in conscious fed rats. Am J Physiol Gastrointest Liver Physiol 2000; 279: G32-G38.
4. Fujino K, Inui A, Asakawa A, Kihara N, Fujimura M, Fujimia M. Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J Physiol 2003; 550: 227-240.
5. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S. A role for ghrelin in the central regulation of feeding. Nature 2001; 409: 194-198.
6. Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka S, Itoh Z, Hosoda H, Kojima M, Kangawa K. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 2000; 276: 905-908.
7. Mönnikes H, Schmid BG, Tache Y. Psychological stress-induced accelerated colonic transit in rats involves hypothalamic corticotropin-releasing factor. Gastroenterology 1993; 104: 716-723.
8. Trudel L, Tomasetto C, Rio C, Bouin M, Plourde V, Eberling P, Poitras P. Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. Am J Physiol Gastrointest Liver Physiol 2002; 282: G948-G952.
9. Chen HY, Trumbauer ME, Chen AS, Weingarth DT, Adams JR, Frazier EG, Shen Z, Marsh DJ, Feighner SD, Guan XM, Ye Z, Nargund RP, Smith RG, Van der Ploeg LHT, Howard AD, Macneil DJ, Qian S. Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology 2004; 145: 2607-2612.
10. Guan JL, Wang QP, Kageyama H, Takenoya F, Kita T, Matsuoka T, Funahashi H, Shioda S. Synaptic interactions between ghrelin- and neuropeptide Y-containing neurons in the rat arcuate nucleus. Peptides 2003; 24: 1921-1928.
11. Kamegai J, Tamura H, Shimizu T, Ishii H, Sugihara H, Wakabayashi I. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and aguoti-related protein mRNA levels and body weight in rats. Diabetes 2001; 50: 2438-2443.
12. Seoane LM, Lopez M, Tovar S, Casanueva FF, Senaris R, Dieguez C. Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus. Endocrinology 2003; 144: 544-551.
13. Wang L, Saint P, Tache Y. Peripheral ghrelin selectively increases Fos expression in neuropeptide Y-synthesizing neurons in mouse hypothalamic arcuate nucleus. Neurosci Lett 2002; 325: 47-51.
14. Willesen MG, Kristensen P, Romer J. Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 1999; 70: 306-316.
15. Hewson AK, Tung LY, Connell DW, Tookman L, Dickson SL. The rat arcuate nucleus integrates peripheral signals provided by leptin, insulin and a ghrelin mimetic. Diabetes 2002; 51: 3412-3419.
16. Mönnikes H, Tebbe J, Bauer C, Grote C, Arnold R. Neuropeptide Y in the paraventricular nucleus of the hypothalamus stimulates colonic transit by peripheral cholinergic and central CRF pathways. Neurogastroenterol Mot 2000; 12: 343-352.
17. Tebbe JJ, Mronga S, Schäfer M-K-H, Rüter J, Kobelt P, Mönnikes H. Stimulation of neurons in rat ARC inhibits gastric acid secretion via hypothalamic CRF 1/2- and NPY-Y1 receptors. Am J Physiol Gastrointest Liver Physiol 2003; 285: G1075-G1083.
18. Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003; 37: 649-661.
19. Morris MJ, Pava JM. Stimulation of neuropeptide Y overflow in the rat paraventricular nucleus by corticotropin releasing factor. J Neurochem 1998; 71: 1519-1524.
20. Junien JL, Gue M. Interaction between neuropeptide Y and sigma ligands in the modulation of CRF and stress-induced alteration of gastrointestinal function. Ann NY Acad Sci 1993; 697: 244-253.
21. Shintani M, Ogawa Y, Ebihara K, Abe AM, Miyagawa F, Takaya K, Hayashi T, Inoue G, Hosoda K, Kojima M, Kangawa K, Nakao K. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 2001; 50: 227-232.
22. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. San Diego, CA: Academic Press, 1997.
23. Olszewski PK, Grace MK, Billington CJ, Levine AS. Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity. Peptides 2003; 24: 919-923.
24. Hewson AK, Dickson SL. Systemic administration of ghrelin induced Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats. J Neuroendocrinol 2000; 12: 1047-1049.
25. Bednarek MA, Feighner SD, Pong SS, McKee KK, Hreniuk DL, Silva MV, Warren VA, Howard AD, Van Der Ploeg LH, Heck JV. Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J Med Chem 2000; 43: 4370-4376.
26. Ida T, Nakahara K, Murakami T, Hanada R, Nakazato M, Murakami N. Possible involvement of orexin in the stress reaction in rats. Biochem Biophys Res Commun 2000; 270: 318-323.
27. Tache Y, Perdue MH. Role of peripheral CRF signalling pathways in stress-related alterations of gut motility and mucosal function. Neurogastroenterol Motil 2004; 16 (Suppl. 1): 137-142.
28. Ueta Y, Ozaki Y, Saito J, Onaka T. Involvement of novel feeding-related peptides in neuroendocrine response to stress. Exp Biol Med 2003; 228: 1168-1174.
29. Martinez V, Tache Y. Role of CRF receptor 1 in central CRF-induced stimulation of colonic propulsion in rats. Brain Res 2001; 893: 29-35.
30. Martinez V, Wang L, Rivier J, Grigoriadis D, Tache Y. Central CRF, urocortins and stress increase colonic transit via CRF1 receptors while activation of CRF2 receptors delays gastric transit in mice. J Physiol 2004; 556: 221-234.
31. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Fujimiya M, Katsuura G, Makino S, Fujino MA, Kasuga M. A role of ghrelin in neuroendocrine and behavioral responses to stress in mice. Neuroendocrinology 2001; 74: 143-147.
32. Ida T, Nakahara K, Kuroiwa T, Fukui K, Nakazato M, Murakami T, Murakami N. Both corticotropin releasing factor and neuro-peptide Y are involved in the effect of orexin (hyocretin) on the food intake in rats. Neurosci Lett 2000; 293: 119-122.
33. Jimenez M, Bueno L. Inhibitory effects of neuropeptide Y (NPY) on CRF and stress-induced cecal motor response in rats. Life Sci 1990; 47: 205-211.
34. Clark RG, Thomas GB, Mortensen DL, Won WB, Ma YH, Tomlinson EE, Fairhall KM, Robinson ICA. Growth hormone secretagogues stimulate the hypothalamic-pituitary-adrenal axis and are diabetogenic in the zucker diabetic fatty rat. Endocrinology 1997; 138: 4316-4323.
35. Tschop M, Flora DB, Mayer JP, Heiman ML. Hypophysectomy prevents ghrelin-induced adiposity and increases gastric ghrelin secretion in rats. Obes Res 2002; 10: 991-999.
36. Dass NB, Munonyara M, Bassil AK, Hervieu. GJ, Osbourne S, Corcoran S, Morgan M, Sanger GJ. Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin. Neuroscience 2003; 120: 443-453.