Expansion of CD27high plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation

Genes and Immunity

Volumn 14, Issue 5, 2013, Pages 291-301

  Ligocki, A J ^a   Rounds, W H ^a   Cameron, E M ^a   Harp, C T ^a   Frohman, E M ^a   Courtney, A M ^a   Vernino, S ^a   Cowell, L G ^b   Greenberg, B ^a   Monson, N L ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Antibody repertoire; Clinically isolated syndrome; Multiple sclerosis; Optic neuritis; Plasmablast; Transverse myelitis

Indexed keywords

CD27 ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; ARTICLE; CELL EXPANSION; CELL SELECTION; CELL SUBPOPULATION; CEREBROSPINAL FLUID; CLINICAL ARTICLE; COMPLEMENTARITY DETERMINING REGION; DISEASE DURATION; HUMAN; HUMAN CELL; MEMORY CELL; MYELITIS; PLASMA CELL; PLASMABLAST; PRIORITY JOURNAL; SOMATIC HYPERMUTATION; B LYMPHOCYTE; BLOOD; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; FLOW CYTOMETRY; GENE REARRANGEMENT; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; MIDDLE AGED; POLYMERASE CHAIN REACTION; YOUNG ADULT;

ADULT; ANTIGENS, CD27; B-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; FLOW CYTOMETRY; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MIDDLE AGED; MYELITIS, TRANSVERSE; PLASMA CELLS; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, B-CELL; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; YOUNG ADULT;

EID: 84880920241     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2013.18     Document Type: Article

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