Immune surveillance of the human central nervous system (CNS): Different migration pathways of immune cells through the blood-brain barrier and blood-cerebrospinal fluid barrier in healthy persons

Cytometry Part A

Volumn 69, Issue 3, 2006, Pages 147-151

  Kleine, Tilmann O ^a   Benes, Ludwig ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Blood brain barrier; Blood cerebrospinal fluid barrier; Human central nervous system; Immune surveillance; Migration pathways of immune cells

Indexed keywords

CELL ADHESION MOLECULE;

ARTICLE; B LYMPHOCYTE; BLOOD BRAIN BARRIER; BLOOD CEREBROSPINAL FLUID BARRIER; BRAIN BLOOD VESSEL; CELL INTERACTION; CELL MIGRATION; CENTRAL NERVOUS SYSTEM; CHOROID PLEXUS; CONTROLLED STUDY; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOSURVEILLANCE; LYMPHOCYTE TRANSFER; MEMORY CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TIGHT JUNCTION;

B-LYMPHOCYTES; BLOOD-BRAIN BARRIER; CELL ADHESION MOLECULES; CELL MOVEMENT; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CHOROID PLEXUS; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; HUMANS; IMMUNOLOGIC SURVEILLANCE; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 33645956179     PISSN: 15524922     EISSN: 15524930     Source Type: Journal    
DOI: 10.1002/cyto.a.20225     Document Type: Article

References (20)

1. Butcher EC. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 1991;67:1033-1036.
2. Hickey WF, Hsu BL, Kimura H. T-lymphocyte entry into the central nervous system. J Neurosci Res 1991;28:254-260.
3. Kleine TO, Albrecht J, Zöfel P. Flow cytometry of cerebrospinal fluid (CSF) lymphocytes: alterations of blood/CSF ratios of lymphocyte subsets in inflammation disorders of human central nervous system (CNS). Clin Chem Lab Med 1999;37:231-241.
4. Barclay AN, Brown MH, Law SKA, McKnight AJ, Tomlinson MG, van der Merwe PA. The Leukocyte Antigen Facts Book. San Diego: Academic Press; 1997.
5. 2 integrin LFA-1 involved in transendothelial migration of leukocytes. Nat Immunol 2002;3:151-158.
6. Navratil E, Couvelard A, Rey A, Hénin D, Scoazec JY. Expression of cell adhesion molecules by microvascular endothelial cells in the cortical and subcortical regions of the normal human brain: an immunohistochemical analysis. Neuropath appl Neurobiol 1997;23:68-80.
7. + T cell adhesion to endothelium. J Neuroimmunol 2003;134:166-178.
8. + T cells: evidence for trafficking through choroid plexus and meninges via P-selectin. PNAS 2003;100:8389-8394.
9. Svenningsson A, Andersen O, Edsbagge M, Stemme S. Lymphocyte phenotype and subset distribution in normal cerebrospinal fluid. J Neuroimmunol 1995;63:39-46.
10. Neumann H, Medana IM, Bauer J, Lassmann H. Cytotoxic T lymphocytes in autoimmune and degenerative CNS disease. Trends Neurosci 2002;25:313-319.
11. Wong D, Prameya R, Dorovini-Zis K. In vitro adhesion and migration of T lymphocytes across monolayers of human brain micro-vessel endothelial cells: regulation by ICAM-1, VCAM-1, E-selectin and PECAM-1. J Neuropathol Exp Neurol 1999;57:138-152.
12. Aurrand-Lions M, Johnson-Leger C, Lamagna C, Ozaki H, Kita T, Imhof BA. Junction adhesion molecules and interendothelial junctions. Cells Tissues Organs 2002;172:152-160.
13. Omari KIM, Dorovini-Zis K. Expression and function of lymphocyte function associated antigen-3 (LFA-3) at the blood-brain barrier. Cell Mol Biol 1999;45:25-35.
14. Vajkoczy P, Lachinger M, Engelhardt B. α4-integrin-VCAM-1 binding mediates G Protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. J Clin Invest 2001;108:557-565.
15. Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-κ B and cytokine-inducible enhancers. FASEB J 1995;9:899-909.
16. Steffen BJ, Breier G, Butcher EC, Schulz M, Engelhardt B. ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro. Am J Pathol 1996;148:1819-1838.
17. Wolburg K, Gerhardt H, Schulz M, Wolburg H, Engelhardt B. Ultrastructural localization of adhesion molecules in the healthy and inflamed choroid plexus of the mouse. Cell Tissue Res 1999;296:259-269.
18. Carrithers MD, Visintin I, Viret C, Janeway CA. Role of genetic background in P selectin-dependent immune surveillance of the central nervous system. J Neuroimmunol 2002;129:51-57.
19. Macintyre A, Hammond CJ, Little CS, Appelt DM, Balin BJ. Chlamydia pneumoniae infection alters the junctional complex proteins of human brain microvascular endothelial cells. FEMS Microbiol Lett 2002;217:167-172.
20. Kleine TO, Wakat JP. Blood/cerebrospinal fluid barrier to lymphocytes and subsets. In: Melo E, editor. XX World Congress of Pathology and Laboratory Medicine: IV Mercosul, XXXIII Brazilian, III Laboratory Management. Bologna: Monduzzi Editore SpA; 1999. p 95-100.