B cells undergo unique compartmentalized redistribution in multiple sclerosis

Journal of Autoimmunity

Volumn 37, Issue 4, 2011, Pages 289-299

  Haas, Jürgen ^a   Bekeredjian Ding, Isabelle ^a   Milkova, Miriam ^a   Balint, Bettina ^a   Schwarz, Alexander ^a   Korporal, Mirjam ^a   Jarius, Sven ^a   Fritz, Brigitte ^a   Lorenz, Hanns Martin ^a   Wildemann, Brigitte ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

B lymphocytes; Chemokines; Multiple sclerosis; Neuroimmunology

Indexed keywords

BETA INTERFERON; CXCL13 CHEMOKINE; GLATIRAMER; NATALIZUMAB;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MALE; MEMORY CELL; MULTIPLE SCLEROSIS; PHENOTYPE; PLASMA CELL; PRIORITY JOURNAL; REMISSION; RHEUMATOID ARTHRITIS;

ADOLESCENT; ADULT; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIBODY SPECIFICITY; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; CELL MOVEMENT; CHEMOKINE CXCL13; DISEASE PROGRESSION; HOMEOSTASIS; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INTERFERON-BETA; MIDDLE AGED; MULTIPLE SCLEROSIS; TRACHEA;

EID: 82955186310     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2011.08.003     Document Type: Article

References (43)

1. Lucchinetti C.F., Brueck W., Parisi J., Scheithauer B., Rodriguez M., Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of multiple sclerosis. Ann Neurol 2000, 47:707-717.
2. Serafini B., Rosicarelli B., Magliozzi R., Stigliano E., Aloisi F. Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol 2004, 14:164-174.
3. Cepok S., Zhou D., Vogel F., Rosche B., Grummel V., Sommer N., et al. The immune response at onset and during recovery from Borrelia burgdorferi meningoradiculitis. Arch Neurol 2003, 60:849-855.
4. Cepok S., Rosche B., Grummel V., Vogel F., Zhou D., Sayn J., et al. Short-lived plasma blasts are the main B-cell effector subset during the course of multiple sclerosis. Brain 2005, 128:1667-1676.
5. Cepok S., von Geldern G., Grummel V., Hochgesand S., Celik H., Hartung H., et al. Accumulation of class switched IgD-IgM - memory B-cells in the cerebrospinal fluid during neuroinflammation. J Neuroimmunol 2006, 180:33-39.
6. Krumbholz M., Theil D., Cepok S., Hemmer B., Kivisäkk P., Ransohoff R.M., et al. Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Brain 2006, 129:200-211.
7. Kuenz B., Lutterotti A., Ehling R., Gneiss C., Haemmerle M., Rainer C., et al. Cerebrospinal fluid B-cells correlate with early brain inflammation in multiple sclerosis. PLoS One 2008, 3:e2559.
8. Sellebjerg F., Boernsen L., Khademi M., Krakauer M., Olsson T., Frederiksen J.L., et al. Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS. Neurology 2009, 73:2003-2010.
9. Mahler M., Raijmakers R., Fritzler M. Challenges and controversies in autoantibodies associated with systemic rheumatic diseases. Curr Rheumatol Rev 2007, 3:67-78.
10. Klein U., Rajewsky K., Kuppers R. Human immunoglobulin (Ig) M+IgD+ peripheral blood B-cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B-cells. J Exp Med 1998, 188:1679-1689.
11. Caraux A., Klein B., Paiva B., Bret C., Schmitz A., Fuhler G.M., et al. Circulating human B and plasma cells. Age-associated changes in counts and detailed characterization of circulating normal CD138- and CD138+ plasma cells. Haematologica 2010, 95:1016-1020.
12. Polman C.H., Reingold S.C., Edan G., Filippi M., Hartung H.P., Kappos L., et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria" Ann Neurol 2005, 58:840-846.
13. Ransohoff R.M., Kivisäkk P., Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat Rev Immunol 2003, 7:569-581.
14. Baranzini S.E., Jeong M.C., Butunoi C., Murray R.S., Bernard C.C., Oksenberg J.R. B-cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions. J Immunol 1999, 163:5133-5144.
15. Duddy M., Niino M., Adatia F., Hebert S., Freedman M., Atkins H., et al. Distinct effector cytokine profiles of memory and naive human B-cell subsets and implication in multiple sclerosis. J Immunol 2007, 178:6092-6099.
16. Corcione A., Casazza S., Ferretti E., Giunti D., Zappia E., Pistorio A., et al. Recapitulation of B-cell differentiation in the central nervous system of patients with multiple sclerosis. Proc Natl Acad Sci U S A 2004, 101:11064-11069.
17. Hafler D.A., Weiner H.L. In vivo labeling of blood T cells: rapid traffic into cerebrospinal fluid in multiple sclerosis. Ann Neurol 1987, 22:89-93.
18. Man S., Ubogu E.E., Ransohoff R.M. Inflammatory cell migration into the central nervous system: a few new twists on an old tale. Brain Pathol 2007, 17:243-250. [Review].
19. Kivisäkk P., Mahad D.J., Callahan M.K., Trebst C., Tucky B., Wei T., et al. Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin. Proc Natl Acad Sci U S A 2003, 100:8389-8394.
20. Reboldi A., Coisne C., Baumjohann D., Benvenuto F., Bottinelli D., Lira S., et al. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol 2009, 10:514-523.
21. Llinàs L., Lázaro A., de Salort J., Matesanz-Isabel J., Sintes J., Engel P. Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry. Immunol Lett 2011, 134:113-121.
22. Vachino G., Chang X.J., Veldman G.M., Kumar R., Sako D., Fouser L.A., et al. P-selectin glycoprotein ligand-1 is the major counter-receptor for P-selectin on stimulated T cells and is widely distributed in non-functional form on many lymphocytic cells. J Biol Chem 1995, 270:21966-21974.
23. Alter A., Duddy M., Hebert S., Biernacki K., Prat A., Antel J.P., et al. Determinants of human B cell migration across brain endothelial cells. J Immunol 2003, 170:4497-4505.
24. Stüve O., Marra C.M., Jerome K.R., Cook L., Cravens P.D., Cepok S., et al. Immune surveillance in multiple sclerosis patients treated with natalizumab. Ann Neurol 2006, 59:743-747.
25. Rupprecht T.A., Plate A., Adam M., Wick M., Kastenbauer S., Schmidt C., et al. The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis. J Neuroinflammation 2009, 6:42.
26. Bekeredjian-Ding I., Wagner M., Hornung V., Giese T., Schnurr M., Endres S., et al. Plasmacytoid dendritic cells control TLR7 sensitivity of naive B-cells via type I IFN. J Immunol 2005, 174:4043-4050.
27. Bekeredjian-Ding I., Jego G. Toll-like receptors-sentries in the B-cell response. Immunology 2009, 128:311-323.
28. Choe J., Choi Y.S. IL-10 interrupts memory B-cell expansion in the germinal center by inducing differentiation into plasma cells. Eur J Immunol 1998, 28:508-515.
29. Martins G., Calame K. Regulation and functions of Blimp-1 in T and B-lymphocytes. Annu Rev Immunol 2008, 26:133-169.
30. Bar-Or A., Fawaz L., Fan B., Darlington P.J., Rieger A., Ghorayeb C., et al. Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?. Ann Neurol 2010, 67:452-461.
31. Hirotani M., Niino M., Fukazawa T., Kikuchi S., Yabe I., Hamada S., et al. Decreased IL-10 production mediated by Toll-like receptor 9 in B-cells in multiple sclerosis. J Neuroimmunol 2010, 221:95-100.
32. Iwata Y., Matsushita T., Horikawa M., Dilillo D.J., Yanaba K., Venturi G.M., et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 2011, 117:530-541.
33. Hansen A., Odendahl M., Reiter K., Jacobi A.M., Feist E., Scholze J., et al. Diminished peripheral blood memory B-cells and accumulation of memory B-cells in the salivary glands of patients with Sjögren's syndrome. Arthritis Rheum 2002, 46:2160-2171.
34. Silverman G.J., Carson D.A. Roles of B-cells in rheumatoid arthritis. Arthritis Res Ther 2003, 5(Suppl 4):S1-S6.
35. Bombardieri M., Barone F., Humby F., Kelly S., McGurk M., Morgan P., et al. Activation induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B-cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjögren's syndrome. J Immunol 2007, 179:4929-4938.
36. Youinou P.Y., Morrow J.W., Lettin A.W., Lydyard P.M., Roitt I.M. Specificity of plasma cells in the rheumatoid synovium. I. Immunoglobulin class of antiglobulin-producing cells. Scand J Immunol 1984, 20:307-315.
37. Fehr K., Velvart M., Rauber M., Knöpfel M., Baici A., Salgam P., et al. Production of agglutinators and rheumatoid factors in plasma cells of rheumatoid and nonrheumatoid synovial tissues. Arthritis Rheum 1981, 24:510-519.
38. Wei C., Anolik J., Cappione A., Zheng B., Pugh-Bernard A., Brooks J., et al. A new population of cells lacking expression of CD27 represents a notable component of the B-cell memory compartment in systemic lupus erythematosus. J Immunol 2007, 178:6624-6633.
39. Ramgolam V.S., Sha Y., Marcus K.L., Choudhary N., Troiani L., Chopra M., et al. B-cells as a therapeutic target for IFN-β in relapsing-remitting multiple sclerosis. J Immunol 2011, 186:4518-4526.
40. Genç K., Dona D.L., Reder A.T. Increased CD80(+) B-cells in active multiple sclerosis and reversal by interferon beta-1b therapy. J Clin Invest 2006, 99:2664-2671.
41. Sørensen T.L., Roed H., Sellebjerg F. Chemokine receptor expression on B-cells and effect of interferon-beta in multiple sclerosis. J Neuroimmunol 2002, 122:125-131.
42. Krumbholz M., Meinl I., Kuempfel T., Hohlfeld R., Meinl E. Natalizumab disproportionately increases circulating pre-B and B-cells in multiple sclerosis. Neurology 2008, 71:1350-1354.
43. Zohren F., Toutzaris D., Klaerner V., Hartung H.P., Kieseier B., Haas R. The monoclonal anti-VLA-4 antibody natalizumab mobilizes CD34+ hematopoietic progenitor cells in humans. Blood 2008, 111:3893-3895.