Alternative mechanisms of receptor editing in autoreactive B cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 17, 2011, Pages 7125-7130

  Kalinina, Olga ^a   Doyle Cooper, Colleen M ^a   Miksanek, Jennifer ^a   Meng, Wenzhao ^b   Prak, Eline Luning ^b   Weigert, Martin G ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Autoimmunity; Tolerance

Indexed keywords

ARGININE; ASPARTIC ACID; DNA ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; PHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; BINDING SITE; CODON; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DNA BINDING; DNA FOOTPRINTING; ELECTRIC POTENTIAL; FEMALE; GENE FREQUENCY; GENE LOCUS; GENE REARRANGEMENT; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN MODIFICATION; RECEPTOR EDITING; REGULATORY MECHANISM; SEQUENCE ANALYSIS; SYSTEMIC LUPUS ERYTHEMATOSUS; TRANSGENIC MOUSE; UNINDEXED SEQUENCE;

ANIMALS; ANTIBODIES, ANTINUCLEAR; AUTOIMMUNITY; B-LYMPHOCYTES; BASE SEQUENCE; COMPLEMENTARITY DETERMINING REGIONS; GENE REARRANGEMENT, B-LYMPHOCYTE; GENETIC LOCI; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, B-CELL;

MUS;

EID: 79955554746     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1019389108     Document Type: Article

References (60)

1. Radic MZ, et al. (1993) Residues that mediate DNA binding of autoimmune antibodies. J Immunol 150:4966-4977. (Pubitemid 23150364)
2. ShlomchikM, et al. (1990) Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J Exp Med 171:265-292.
3. Radic MZ, et al. (1989) Structural patterns in anti-DNA antibodies from MRL/lpr mice. Cold Spring Harb Symp Quant Biol 54:933-946. (Pubitemid 20190215)
4. Li H, Jiang Y, Prak EL, Radic M, Weigert M (2001) Editors and editing of anti-DNA receptors. Immunity 15:947-957. (Pubitemid 34075375)
5. Ibrahim SM, Weigert M, Basu C, Erikson J, Radic MZ (1995) Light chain contribution to specificity in anti-DNA antibodies. J Immunol 155:3223-3233.
6. Radic MZ, Ibrahim SM, Rauch J, Camper SA, Weigert M (1995) Constitutive secretion of transgene-encoded IgG2b autoantibodies leads to symptoms of autoimmune disease. J Immunol 155:3213-3222.
7. Gay D, Saunders T, Camper S, Weigert M (1993) Receptor editing: an approach by autoreactive B cells to escape tolerance. J Exp Med 177:999-1008. (Pubitemid 23097389)
8. Brekke KM, Garrard WT (2004) Assembly and analysis of the mouse immunoglobulin kappa gene sequence. Immunogenetics 56:490-505. (Pubitemid 39517831)
9. Tiegs SL, Russell DM, Nemazee D (1993) Receptor editing in self-reactive bone marrow B cells. J Exp Med 177:1009-1020. (Pubitemid 23097390)
10. Pelanda R, et al. (1997) Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification. Immunity 7:765-775. (Pubitemid 28064890)
11. Chen J, et al. (1993) B cell development in mice that lack one or both immunoglobulin kappa light chain genes. EMBO J 12:821-830. (Pubitemid 23095830)
12. Sanchez P, Marche PN, Le Guern C, Cazenave PA (1987) Structure of a third murine immunoglobulin lambda light chain variable region that is expressed in laboratory mice. Proc Natl Acad Sci USA 84:9185-9188. (Pubitemid 18055338)
13. Doyle CM, Han J, Weigert MG, Prak ET (2006) Consequences of receptor editing at the lambda locus: multireactivity and light chain secretion. Proc Natl Acad Sci USA 103: 11264-11269. (Pubitemid 44156507)
14. Radic MZ, Mascelli MA, Erikson J, Shan H, Weigert M (1991) Ig H and L chain contributions to autoimmune specificities. J Immunol 146:176-182.
15. Viale AC, Coutinho A, Freitas AA (1992) Differential expression of VH gene families in peripheral B cell repertoires of newborn or adult immunoglobulin H chain congenic mice. J Exp Med 175:1449-1456.
16. Levine MH, et al. (2000) A B-cell receptor-specific selection step governs immature to mature B cell differentiation. Proc Natl Acad Sci USA 97:2743-2748. (Pubitemid 30159242)
17. Hachemi-Rachedi S, Cumano A, Drapier AM, Cazenave PA, Sanchez P (1997) Does positive selection determine the B cell repertoire? Eur J Immunol 27:1069-1074.
18. Hachemi-Rachedi S, Drapier AM, Cazenave PA, Sanchez P (2000) Affiliation to mature B cell repertoire and positive selection can be separated in two distinct processes. Int Immunol 12:385-395. (Pubitemid 30142710)
19. Decker DJ, Kline GH, Hayden TA, Zaharevitz SN, Klinman NR (1995) Heavy chain V gene-specific elimination of B cells during the pre-B cell to B cell transition. J Immunol 154:4924-4935.
20. Bloom DD, et al. (1993) V region gene analysis of anti-Sm hybridomas from MRL/Mplpr/ lpr mice. J Immunol 150:1591-1610. (Pubitemid 23127450)
21. Feeney AJ (1990) Lack of N regions in fetal and neonatal mouse immunoglobulin V-DJ junctional sequences. J Exp Med 172:1377-1390.
22. Chang Y, Paige CJ, Wu GE (1992) Enumeration and characterization of DJH structures in mouse fetal liver. EMBO J 11:1891-1899.
23. Reth MG, Alt FW (1984) Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells. Nature 312:418-423. (Pubitemid 15217834)
24. Louzoun Y, Luning Prak E, Litwin S, Weigert M (2002) D is for different-differences between H and L chain rearrangement. Semin Immunol 14:239-241.
25. Durdik J, Moore MW, Selsing E (1984) Novel kappa light-chain gene rearrangements in mouse lambda light chain-producing B lymphocytes. Nature 307:749-752. (Pubitemid 14133949)
26. Moore MW, Durdik J, Persiani DM, Selsing E (1985) Deletions of kappa chain constant region genes in mouse lambda chain-producing B cells involve intrachromosomal DNA recombinations similar to V-J joining. Proc Natl Acad Sci USA 82:6211-6215. (Pubitemid 16223928)
27. Radic MZ, Erikson J, Litwin S, Weigert M (1993) B lymphocytes may escape tolerance by revising their antigen receptors. J Exp Med 177:1165-1173. (Pubitemid 23097405)
28. Huang H, Kearney JF, Grusby MJ, Benoist C, Mathis D (2006) Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen. Proc Natl Acad Sci USA 103:3734-3739. (Pubitemid 43376624)
29. Li Y, Li H, Weigert M (2002) Autoreactive B cells in the marginal zone that express dual receptors. J Exp Med 195:181-188. (Pubitemid 34461262)
30. Kleinfield R, et al. (1986) Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma. Nature 322:843-846. (Pubitemid 16055258)
31. Kleinfield RW, Weigert MG (1989) Analysis of VH gene replacement events in a B cell lymphoma. J Immunol 142:4475-4482. (Pubitemid 19162342)
32. Reth M, Gehrmann P, Petrac E, Wiese P (1986) A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production. Nature 322:840-842. (Pubitemid 16055257)
33. Wilson PC, et al. (2000) Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes. J Exp Med 191:1881-1894. (Pubitemid 30390351)
34. Chen C, Nagy Z, Prak EL, Weigert M (1995) Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity 3:747-755. (Pubitemid 26091148)
35. Pewzner-Jung Y, et al. (1998) B cell deletion, anergy, and receptor editing in "knock in" mice targeted with a germline-encoded or somatically mutated anti-DNA heavy chain. J Immunol 161:4634-4645. (Pubitemid 28492037)
36. Zhang Z, et al. (2003) Contribution of Vh gene replacement to the primary B cell repertoire. Immunity 19:21-31. (Pubitemid 36859898)
37. Koralov SB, Novobrantseva TI, Königsmann J, Ehlich A, Rajewsky K (2006) Antibody repertoires generated by VH replacement and direct VH to JH joining. Immunity 25: 43-53. (Pubitemid 44066831)
38. Collins AM, et al. (2004) Partitioning of rearranged Ig genes by mutation analysis demonstrates D-D fusion and V gene replacement in the expressed human repertoire. J Immunol 172:340-348. (Pubitemid 38020488)
39. Ohm-Laursen L, Nielsen M, Larsen SR, Barington T (2006) No evidence for the use of DIR, D-D fusions, chromosome 15 open reading frames or VH replacement in the peripheral repertoire was found on application of an improved algorithm, JointML, to 6329 human immunoglobulin H rearrangements. Immunology 119:265-277. (Pubitemid 44401645)
40. Ait-Azzouzene D, et al. (2005) An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system. J Exp Med 201:817-828. (Pubitemid 40395125)
41. Velez MG, et al. (2007) Ig allotypic inclusion does not prevent B cell development or response. J Immunol 179:1049-1057.
42. Casellas R, et al. (2007) Igkappa allelic inclusion is a consequence of receptor editing. J Exp Med 204:153-160. (Pubitemid 46148765)
43. Liu S, et al. (2005) Receptor editing can lead to allelic inclusion and development of B cells that retain antibodies reacting with high avidity autoantigens. J Immunol 175: 5067-5076. (Pubitemid 41456390)
44. Covey LR, Ferrier P, Alt FW (1990) VH to VHDJH rearrangement is mediated by the internal VH heptamer. Int Immunol 2:579-583. (Pubitemid 20218436)
45. Taki S, Schwenk F, Rajewsky K (1995) Rearrangement of upstream DH and VH genes to a rearranged immunoglobulin variable region gene inserted into the DQ52-JH region of the immunoglobulin heavy chain locus. Eur J Immunol 25:1888-1896.
46. Koti M, Kataeva G, Kaushik AK (2010) Novel atypical nucleotide insertions specifically at VH-DH junction generate exceptionally long CDR3H in cattle antibodies. Mol Immunol 47:2119-2128.
47. Davila M, et al. (2007) Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells. J ExpMed 204:3195-3208.
48. Yunk L, Meng W, Cohen PL, Eisenberg RA, Luning Prak ET (2009) Antibodies in a heavy chain knock-in mouse exhibit characteristics of early heavy chain rearrangement. J Immunol 183:452-461.
49. Nakajima PB, Kiefer K, Price A, Bosma GC, Bosma MJ (2009) Two distinct populations of H chain-edited B cells show differential surrogate L chain dependence. J Immunol 182:3583-3596.
50. Lutz J, Müller W, Jäck HM (2006) VH replacement rescues progenitor B cells with two nonproductive VDJ alleles. J Immunol 177:7007-7014. (Pubitemid 44715067)
51. Liu Y, Li L, Mohan C (2008) The role of rearrangement at the second Ig heavy chain locus in maintaining B cell tolerance to DNA. J Immunol 180:7721-7727.
52. Prak EL, Weigert M (1995) Light chain replacement: a new model for antibody gene rearrangement. J Exp Med 182:541-548.
53. Li Y, Louzoun Y, Weigert M (2004) Editing anti-DNA B cells by Vlambdax. J Exp Med 199:337-346.
54. Witsch EJ, Cao H, Fukuyama H, Weigert M (2006) Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction. J Exp Med 203:1761-1772. (Pubitemid 44036281)
55. Weiss S, Lehmann K, Cohn M (1983) Monoclonal antibodies to murine immunoglobulin isotypes. Hybridoma 2:49-54. (Pubitemid 13085606)
56. Kim JY, Kurtz B, Huszar D, Storb U (1994) Crossing the SJL lambda locus into kappaknockout mice reveals a dysfunction of the lambda 1-containing immunoglobulin receptor in B cell differentiation. EMBO J 13:827-834.
57. Sanchez P, Nadel B, Cazenave PA (1991) V lambda-J lambda rearrangements are restricted within a V-J-C recombination unit in the mouse. Eur J Immunol 21:907-911.
58. Wardemann H, et al. (2003) Predominant autoantibody production by early human B cell precursors. Science 301:1374-1377. (Pubitemid 37075812)
59. Kabat EA, Wu TT, Perry HM, Gottesman KS, Foeller C (1991) Sequences of Proteins of Immunological Interest (5th ed. Natl Inst Health, Bethesda), DHHS Publ No (NIH) 91-3242.
60. Prak EL, Trounstine M, Huszar D, Weigert M (1994) Light chain editing in kappadeficient animals: a potential mechanism of B cell tolerance. J ExpMed 180:1805-1815. (Pubitemid 24328571)