Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus

Journal of Immunology

Volumn 165, Issue 10, 2000, Pages 5970-5979

  Odendahl, M ^a   Jacobi, A ^a   Hansen, A ^a   Feist, E ^a   Hiepe, F ^a   Burmester, G R ^a   Lipsky, P E ^a   Radbruch, A ^a   Dorner, T ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD20 ANTIGEN; CD27 ANTIGEN; CD38 ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE MEMBRANE IMMUNOGLOBULIN; SYNDECAN 1; UNCLASSIFIED DRUG;

ADULT; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTOPENIA; MALE; MEMORY CELL; PERIPHERAL LYMPHOCYTE; PLASMA CELL; PRIORITY JOURNAL; SOMATIC MUTATION; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0034669990     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.10.5970     Document Type: Article

References (54)

1. Autoantibodies and autoimmunity: A three-decade perspective: A tribute to Henry G. Kunkel
2. The central and multiple roles of B cells in lupus pathogenesis
3. Abnormalities in B cell activity and the immunoglobulin repertoire in human systemic lupus erythematosus
4. B-cell epitope spreading in autoimmunity
5. It's not the same old lupus or Sjogren's any more: One hundred new insights, approaches, and options since 1990
6. Circulating and pokeweed mitogen-induced immunoglobulin-secreting cells in systemic lupus erythematosus
7. Immunopathogenesis of SLE
8. Anti-dsDNA production coincides with concurrent B and T cell activation during development of active disease in systemic lupus (SLE)
9. B cell activation in clinically quiescent systemic lupus erythematosus (SLE) is related to immunoglobulin levels, but not to levels of anti -dsDNA, nor to concurrent T cell activation
10. Spontaneous immunoglobulin-producing capacity of cultures from lupus patients and normal donors following depletion of cells expressing CD19 or CD38
11. Precursor frequencies for DNA-specific B lymphocytes in patients with systemic lupus erythematosus (SLE)
12. Maturation and dispersal of B-cell clones during T cell-dependent antibody responses
13. Immunosenescence and germinal center reaction
14. Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development
15. Regulation of B-cell commitment to plasma cells or to memory B cells
16. Germinal center development
17. Evolutionary and somatic selection of the antibody repertoire in the mouse
18. Burnet's unhappy hybrid
19. The changing preference of T and B cells for partners as T-dependent antibody responses develop
20. Analysis of somatic mutation in five B cell subsets of human tonsil
21. + B cells, the major B cell subset in the peripheral blood, express Vκ genes with no or little somatic mutation throughout life
22. Memory B lymphocytes migrate to bone marrow in humans
23. Evidence for a large compartment of IgM-expressing memory B cells in humans
24. + B cells
25. + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory.) B cells
26. Cellular origin of human B-cell lymphomas
27. The 1982 revised criteria for the classification of systemic lupus erythematosus
28. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction
29. Analysis of the frequency and pattern of somatic mutations within non-productively rearranged human V(H) genes
30. Human naive B cells cultured with EL-4 T cells mimic a germinal center-relined B cell stage before generating plasma cells: Concordant in Bcl-2 protein and messenger RNA levels
31. + tonsillar plasma cells are rescued from apoptosis by bone marrow fibroblasts
32. Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus
33. CD27/CD70 interaction augments IgE secretion by promoting the differentiation of memory B cells into plasma cells
34. Generation of plasma cells from peripheral blood memory B cells: Synergistic effect of interleukin-10 and CD27/CD70 interaction
35. + B cells and helper T cells in immunoglobulin production
36. Identification of functional human splenic memory B cells by expression of CD148 and CD27
37. Plasma cell development in synovial germinal centers in patients with rheumatoid and reactive arthritis
38. Evidence for a selected humoral immune response encoded by VH4 family genes in the synovial membrane of a patient with RA
39. The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells
40. Sequence analysis of V(4-34)-encoded antibodies from single B cells of two patients with systemic lupus erythematosus (SLE)
41. VH4-34 encoded antibodies in systemic lupus erythematosus: A specific diagnostic marker that correlates with clinical disease characteristics
42. Correlation of 9G4 idiotope with disease activity in patients with systemic lupus erythematosus
43. Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment
44. VH4.21-encoded natural autoantibodies with anti-i specificity mirror those associated with cold hemagglutinin disease
45. Identification of normal B-cell counterparts of neoplastic cells which secrete cold agglutinins of anti-I and anti-i specificity
46. Autoanti-red cell antibodies synthesized by patients with infectious mononucleosis utilize the VH4-21 gene segment
47. Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire
48. Utilization of the VH4-21 gene segment by anti-DNA antibodies from patients with systemic lupus erythematosus
49. Identification of early plasma cells in peripheral blood and their clinical significance
50. Enforced CD19 expression leads to growth inhibition and reduced tumorigenicity
51. Normal and clonal B lineage cells can be distinguished by their differential expression of B cell antigens and adhesion molecules in peripheral blood from multiple myeloma (MM) patients: Diagnostic and clinical implications
52. - B cells of patients with systemic lupus erythematosus
53. Human in vivo-induced spontaneous IgG-secreting cells from tonsil, blood and bone marrow exhibit different phenotype and functional of maturation
54. Combined immunomagnetic cell sorting and ELISPOT assay for the phenotypic characterization of specific antibody-forming cells