Axonal and oligodendrocyte-localized IgM and IgG deposits in MS lesions

Journal of Neuroimmunology

Volumn 247, Issue 1-2, 2012, Pages 86-94

  Sádaba, María C ^a,d   Tzartos, John ^a   Paíno, Carlos ^c   García Villanueva, Mercedes ^c   Álvarez Cermeño, José C ^c   Villar, Luisa M ^c   Esiri, Margaret M ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

^d UNIVERSIDAD SAN PABLO CEU   (Spain)

Author keywords

Antibodies; Complement; Multiple sclerosis

Indexed keywords

COMPLEMENT COMPONENT C3B; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ADULT; AGED; ARTICLE; BRAIN TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MULTIPLE SCLEROSIS; NERVE FIBER; OLIGODENDROGLIA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; SPINAL CORD;

ADULT; AGED; AGED, 80 AND OVER; AXONS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CEREBELLUM; COMPLEMENT C3B; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MACROPHAGES; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; NERVE TISSUE PROTEINS; OLIGODENDROGLIA; PHOSPHOPYRUVATE HYDRATASE; TRANSCRIPTION FACTORS;

EID: 84860840104     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2012.03.020     Document Type: Article

References (38)

1. Andersson M., Álvarez-Cermeño J., Bernardi G., Cogato I., Fredman P., Frederiksen J., Fredrikson S., Gallo P., Grimaldi L.M., Gronning M., Keir G, Lamers K., Link H., Magahaes A., Massaro A.R., Ohman S., Reiber H., Ronnback L., Schluep M., Schuller E., Sindic C.J.M., Thompson E.J., Trojano M., Wurster U. Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report. J. Neurol. Neurosurg. Psychiatry 1994, 57:897-902.
2. Barnett M.H., Parratt J.D., Cho E.S., Prineas J.W. Immunoglobulins and complement in postmortem multiple sclerosis tissue. Ann. Neurol. 2009, 65:32-46.
3. Bitsch A., Schuchardt J., Bunkowski S., Kuhlmann T., Bruck W. Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation. Brain 2000, 123(Pt 6):1174-1183.
4. Breij E.C., Brink B.P., Veerhuis R., van den Berg C., Vloet R., Yan R., Dijkstra C.D., van der Valk P., Bö L. Homogeneity of active demyelinating lesions in established multiple sclerosis. Ann. Neurol. 2008, 63:16-25.
5. Codarri L., Fontana A., Becher B. Cytokine networks in multiple sclerosis: lost in translation. Curr. Opin. Neurol. 2010, 23:205-211.
6. Corcione A., Casazza S., Ferretti E., Giunti D., Zappia E., Pistorio A., Gambini C., Mancardi G.L., Uccelli A., Pistoia V. Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:11064-11069.
7. DeVries G.H., Zetusky W.J., Zmachinski C., Calabrese V.P. Lipid composition of axolemma-enriched fractions from human brains. J. Lipid Res. 1981, 22:208-216.
8. Esiri M.M. Immunoglobulin-containing cells in multiple-sclerosis plaques. Lancet 1977, 2:478.
9. Ferguson B., Matyszak M.K., Esiri M.M., Perry V.H. Axonal damage in acute multiple sclerosis lesions. Brain 1997, 120(Pt 3):393-399.
10. Frequin S.T., Barkhof F., Lamers K.J., Hommes O.R., Borm G.F. CSF myelin basic protein, IgG and IgM levels in 101 MS patients before and after treatment with high-dose intravenous methylprednisolone. Acta Neurol. Scand. 1992, 86:291-297.
11. Gay F.W., Drye T.J., Dick G.W., Esiri M.M. The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Identification and characterization of the primary demyelinating lesion. Brain 1997, 120(Pt 8):1461-1483.
12. Kannagi R., Stroup R., Cochran N.A., Urdal D.L., Young W.W., Hakomori S. Factors affecting expression of glycolipid tumor antigens: influence of ceramide composition and coexisting glycolipid on the antigenicity of gangliotriaosylceramide in murine lymphoma cells. Cancer Res. 1983, 43:4997-5005.
13. Kim S.H., Kook M.C., Shin Y.K., Park S.H., Song H.G. Evaluation of antigen retrieval buffer systems. J. Mol. Histol. 2004, 35:409-416.
14. Lucchinetti C.F., Brück W., Rodriguez M., Lassmann H. Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis. Brain Pathol. 1996, 6:259-274.
15. Lucchinetti C., Brück W., Parisi J., Scheithauer B., Rodriguez M., Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann. Neurol. 2000, 47:707-717.
16. Magliozzi R., Howell O., Vora A., Serafini B., Nicholas R., Puopolo M., Reynolds R., Aloisi F. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 2007, 130:1089-1104.
17. McDonald W.I., Compston A., Edan G., Goodkin D., Hartung H.P., Lublin F.D., McFarland H.F., Paty D.W., Polman C.H., Reingold S.C., Sandberg-Wollheim M., Sibley W., Thompson A., van den Noort S., Weinshenker B.Y., Wolinsky J.S. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Ann. Neurol. 2001, 50:121-127.
18. McFarland H.F., Martin R. Multiple sclerosis: a complicated picture of autoimmunity. Nat. Immunol. 2007, 8:913-919.
19. Mead R.J., Singhrao S.K., Neal J.W., Lassmann H., Morgan B.P. The membrane attack complex of complement causes severe demyelination associated with acute axonal injury. J. Immunol. 2002, 168:458-465.
20. Noseworthy J.H., Lucchinetti C., Rodriguez M., Weinshenker B.G. Multiple sclerosis. N. Engl. J. Med. 2000, 343:938-952.
21. Pender M.P. The pathogenesis of primary progressive multiple sclerosis: antibody-mediated attack and no repair?. J. Clin. Neurosci. 2004, 11:689-692.
22. Prineas J.W., Graham J.S. Multiple sclerosis: capping of surface immunoglobulin G on macrophages engaged in myelin breakdown. Ann. Neurol. 1981, 10:149-158.
23. Sabattini E., Bisgaard K., Ascani S., Poggi S., Piccioli M., Ceccarelli C., Pieri F., Fraternali-Orcioni G., Pileri S.A. The EnVision++ system: a new immunohistochemical method for diagnostics and research. Critical comparison with the APAAP, ChemMate, CSA, LABC, and SABC techniques. J. Clin. Pathol. 1998, 51:506-511.
24. Sádaba M.C., Gonzalez-Porque P., Masjuan J., Álvarez-Cermeño J.C., Bootello A., Villar L.M. An ultrasensitive method for the detection of oligoclonal IgG bands. J. Immunol. Methods 2004, 284:141-145.
25. Sellebjerg F., Christiansen M., Garred P. MBP, anti-MBP and anti-PLP antibodies, and intrathecal complement activation in multiple sclerosis. Mult. Scler. 1998, 4:127-131.
26. Sola P., Mandrioli J., Simone A.M., Ferraro D., Bedin R., Annecca R., Venneri M.G., Nichelli P.F., Merelli E. Primary progressive versus relapsing-onset multiple sclerosis: presence and prognostic value of cerebrospinal fluid oligoclonal IgM. Mult. Scler. 2011, 17:303-311.
27. Steinman L. Multiple sclerosis: a two-stage disease. Nat. Immunol. 2001, 2:762-764.
28. Storch M.K., Piddlesden S., Haltia M., Iivanainen M., Morgan P., Lassmann H. Multiple sclerosis: in situ evidence for antibody- and complement-mediated demyelination. Ann. Neurol. 1998, 43:465-471.
29. Thangarajh M., Gomez-Rial J., Hedstrom A.K., Hillert J., Álvarez-Cermeño J.C., Masterman T., Villar L.M. Lipid-specific immunoglobulin M in CSF predicts adverse long-term outcome in multiple sclerosis. Mult. Scler. 2008, 14:1208-1213.
30. Trapp B.D., Nave K.A. Multiple sclerosis: an immune or neurodegenerative disorder?. Annu. Rev. Neurosci. 2008, 31:247-269.
31. Trapp B.D., Peterson J., Ransohoff R.M., Rudick R., Mörk S., Bö Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med. 1998, 338:278-285.
32. Tzartos J.S., Friese M.A., Craner M.J., Palace J., Newcombe J., Esiri M.M., Fugger L. Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am. J. Pathol. 2008, 172:146-155.
33. Villar L.M., Masjuan J., Sádaba M.C., Gonzalez-Porque P., Plaza J., Bootello A., Álvarez-Cermeño J.C. Early differential diagnosis of multiple sclerosis using a new oligoclonal band test. Arch. Neurol. 2005, 62:574-577.
34. Villar L.M., Sádaba M.C., Roldan E., Masjuan J., Gonzalez-Porque P., Villarrubia N., Espiño M., Garcia-Trujillo J.A., Bootello A., Álvarez-Cermeño J.C. Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS. J. Clin. Invest. 2005, 115:187-194.
35. Villar L., Garcia-Barragan N., Espiño M., Roldan E., Sádaba M., Gomez-Rial J., Gonzalez-Porque P., Álvarez-Cermeño J. Influence of oligoclonal IgM specificity in multiple sclerosis disease course. Mult. Scler. 2008, 14:183-187.
36. Villar L.M., Masterman T., Casanova B., Gomez-Rial J., Espiño M., Sádaba M.C., Gonzalez-Porque P., Coret F., Álvarez-Cermeño J.C. CSF oligoclonal band patterns reveal disease heterogeneity in multiple sclerosis. J. Neuroimmunol. 2009, 211:101-104.
37. Walsh M.J., Tourtellotte W.W. Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA, and IgM in multiple sclerosis. J. Exp. Med. 1986, 163:41-53.
38. Zhang Y., Da R.-R., Hilgenberg L.G., Tourtellotte W.W., Sobel R.A., Smith M.A., Olek M., Nagra R., Sudhir G., van den Noort S., Qin Y. Clonal expansion of IgA-positive plasma cells and axon-reactive antibodies in MS lesions. J. Neuroimmunol. 2005, 167:120-130.