Primed status of transitional B cells associated with their presence in the cerebrospinal fluid in early phases of multiple sclerosis

Clinical Immunology

Volumn 139, Issue 1, 2011, Pages 12-20

  Lee Chang, Catalina ^a,b   Top, Isabelle ^a,b   Zéphir, Hélène ^a,b   Dubucquoi, Sylvain ^a,b   Trauet, Jacques ^a,b   Dussart, Patricia ^a,b   Prin, Lionel ^a,b   Vermersch, Patrick ^a,b  

^a UNIV LILLE   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

Cerebrospinal fluid; Clinically isolated syndrome; Integrins; Multiple sclerosis; Transitional B cell

Indexed keywords

ALPHA4 INTEGRIN; B7 ANTIGEN; BETA1 INTEGRIN; BETA7 INTEGRIN;

ADULT; ANTIGEN EXPRESSION; ARTICLE; BLOOD BRAIN BARRIER; CELL MATURATION; CEREBROSPINAL FLUID; CLINICALLY ISOLATED SYNDROME; CONTROLLED STUDY; FEMALE; FUNCTIONAL STATUS; HUMAN; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PRE B LYMPHOCYTE; PRIORITY JOURNAL; RELAPSE; SYNDROME;

EID: 79953024547     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2010.11.004     Document Type: Article

References (44)

1. Noseworthy J.H., Lucchinetti C., Rodriguez M., Weinshenker B.G. Multiple sclerosis. N. Engl. J. Med. 2000, 343:938-952.
2. Durelli L., Conti L., Clerico M., Boselli D., Contessa G., Ripellino P., Ferrero B., Eid P., Novelli F. T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-beta. Ann. Neurol. 2009, 65:499-509.
3. Jäger A., Dardalhon V., Sobel R.A., Bettelli E., Kuchroo V.K. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J. Immunol. 2009, 183:7169-7177.
4. Stromnes I.M., Cerretti L.M., Liggitt D., Harris R.A., Goverman J.M. Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells. Nat. Med. 2008, 14:337-342.
5. Pachner A.R., Brady J., Narayan K. Antibody-secreting cells in the central nervous system in an animal model of MS: phenotype, association with disability, and in vitro production of antibody. J. Neuroimmunol. 2007, 190:112-120.
6. Genain C.P., Cannella B., Hauser S.L., Raine C.S. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat. Med. 1999, 5:170-175.
7. Harp C.T., Lovett-Racke A.E., Racke M.K., Frohman E.M., Monson N.L. Impact of myelin-specific antigen presenting B cells on T cell activation in multiple sclerosis. Clin. Immunol. 2008, 128:382-391.
8. Harris D.P., Haynes L., Sayles P.C., Duso D.K., Eaton S.M., Lepak N.M., Johnson L.L., Swain S.L., Lund F.E. Reciprocal regulation of polarized cytokine production by effector B and T cells. Nat. Immunol. 2000, 1:475-482.
9. Cyster J.G. Lymphoid organ development and cell migration. Immunol. Rev. 2003, 195:5-14.
10. Endres R., Alimzhanov M.B., Plitz T., Fütterer A., Kosco-Vilbois M.H., Nedospasov S.A., Rajewsky K., Pfeffer K. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J. Exp. Med. 1999, 189:159-168.
11. Fu Y.X., Huang G., Wang Y., Chaplin D.D. B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion. J. Exp. Med. 1998, 187:1009-1018.
12. Magliozzi R., Columba-Cabezas S., Serafini B., Aloisi F. Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2004, 148:11-23.
13. Cepok S., Rosche B., Grummel V., Vogel F., Zhou D., Sayn J., Sommer N., Hartung H.P., Hemmer B. Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis. Brain 2005, 128:1667-1676.
14. Corcione A., Casazza S., Ferretti E., Giunti D., Zappia E., Pistorio A., Gambini C., Mancardi G.L., Uccelli A., Pistoia V. Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis. Proc. Natl Acad. Sci. USA 2004, 101:11064-11069.
15. Owens G.P., Ritchie A.M., Burgoon M.P., Williamson R.A., Corboy J.R., Gilden D.H. Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid. J. Immunol. 2003, 171:2725-2733.
16. Qin Y., Duquette P., Zhang Y., Talbot P., Poole R., Antel J. Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis. J. Clin. Invest. 1998, 102:1045-1050.
17. Lefranc D., Almeras L., Dubucquoi S., de Seze J., Vermersch P., Prin L. Distortion of the self-reactive IgG antibody repertoire in multiple sclerosis as a new diagnostic tool. J. Immunol. 2004, 172:669-678.
18. Zéphir H., Lefranc D., Dubucquoi S., de Seze J., Boron L., Prin L., Vermersch P. Serum IgG repertoire in clinically isolated syndrome predicts multiple sclerosis. Mult. Scler. 2009, 15:593-600.
19. Lefranc D., Launay D., Dubucquoi S., de Seze J., Dussart P., Vermersch M., Hachulla E., Hatron P.Y., Vermersch P., Mouthon L., Prin L. Characterization of discriminant human brain antigenic targets in neuropsychiatric systemic lupus erythematosus using an immunoproteomic approach. Arthritis Rheum. 2007, 56:3420-3432.
20. Lionel A., de Seze J., Didier L., Sandrine F.N., Sylvain D., Patrick V., Lionel P. Evolution of self-reactive IgG antibody repertoires in patients with relapsing-remitting multiple sclerosis. Immunol. Lett. 2005, 97:55-62.
21. Zephir H., Almeras L., El Behi M., Dussart P., de Seze J., Steibel J., Trifilieff E., Dubucquoi S., Dessaint J.P., Vermersch P., Prin L., Lefranc D. Diversified serum IgG response involving non-myelin CNS proteins during experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2006, 179:53-64.
22. El Behi M., Zéphir H., Lefranc D., Dutoit V., Dussart P., Devos P., Dessaint J.P., Vermersch P., Prin L. Changes in self-reactive IgG antibody repertoire after treatment of experimental autoimmune encephalomyelitis with anti-allergic drugs. J. Neuroimmunol. 2007, 182:80-88.
23. Hauser S.L., Waubant E., Arnold D.L., Vollmer T., Antel J., Fox R.J., Bar-Or A., Panzara M., Sarkar N., Agarwal S., Langer-Gould A., Smith C.H. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N. Engl. J. Med. 2008, 358:676-688. HERMES Trial Group.
24. McDonald W.I., Compston A., Edan G., Goodkin D., Hartung H.P., Lublin F.D., McFarland H.F., Paty D.W., Polman C.H., Reingold S.C., Sandberg-Wollheim M., Sibley W., Thompson A., van den Noort S., Weinshenker B.Y., Wolinsky J.S. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 2001, 50:121-127.
25. Sims G.P., Ettinger R., Shirota Y., Yarboro C.H., Illei G.G., Lipsky P.E. Identification and characterization of circulating human transitional B cells. Blood 2005, 105:4390-4398.
26. Jacquot S., Boyer O. Heterogeneity and function of human B lymphocytes. Med. Sci. Paris 2006, 22:1075-1080.
27. Meinl E., Krumbholz M., Hohlfeld R. B lineage cells in the inflammatory central nervous system environment: migration, maintenance, local antibody production, and therapeutic modulation. Ann. Neurol. 2006, 59:880-892.
28. Magliozzi R., Howell O., Vora A., Serafini B., Nicholas R., Puopolo M., Reynolds R., Aloisi F. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 2007, 130:1089-1104.
29. Serafini B., Rosicarelli B., Magliozzi R., Stigliano E., Aloisi F. Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol. 2004, 14:164-174.
30. Niino M., Hirotani M., Miyazaki Y., Sasaki H. Memory and naïve B-cell subsets in patients with multiple sclerosis. Neurosci. Lett. 2009, 464:74-78.
31. Schneider P., Takatsuka H., Wilson A., Mackay F., Tardivel A., Lens S., Cachero T.G., Finke D., Beermann F., Tschopp J. Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen. J. Exp. Med. 2001, 194:1691-1697.
32. Schiemann B., Gommerman J.L., Vora K., Cachero T.G., Shulga-Morskaya S., Dobles M., Frew E., Scott M.L. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 2001, 293:2111-2114.
33. Thangarajh M., Gomes A., Masterman T., Hillert J., Hjelmström P. Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis. J. Neuroimmunol. 2004, 152:183-190.
34. Krumbholz M., Faber H., Steinmeyer F., Hoffmann L.A., Kümpfel T., Pellkofer H., Derfuss T., Ionescu C., Starck M., Hafner C., Hohlfeld R., Meinl E. Interferon-beta increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity. Brain 2008, 131:1455-1463.
35. Ley K., Laudanna C., Cybulsky M.I., Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat. Rev. Immunol. 2007, 7:678-689.
36. Berlin C., Bargatze R.F., Campbell J.J., von Andrian U.H., Szabo M.C., Hasslen S.R., Nelson R.D., Berg E.L., Erlandsen S.L., Butcher E.C. Alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 1995, 80:413-422.
37. Kallmann B.A., Hummel V., Lindenlaub T., Ruprecht K., Toyka K.V., Rieckmann P. Cytokine-induced modulation of cellular adhesion to human cerebral endothelial cells is mediated by soluble vascular cell adhesion molecule-1. Brain 2000, 123(Pt 4):687-697.
38. Stüve O., Marra C.M., Jerome K.R., Cook L., Cravens P.D., Cepok S., Frohman E.M., Phillips J.T., Arendt G., Hemmer B., Monson N.L., Racke M.K. Immune surveillance in multiple sclerosis patients treated with natalizumab. Ann. Neurol. 2006, 59:743-747.
39. Genç K., Dona D.L., Reder A.T. Increased CD80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy. J. Clin. Invest. 1997, 99:2664-2671.
40. Krumbholz M., Theil D., Cepok S., Hemmer B., Kivisäkk P., Ransohoff R.M., Hofbauer M., Farina C., Derfuss T., Hartle C., Newcombe J., Hohlfeld R., Meinl E. Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Brain 2006, 129:200-211.
41. Sellebjerg F., Börnsen L., Khademi M., Krakauer M., Olsson T., Frederiksen J.L., Sørensen P.S. Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS. Neurology 2009, 73:2003-2010.
42. Wardemann H., Yurasov S., Schaefer A., Young J.W., Meffre E., Nussenzweig M.C. Predominant autoantibody production by early human B cell precursors. Science 2003, 301:1374-1377.
43. Chung J.B., Wells A.D., Adler S., Jacob A., Turka L.A., Monroe J.G. Incomplete activation of CD4 T cells by antigen-presenting transitional immature B cells: implications for peripheral B and T cell responsiveness. J. Immunol. 2003, 171:1758-1767.
44. Krumbholz M., Theil D., Derfuss T., Rosenwald A., Schrader F., Monoranu C.M., Kalled S.L., Hess D.M., Serafini B., Aloisi F., Wekerle H., Hohlfeld R., Meinl E. BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J. Exp. Med. 2005, 201:195-200.