Restricted use of V(H)4 germline segments in an acute multiple sclerosis brain

Annals of Neurology

Volumn 43, Issue 2, 1998, Pages 236-243

  Owens, Gregory P ^a   Kraus, Hanna ^a   Burgoon, Mark P ^a   Smith Jensen, Tracey ^a   Devlin, Mary E ^a   Gilden, Donald H ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; POLYCLONAL ANTIBODY; COMPLEMENTARY DNA; MESSENGER RNA;

ANTIBODY DETECTION; ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DNA LIBRARY; HUMAN; HUMAN TISSUE; IMMUNOMODULATION; IMMUNOPATHOGENESIS; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; AMINO ACID SEQUENCE; BRAIN LEVEL; CEREBROSPINAL FLUID; COMPARATIVE STUDY; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; GENETICS; IMMUNOLOGY; MOLECULAR GENETICS; MUTATION; POLYMERASE CHAIN REACTION; REFERENCE VALUE; SUBACUTE SCLEROSING PANENCEPHALITIS;

AMINO ACID SEQUENCE; BRAIN CHEMISTRY; DNA, COMPLEMENTARY; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; GERM-LINE MUTATION; IMMUNOGLOBULIN G; MOLECULAR SEQUENCE DATA; MULTIPLE SCLEROSIS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; REFERENCE VALUES; RNA, MESSENGER; SUBACUTE SCLEROSING PANENCEPHALITIS;

EID: 0031594141     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410430214     Document Type: Article

References (23)

1. Reder AT, Arnason BWG. Immunology of multiple sclerosis. In: Koetsier JC, ed. Handbook of clinical neurology, vol 3. Amsterdam: Elsevier Science Publishers, 1985:337-395
2. Martin R, McFarland HF, McFarlin DE. Immunological aspects of demyelinating diseases. Ann Rev Immunol 1992;10: 153-187
3. Owens GP, Burgoon MP, Devlin ME, Gilden DH. Strategies to identify sequences or antigens unique to multiple sclerosis. Multiple Sclerosis 1996;2:184-194
4. Maniatis T, Fritsch EF, Sambrook J, eds. Molecular cloning: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1982
5. H locus completed by analysis of the telomeric region of chromosome 14q. Nat Genet 1994;7:162-168
6. Higgins DG, Sharp PM. Clustal: a package for performing multiple sequence alignment on a microcomputer. Gene 1988; 73:237-244
7. Owens GP, Burgoon MP, Devlin ME, Gilden DH. Extraction and purification of active IgG from SSPE and MS brain. J Virol Meth 1997;68:119-125
8. H repertoire. Immunol Today 1995;16:237-242
9. Huang C, Stollar BD. A majority of Ig H chain cDNA of normal human adult blood lymphocytes resembles cDNA for fetal Ig and natural autoantibodies. J Immunol 1993;151:5290-5300
10. Brezinschek HP, Brezinschek RI, Lipsky P. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J Immunol 1995;155:190-202
11. Berek C, Milstein C. The dynamic nature of the antibody repertoire. Immunol Rev 1988;105:5-26
12. Rajewsky K. Clonal selection and learning in the antibody system. Nature 1996;381:751-758
13. Mattson DH, Roos RP, Arnason BGW. Isoelectric focusing of IgG eluted from multiple sclerosis and subacute sclerosing panencephalitis brains. Nature 1980;287:335-336
14. Mehta PD, Frisch S, Thormar H, et al. Bound antibody in multiple sclerosis brains. J Neurol Sci 1981;49:91-98
15. Link H, Laurenzi MA. Immunoglobulin class and light chain type of oligoclonal bands in CSF in multiple sclerosis determined by agarose gel electrophoresis and immunofixation. Ann Neurol 1979;6:107-110
16. Mattson DH, Roos RP, Hopper JE, Arnason BGW. Light chain composition of CSF oligoclonal IgG bands in multiple sclerosis and subacute sclerosing panencephalitis. J Neuroimmunol 1982;3:63-76
17. Prineas JW. The neuropathology of multiple sclerosis. In: Vinken PJ, Bruyn GW, Klawans HL, Koetsier JC, eds. Handbook of clinical neurology, vol 3. Amsterdam: Elsevier Science Publishers, 1985:213-257
18. Marks JD, Tristem M, Karpas A, Winter G. Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific oligonucleotide probes. Eur J Immunol 1991;21:985-991
19. H gene in the expressed human B cell repertoire. J Exp Med 1993;177:409-418
20. H gene segment overrepresented in the autoimmune repertoire. Arthritis Rheum 1992;35:11-18
21. H framework region 1 and complementarity determining region 3. J Mol Biol 1996;256:577-589
22. H4-21 gene segment. J Immunol 1993;151: 1051-1061
23. Mattson DH, Roos RP, Arnason BWG. Oligoclonal IgG in multiple sclerosis and subacute sclerosing panencephalitis brains. J Neuroimmunol 1982;2:261-276