Analysis of the human V(H) gene repertoire: Differential effects of selection and somatic hypermutation on human peripheral CD5+/IgM+ and CD5- /IgM+ B cells

Journal of Clinical Investigation

Volumn 99, Issue 10, 1997, Pages 2488-2501

  Brezinschek, Hans Peter ^a   Foster, Sandra J ^a   Brezinschek, Ruth I ^a   Dörner, Thomas ^a   Domiati Saad, Rana ^a   Lipsky, Peter E ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

hypermutation; immunoglobulin; selection; variable heavy chain genes; VDJ rearrangement

Indexed keywords

CD5 ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M; CD19 ANTIGEN; HLA D ANTIGEN; LEUKOCYTE ANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; GENE REARRANGEMENT; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE SUBPOPULATION; PRIORITY JOURNAL; SOMATIC MUTATION; ADULT; AMINO ACID SEQUENCE; ANIMAL; BLOOD; GENETICS; IMMUNOLOGY; MALE; MIDDLE AGED; MOLECULAR GENETICS; MOUSE; POLYMERASE CHAIN REACTION;

ADULT; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD; ANTIGENS, CD19; ANTIGENS, CD5; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; GENE REARRANGEMENT; GENES, IMMUNOGLOBULIN; HLA-D ANTIGENS; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; MALE; MICE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION;

EID: 0030610529     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119433     Document Type: Article

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