Central memory CD4+ T cells dominate the normal cerebrospinal fluid

Cytometry Part B - Clinical Cytometry

Volumn 80 B, Issue 1, 2011, Pages 43-50

  De Graaf, Marieke T ^a   Sillevis Smitt, Peter A E ^a   Luitwieler, Ronald L ^b   Van Velzen, Chris ^b   Van Den Broek, Patricia D M ^a   Kraan, Jaco ^a   Gratama, Jan W ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Erasmus University Medical Center ^*  (Netherlands)

Author keywords

Cerebrospinal fluid; Flow cytometry; Lymphocytes

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; B LYMPHOCYTE; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CENTRAL MEMORY T LYMPHOCYTE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DENDRITIC CELL; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; GRANULOCYTE; HUMAN; HUMAN CELL; LEUKOCYTE; LEUKOCYTE COUNT; LYMPHOCYTE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; MONOCYTE; MYELOID DENDRITIC CELL; NATURAL KILLER CELL; NATURAL KILLER T CELL; PHENOTYPE; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; REFERENCE VALUE; REGULATORY T LYMPHOCYTE; SPINAL ANESTHESIA; SURGICAL TECHNIQUE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD4; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CEREBROSPINAL FLUID; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; KILLER CELLS, NATURAL; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; MYELOID CELLS; NATURAL KILLER T-CELLS; REFERENCE VALUES; T-LYMPHOCYTE SUBSETS; YOUNG ADULT;

EID: 78650839450     PISSN: 15524949     EISSN: 15524957     Source Type: Journal    
DOI: 10.1002/cyto.b.20542     Document Type: Article

References (28)

1. Bromberg JE, Breems DA, Kraan J, Bikker G, van der Holt B, Smitt PS, van den Bent MJ, van't Veer M, Gratama JW,. CSF flow cytometry greatly improves diagnostic accuracy in CNS hematologic malignancies. Neurology 2007; 68: 1674 - 1679.
2. Kraan J, Gratama JW, Haioun C, Orfao A, Plonquet A, Porwit A, Quijano S, Stetler Stevenson M, Subira D, Wilson W,. Flow cytometric immunophenotyping of cerebrospinal fluid. Curr Protoc Cytom 2008; Chapter 6: Unit 6.25.
3. Holub M, Kluckova Z, Beran O, Aster V, Lobovska A,. Lymphocyte subset numbers in cerebrospinal fluid: Comparison of tick borne encephalitis and neuroborreliosis. Acta Neurol Scand 2002; 106: 302 - 308.
4. Feger U, Luther C, Poeschel S, Melms A, Tolosa E, Wiendl H,. Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients. Clin Exp Immunol 2007; 147: 412 - 418.
5. de Graaf M, de Beukelaar J, Bergsma J, Kraan J, van den Bent M, Klimek M, van Norden Y, Kusuma A, Smitt PS, Gratama JW,. B and T cell imbalances in CSF of patients with Hu antibody associated PNS. J Neuroimmunol 2008; 195: 164 - 170.
6. Pranzatelli MR, Travelstead AL, Tate ED, Allison TJ, Moticka EJ, Franz DN, Nigro MA, Parke JT, Stumpf DA, Verhulst SJ,. B and T cell markers in opsoclonus myoclonus syndrome: Immunophenotyping of CSF lymphocytes. Neurology 2004; 62: 1526 - 1532.
7. Svenningsson A, Hansson GK, Andersen O, Andersson R, Patarroyo M, Stemme S,. Adhesion molecule expression on cerebrospinal fluid T lymphocytes: Evidence for common recruitment mechanisms in multiple sclerosis, aseptic meningitis, and normal controls. Ann Neurol 1993; 34: 155 - 161.
8. Svenningsson A, Andersen O, Edsbagge M, Stemme S,. Lymphocyte phenotype and subset distribution in normal cerebrospinal fluid. J Neuroimmunol 1995; 63: 39 - 46.
9. Brando B, Barnett D, Janossy G, Mandy F, Autran B, Rothe G, Scarpati B, D'Avanzo G, D'Hautcourt JL, Lenkei R, et al. Cytofluorometric methods for assessing absolute numbers of cell subsets in blood. European Working Group on Clinical Cell Analysis. Cytometry 2000; 42: 327 - 346.
10. O'Gorman MR, Zijenah LS,. CD4 T cell measurements in the management of antiretroviral therapy-A review with an emphasis on pediatric HIV infected patients. Cytometry B Clin Cytom 2008; 74B [ Suppl 1 ]: S19 - S26.
11. Gratama JW, Orfao A, Barnett D, Brando B, Huber A, Janossy G, Johnsen HE, Keeney M, Marti GE, Preijers F, et al. Flow cytometric enumeration of CD34+ hematopoietic stem and progenitor cells. European Working Group on Clinical Cell Analysis. Cytometry 1998; 34: 128 - 142.
12. Della Bella S, Giannelli S, Taddeo A, Presicce P, Villa ML,. Application of six color flow cytometry for the assessment of dendritic cell responses in whole blood assays. J Immunol Methods 2008; 339: 153 - 164.
13. Mandy FF, Nicholson JK, McDougal JS,. Guidelines for performing single platform absolute CD4+ T cell determinations with CD45 gating for persons infected with human immunodeficiency virus. Centers for Disease Control and Prevention. MMWR Recomm Rep 2003; 52 (RR 2): 1 - 13.
14. Jentsch Ullrich K, Koenigsmann M, Mohren M, Franke A,. Lymphocyte subsets' reference ranges in an age and gender balanced population of 100 healthy adults-A monocentric German study. Clin Immunol 2005; 116: 192 - 197.
15. Nakamura H, Kawasaki N, Hagiwara M, Saito M, Konaka C, Kato H,. Cellular immunologic parameters related to age, gender, and stage in lung cancer patients. Lung Cancer 2000; 28: 139 - 145.
16. Olsson J, Wikby A, Johansson B, Lofgren S, Nilsson BO, Ferguson FG,. Age related change in peripheral blood T lymphocyte subpopulations and cytomegalovirus infection in the very old: The Swedish longitudinal OCTO immune study. Mech Ageing Dev 2000; 121 (1-3): 187 - 201.
17. Kim TK, St John LS, Wieder ED, Khalili J, Ma Q, Komanduri KV,. Human late memory CD8+ T cells have a distinct cytokine signature characterized by CC chemokine production without IL 2 production. J Immunol 2009; 183: 6167 - 6174.
18. Kivisakk P, Trebst C, Liu Z, Tucky BH, Sorensen TL, Rudick RA, Mack M, Ransohoff RM,. T cells in the cerebrospinal fluid express a similar repertoire of inflammatory chemokine receptors in the absence or presence of CNS inflammation: Implications for CNS trafficking. Clin Exp Immunol 2002; 129: 510 - 518.
19. Provencio JJ, Kivisakk P, Tucky BH, Luciano MG, Ransohoff RM,. Comparison of ventricular and lumbar cerebrospinal fluid T cells in non inflammatory neurological disorder (NIND) patients. J Neuroimmunol 2005; 163 (1-2): 179 - 184.
20. Engelhardt B, Ransohoff RM,. The ins and outs of T lymphocyte trafficking to the CNS: Anatomical sites and molecular mechanisms. Trends Immunol 2005; 26: 485 - 495.
21. Kivisakk P, Mahad DJ, Callahan MK, Trebst C, Tucky B, Wei T, Wu L, Baekkevold ES, Lassmann H, Staugaitis SM, et al. Human cerebrospinal fluid central memory CD4+ T cells: Evidence for trafficking through choroid plexus and meninges via P selectin. Proc Natl Acad Sci USA 2003; 100: 8389 - 8394.
22. Hickey WF,. Basic principles of immunological surveillance of the normal central nervous system. Glia 2001; 36: 118 - 124.
23. Hickey WF,. Leukocyte traffic in the central nervous system: The participants and their roles. Semin Immunol 1999; 11: 125 - 137.
24. Vora AJ, Perry ME, Hobbs C, Dumonde DC, Brown KA,. Selective binding of peripheral blood lymphocytes to the walls of cerebral vessels in frozen sections of human brain. J Immunol Methods 1995; 180: 165 - 180.
25. Hickey WF,. Migration of hematogenous cells through the blood brain barrier and the initiation of CNS inflammation. Brain Pathol 1991; 1: 97 - 105.
26. Pashenkov M, Huang YM, Kostulas V, Haglund M, Soderstrom M, Link H,. Two subsets of dendritic cells are present in human cerebrospinal fluid. Brain 2001; 124 (Part 3): 480 - 492.
27. Pashenkov M, Soderstrom M, Huang YM, Link H,. Cerebrospinal fluid affects phenotype and functions of myeloid dendritic cells. Clin Exp Immunol 2002; 128: 379 - 387. (Pubitemid 34534056)
28. Press R, Nennesmo I, Kouwenhoven M, Huang YM, Link H, Pashenkov M,. Dendritic cells in the cerebrospinal fluid and peripheral nerves in Guillain Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. J Neuroimmunol 2005; 159 (1-2): 165 - 176.