-
1
-
-
34247586674
-
2′-Modified oligonucleotides for antisense therapeutics
-
Prakash,T.P. and Bhat,B. (2007) 2′-Modified oligonucleotides for antisense therapeutics. Curr. Top. Med. Chem., 7, 641-649.
-
(2007)
Curr. Top. Med. Chem.
, vol.7
, pp. 641-649
-
-
Prakash, T.P.1
Bhat, B.2
-
2
-
-
77949512140
-
RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform
-
Bennett,C.F. and Swayze,E.E. (2010) RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu. Rev. Pharmacol. Toxicol., 50, 259-293.
-
(2010)
Annu. Rev. Pharmacol. Toxicol.
, vol.50
, pp. 259-293
-
-
Bennett, C.F.1
Swayze, E.E.2
-
3
-
-
34247642239
-
Chemical modifications to improve the cellular uptake of oligonucleotides
-
Debart,F., Abes,S., Deglane,G., Moulton,H.M., Clair,P., Gait,M.J., Vasseur,J.J. and Lebleu,B. (2007) Chemical modifications to improve the cellular uptake of oligonucleotides. Curr. Top. Med. Chem., 7, 727-737.
-
(2007)
Curr. Top. Med. Chem.
, vol.7
, pp. 727-737
-
-
Debart, F.1
Abes, S.2
Deglane, G.3
Moulton, H.M.4
Clair, P.5
Gait, M.J.6
Vasseur, J.J.7
Lebleu, B.8
-
4
-
-
36849094017
-
Chemical modification: the key to clinical application of RNA interference?
-
Corey,D.R. (2007) Chemical modification: the key to clinical application of RNA interference? J. Clin. Invest., 117, 3615-3622.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3615-3622
-
-
Corey, D.R.1
-
5
-
-
0036788304
-
Gene silencing in mammals by small interfering RNAs
-
McManus,M.T. and Sharp,P.A. (2002) Gene silencing in mammals by small interfering RNAs. Nat. Rev. Genet., 3, 737-747.
-
(2002)
Nat. Rev. Genet.
, vol.3
, pp. 737-747
-
-
McManus, M.T.1
Sharp, P.A.2
-
6
-
-
58749104364
-
The promises and pitfalls of RNA-interference-based therapeutics
-
Castanotto,D. and Rossi,J.J. (2009) The promises and pitfalls of RNA-interference-based therapeutics. Nature, 457, 426-433.
-
(2009)
Nature
, vol.457
, pp. 426-433
-
-
Castanotto, D.1
Rossi, J.J.2
-
7
-
-
67249122712
-
Biological barriers to therapy with antisense and siRNA oligonucleotides
-
Juliano,R., Bauman,J., Kang,H. and Ming,X. (2009) Biological barriers to therapy with antisense and siRNA oligonucleotides. Mol. Pharm., 6, 686-695.
-
(2009)
Mol. Pharm.
, vol.6
, pp. 686-695
-
-
Juliano, R.1
Bauman, J.2
Kang, H.3
Ming, X.4
-
8
-
-
59349116903
-
Knocking down barriers: advances in siRNA delivery
-
Whitehead,K.A., Langer,R. and Anderson,D.G. (2009) Knocking down barriers: advances in siRNA delivery. Nat. Rev. Drug Discov., 8, 129-138.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 129-138
-
-
Whitehead, K.A.1
Langer, R.2
Anderson, D.G.3
-
9
-
-
67249096677
-
Nonviral methods for siRNA delivery
-
Gao,K. and Huang,L. (2009) Nonviral methods for siRNA delivery. Mol. Pharm., 6, 651-658.
-
(2009)
Mol. Pharm.
, vol.6
, pp. 651-658
-
-
Gao, K.1
Huang, L.2
-
10
-
-
72949119713
-
Lipidic systems for in vivo siRNA delivery
-
Wu,S.Y. and McMillan,N.A. (2009) Lipidic systems for in vivo siRNA delivery. AAPS J., 11, 639-652.
-
(2009)
AAPS J.
, vol.11
, pp. 639-652
-
-
Wu, S.Y.1
McMillan, N.A.2
-
11
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
Zimmermann,T.S., Lee,A.C., Akinc,A., Bramlage,B., Bumcrot,D., Fedoruk,M.N., Harborth,J., Heyes,J.A., Jeffs,L.B., John,M. et al. (2006) RNAi-mediated gene silencing in non-human primates. Nature, 441, 111-114.
-
(2006)
Nature
, vol.441
, pp. 111-114
-
-
Zimmermann, T.S.1
Lee, A.C.2
Akinc, A.3
Bramlage, B.4
Bumcrot, D.5
Fedoruk, M.N.6
Harborth, J.7
Heyes, J.A.8
Jeffs, L.B.9
John, M.10
-
12
-
-
50149101511
-
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
-
Frank-Kamenetsky,M., Grefhorst,A., Anderson,N.N., Racie,T.S., Bramlage,B., Akinc,A., Butler,D., Charisse,K., Dorkin,R., Fan,Y. et al. (2008) Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc. Natl Acad. Sci. USA, 105, 11915-11920.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 11915-11920
-
-
Frank-Kamenetsky, M.1
Grefhorst, A.2
Anderson, N.N.3
Racie, T.S.4
Bramlage, B.5
Akinc, A.6
Butler, D.7
Charisse, K.8
Dorkin, R.9
Fan, Y.10
-
13
-
-
33746438424
-
Toxicity of cationic lipids and cationic polymers in gene delivery
-
Lv,H., Zhang,S., Wang,B., Cui,S. and Yan,J. (2006) Toxicity of cationic lipids and cationic polymers in gene delivery. J. Control Release, 114, 100-109.
-
(2006)
J. Control Release
, vol.114
, pp. 100-109
-
-
Lv, H.1
Zhang, S.2
Wang, B.3
Cui, S.4
Yan, J.5
-
14
-
-
47249138782
-
Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides
-
Juliano,R., Alam,M.R., Dixit,V. and Kang,H. (2008) Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides. Nucleic Acids Res., 36, 4158-4171.
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 4158-4171
-
-
Juliano, R.1
Alam, M.R.2
Dixit, V.3
Kang, H.4
-
15
-
-
43349103903
-
Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis
-
Alam,M.R., Dixit,V., Kang,H., Li,Z.B., Chen,X., Trejo,J., Fisher,M. and Juliano,R.L. (2008) Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis. Nucleic Acids Res., 36, 2764-2776.
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 2764-2776
-
-
Alam, M.R.1
Dixit, V.2
Kang, H.3
Li, Z.B.4
Chen, X.5
Trejo, J.6
Fisher, M.7
Juliano, R.L.8
-
16
-
-
77951957881
-
The biological effect of an antisense oligonucleotide depends on its route of endocytosis and trafficking
-
Alam,M.R., Ming,X., Dixit,V., Fisher,M., Chen,X. and Juliano,R.L. (2010) The biological effect of an antisense oligonucleotide depends on its route of endocytosis and trafficking. Oligonucleotides, 20, 103-109.
-
(2010)
Oligonucleotides
, vol.20
, pp. 103-109
-
-
Alam, M.R.1
Ming, X.2
Dixit, V.3
Fisher, M.4
Chen, X.5
Juliano, R.L.6
-
17
-
-
36849081485
-
Insulin receptor substrate 1 knockdown in human MCF7 ER+breast cancer cells by nuclease-resistant IRS1 siRNA conjugated to a disulfide-bridged D-peptide analogue of insulin-like growth factor 1
-
Cesarone,G., Edupuganti,O.P., Chen,C.P. and Wickstrom,E. (2007) Insulin receptor substrate 1 knockdown in human MCF7 ER+breast cancer cells by nuclease-resistant IRS1 siRNA conjugated to a disulfide-bridged D-peptide analogue of insulin-like growth factor 1. Bioconjug. Chem., 18, 1831-1840.
-
(2007)
Bioconjug. Chem.
, vol.18
, pp. 1831-1840
-
-
Cesarone, G.1
Edupuganti, O.P.2
Chen, C.P.3
Wickstrom, E.4
-
19
-
-
0029282131
-
Nobel lecture. G proteins and regulation of adenylyl cyclase
-
Gilman,A.G. (1995) Nobel lecture. G proteins and regulation of adenylyl cyclase. Biosci. Rep., 15, 65-97.
-
(1995)
Biosci. Rep.
, vol.15
, pp. 65-97
-
-
Gilman, A.G.1
-
20
-
-
33748751670
-
Trafficking of G protein-coupled receptors
-
Drake,M.T., Shenoy,S.K. and Lefkowitz,R.J. (2006) Trafficking of G protein-coupled receptors. Circ. Res., 99, 570-582.
-
(2006)
Circ. Res.
, vol.99
, pp. 570-582
-
-
Drake, M.T.1
Shenoy, S.K.2
Lefkowitz, R.J.3
-
21
-
-
3843128644
-
Intracellular trafficking of hormone receptors
-
Gaborik,Z. and Hunyady,L. (2004) Intracellular trafficking of hormone receptors. Trends Endocrinol. Metab., 15, 286-293.
-
(2004)
Trends Endocrinol. Metab.
, vol.15
, pp. 286-293
-
-
Gaborik, Z.1
Hunyady, L.2
-
22
-
-
41149090339
-
Regulation of GPCRs by endocytic membrane trafficking and its potential implications
-
Hanyaloglu,A.C. and von Zastrow,M. (2008) Regulation of GPCRs by endocytic membrane trafficking and its potential implications. Annu. Rev. Pharmacol. Toxicol., 48, 537-568.
-
(2008)
Annu. Rev. Pharmacol. Toxicol.
, vol.48
, pp. 537-568
-
-
Hanyaloglu, A.C.1
von Zastrow, M.2
-
23
-
-
34247383616
-
Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis
-
Wolfe,B.L. and Trejo,J. (2007) Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis. Traffic, 8, 462-470.
-
(2007)
Traffic
, vol.8
, pp. 462-470
-
-
Wolfe, B.L.1
Trejo, J.2
-
24
-
-
58149389523
-
Nuclear imaging of prostate cancer with gastrin-releasing-peptide-receptor targeted radiopharmaceuticals
-
Ananias,H.J., de Jong,I.J., Dierckx,R.A., van de Wiele,C., Helfrich,W. and Elsinga,P.H. (2008) Nuclear imaging of prostate cancer with gastrin-releasing-peptide-receptor targeted radiopharmaceuticals. Curr. Pharm. Des., 14, 3033-3047.
-
(2008)
Curr. Pharm. Des.
, vol.14
, pp. 3033-3047
-
-
Ananias, H.J.1
de Jong, I.J.2
Dierckx, R.A.3
van de Wiele, C.4
Helfrich, W.5
Elsinga, P.H.6
-
25
-
-
34548459014
-
Gastrin-releasing peptide receptor as a molecular target in experimental anticancer therapy
-
Cornelio,D.B., Roesler,R. and Schwartsmann,G. (2007) Gastrin-releasing peptide receptor as a molecular target in experimental anticancer therapy. Ann. Oncol., 18, 1457-1466.
-
(2007)
Ann. Oncol.
, vol.18
, pp. 1457-1466
-
-
Cornelio, D.B.1
Roesler, R.2
Schwartsmann, G.3
-
26
-
-
41149176081
-
International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states
-
Jensen,R.T., Battey,J.F., Spindel,E.R. and Benya,R.V. (2008) International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol. Rev, 60, 1-42.
-
(2008)
Pharmacol. Rev.
, vol.60
, pp. 1-42
-
-
Jensen, R.T.1
Battey, J.F.2
Spindel, E.R.3
Benya, R.V.4
-
27
-
-
27144533633
-
Radiolabeled peptide conjugates for targeting of the bombesin receptor superfamily subtypes
-
Smith,C.J., Volkert,W.A. and Hoffman,T.J. (2005) Radiolabeled peptide conjugates for targeting of the bombesin receptor superfamily subtypes. Nucl. Med. Biol., 32, 733-740.
-
(2005)
Nucl. Med. Biol.
, vol.32
, pp. 733-740
-
-
Smith, C.J.1
Volkert, W.A.2
Hoffman, T.J.3
-
28
-
-
35548944383
-
Targeted therapy of breast and gynecological cancers with cytotoxic analogues of peptide hormones
-
Engel,J.B., Schally,A.V., Dietl,J., Rieger,L. and Honig,A. (2007) Targeted therapy of breast and gynecological cancers with cytotoxic analogues of peptide hormones. Mol. Pharm., 4, 652-658.
-
(2007)
Mol. Pharm.
, vol.4
, pp. 652-658
-
-
Engel, J.B.1
Schally, A.V.2
Dietl, J.3
Rieger, L.4
Honig, A.5
-
29
-
-
0032485884
-
Up-regulation of luciferase gene expression with antisense oligonucleotides: implications and applications in functional assay development
-
Kang,S.H., Cho,M.J. and Kole,R. (1998) Up-regulation of luciferase gene expression with antisense oligonucleotides: implications and applications in functional assay development. Biochemistry, 37, 6235-6239.
-
(1998)
Biochemistry
, vol.37
, pp. 6235-6239
-
-
Kang, S.H.1
Cho, M.J.2
Kole, R.3
-
30
-
-
60549098667
-
Dual integrin and gastrin-releasing peptide receptor targeted tumor imaging using 18F-labeled PEGylated RGD-bombesin heterodimer 18F-FB-PEG3-Glu-RGD-BBN
-
Liu,Z., Yan,Y., Chin,F.T., Wang,F. and Chen,X. (2009) Dual integrin and gastrin-releasing peptide receptor targeted tumor imaging using 18F-labeled PEGylated RGD-bombesin heterodimer 18F-FB-PEG3-Glu-RGD-BBN. J. Med. Chem., 52, 425-432.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 425-432
-
-
Liu, Z.1
Yan, Y.2
Chin, F.T.3
Wang, F.4
Chen, X.5
-
31
-
-
33644593889
-
Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery
-
Khalil,I.A., Kogure,K., Akita,H. and Harashima,H. (2006) Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol. Rev., 58, 32-45.
-
(2006)
Pharmacol. Rev.
, vol.58
, pp. 32-45
-
-
Khalil, I.A.1
Kogure, K.2
Akita, H.3
Harashima, H.4
-
32
-
-
0028026793
-
The role of clathrin, adaptors and dynamin in endocytosis
-
Robinson,M.S. (1994) The role of clathrin, adaptors and dynamin in endocytosis. Curr. Opin. Cell Biol., 6, 538-544.
-
(1994)
Curr. Opin. Cell Biol.
, vol.6
, pp. 538-544
-
-
Robinson, M.S.1
-
33
-
-
68049105101
-
Rab GTPases as coordinators of vesicle traffic
-
Stenmark,H. (2009) Rab GTPases as coordinators of vesicle traffic. Nat. Rev. Mol. Cell Biol., 10, 513-525.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 513-525
-
-
Stenmark, H.1
-
34
-
-
0029022259
-
Co-operative regulation of endocytosis by three Rab5 isoforms
-
Bucci,C., Lutcke,A., Steele-Mortimer,O., Olkkonen,V.M., Dupree,P., Chiariello,M., Bruni,C.B., Simons,K. and Zerial,M. (1995) Co-operative regulation of endocytosis by three Rab5 isoforms. FEBS Lett., 366, 65-71.
-
(1995)
FEBS Lett.
, vol.366
, pp. 65-71
-
-
Bucci, C.1
Lutcke, A.2
Steele-Mortimer, O.3
Olkkonen, V.M.4
Dupree, P.5
Chiariello, M.6
Bruni, C.B.7
Simons, K.8
Zerial, M.9
-
35
-
-
0029850677
-
Rab11 regulates recycling through the pericentriolar recycling endosome
-
Ullrich,O., Reinsch,S., Urbe,S., Zerial,M. and Parton,R.G. (1996) Rab11 regulates recycling through the pericentriolar recycling endosome. J. Cell Biol., 135, 913-924.
-
(1996)
J. Cell Biol.
, vol.135
, pp. 913-924
-
-
Ullrich, O.1
Reinsch, S.2
Urbe, S.3
Zerial, M.4
Parton, R.G.5
-
36
-
-
0033999818
-
Rab7: a key to lysosome biogenesis
-
Bucci,C., Thomsen,P., Nicoziani,P., McCarthy,J. and van Deurs,B. (2000) Rab7: a key to lysosome biogenesis. Mol. Biol. Cell., 11, 467-480.
-
(2000)
Mol. Biol. Cell.
, vol.11
, pp. 467-480
-
-
Bucci, C.1
Thomsen, P.2
Nicoziani, P.3
McCarthy, J.4
van Deurs, B.5
-
37
-
-
0027398577
-
Rab9 functions in transport between late endosomes and the trans golgi network
-
Lombardi,D., Soldati,T., Riederer,M.A., Goda,Y., Zerial,M. and Pfeffer,S.R. (1993) Rab9 functions in transport between late endosomes and the trans golgi network. EMBO J., 12, 677-682.
-
(1993)
EMBO J.
, vol.12
, pp. 677-682
-
-
Lombardi, D.1
Soldati, T.2
Riederer, M.A.3
Goda, Y.4
Zerial, M.5
Pfeffer, S.R.6
-
38
-
-
64549142329
-
Chemokine receptors as targets for cancer therapy
-
Wu,X., Lee,V.C., Chevalier,E. and Hwang,S.T. (2009) Chemokine receptors as targets for cancer therapy. Curr. Pharm. Des., 15, 742-757.
-
(2009)
Curr. Pharm. Des.
, vol.15
, pp. 742-757
-
-
Wu, X.1
Lee, V.C.2
Chevalier, E.3
Hwang, S.T.4
-
39
-
-
33644662506
-
Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression
-
Li,S., Huang,S. and Peng,S.B. (2005) Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression. Int. J. Oncol., 27, 1329-1339.
-
(2005)
Int. J. Oncol.
, vol.27
, pp. 1329-1339
-
-
Li, S.1
Huang, S.2
Peng, S.B.3
-
40
-
-
33645958934
-
18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer
-
Zhang,X., Cai,W., Cao,F., Schreibmann,E., Wu,Y., Wu,J.C., Xing,L. and Chen,X. (2006) 18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer. J. Nucl. Med., 47, 492-501.
-
(2006)
J. Nucl. Med.
, vol.47
, pp. 492-501
-
-
Zhang, X.1
Cai, W.2
Cao, F.3
Schreibmann, E.4
Wu, Y.5
Wu, J.C.6
Xing, L.7
Chen, X.8
-
41
-
-
33646050623
-
Comparative in vitro and in vivo evaluation of two 64Cu-labeled bombesin analogs in a mouse model of human prostate adenocarcinoma
-
Yang,Y.S., Zhang,X., Xiong,Z. and Chen,X. (2006) Comparative in vitro and in vivo evaluation of two 64Cu-labeled bombesin analogs in a mouse model of human prostate adenocarcinoma. Nucl. Med. Biol., 33, 371-380.
-
(2006)
Nucl. Med. Biol.
, vol.33
, pp. 371-380
-
-
Yang, Y.S.1
Zhang, X.2
Xiong, Z.3
Chen, X.4
-
42
-
-
4544291850
-
microPET and autoradiographic imaging of GRP receptor expression with 64Cu-DOTA-[Lys3]bombesin in human prostate adenocarcinoma xenografts
-
Chen,X., Park,R., Hou,Y., Tohme,M., Shahinian,A.H., Bading,J.R. and Conti,P.S. (2004) microPET and autoradiographic imaging of GRP receptor expression with 64Cu-DOTA-[Lys3]bombesin in human prostate adenocarcinoma xenografts. J. Nucl. Med., 45, 1390-1397.
-
(2004)
J. Nucl. Med.
, vol.45
, pp. 1390-1397
-
-
Chen, X.1
Park, R.2
Hou, Y.3
Tohme, M.4
Shahinian, A.H.5
Bading, J.R.6
Conti, P.S.7
-
43
-
-
2542506187
-
Gastrin-releasing peptide (GRP) analogues for cancer imaging
-
Varvarigou,A., Bouziotis,P., Zikos,C., Scopinaro,F. and De Vincentis,G. (2004) Gastrin-releasing peptide (GRP) analogues for cancer imaging. Cancer Biother. Radiopharm., 19, 219-229.
-
(2004)
Cancer Biother. Radiopharm.
, vol.19
, pp. 219-229
-
-
Varvarigou, A.1
Bouziotis, P.2
Zikos, C.3
Scopinaro, F.4
De Vincentis, G.5
-
44
-
-
15544371477
-
Targeting cytotoxic conjugates of somatostatin, luteinizing hormone-releasing hormone and bombesin to cancers expressing their receptors: a "smarter" chemotherapy
-
Nagy,A. and Schally,A.V. (2005) Targeting cytotoxic conjugates of somatostatin, luteinizing hormone-releasing hormone and bombesin to cancers expressing their receptors: a "smarter" chemotherapy. Curr. Pharm. Des., 11, 1167-1180.
-
(2005)
Curr. Pharm. Des.
, vol.11
, pp. 1167-1180
-
-
Nagy, A.1
Schally, A.V.2
-
45
-
-
0037347183
-
Synthesis and biological evaluation of paclitaxel-C225 conjugate as a model for targeted drug delivery
-
Safavy,A., Bonner,J.A., Waksal,H.W., Buchsbaum,D.J., Gillespie,G.Y., Khazaeli,M.B., Arani,R., Chen,D.T., Carpenter,M. and Raisch,K.P. (2003) Synthesis and biological evaluation of paclitaxel-C225 conjugate as a model for targeted drug delivery. Bioconjugate Chem., 14, 302-310.
-
(2003)
Bioconjugate Chem.
, vol.14
, pp. 302-310
-
-
Safavy, A.1
Bonner, J.A.2
Waksal, H.W.3
Buchsbaum, D.J.4
Gillespie, G.Y.5
Khazaeli, M.B.6
Arani, R.7
Chen, D.T.8
Carpenter, M.9
Raisch, K.P.10
|