Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic muscle and cardiac dystrophin expression and function

Human Molecular Genetics

Volumn 17, Issue 24, 2008, Pages 3909-3918

  Yin, Haifang ^a   Moulton, Hong M ^b   Seow, Yiqi ^a   Boyd, Corinne ^a   Boutilier, Jordan ^b   Iverson, Patrick ^b   Wood, Matthew J A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b AVI BIOPHARMA INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' O METHYLPHOSPHOROTHIOATE RNA; ANTISENSE OLIGONUCLEOTIDE; ARGININE DERIVATIVE; B PEPTIDE; DYSTROPHIN; P007 MORPHOLINOPHOSPHOROAMIDATE CONJUGATE; PEPTIDE CONJUGATED MORPHOLINOPHOSPHOROAMIDATE; PEPTIDE DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; PHOSPHOROTHIOIC ACID; PROTEIN DERIVATIVE; RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG MEGADOSE; DRUG PENETRATION; DRUG SYNTHESIS; DUCHENNE MUSCULAR DYSTROPHY; LOW DRUG DOSE; MOUSE; MYOCARDIAL DISEASE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SARCOLEMMA; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE;

ANIMALS; CELL MEMBRANE PERMEABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; DYSTROPHIN; GENE EXPRESSION REGULATION; HEART INJURIES; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MORPHOLINES; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, ANIMAL; OLIGONUCLEOTIDES, ANTISENSE; PEPTIDES;

MURINAE; MUS;

EID: 57049102809     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddn293     Document Type: Article

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