Comparing the intracellular fate of components within a noncovalent streptavidin nanoparticle with covalent conjugation

Nuclear Medicine and Biology

Volumn 39, Issue 1, 2012, Pages 101-107

  Liu, Yuxia ^a   Cheng, Dengfeng ^a   Liu, Xinrong ^a   Liu, Guozheng ^a   Dou, Shuping ^a   Xiao, Nan ^a   Chen, Ling ^a   Rusckowski, Mary ^a   Hnatowich, Donald J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Antisense oligomer; Herceptin; Nanoparticle; Streptavidin

Indexed keywords

ANTIBODY; ANTISENSE PHOSPHORODIAMIDATE MORPHOLINO OLIGOMER; BIOTIN; COMPLEMENTARY DNA; HER2 HERCEPTIN ANTIBODY; INDIUM 111; NANOPARTICLE; OLIGOMER; PENTETATE INDIUM IN 111; STREPTAVIDIN; TECHNETIUM 99M; TRASTUZUMAB; UNCLASSIFIED DRUG;

ARTICLE; CELL FATE; CELL NUCLEUS; COMPARATIVE STUDY; CONJUGATION; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; ISOTOPE LABELING;

ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; BIOTIN; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; FLOW CYTOMETRY; HUMANS; INDICATORS AND REAGENTS; INDIUM RADIOISOTOPES; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; NEOPLASMS; STREPTAVIDIN; VITAMIN B COMPLEX;

EID: 84855307641     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2011.06.006     Document Type: Article

References (20)

1. 99mTc-labeled antisense DNA. J Nucl Med 2001, 42:1660-1669.
2. Hnatowich D.J., Nakamura K. Antisense targeting in cell culture with radiolabeled DNAs-a brief review of recent progress. Ann Nucl Med 2004, 18:363-368.
3. Nakamura K., Fan C., Liu G., He J., Dou S., Kubo A., et al. Evidence of antisense tumor targeting in mice. Bioconjugate Chem 2004, 15:1475-1480.
4. Nakamura K., Kubo A., Hnatowich D.J. Antisense targeting of P-glycoprotein expression in tissue culture. J Nucl Med 2005, 46:509-513.
5. Liu X., Nakamura K., Wang Y., Zhang S., He J., Liu G., et al. Improved delivery in cell culture of radiolabeled antisense DNAs by duplex formation. Mol Imaging Biol 2006, 8:278-283.
6. 111In. J Nucl Med 2009, 50:582-590.
7. 125I-antisense oligomer delivered as a three-component streptavidin nanoparticle. J Biomed Nanotech 2010, 6:153-157.
8. Goldenberg D.M., Sharkey R.M., Barbet J., Chatal J.F. Radioactive antibodies: selective targeting and treatment of cancer and other diseases. Appl Radiol 2007, 36:10-29.
9. Bhorade R., Weissleder R., Nakakoshi T., Moore A., Tung C.H. Macrocyclic chelators with paramagnetic cations are internalized into mammalian cells via a HIV-tat derived membrane translocation peptide. Bioconjugate Chem 2000, 11:301-305.
10. Astriab-Fisher A., Sergueev D.S., Fisher M., Shaw B.R., Juliano R.L. Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates. Biochem Pharmacol 2000, 60:83-90.
11. Moulton H.M., Hase M.C., Smith K.M., Iverson P.L. HIV tat peptide enhances cellular delivery of antisense morpholino oligomers. Antisense Nucleic Acid Drug Dev 2003, 13:31-43.
12. Nakamura K., Wang Y., Liu X., Kubo A., Hnatowich D.J. Cell culture and xenograft-bearing animal studies of radiolabeled antisense DNA-carrier nanoparticles with streptavidin as a linker. J Nucl Med 2007, 48:1845-1852.
13. Wang Y., Nakamura K., Liu X., Kitamura N., Kubo A., Hnatowich D.J. Simplified preparation via streptavidin of antisense oligomers/carriers nanoparticles showing improved cellular delivery in culture. Bioconjugate Chem 2007, 18:1338-1343.
14. Liu X., Wang Y., Nakamura K., Kubo A., Hnatowich D.J. Cell studies of a three-component antisense MORF/tat/herceptin nanoparticle designed for improved tumor delivery. Cancer Gene Ther 2008, 15:126-132.
15. Nakamura K., Wang Y., Liu X., Kubo A., Hnatowich D.J. Addition of TAT, polyarginine and cholesterol carriers to mdr1 antisense DNA using streptavidin as linker. J Nucl Med 2006, 47(Suppl). 512P.
16. Chu T.C., Twu K.Y., Ellington A.D., Levy M. Aptamer mediated siRNA delivery. Nucleic Acids Res 2006, 34:e73.
17. Tung C.H., Stein S. Preparation and applications of peptide-oligonucleotide conjugate. Bioconjugate Chem 2000, 11:605-618.
18. Hnatowich D.J., Winnard P., Virzi F., Fogarasi M., Sano T., Smith C.L., et al. Technetium-99m labeling of DNA oligonucleotides. J Nucl Med 1995, 36:2306-2314.
19. Wang Y., Liu X., Chen L., Cheng D., Rusckowski M., Hnatowich D.J. Tumor delivery of antisense oligomer using trastuzumab within a streptavidin nanoparticle. Eur J Nucl Mol Imaging 2009, 36:1977-1986.
20. Liu X., Nakamura K., Wang Y., Wang Y., Liu G., He J., et al. Initial mechanistic studies of antisense targeting in cells. J Nucl Med 2006, 47:360-368.