메뉴 건너뛰기




Volumn 199, Issue 3, 2012, Pages 407-412

Discovering the first microrna-targeted drug

Author keywords

[No Author keywords available]

Indexed keywords

ANTAGOMIR; ANTAGOMIR 122; ANTISENSE OLIGONUCLEOTIDE; LOCKED NUCLEIC ACID; MICRORNA; MICRORNA 122; MICRORNA 155; MICRORNA 15A; MICRORNA 17; MICRORNA 92; MIRAVIRSEN; UNCLASSIFIED DRUG;

EID: 84869120708     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201208082     Document Type: Article
Times cited : (265)

References (52)
  • 1
    • 79960924567 scopus 로고    scopus 로고
    • MicroRNAs and developmental timing
    • Ambros, V. 2011. MicroRNAs and developmental timing. Curr. Opin. Genet. Dev. 21:511-517. http://dx.doi.org/10.1016/j.gde.2011.04.003
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 511-517
    • Ambros, V.1
  • 2
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • Bartel, D.P. 2009. MicroRNAs: target recognition and regulatory functions. Cell. 136:215-233. http://dx.doi.org/10.1016/j.cell.2009.01.002
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 3
    • 0035113736 scopus 로고    scopus 로고
    • Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA
    • Braasch, D.A., and D.R. Corey. 2001. Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA. Chem. Biol. 8:1-7. http://dx.doi.org/10.1016/S1074-5521(00)00058-2
    • (2001) Chem. Biol. , vol.8 , pp. 1-7
    • Braasch, D.A.1    Corey, D.R.2
  • 4
    • 34547960488 scopus 로고    scopus 로고
    • microRNA functions
    • Bushati, N., and S.M. Cohen. 2007. microRNA functions. Annu. Rev. Cell Dev. Biol. 23:175-205. http://dx.doi.org/10.1146/annurev.cellbio.23.090506.123406
    • (2007) Annu. Rev. Cell Dev. Biol. , vol.23 , pp. 175-205
    • Bushati, N.1    Cohen, S.M.2
  • 7
    • 33646471662 scopus 로고    scopus 로고
    • Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice
    • Costinean, S., N. Zanesi, Y. Pekarsky, E. Tili, S. Volinia, N. Heerema, and C.M. Croce. 2006. Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc. Natl. Acad. Sci. USA. 103:7024-7029. http://dx.doi.org/10.1073/pnas.0602266103
    • (2006) Proc. Natl. Acad. Sci. USA. , vol.103 , pp. 7024-7029
    • Costinean, S.1    Zanesi, N.2    Pekarsky, Y.3    Tili, E.4    Volinia, S.5    Heerema, N.6    Croce, C.M.7
  • 10
    • 40249106014 scopus 로고    scopus 로고
    • Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver
    • Elmén, J., M. Lindow, A.N. Silahtaroglu, M. Bak, M. Christensen, A. Lind-Thomsen, M. Hedtjärn, J.B. Hansen, H.F. Hansen, E.M. Straarup, et al. 2008a. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res. 36:1153-1162. http://dx.doi.org/10.1093/nar/gkm1113
    • (2008) Nucleic Acids Res , vol.36 , pp. 1153-1162
    • Elmén, J.1    Lindow, M.2    Silahtaroglu, A.N.3    Bak, M.4    Christensen, M.5    Lind-Thomsen, A.6    Hedtjärn, M.7    Hansen, J.B.8    Hansen, H.F.9    Straarup, E.M.10
  • 13
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • Friedman, R.C., K.K.-H. Farh, C.B. Burge, and D.P. Bartel. 2009. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19:92-105. http://dx.doi.org/10.1101/gr.082701.108
    • (2009) Genome Res , vol.19 , pp. 92-105
    • Friedman, R.C.1    Farh, K.-H.2    Burge, C.B.3    Bartel, D.P.4
  • 14
    • 44649110160 scopus 로고    scopus 로고
    • Viral and cellular microRNAs as determinants of viral pathogenesis and immunity
    • Gottwein, E., and B.R. Cullen. 2008. Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe. 3:375-387. http://dx.doi.org/10.1016/j.chom.2008.05.002
    • (2008) Cell Host Microbe , vol.3 , pp. 375-387
    • Gottwein, E.1    Cullen, B.R.2
  • 16
    • 84869112137 scopus 로고    scopus 로고
    • A unique therapy for HCV inhibits microRNA-122 in humans and results in HCV RNA suppression in chronically infected chimpanzees: results from primate and first-in-human studies
    • Hildebrandt-Eriksen, E.S., Y.Z. Bagger, and T.B. Knudsen. 2009. A unique therapy for HCV inhibits microRNA-122 in humans and results in HCV RNA suppression in chronically infected chimpanzees: results from primate and first-in-human studies. Hepatology. 50:12A.
    • (2009) Hepatology , vol.50
    • Hildebrandt-Eriksen, E.S.1    Bagger, Y.Z.2    Knudsen, T.B.3
  • 17
    • 84862310323 scopus 로고    scopus 로고
    • A locked nucleic acid oligonucleotide targeting microRNA 122 is well-tolerated in cynomolgus monkeys
    • Hildebrandt-Eriksen, E.S., V. Aarup, R. Persson, H.F. Hansen, M.E. Munk, and H. Ørum. 2012. A locked nucleic acid oligonucleotide targeting microRNA 122 is well-tolerated in cynomolgus monkeys. Nucleic Acid Ther. 22:152-161.
    • (2012) Nucleic Acid Ther , vol.22 , pp. 152-161
    • Hildebrandt-Eriksen, E.S.1    Aarup, V.2    Persson, R.3    Hansen, H.F.4    Munk, M.E.5    Orum, H.6
  • 18
    • 84861537600 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo (plb) controlled safety and anti-viral proof of concept study of miravirsen (MIR), an oligonucleotide targeting miR-122, in treatment naïve patients with genotype 1 (gt1) chronic HCV infection
    • Janssen, H.L., H.W. Reesink, S. Zeuzem, E. Lawitz, M. Rodriguez-Torres, A. Chen, C. Davis, B. King, A.A. Levin, and M.R. Hodges. 2011. A randomized, double-blind, placebo (plb) controlled safety and anti-viral proof of concept study of miravirsen (MIR), an oligonucleotide targeting miR-122, in treatment naïve patients with genotype 1 (gt1) chronic HCV infection. Hepatology. 54:1430A.
    • (2011) Hepatology , vol.54
    • Janssen, H.L.1    Reesink, H.W.2    Zeuzem, S.3    Lawitz, E.4    Rodriguez-Torres, M.5    Chen, A.6    Davis, C.7    King, B.8    Levin, A.A.9    Hodges, M.R.10
  • 19
    • 24644483623 scopus 로고    scopus 로고
    • Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA
    • Jopling, C.L., M. Yi, A.M. Lancaster, S.M. Lemon, and P. Sarnow. 2005. Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science. 309:1577-1581. http://dx.doi.org/10.1126/science.1113329
    • (2005) Science , vol.309 , pp. 1577-1581
    • Jopling, C.L.1    Yi, M.2    Lancaster, A.M.3    Lemon, S.M.4    Sarnow, P.5
  • 20
    • 33748928159 scopus 로고    scopus 로고
    • The diverse functions of microRNAs in animal development and disease
    • Kloosterman, W.P., and R.H.A. Plasterk. 2006. The diverse functions of microRNAs in animal development and disease. Dev. Cell. 11:441-450. http://dx.doi.org/10.1016/j.devcel.2006.09.009
    • (2006) Dev. Cell. , vol.11 , pp. 441-450
    • Kloosterman, W.P.1    Plasterk, R.H.A.2
  • 21
    • 31344454565 scopus 로고    scopus 로고
    • In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes
    • Kloosterman, W.P., E. Wienholds, E. de Bruijn, S. Kauppinen, and R.H.A. Plasterk. 2006. In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes. Nat. Methods. 3:27-29. http://dx.doi.org/10.1038/nmeth843
    • (2006) Nat. Methods. , vol.3 , pp. 27-29
    • Kloosterman, W.P.1    Wienholds, E.2    de Bruijn, E.3    Kauppinen, S.4    Plasterk, R.H.A.5
  • 22
    • 0032473890 scopus 로고    scopus 로고
    • LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition
    • Koshkin, A.A., S.K. Singh, P. Nielsen, V.K. Rajwanshi, R. Kumar, M. Meldgaard, C.E. Olsen, and J. Wengel. 1998. LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition. Tetrahedron. 54:3607-3630. http://dx.doi.org/10.1016/S0040-4020(98)00094-5
    • (1998) Tetrahedron , vol.54 , pp. 3607-3630
    • Koshkin, A.A.1    Singh, S.K.2    Nielsen, P.3    Rajwanshi, V.K.4    Kumar, R.5    Meldgaard, M.6    Olsen, C.E.7    Wengel, J.8
  • 23
    • 78651293534 scopus 로고    scopus 로고
    • miRBase: integrating microRNA annotation and deep-sequencing data
    • Kozomara, A., and S. Griffiths-Jones. 2011. miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res. 39(Database issue):D152-D157. http://dx.doi.org/10.1093/nar/gkq1027
    • (2011) Nucleic Acids Res , vol.39 , Issue.DATABASE ISSUE
    • Kozomara, A.1    Griffiths-Jones, S.2
  • 26
    • 0036567147 scopus 로고    scopus 로고
    • Design of antisense oligonucleotides stabilized by locked nucleic acids
    • Kurreck, J., E. Wyszko, C. Gillen, and V.A. Erdmann. 2002. Design of antisense oligonucleotides stabilized by locked nucleic acids. Nucleic Acids Res. 30:1911-1918. http://dx.doi.org/10.1093/nar/30.9.1911
    • (2002) Nucleic Acids Res , vol.30 , pp. 1911-1918
    • Kurreck, J.1    Wyszko, E.2    Gillen, C.3    Erdmann, V.A.4
  • 27
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • Lagos-Quintana, M., R. Rauhut, W. Lendeckel, and T. Tuschl. 2001. Identification of novel genes coding for small expressed RNAs. Science. 294:853-858. http://dx.doi.org/10.1126/science.1064921
    • (2001) Science , vol.294 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3    Tuschl, T.4
  • 30
    • 0035955361 scopus 로고    scopus 로고
    • An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    • Lau, N.C., L.P. Lim, E.G. Weinstein, and D.P. Bartel. 2001. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science. 294:858-862. http://dx.doi.org/10.1126/science.1065062
    • (2001) Science , vol.294 , pp. 858-862
    • Lau, N.C.1    Lim, L.P.2    Weinstein, E.G.3    Bartel, D.P.4
  • 31
    • 0035955366 scopus 로고    scopus 로고
    • An extensive class of small RNAs in Caenorhabditis elegans
    • Lee, R.C., and V. Ambros. 2001. An extensive class of small RNAs in Caenorhabditis elegans. Science. 294:862-864. http://dx.doi.org/10.1126/science.1065329
    • (2001) Science , vol.294 , pp. 862-864
    • Lee, R.C.1    Ambros, V.2
  • 32
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee, R.C., R.L. Feinbaum, and V. Ambros. 1993. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 75:843-854. http://dx.doi.org/10.1016/0092-8674(93)90529-Y
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 33
    • 33645763485 scopus 로고    scopus 로고
    • Cleavage of the siRNA passenger strand during RISC assembly in human cells
    • Leuschner, P.J.F., S.L. Ameres, S. Kueng, and J. Martinez. 2006. Cleavage of the siRNA passenger strand during RISC assembly in human cells. EMBO Rep. 7:314-320. http://dx.doi.org/10.1038/sj.embor.7400637
    • (2006) EMBO Rep , vol.7 , pp. 314-320
    • Leuschner, P.J.F.1    Ameres, S.L.2    Kueng, S.3    Martinez, J.4
  • 34
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis, B.P., C.B. Burge, and D.P. Bartel. 2005. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 120:15-20. http://dx.doi.org/10.1016/j.cell.2004.12.035
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 35
    • 79953201904 scopus 로고    scopus 로고
    • MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR
    • Li, Y.P., J.M. Gottwein, T.K. Scheel, T.B. Jensen, and J. Bukh. 2011. MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR. Proc. Natl. Acad. Sci. USA. 108:4991-4996. http://dx.doi.org/10.1073/pnas.1016606108
    • (2011) Proc. Natl. Acad. Sci. USA. , vol.108 , pp. 4991-4996
    • Li, Y.P.1    Gottwein, J.M.2    Scheel, T.K.3    Jensen, T.B.4    Bukh, J.5
  • 36
    • 15844371219 scopus 로고    scopus 로고
    • Structural basis for 5'-end-specific recognition of guide RNA bythe A. fulgidus Piwi protein
    • Ma, J.-B., Y.-R. Yuan, G. Meister, Y. Pei, T. Tuschl, and D.J. Patel. 2005. Structural basis for 5'-end-specific recognition of guide RNA bythe A. fulgidus Piwi protein. Nature. 434:666-670. http://dx.doi.org/10.1038/nature03514
    • (2005) Nature , vol.434 , pp. 666-670
    • Ma, J.-B.1    Yuan, Y.-R.2    Meister, G.3    Pei, Y.4    Tuschl, T.5    Patel, D.J.6
  • 37
    • 79952768199 scopus 로고    scopus 로고
    • Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNAtarget RNA complex
    • Machlin, E.S., P. Sarnow, and S.M. Sagan. 2011. Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNAtarget RNA complex. Proc. Natl. Acad. Sci. USA. 108:3193-3198. http://dx.doi.org/10.1073/pnas.1012464108
    • (2011) Proc. Natl. Acad. Sci. USA. , vol.108 , pp. 3193-3198
    • Machlin, E.S.1    Sarnow, P.2    Sagan, S.M.3
  • 38
    • 27744590896 scopus 로고    scopus 로고
    • Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
    • Matranga, C., Y. Tomari, C. Shin, D.P. Bartel, and P.D. Zamore. 2005. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell. 123:607-620. http://dx.doi.org/10.1016/j.cell.2005.08.044
    • (2005) Cell , vol.123 , pp. 607-620
    • Matranga, C.1    Tomari, Y.2    Shin, C.3    Bartel, D.P.4    Zamore, P.D.5
  • 39
    • 84858379476 scopus 로고    scopus 로고
    • MicroRNAs in stress signaling and human disease
    • Mendell, J.T., and E.N. Olson. 2012. MicroRNAs in stress signaling and human disease. Cell. 148:1172-1187. http://dx.doi.org/10.1016/j.cell.2012.02.005
    • (2012) Cell , vol.148 , pp. 1172-1187
    • Mendell, J.T.1    Olson, E.N.2
  • 40
    • 33646027887 scopus 로고    scopus 로고
    • LNA-modified oligonucleotides mediate specific inhibition of microRNA function
    • Orom, U.A., S. Kauppinen, and A.H. Lund. 2006. LNA-modified oligonucleotides mediate specific inhibition of microRNA function. Gene. 372:137-141. http://dx.doi.org/10.1016/j.gene.2005.12.031
    • (2006) Gene , vol.372 , pp. 137-141
    • Orom, U.A.1    Kauppinen, S.2    Lund, A.H.3
  • 41
    • 15844402005 scopus 로고    scopus 로고
    • Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex
    • Parker, J.S., S.M. Roe, and D. Barford. 2005. Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex. Nature. 434:663-666. http://dx.doi.org/10.1038/nature03462
    • (2005) Nature , vol.434 , pp. 663-666
    • Parker, J.S.1    Roe, S.M.2    Barford, D.3
  • 44
    • 84864147817 scopus 로고    scopus 로고
    • Base pairing between hepatitis C virus RNA and microRNA 122 3' of its seed sequence is essential for genome stabilization and production of infectious virus
    • Shimakami, T., D. Yamane, C. Welsch, L. Hensley, R.K. Jangra, and S.M. Lemon. 2012. Base pairing between hepatitis C virus RNA and microRNA 122 3' of its seed sequence is essential for genome stabilization and production of infectious virus. J. Virol. 86:7372-7383. http://dx.doi.org/10.1128/JVI.00513-12
    • (2012) J. Virol. , vol.86 , pp. 7372-7383
    • Shimakami, T.1    Yamane, D.2    Welsch, C.3    Hensley, L.4    Jangra, R.K.5    Lemon, S.M.6
  • 45
    • 84858782897 scopus 로고    scopus 로고
    • Inhibition of microRNA function by antimiR oligonucleotides
    • Stenvang, J., A. Petri, M. Lindow, S. Obad, and S. Kauppinen. 2012. Inhibition of microRNA function by antimiR oligonucleotides. Silence. 3:1. http://dx.doi.org/10.1186/1758-907X-3-1
    • (2012) Silence , vol.3 , pp. 1
    • Stenvang, J.1    Petri, A.2    Lindow, M.3    Obad, S.4    Kauppinen, S.5
  • 46
    • 16544365954 scopus 로고    scopus 로고
    • Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes
    • Válóczi, A., C. Hornyik, N. Varga, J. Burgyán, S. Kauppinen, and Z. Havelda. 2004. Sensitive and specific detection of microRNAs by northern blot analysis using LNA-modified oligonucleotide probes. Nucleic Acids Res. 32:e175. http://dx.doi.org/10.1093/nar/gnh171
    • (2004) Nucleic Acids Res , vol.32
    • Válóczi, A.1    Hornyik, C.2    Varga, N.3    Burgyán, J.4    Kauppinen, S.5    Havelda, Z.6
  • 47
    • 33745107518 scopus 로고    scopus 로고
    • Spatio-temporal accumulation of microRNAs is highly coordinated in developing plant tissues
    • Válóczi, A., E. Várallyay, S. Kauppinen, J. Burgyán, and Z. Havelda. 2006. Spatio-temporal accumulation of microRNAs is highly coordinated in developing plant tissues. Plant J. 47:140-151. http://dx.doi.org/10.1111/j.1365-313X.2006.02766.x
    • (2006) Plant J , vol.47 , pp. 140-151
    • Válóczi, A.1    Várallyay, E.2    Kauppinen, S.3    Burgyán, J.4    Havelda, Z.5
  • 48
    • 84856751210 scopus 로고    scopus 로고
    • Developing microRNA therapeutics
    • van Rooij, E., A.L. Purcell, and A.A. Levin. 2012. Developing microRNA therapeutics. Circ. Res. 110:496-507. http://dx.doi.org/10.1161/CIRCRESAHA.111.247916
    • (2012) Circ. Res. , vol.110 , pp. 496-507
    • van Rooij, E.1    Purcell, A.L.2    Levin, A.A.3
  • 49
    • 60149084560 scopus 로고    scopus 로고
    • MicroRNAs and cancer: short RNAs go a long way
    • Ventura, A., and T. Jacks. 2009. MicroRNAs and cancer: short RNAs go a long way. Cell. 136:586-591. http://dx.doi.org/10.1016/j.cell.2009.02.005
    • (2009) Cell , vol.136 , pp. 586-591
    • Ventura, A.1    Jacks, T.2
  • 51
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    • Wightman, B., I. Ha, and G. Ruvkun. 1993. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell. 75:855-862. http://dx.doi.org/10.1016/0092-8674(93)90530-4
    • (1993) Cell , vol.75 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 52
    • 66049132154 scopus 로고    scopus 로고
    • MicroRNA control of muscle development and disease
    • Williams, A.H., N. Liu, E. van Rooij, and E.N. Olson. 2009. MicroRNA control of muscle development and disease. Curr. Opin. Cell Biol. 21:461-469. http://dx.doi.org/10.1016/j.ceb.2009.01.029
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 461-469
    • Williams, A.H.1    Liu, N.2    van Rooij, E.3    Olson, E.N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.