Lipid modification of GRN163, an N3′→P5′ thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition

Oncogene

Volumn 24, Issue 33, 2005, Pages 5262-5268

  Herbert, Brittney Shea ^a,b,c   Gellert, Ginelle C ^a   Hochreiter, Amelia ^b,c   Pongracz, Krisztina ^d   Wright, Woodring E ^a   Zielinska, Daria ^d   Chin, Allison C ^d   Harley, Calvin B ^d   Shay, Jerry W ^a   Gryaznov, Sergei M ^d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d GERON CORPORATION   (United States)

Author keywords

Lipid conjugates; Oligonucleotide; Telomerase inhibitors; Thio phosphoramidates

Indexed keywords

GRN 163; OLIGONUCLEOTIDE; PHOSPHORAMIDIC ACID DERIVATIVE; TELOMERASE INHIBITOR; ANTINEOPLASTIC AGENT; GRN163; LIPID; TELOMERASE;

ARTICLE; CANCER THERAPY; CELL GROWTH; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; TELOMERE; ANIMAL; CELL CULTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG SCREENING; ENZYMOLOGY; METABOLISM; MOUSE; NUDE MOUSE; SOLUBILITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIPIDS; MICE; MICE, NUDE; OLIGONUCLEOTIDES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERASE; TUMOR CELLS, CULTURED;

EID: 23444453219     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208760     Document Type: Article

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