메뉴 건너뛰기




Volumn 14, Issue 3, 2013, Pages 31-41

A decade of RNAi screening: Too much hay and very few needles

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENE FUNCTION; GENE TARGETING; HIGH THROUGHPUT SCREENING; RNA ANALYSIS; SCREENING TEST;

EID: 84880868817     PISSN: 14694344     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (11)

References (99)
  • 1
    • 0029024475 scopus 로고
    • Par-1, a gene required for establishing polarity in C elegans embryos, encodes a putative ser/thr kinase that is asymmetrically distributed
    • Guo, S and Kemphues, KJ. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell 81, 611-20 (1995).
    • (1995) Cell , vol.81 , pp. 611-620
    • Guo, S.1    Kemphues, K.J.2
  • 2
    • 77953626646 scopus 로고    scopus 로고
    • Genomic screening with RNAi: Results and challenges
    • Mohr, S et al. Genomic screening with RNAi: results and challenges. Annu Rev Biochem 79, 37-64 (2010).
    • (2010) Annu Rev Biochem , vol.79 , pp. 37-64
    • Mohr, S.1
  • 3
    • 74049124186 scopus 로고    scopus 로고
    • Recognizing and avoiding siRNA OTEs for target identification and therapeutic application
    • Jackson, AL and Linsley, PS. Recognizing and avoiding siRNA OTEs for target identification and therapeutic application. Nat Rev Drug Discov 9, 57-67 (2010).
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 57-67
    • Jackson, A.L.1    Linsley, P.S.2
  • 4
    • 79251469386 scopus 로고    scopus 로고
    • Vigilance and validation: Keys to success in RNAi screening
    • Sigoillot, FD and King, RW. Vigilance and validation: Keys to success in RNAi screening. ACS Chem Biol 6, 47-60 (2011).
    • (2011) ACS Chem Biol , vol.6 , pp. 47-60
    • Sigoillot, F.D.1    King, R.W.2
  • 5
    • 0035195942 scopus 로고    scopus 로고
    • Non-coding RNAs: The architects of eukaryotic complexity
    • Mattick, JS. Non-coding RNAs:the architects of eukaryotic complexity. EMBO reports 2, 986-91 (2001).
    • (2001) EMBO Reports , vol.2 , pp. 986-991
    • Mattick, J.S.1
  • 6
    • 84874266637 scopus 로고    scopus 로고
    • Rfam 11.0: 10 years of RNA families
    • Burge, SW et al. Rfam 11.0: 10 years of RNA families. Nucleic Acids Res 41, D226-32 (2013).
    • (2013) Nucleic Acids Res , vol.41
    • Burge, S.W.1
  • 7
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of MicroRNAs
    • Friedman, RC et al. Most mammalian mRNAs are conserved targets of MicroRNAs. Genome Res 19, 92-105 (2009).
    • (2009) Genome Res , vol.19 , pp. 92-105
    • Friedman, R.C.1
  • 8
    • 84875200257 scopus 로고    scopus 로고
    • Long noncoding RNAs: Cellular address codes in development and disease
    • Batista, PJ and Chang, HY. Long noncoding RNAs: cellular address codes in development and disease. Cell 152, 1298-307 (2013).
    • (2013) Cell , vol.152 , pp. 1298-1307
    • Batista, P.J.1    Chang, H.Y.2
  • 9
    • 7244245762 scopus 로고    scopus 로고
    • Finishing the euchromatic sequence of the human genome
    • International Human Genome Sequencing Consortium
    • International Human Genome Sequencing Consortium. Finishing the Euchromatic Sequence of the Human Genome. Nature 431, 931-45 (2004).
    • (2004) Nature , vol.431 , pp. 931-945
  • 10
    • 0041930775 scopus 로고    scopus 로고
    • Gene counters struggle to get the right answer
    • Pennisi, E. Gene Counters Struggle to Get the Right Answer. Science 301, 1040-1 (2003).
    • (2003) Science , vol.301 , pp. 1040-1041
    • Pennisi, E.1
  • 11
    • 61849127843 scopus 로고    scopus 로고
    • RNA interference screening demystified
    • Lord, CJ et al. RNA interference screening demystified. J Clin Pathol 62, 195-200 (2009).
    • (2009) J Clin Pathol , vol.62 , pp. 195-200
    • Lord, C.J.1
  • 12
    • 77950668281 scopus 로고    scopus 로고
    • High-throughput RNAi screening to dissect cellular pathways: A how-to guide
    • Falschlehner, C et al. High-throughput RNAi screening to dissect cellular pathways: a how-to guide. Biotechnol J 5, 368-76 (2010).
    • (2010) Biotechnol J , vol.5 , pp. 368-376
    • Falschlehner, C.1
  • 13
    • 78649561297 scopus 로고    scopus 로고
    • Functional gene discovery using RNA interference-based genomic screens to combat pathogen infection
    • Hong-Geller, E and Micheva-Viteva, SN. Functional gene discovery using RNA interference-based genomic screens to combat pathogen infection. Curr Drug Discov Technol 7, 86-94 (2010).
    • (2010) Curr Drug Discov Technol , vol.7 , pp. 86-94
    • Hong-Geller, E.1    Micheva-Viteva, S.N.2
  • 14
    • 68549122864 scopus 로고    scopus 로고
    • RNA interference screening for the discovery of oncology targets
    • Quon, K and Kassner, PD. RNA interference screening for the discovery of oncology targets. Expert Opin Ther Targets 13, 1027-35 (2009).
    • (2009) Expert Opin Ther Targets , vol.13 , pp. 1027-1035
    • Quon, K.1    Kassner, P.D.2
  • 15
    • 78649330694 scopus 로고    scopus 로고
    • Synthetic lethal interactions for the development of cancer therapeutics: Biological and methodological advancements
    • Mizuarai, S and Kotani, H. Synthetic lethal interactions for the development of cancer therapeutics: biological and methodological advancements. Hum Genet 128, 567-75 (2010).
    • (2010) Hum Genet , vol.128 , pp. 567-575
    • Mizuarai, S.1    Kotani, H.2
  • 16
    • 78751693800 scopus 로고    scopus 로고
    • Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets
    • Swanton, C et al. Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets. Genome Med 2, 53 (2010).
    • (2010) Genome Med , vol.2 , pp. 53
    • Swanton, C.1
  • 17
    • 84858774472 scopus 로고    scopus 로고
    • The ups and downs of DNA repair biomarkers for PARP inhibitor therapies
    • Wang, XZ and Weaver, DT. The ups and downs of DNA repair biomarkers for PARP inhibitor therapies. Am J Cancer Res 1, 301-27 (2011).
    • (2011) Am J Cancer Res , vol.1 , pp. 301-327
    • Wang, X.Z.1    Weaver, D.T.2
  • 18
    • 84880905618 scopus 로고    scopus 로고
    • Molecular Biology of the Cell 4th edition, Garland Science, New York
    • Alberts, B et al. Studying Gene Expression and Function. Molecular Biology of the Cell 4th edition. Garland Science, New York (2002).
    • (2002) Studying Gene Expression and Function
    • Alberts, B.1
  • 19
    • 2542485466 scopus 로고    scopus 로고
    • The microrevolution: Applications and impacts of microarray technology on molecular biology and medicine (review)
    • Goldsmith, ZG and Dhanasekaran, N. The microrevolution: applications and impacts of microarray technology on molecular biology and medicine (review). Int J Mol Med 13, 483-95 (2004).
    • (2004) Int J Mol Med , vol.13 , pp. 483-495
    • Goldsmith, Z.G.1    Dhanasekaran, N.2
  • 20
    • 84870465072 scopus 로고    scopus 로고
    • A simple method for analyzing actives in random rnai screens: Introducing the "H score" for gene nomination &prioritization
    • Bhinder, B and Djaballah, H. A Simple Method for Analyzing Actives in Random RNAi Screens: Introducing the "H Score" for Gene Nomination &Prioritization. Comb Chem High Throughput Screen 15, 686-704 (2012).
    • (2012) Comb Chem High Throughput Screen , vol.15 , pp. 686-704
    • Bhinder, B.1    Djaballah, H.2
  • 21
    • 39349097864 scopus 로고    scopus 로고
    • Identification of host proteins required for HIV infection through a functional genomic screen
    • Brass, AL et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science 319, 921-6 (2008).
    • (2008) Science , vol.319 , pp. 921-926
    • Brass, A.L.1
  • 22
    • 52949130695 scopus 로고    scopus 로고
    • Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication
    • König, R et al. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell 135, 49-60 (2008).
    • (2008) Cell , vol.135 , pp. 49-60
    • König, R.1
  • 23
    • 55249088255 scopus 로고    scopus 로고
    • Genome-scale RNAi screen for host factors required for HIV replication
    • Zhou, H et al. Genome-scale RNAi screen for host factors required for HIV replication. Cell Host Microbe 4, 495-504 (2008).
    • (2008) Cell Host Microbe , vol.4 , pp. 495-504
    • Zhou, H.1
  • 24
    • 67249143012 scopus 로고    scopus 로고
    • Host cell factors in HIV replication: Meta-analysis of genome-wide studies
    • Bushman, FD et al. Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoS Pathog 5, e1000437 (2009).
    • (2009) PLoS Pathog , vol.5
    • Bushman, F.D.1
  • 25
    • 78651469589 scopus 로고    scopus 로고
    • Identifying HIV-1 host cell factors by genome-scale RNAi screening
    • Pache, L et al. Identifying HIV-1 host cell factors by genome-scale RNAi screening. Methods 53, 3-12 (2011).
    • (2011) Methods , vol.53 , pp. 3-12
    • Pache, L.1
  • 26
    • 72549116887 scopus 로고    scopus 로고
    • The IFITM proteins mediate cellular resistance to influenza A HINI virus, West Nile virus, and dengue virus
    • Brass. AL et al. The IFITM proteins mediate cellular resistance to influenza A HINI virus, West Nile virus, and dengue virus. Cell 139, 1243-54 (2009).
    • (2009) Cell , vol.139 , pp. 1243-1254
    • Brass, A.L.1
  • 27
    • 66149091940 scopus 로고    scopus 로고
    • Genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
    • Luo. JL et al. Genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 137, 835-48 (2009).
    • (2009) Cell , vol.137 , pp. 835-848
    • Luo, J.L.1
  • 28
    • 84875980445 scopus 로고    scopus 로고
    • An arrayed genome-scale lentiviralenabled short hairpin RNA screen identifies lethal and rescuer gene candidates
    • Bhinder, B et al. An arrayed genome-scale lentiviralenabled short hairpin RNA screen identifies lethal and rescuer gene candidates. Assay Drug Dev Technol 11, 173-90 (2013).
    • (2013) Assay Drug Dev Technol , vol.11 , pp. 173-190
    • Bhinder, B.1
  • 29
    • 79961062492 scopus 로고    scopus 로고
    • Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineagespecific dependencies in ovarian cancer
    • Cheung, HW et al. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineagespecific dependencies in ovarian cancer. Proc Natl Acad Sci USA 108, 12372-77 (2011).
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 12372-12377
    • Cheung, H.W.1
  • 30
    • 65849111219 scopus 로고    scopus 로고
    • Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells
    • Scholl, C et al. Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell 137, 821-34 (2009).
    • (2009) Cell , vol.137 , pp. 821-834
    • Scholl, C.1
  • 31
    • 70449091786 scopus 로고    scopus 로고
    • Systematic RNA interference reveals that oncogenic KRAS-driven cancers requireTBKI
    • Barbie, DA et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers requireTBKI. Nature 462, 108-12 (2009).
    • (2009) Nature , vol.462 , pp. 108-112
    • Barbie, D.A.1
  • 33
    • 80052187354 scopus 로고    scopus 로고
    • STK33 kinase activity is non-essential in KRAS-dependent cancer cells
    • Babij, C et al. STK33 kinase activity is non-essential in KRAS-dependent cancer cells. Cancer Res 71, 5818-26 (2011).
    • (2011) Cancer Res , vol.71 , pp. 5818-5826
    • Babij, C.1
  • 34
    • 84857422433 scopus 로고    scopus 로고
    • STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability
    • Luo, T et al. STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability. Proc Natl Acad Sci U SA 109, 2860-5 (2012).
    • (2012) Proc Natl Acad Sci U SA , vol.109 , pp. 2860-2865
    • Luo, T.1
  • 35
    • 84880869427 scopus 로고    scopus 로고
    • Evaluation of TBKI as a novel cancer target in the K-Ras pathway
    • Abstract nr
    • Vangamudi, B et al. Evaluation of TBKI as a novel cancer target in the K-Ras pathway. Cancer Res 72, Abstract nr 1813 (2012).
    • (2012) Cancer Res , vol.72 , pp. 1813
    • Vangamudi, B.1
  • 36
    • 81255137880 scopus 로고    scopus 로고
    • Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLKI and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma
    • Watt, SA et al. Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLKI and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma. Oncogene 30, 4666-77 (2011).
    • (2011) Oncogene , vol.30 , pp. 4666-4677
    • Watt, S.A.1
  • 37
    • 79960965895 scopus 로고    scopus 로고
    • Combined gene expression profiling and RNAi screening in clear cell renal cell carcinoma identify PLKI and other therapeutic kinase targets
    • Ding. Y et al. Combined gene expression profiling and RNAi screening in clear cell renal cell carcinoma identify PLKI and other therapeutic kinase targets. Cancer Res 71, 5225-34 (2011).
    • (2011) Cancer Res , vol.71 , pp. 5225-5234
    • Ding, Y.1
  • 38
    • 77952518695 scopus 로고    scopus 로고
    • Lentiviral shRNA screen of human kinases identifies PLK I as a potential therapeutic target for osteosarcoma
    • Duan, Z et al. Lentiviral shRNA screen of human kinases identifies PLK I as a potential therapeutic target for osteosarcoma. Cancer Lett 293, 220-9 (2010).
    • (2010) Cancer Lett , vol.293 , pp. 220-229
    • Duan, Z.1
  • 39
    • 84856575716 scopus 로고    scopus 로고
    • Small interfering RNA library screen identified polo-like kinase-1 (PLKI) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells
    • Hu, K et al. Small interfering RNA library screen identified polo-like kinase-1 (PLKI) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells. Breast Cancer Res 14, R22 (2012).
    • (2012) Breast Cancer Res , vol.14
    • Hu, K.1
  • 40
    • 0033678020 scopus 로고    scopus 로고
    • Polo-like kinase: A novel marker of proliferation: Correlation with estrogen-receptor expression in human breast cancer
    • Wolf, G et al. Polo-like kinase: a novel marker of proliferation: correlation with estrogen-receptor expression in human breast cancer. Pathol Res Pract 196, 753-9 (2000).
    • (2000) Pathol Res Pract , vol.196 , pp. 753-759
    • Wolf, G.1
  • 41
    • 0037648703 scopus 로고    scopus 로고
    • Polo-like kinase I (PLKI) is overexpressed in primary colorectal cancers
    • Takahashi. T et al. Polo-like kinase I (PLKI) is overexpressed in primary colorectal cancers. Cancer Sci 94, 148-52 (2003).
    • (2003) Cancer Sci , vol.94 , pp. 148-152
    • Takahashi, T.1
  • 42
    • 0033210869 scopus 로고    scopus 로고
    • Prognostic significance of polo-like kinase expression in esophageal carcinoma
    • Tokumitsu. Y et al. Prognostic significance of polo-like kinase expression in esophageal carcinoma. Int J Oncol 15, 687-92 (1999).
    • (1999) Int J Oncol , vol.15 , pp. 687-692
    • Tokumitsu, Y.1
  • 43
    • 33846846261 scopus 로고    scopus 로고
    • Survivin depletion preferentially reduces the survival of activated KO-Ras-transformed cells
    • Sarthy. AV et al. Survivin depletion preferentially reduces the survival of activated KO-Ras-transformed cells. Mol Cancer Ther 6, 269-76 (2007).
    • (2007) Mol Cancer Ther , vol.6 , pp. 269-276
    • Sarthy, A.V.1
  • 44
    • 54749113690 scopus 로고    scopus 로고
    • Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2
    • Zheng, M et al. Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2. Cancer Res 68, 7570-8 (2008).
    • (2008) Cancer Res , vol.68 , pp. 7570-7578
    • Zheng, M.1
  • 45
    • 79952775174 scopus 로고    scopus 로고
    • RNAi screen of the protein kinome identifies checkpoint kinase I (CHKI) as a therapeutic target in neuroblastoma
    • Cole, KA et al. RNAi screen of the protein kinome identifies checkpoint kinase I (CHKI) as a therapeutic target in neuroblastoma. Proc Natl Acad Sci USA 108, 3336-41 (2011).
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 3336-3341
    • Cole, K.A.1
  • 46
    • 33645306041 scopus 로고    scopus 로고
    • A loss-of-function RNA interference screen for molecular targets in cancer
    • Ngo. VN et al. A loss-of-function RNA interference screen for molecular targets in cancer. Nature 441, 106-10 (2006).
    • (2006) Nature , vol.441 , pp. 106-110
    • Ngo, V.N.1
  • 47
    • 79952730520 scopus 로고    scopus 로고
    • A20, ABIN-1/2, and CARD I I mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma
    • Dong, G et al. A20, ABIN-1/2, and CARD I I mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma. Clin Cancer Res 17, 1440-51 (2011).
    • (2011) Clin Cancer Res , vol.17 , pp. 1440-1451
    • Dong, G.1
  • 48
    • 84866930893 scopus 로고    scopus 로고
    • Ifitm3 limits the severity of acute influenza in mice
    • Bailey, CC et al. Ifitm3 limits the severity of acute influenza in mice. PLoS Pathog 8, e 1002909 (2012).
    • (2012) PLoS Pathog , vol.8
    • Bailey, C.C.1
  • 49
    • 67749148923 scopus 로고    scopus 로고
    • A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-I replication
    • Yeung, ML et al. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-I replication. j Biol Chem 284, 19463-73 (2009).
    • (2009) J Biol Chem , vol.284 , pp. 19463-19473
    • Yeung, M.L.1
  • 50
    • 77949530684 scopus 로고    scopus 로고
    • Novel HIV-I knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells
    • Rato, S et al. Novel HIV-I knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells. PLoS One 5, e9276 (2010).
    • (2010) PLoS One , vol.5
    • Rato, S.1
  • 51
    • 79551715390 scopus 로고    scopus 로고
    • The IFITM proteins inhibit HIV-I infection
    • Lu, J et al. The IFITM proteins inhibit HIV-I infection. J Virol 85, 2126-37 (2011).
    • (2011) J Virol , vol.85 , pp. 2126-2137
    • Lu, J.1
  • 52
    • 84880900191 scopus 로고    scopus 로고
    • Systematic analysis of RNAi reports finds zero gene commonality & reveal an unprecedented enrichment in pooled screens: Does depletion warrant essentiality?
    • Bhinder, B and Djaballah, H. Systematic analysis of RNAi reports finds zero gene commonality & reveal an unprecedented enrichment in pooled screens: does depletion warrant essentiality? Assay Drug Dev Technol (2013) (under review).
    • (2013) Assay Drug Dev Technol
    • Bhinder, B.1    Djaballah, H.2
  • 53
    • 38849098442 scopus 로고    scopus 로고
    • Cancer proliferation gene discovery through functional genomics
    • Schlabach, MR et al. Cancer proliferation gene discovery through functional genomics. Science 319, 620-4 (2008).
    • (2008) Science , vol.319 , pp. 620-624
    • Schlabach, M.R.1
  • 54
    • 80052890070 scopus 로고    scopus 로고
    • Off-target effects dominate a largescale RNAi screen for modulators of the TGF-ß pathway and reveal microRNA regulation of TGFBR2
    • Schultz, N et al. Off-target effects dominate a largescale RNAi screen for modulators of the TGF-ß pathway and reveal microRNA regulation of TGFBR2. Silence 2, 3 (2011).
    • (2011) Silence , vol.2 , pp. 3
    • Schultz, N.1
  • 55
    • 84870397172 scopus 로고    scopus 로고
    • Editorial: Random RNAi screening data analysis: A call for standardization
    • Djaballah, H. Editorial: Random RNAi Screening Data Analysis: A Call for Standardization. Comb. Chem. High Throughput Screen 15, 685 (2012).
    • (2012) Comb. Chem. High Throughput Screen , vol.15 , pp. 685
    • Djaballah, H.1
  • 56
    • 84864326893 scopus 로고    scopus 로고
    • Use and abuse of RNAi to study mammalian gene function
    • Kaelin Jr, WG. Use and Abuse of RNAi to study Mammalian Gene Function. Science 337, 421-2 (2012).
    • (2012) Science , vol.337 , pp. 421-422
    • Kaelin Jr., W.G.1
  • 57
    • 80055000824 scopus 로고    scopus 로고
    • RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
    • Zuber. J et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 478, 524-8 (2011).
    • (2011) Nature , vol.478 , pp. 524-528
    • Zuber, J.1
  • 58
    • 12144289681 scopus 로고    scopus 로고
    • A large-scale RNAi screen in human cells identifies new components of the p53 pathway
    • Berns, K et al. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428, 431-7 (2004).
    • (2004) Nature , vol.428 , pp. 431-437
    • Berns, K.1
  • 59
    • 33646033137 scopus 로고    scopus 로고
    • A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
    • Moffat, J et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124, 1283-98 (2006).
    • (2006) Cell , vol.124 , pp. 1283-1298
    • Moffat, J.1
  • 60
    • 33747754760 scopus 로고    scopus 로고
    • Lessons from nature: Microrna-based shRNA libraries
    • Chang, K et al. Lessons from nature: microRNA-based shRNA libraries. Nat Methods 3, 707-14 (2006).
    • (2006) Nat Methods , vol.3 , pp. 707-714
    • Chang, K.1
  • 61
    • 84869037267 scopus 로고    scopus 로고
    • The loop position of shRNAs and premiRNAs is critical for the accuracy of dicer processing in vivo
    • Gu, S et al. The loop position of shRNAs and premiRNAs is critical for the accuracy of dicer processing in vivo. Cell 151, 900-11 (2012).
    • (2012) Cell , vol.151 , pp. 900-911
    • Gu, S.1
  • 62
    • 79960185923 scopus 로고    scopus 로고
    • Dicer recognizes the 5' end of RNA for efficient and accurate processing
    • Park. JE et al. Dicer recognizes the 5' end of RNA for efficient and accurate processing. Nature 475, 201-5 (2011).
    • (2011) Nature , vol.475 , pp. 201-205
    • Park, J.E.1
  • 63
    • 17844363243 scopus 로고    scopus 로고
    • The contributions of dsRNA structure to Dicer specificity and efficiency
    • Vermeulen. A et al. The contributions of dsRNA structure to Dicer specificity and efficiency. RNA 11, 674-82 (2005).
    • (2005) RNA , vol.11 , pp. 674-682
    • Vermeulen, A.1
  • 64
    • 77952489759 scopus 로고    scopus 로고
    • Pooled RNAi screens-technical and biological aspects
    • Boettcher, M and Hoheisel. JD. Pooled RNAi Screens-Technical and Biological Aspects. Curr Genomics 11, 162-7 (2010).
    • (2010) Curr Genomics , vol.11 , pp. 162-167
    • Boettcher, M.1    Hoheisel, J.D.2
  • 65
    • 80054744229 scopus 로고    scopus 로고
    • High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing
    • Sims, D et al. High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing. Genome Biol 12, R104 (2011).
    • (2011) Genome Biol , vol.12
    • Sims, D.1
  • 66
    • 0033457336 scopus 로고    scopus 로고
    • PCR error and molecular population genetics
    • Kobayashi, N. Tamura, K and Aotsuka T. PCR error and molecular population genetics. Biochem Genet 37, 317-21 (1999).
    • (1999) Biochem Genet , vol.37 , pp. 317-321
    • Kobayashi, N.1    Tamura, K.2    Aotsuka, T.3
  • 67
    • 80052578609 scopus 로고    scopus 로고
    • Retraction for Lipardi and Paterson. Identification of an RNA-dependent RNA polymerase in Drosophila involved in RNAi and transposon suppression
    • Lipardi, C and Paterson, BM. Retraction for Lipardi and Paterson. Identification of an RNA-dependent RNA polymerase in Drosophila involved in RNAi and transposon suppression. Proc Natl Acad Sci U S A 108, 15010 (2011).
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 15010
    • Lipardi, C.1    Paterson, B.M.2
  • 68
    • 85046916163 scopus 로고    scopus 로고
    • Retracted manuscript: Overexpression of transketolase protein TKTLI is associated with occurrence and progression in nasopharyngeal carcinoma
    • Zhang, S et al. Retracted manuscript: Overexpression of transketolase protein TKTLI is associated with occurrence and progression in nasopharyngeal carcinoma. Cancer Biol Ther 10, 110 (2010).
    • (2010) Cancer Biol Ther , vol.10 , pp. 110
    • Zhang, S.1
  • 69
    • 84880881386 scopus 로고    scopus 로고
    • accessed May 16, 2013
    • Department Of Health And Human Services: Findings of Scientific Misconduct. www.gpo.gov/fdsys/pkg/FR-2010-08-25/html/2010-21048.htm (accessed May 16, 2013).
  • 71
    • 78649466225 scopus 로고    scopus 로고
    • Drug giants turn their backs on RNA interference
    • Ledford, H. Drug giants turn their backs on RNA interference. Nature 468, 487 (2010).
    • (2010) Nature , vol.468 , pp. 487
    • Ledford, H.1
  • 72
    • 84863229445 scopus 로고    scopus 로고
    • The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia
    • Banerji. V et al. The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia. J Clin Invest 122, 935-47 (2012).
    • (2012) J Clin Invest , vol.122 , pp. 935-947
    • Banerji, V.1
  • 73
    • 38349088899 scopus 로고    scopus 로고
    • Identification of RPSI4 as a 5qsyndrome gene by RNA interference screen
    • Ebert, BL et al. Identification of RPSI4 as a 5qsyndrome gene by RNA interference screen. Nature 451, 335-9 (2008).
    • (2008) Nature , vol.451 , pp. 335-339
    • Ebert, B.L.1
  • 74
    • 70349643737 scopus 로고    scopus 로고
    • Low RPSI4 expression is common in myelodysplastic syndromes without 5q-aberration and defines a subgroup of patients with prolonged survival
    • Czibere. A et al. Low RPSI4 expression is common in myelodysplastic syndromes without 5q-aberration and defines a subgroup of patients with prolonged survival. Haematologica 94, 1453-5 (2009).
    • (2009) Haematologica , vol.94 , pp. 1453-1455
    • Czibere, A.1
  • 75
    • 84874720284 scopus 로고    scopus 로고
    • Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stemand progenitor cells in acute myeloid leukemia AML
    • Herrmann, H et al. Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stemand progenitor cells in acute myeloid leukemia AML. Oncotarget 3, 1588-99 (2012).
    • (2012) Oncotarget , vol.3 , pp. 1588-1599
    • Herrmann, H.1
  • 76
    • 55749101028 scopus 로고    scopus 로고
    • A genome-wide shRNA screen identifies GAS I as a novel melanoma metastasis suppressor gene
    • Gobeil, S et al. A genome-wide shRNA screen identifies GAS I as a novel melanoma metastasis suppressor gene. Genes Dev 22, 2932-40 (2008).
    • (2008) Genes Dev , vol.22 , pp. 2932-2940
    • Gobeil, S.1
  • 77
    • 38849168162 scopus 로고    scopus 로고
    • Oncogenic BRAF induces senescence and apoptosis through pathways mediated b) the secreted protein IGFBP7
    • Wajapeyee, N et al. Oncogenic BRAF induces senescence and apoptosis through pathways mediated b) the secreted protein IGFBP7. Cell 132, 363-74 (2008).
    • (2008) Cell , vol.132 , pp. 363-374
    • Wajapeyee, N.1
  • 78
    • 77952479288 scopus 로고    scopus 로고
    • IGFBP7 is not required for B-RAF-induced melanocyte senescence
    • Scurr, LL et al. IGFBP7 is not required for B-RAF-induced melanocyte senescence. Cell 141, 717-27 (2010)
    • (2010) Cell , vol.141 , pp. 717-727
    • Scurr, L.L.1
  • 79
    • 76649101414 scopus 로고    scopus 로고
    • Lack of correlation between IGFBP7 expression and BRAF mutational status in melanoma
    • Schrama, D et al. Lack of correlation between IGFBP7 expression and BRAF mutational status in melanoma. J Invest Dermatol 130, 897-8 (2010).
    • (2010) J Invest Dermatol , vol.130 , pp. 897-898
    • Schrama, D.1
  • 80
    • 34249993765 scopus 로고    scopus 로고
    • Integrative genomic approaches identify IKBKE as a breast cancer oncogene
    • Boehm, JS et al. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell 129, 1065-79 (2007).
    • (2007) Cell , vol.129 , pp. 1065-1079
    • Boehm, J.S.1
  • 81
    • 77955038485 scopus 로고    scopus 로고
    • NFI is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome
    • Holzel, M et al. NFI is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome. Cell 142, 218-29 (2010).
    • (2010) Cell , vol.142 , pp. 218-229
    • Holzel, M.1
  • 82
    • 20444426889 scopus 로고    scopus 로고
    • A genetic screen identifies PITXI as a suppressor of RAS activity and tumorigenicity
    • Kolfschoten, IG et al. A genetic screen identifies PITXI as a suppressor of RAS activity and tumorigenicity. Cell 121, 849-58 (2005).
    • (2005) Cell , vol.121 , pp. 849-858
    • Kolfschoten, I.G.1
  • 83
    • 20444376939 scopus 로고    scopus 로고
    • A genetic screen for candidate tumor suppressors identifies REST
    • Westbrook, TF et al. A genetic screen for candidate tumor suppressors identifies REST. Cell 121, 837-48 (2005).
    • (2005) Cell , vol.121 , pp. 837-848
    • Westbrook, T.F.1
  • 84
    • 84858004513 scopus 로고    scopus 로고
    • USPI5 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma
    • Eichhorn, PJ et al. USPI5 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma. Nat Med 18, 429-35 (2012).
    • (2012) Nat Med , vol.18 , pp. 429-435
    • Eichhorn, P.J.1
  • 85
    • 84861999101 scopus 로고    scopus 로고
    • Integrated genomic analyses identify WEE I as a critical mediator of cell fate and a novel therapeutic target in acute myeloid leukemia
    • Porter, CC et al. Integrated genomic analyses identify WEE I as a critical mediator of cell fate and a novel therapeutic target in acute myeloid leukemia. Leukemia 26, 1266-76 (2012).
    • (2012) Leukemia , vol.26 , pp. 1266-1276
    • Porter, C.C.1
  • 86
    • 78049418533 scopus 로고    scopus 로고
    • Wilms tumor I (WTI) regulates KRAS-driven oncogenesis and senescence in mouse and human models
    • Vicent, S et al. Wilms tumor I (WTI) regulates KRAS-driven oncogenesis and senescence in mouse and human models. J Clin Invest 120, 3940-52 (2010).
    • (2010) J Clin Invest , vol.120 , pp. 3940-3952
    • Vicent, S.1
  • 87
    • 80455143829 scopus 로고    scopus 로고
    • BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol
    • Geiger, R et al. BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol. Nat Cell Biol 13, 1305-14 (2011).
    • (2011) Nat Cell Biol , vol.13 , pp. 1305-1314
    • Geiger, R.1
  • 88
    • 51649095289 scopus 로고    scopus 로고
    • RNA interference screen for human genes associated with West Nile virus infection
    • Krishnan, MN et al. RNA interference screen for human genes associated with West Nile virus infection. Nature 455, 242-5 (2008).
    • (2008) Nature , vol.455 , pp. 242-245
    • Krishnan, M.N.1
  • 89
    • 79952427119 scopus 로고    scopus 로고
    • Appraising the roles of CBLLI and the ubiquitin/proteasome system for flavivirus entry and replication
    • Fernandez-Garcia, MD et al. Appraising the roles of CBLLI and the ubiquitin/proteasome system for flavivirus entry and replication. J Virol 85, 2980-9 (2011).
    • (2011) J Virol , vol.85 , pp. 2980-2989
    • Fernandez-Garcia, M.D.1
  • 90
    • 34249828179 scopus 로고    scopus 로고
    • Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs
    • Swanton, C et al. Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell 11, 498-512 (2007).
    • (2007) Cancer Cell , vol.11 , pp. 498-512
    • Swanton, C.1
  • 91
    • 79955692689 scopus 로고    scopus 로고
    • EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy
    • Lupberger. J et al. EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nat Med 17, 589-95 (2011).
    • (2011) Nat Med , vol.17 , pp. 589-595
    • Lupberger, J.1
  • 92
    • 79958093406 scopus 로고    scopus 로고
    • Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer
    • Giamas, G et al. Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer. Nat Med 17, 715-9 (2011).
    • (2011) Nat Med , vol.17 , pp. 715-719
    • Giamas, G.1
  • 93
    • 84859104295 scopus 로고    scopus 로고
    • LMTK3 expression in breast cancer: Association with tumor phenotype and clinical outcome
    • Stebbing. J et al. LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome. Breast Cancer Res Treat 132, 537-44 (2012).
    • (2012) Breast Cancer Res Treat , vol.132 , pp. 537-544
    • Stebbing, J.1
  • 94
    • 84867085097 scopus 로고    scopus 로고
    • Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells
    • Bajrami, I et al. Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells. EMBO Mol Med 4, 1087-96 (2012).
    • (2012) EMBO Mol Med , vol.4 , pp. 1087-1096
    • Bajrami, I.1
  • 95
    • 84874635096 scopus 로고    scopus 로고
    • Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression
    • Santidrian. AF et al. Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest 123, 1068-81 (2013).
    • (2013) J Clin Invest , vol.123 , pp. 1068-1081
    • Santidrian, A.F.1
  • 96
    • 34249285532 scopus 로고    scopus 로고
    • Identification of Ras-related nuclear protein, targeting protein for xenopus kinesinlike protein 2, and stearoyl-CoA desaturase I as promising cancer targets from an RNAi-based screen
    • Morgan-Lappe, SE et al. Identification of Ras-related nuclear protein, targeting protein for xenopus kinesinlike protein 2, and stearoyl-CoA desaturase I as promising cancer targets from an RNAi-based screen. Cancer Res 67, 4390-8 (2007).
    • (2007) Cancer Res , vol.67 , pp. 4390-4398
    • Morgan-Lappe, S.E.1
  • 97
    • 84861385403 scopus 로고    scopus 로고
    • Scd l Plays a Tumor-Suppressive Role in Survival of Leukemia Stem Cells and the Development of Chronic Myeloid Leukemia
    • Zhang, H et al. Scd l Plays a Tumor-Suppressive Role in Survival of Leukemia Stem Cells and the Development of Chronic Myeloid Leukemia. Mol Cell Biol 32, 1776-87 (2012).
    • (2012) Mol Cell Biol , vol.32 , pp. 1776-1787
    • Zhang, H.1
  • 98
    • 84858256289 scopus 로고    scopus 로고
    • Tpx2 controls spindle integrity, genome stability, and tumor development
    • Aguirre-Portolés, C et al. Tpx2 controls spindle integrity, genome stability, and tumor development. Cancer Res 72, 1518-28 (2012).
    • (2012) Cancer Res , vol.72 , pp. 1518-1528
    • Aguirre-Portolés, C.1
  • 99
    • 84874458031 scopus 로고    scopus 로고
    • The CIN4 chromosomal instability qPCR classifier defines tumor aneuploidy and stratifies outcome in grade 2 breast cancer
    • Szász. AM et al. The CIN4 chromosomal instability qPCR classifier defines tumor aneuploidy and stratifies outcome in grade 2 breast cancer. PLoS One 8, e56707 (2013).
    • (2013) PLoS One , vol.8
    • Szász, A.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.