Lack of correlation between IGFBP7 expression and BRAF mutational status in melanoma

Journal of Investigative Dermatology

Volumn 130, Issue 3, 2010, Pages 897-898

  Schrama, David ^a   Kneitz, Hermann ^a   Willmes, Christoph ^a   Adam, Christian ^a   Houben, Roland ^a   Becker, Jürgen C ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; MITOGEN ACTIVATED PROTEIN KINASE; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 7; UNCLASSIFIED DRUG;

APOPTOSIS; CANCER GROWTH; CELL PROLIFERATION; ENZYME ACTIVATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; LETTER; MELANOMA; MELANOMA CELL; PATHOGENESIS; PRIORITY JOURNAL; SENESCENCE; SIGNAL TRANSDUCTION; XENOTRANSPLANTATION;

CELL LINE, TUMOR; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; MELANOMA; PROTO-ONCOGENE PROTEINS B-RAF; SIGNAL TRANSDUCTION; SKIN NEOPLASMS;

EID: 76649101414     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.304     Document Type: Letter

References (4)

1. Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S et al. (2002) Mutations of the BRAF gene in human cancer. Nature 417:949-954
2. Lin J, Lai M, Huang Q, Ruan W, Ma Y, Cui J (2008) Reactivation of IGFBP7 by DNA demethylation inhibits human colon cancer cell growth in vitro. Cancer Biol Ther 7:1896-1900
3. Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM et al. (2005) BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436:720-724
4. Wajapeyee N, Serra RW, Zhu X, Mahalingam M, Green MR (2008) Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132:363-374