An engineered glutamate-gated chloride (GLUCL) channel for sensitive, consistent neuronal silencing by ivermectin

Journal of Biological Chemistry

Volumn 288, Issue 29, 2013, Pages 21029-21042

  Frazier, Shawnalea J ^a,b   Cohen, Bruce N ^b   Lester, Henry A ^b  

^a Biochemistry and Molecular Biophysics Option   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE CHANNELS; CULTURED NEURONS; IVERMECTIN; RATIONAL POINTS; RECEPTOR EXPRESSION; SPIKE SUPPRESSIONS;

CHLORINE COMPOUNDS;

NEURONS;

CHLORIDE CHANNEL; GLUTAMATE GATED CHLORIDE CHANNEL; GLUTAMATE GATED CHLORIDE CHANNEL ALPHA SUBUNIT; GLUTAMATE GATED CHLORIDE CHANNEL BETA SUBUNIT; IVERMECTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL STRAIN HEK293; CELL VIABILITY; CHANNEL GATING; CONTROLLED STUDY; DIMERIZATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; GAIN OF FUNCTION MUTATION; GENE SILENCING; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN MOTIF; RAT;

ARGININE-BASED ER RETENTION MOTIF; CYS-LOOP RECEPTORS; ELECTROPHYSIOLOGY; GLUCL CHANNEL; ION CHANNELS; IVERMECTIN; NEUROSCIENCE; NEUROTRANSMITTER RECEPTORS; SILENCING;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL MEMBRANE; CHLORIDE CHANNELS; ENDOPLASMIC RETICULUM; GLUTAMIC ACID; HEK293 CELLS; HUMANS; ION CHANNEL GATING; IVERMECTIN; LUMINESCENT PROTEINS; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; NEURONS; PROTEIN ENGINEERING; PROTEIN MULTIMERIZATION; PROTEIN SUBUNITS; RATS; RATS, WISTAR;

EID: 84880539359     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.423921     Document Type: Article

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