Perspective: Ion channel assembly: Creating structures that function

Journal of General Physiology

Volumn 113, Issue 2, 1999, Pages 163-169

  Green, William N ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL; MESSENGER RNA; POTASSIUM CHANNEL; PROTEIN SUBUNIT; CHOLINERGIC RECEPTOR;

ENDOPLASMIC RETICULUM; OLIGOMERIZATION; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; ANIMAL; BIOSYNTHESIS; CHEMISTRY; HUMAN; ULTRASTRUCTURE;

ANIMALS; HUMANS; ION CHANNELS; PROTEIN CONFORMATION; RECEPTORS, CHOLINERGIC;

EID: 0033070866     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.113.2.163     Document Type: Review

References (57)

1. Blount, P., and J.P. Merlie. 1991. BIP associates with newly synthesized subunits of the mouse muscle nicotinic receptor. J. Cell Biol. 113:1125-1132.
2. Braakman, I., J. Helenius, and A. Helenius. 1992. Manipulating disulfide bond formation and protein folding in the endoplasmic reticulum. EMBO (Eur. Mol. Biol. Organ.) J. 11:1717-1722.
3. Brillantes, A.B., K. Ondrias, A. Scott, E. Kobrinsky, E. Ondriasova, M.C. Moschella, T. Jayaraman, M. Landers, B.E. Ehrlich, and A.R. Marks. 1994. Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell. 77: 513-523.
4. Brooks, C.R., M. Gruebele, J.N. Onuchic, and P.G. Wolynes. 1998. Chemical physics of protein folding. Proc. Natl. Acad. Sci. USA. 95: 11037-11038.
5. Cheng, S.H., R.J. Gregory, J. Marshall, S. Paul, D.W. Souza, G.A. White, C.R. O'Riordan, and A.E. Smith. 1990. Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis. Cell. 63:827-834.
6. Claudio, T., W.N. Green, D.S. Hartman, D. Hayden, H.L. Paulson, F.J. Sigworth, S.M. Sine, and A. Swedlund. 1987. Genetic reconstitution of functional acetylcholine receptor channels in mouse fibroblasts. Science. 238:1688-1694.
7. Colledge, M., and S.C., Froehner. 1998. Signals mediating ion channel clustering at the neuromuscular junction. Curr. Opin. Neurobiol. 8:357-363.
8. Cooper, S.T., and N.S. Millar. 1997. Most cell-specific folding and assembly of the neuronal nicotinic acetylcholine receptor alpha7 subunit. J. Neurochem. 68:2140-2151.
9. Cooper, S.T., and N.S. Millar. 1998. Host cell-specific folding of the neuronal nicotinic receptor alpha8 subunit. J. Neurochem. 70: 2585-2593.
10. de Silva, A., I. Braakman, and A. Helenius. 1993. Posttranslational folding of vesicular stomatitis virus G protein in the ER: involvement of noncovalent and covalent complexes. J Cell Biol. 120: 647-655.
11. Deal, K.K., D. Lovinger, and M.M. Tamkun. 1994. The brain Kvl.1 potassium channel: in vitro and in vivo studies on subunit assembly and posttranslational processing. J. Neurosci. 14:1666-1676.
12. Dobson, C.M., and R.J. Ellis. 1998. Protein folding and misfolding inside and outside the cell. EMBO (Eur. Mol. Biol. Organ.) J. 17: 5251-5254.
13. Eertmoed, A.L., Y.F. Vallejo, and W.N. Green. 1998. Transient expression of heteromeric ion channels. Methods Enzymol. 293: 564-585.
14. Forsayeth, J.R., Y. Gu, and Z.W. Hall. 1992. BiP forms stable complexes with unassembled subunits of the acetylcholine receptor in transfected COS cells and in C2 muscle cells. J. Cell Biol. 117: 841-847.
15. Froehner, S.C., C.W. Luetje, P.B. Scotland, and J. Patrick. 1990. The postsynaptic 43K protein clusters muscle nicotinic acetylcholine receptors in Xenopus oocytes. Neuron. 5:403-410.
16. Gelman, M.S., W. Chang, D.Y. Thomas, J.J. Bergeron, and J.M. Prives. 1995. Role of the endoplasmic reticulum chaperone calnexin in subunit folding and assembly of nicotinic acetylcholine receptors. J. Biol. Chem. 270:15085-15092.
17. Green, W.N., and T. Claudio. 1993. Acetylcholine receptor assembly: subunit folding and oligomerization occur sequentially. Cell. 74:57-69.
18. Green, W.N., and N.S. Millar. 1995. Ion-channel assembly. Trends Neurosci. 18:280-287.
19. Green, W.N., and C.P. Wanamaker. 1998. Formation of the nicotinic acetylcholine receptor binding sites. J. Neurosci. 18:5555-5564.
20. Green, W.N., and C.P. Wanamaker. 1997. The role of the cystine loop in acetylcholine receptor assembly. J. Biol. Chem. 272:20945-20953.
21. Gu, Y., P. Camacho, P. Gardner, and Z.W. Hall. 1991a. Identification of two amino acid residues in the ∈ subunit that promote mammalian muscle acetylcholine receptor assembly in COS cells. Neuron. 6:879-887.
22. Gu, Y., J.R. Forsayeth, S. Verrall, X.M. Yu, and Z.W. Hall. 1991b. Asembly of mammalian muscle acetylcholine receptors in transfected COS cells. J. Cell Biol 114:799-807.
23. Gurnett, C.A., and K.P. Campbell. 1996. Transmembrane auxiliary subunits of voltage-dependent ion channels. J. Biol. Chem. 271: 27975-27978.
24. Hammond, C., and A. Helenius. 1995. Quality control in the secretory pathway. Curr. Opin. Cell Biol. 7:523-529.
25. Helenius, A., T. Marquardt, and I. Braakman. 1992. The endoplasmic reticulum as a protein-folding compartment. Trends Cell Biol. 2:227-231.
26. Helenius, A., and K. Simons. 1975. Solubilization of membranes by detergents. Biochim. Biophys. Acta. 415:29-79.
27. Hurtley, S.M., and A. Helenius. 1989. Protein oligomerization in the endoplasmic reticulum. Annu. Rev. Cell Biol. 5:277-307.
28. Keller, S.H., J. Lindstrom, and P. Taylor. 1998. Inhibition of glucose trimming with castanospermine reduces calnexin association and promotes proteasome degradation of the alpha-subunit of the nicotinic acetylcholine receptor. J. Biol. Chem. 273:17064-17072.
29. Keller, S.H., J. Lindstrom, and P. Taylor. 1996. Involvement of the chaperone protein calnexin and the acetylcholine receptor beta-subunit in the assembly and cell surface expression of the receptor. J. Biol. Chem. 271:22871-22877.
30. Kopito, R.R. 1997. ER quality control: the cytoplasmic connection. Cell. 88:427-430.
31. Kreienkamp, H.J., R.K. Maeda, S.M. Sine, and P. Taylor. 1995. Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor. Neuron. 14:635-644.
32. Kreusch, A., P.J. Pfaffinger, C.F. Stevens, and S. Choe. 1998. Crystal structure of the tetramerization domain of the Shaker potassium channel. Nature. 392:945-948.
33. Li, M., Y.N. Jan, and L.Y. Jan. 1992. Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel. Science. 257:1225-1230.
34. Merlie, J.P., and J. Lindstrom. 1983. Assembly in vivo of mouse muscle acetylcholine receptor: identification of an alpha subunit species that may be an assembly intermediate. Cell. 34:747-757.
35. Millar, N.S., S.J. Moss, and W.N. Green. 1990. Assembly, post-translational processing and subcellular localisation of ion channels. In Ion Channels: A Practical Approach. R. Ashley, editor. IRL Press, London. 191-217.
36. Nagaya, N., and D.M. Papazian. 1997. Potassium channel alpha and beta subunits assemble in the endoplasmic reticulum. J. Biol. Chem. 272:3022-3027.
37. Nishimune, A., J.T. Isaac, E. Molnar, J. Noel, S.R. Nash, M. Tagaya, G.L. Collingridge, S. Nakanishi, and J.M. Henley. 1998. NSF binding to GluR2 regulates synaptic transmission. Neuron. 21:87-97.
38. Osten, P., S. Srivastava, G.J. Inman, F.S. Vilim, L. Khatri, L.M. Lee, B.A. States, S. Einheber, T.A. Milner, P.I. Hanson, and E.B. Ziff. 1998. The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs. Neuron. 21:99-110.
39. Ou, W.J., P.H. Cameron, D.Y. Thomas, and J.J. Bergeron. 1993. Association of folding intermediates of glycoproteins with calnexin during protein maturation. Nature. 364:771-776.
40. Paulson, H.L., A.F. Ross, W.N. Green, and T. Claudio. 1991. Analysis of early events in acetylcholine receptor assembly. J. Cell Biol. 113:1371-1384.
41. Phillips, W.D., C. Kopta, P. Blount, P.D. Gardner, J.H. Steinbach, and J.P. Merlie. 1991. ACh receptor-rich membrane domains organized in fibroblasts by recombinant 43-kilodalton protein. Science. 251:568-570.
42. Rangwala, F., R.C. Drisdel, S. Rakhilin, E. Ko, P. Atluri, A.B. Harkins, A.P. Fox, S.B. Salman, and W.N. Green. 1997. Neuronal α-bungarotoxin receptors differ structurally from other nicotinic acetylcholine receptors. J. Neurosci. 17:8201-8212.
43. Rosenberg, R.L., and J.E. East. 1992. Cell-free expression of functional Shaker potassium channels. Nature. 360:166-169.
44. Saedi, M.S., W.G. Conroy, and J. Lindstrom. 1991. Assembly of Torpedo acetylcholine receptors in Xenopus oocytes. J. Cell Biol. 112: 1007-1015.
45. Schmidt, J.W., and W.A. Catterall. 1986. Biosynthesis and processing of the alpha subunit of the voltage-sensitive sodium channel in rat brain neurons. Cell. 40:437-444.
46. Schulteis, C.T., N. Nagaya, and D.M. Papazian. 1998. Subunit folding and assembly steps are interspersed during Shaker potassium channel biogenesis. J. Biol. Chem. 273:26210-26217.
47. + channel assembly. Neuron. 11:67-76.
48. Sheng, M., and M. Wyszynski. 1997. Ion channel targeting in neurons. Bioessays. 19:847-853.
49. Sheng, Z., and C. Deutsch. 1998. Assembly of ion channels. Methods Enzymol. 293:17-32.
50. + channel surface expression through effects early in biosynthesis. Neuron. 16: 843-852.
51. Smith, M.M., J. Lindstrom, and J.P. Merlie. 1987. Formation of the α-bungarotoxin binding site and assembly of the acetylcholine receptor subunits occur in the endoplasmic reticulum. J. Biol. Chem. 262:4367-4376.
52. Sumikawa, K. 1992. Sequences on the N-terminus of ACh receptor subunits regulate their assembly, Brain Res. Mol. Brain Res. 13: 3-19-353.
53. + channel biosynthesis and assembly in transfected mammalian cells. Methods Enzymol. 293:32-49.
54. Trimmer, J.S. 1998b. Regulation of ion channel expression by cytoplasmic subunits. Curr. Opin. Neurobiol. 8:370-374.
55. Ward, C.L., and R.R. Kopito. 1994. Intracellular turnover of cystic fibrosis transmembrane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant proteins. J. Biol. Chem. 269:25710-25718.
56. Xu, J., and M. Li. 1998. Methods used to study subunit assembly of potassium channels. Methods Enzymol. 293:3-17.
57. Yu, X.-M., and Z.W. Hall. 1991. Extracellular domains mediating ∈ subunit interactions of muscle acetylcholine receptor. Nature. 352:64-67.