Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation

British Journal of Pharmacology

Volumn 127, Issue 6, 1999, Pages 1349-1358

  Thompson, Sally Anne ^a   Smith, Maria Z ^a   Wingrove, Peter B ^a   Whiting, Paul J ^a   Wafford, Keith A ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Benzodiazepine; GABA(A) receptor; Inverse agonist; Ion channel; Leucine; Modulator; Oocyte

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 PIPERIDINESULFONIC ACID; 4,5,6,7 TETRAHYDROISOXAZOLO[4,5 C]PYRIDIN 3 OL; ANESTHETIC AGENT; BENZODIAZEPINE DERIVATIVE; BICUCULLINE; LEUCINE; MUSCIMOL; SERINE;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FEMALE; MEMBRANE CURRENT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; XENOPUS;

ALLOSTERIC REGULATION; ANESTHETICS; ANIMALS; BENZODIAZEPINES; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GABA AGONISTS; GABA ANTAGONISTS; HUMANS; ION CHANNEL GATING; ION CHANNELS; MEMBRANE POTENTIALS; MUTATION; OOCYTES; PENTOBARBITAL; RECEPTORS, GABA-A; XENOPUS;

EID: 0032773033     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702687     Document Type: Article

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