메뉴 건너뛰기




Volumn 53, Issue 3, 1998, Pages 511-523

Substitutions of the highly conserved M2 leucine create spontaneously opening ρ γ-aminobutyric acid receptors

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOPROPYL(METHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; ION CHANNEL; LEUCINE; PICROTOXIN;

EID: 0031967525     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.53.3.511     Document Type: Article
Times cited : (70)

References (40)
  • 1
    • 0028171915 scopus 로고
    • Homomeric ρ1 GABA channels: Activation properties and domains
    • Amin J and Weiss DS (1994) Homomeric ρ1 GABA channels: activation properties and domains. Recept Channels 2:227-236.
    • (1994) Recept Channels , vol.2 , pp. 227-236
    • Amin, J.1    Weiss, D.S.2
  • 2
    • 0029944870 scopus 로고    scopus 로고
    • Insights into the activation of D1 GABA receptors obtained by coexpression of wild type and activation-impaired subunits
    • Amin J and Weiss DS (1996) Insights into the activation of D1 GABA receptors obtained by coexpression of wild type and activation-impaired subunits. Proc R Soc Lond Ser B Biol Sci 263:273-282.
    • (1996) Proc R Soc Lond Ser B Biol Sci , vol.263 , pp. 273-282
    • Amin, J.1    Weiss, D.S.2
  • 3
    • 0029934560 scopus 로고    scopus 로고
    • Voltage dependence of mouse acetylcholine receptor gating: Different charge movements in di-, mono-, and unliganded receptors
    • Auerbach A, Sigurdson W, Chen J, and Akk G (1996) Voltage dependence of mouse acetylcholine receptor gating: different charge movements in di-, mono-, and unliganded receptors. J Physiol (Lond) 494:155-170.
    • (1996) J Physiol (Lond) , vol.494 , pp. 155-170
    • Auerbach, A.1    Sigurdson, W.2    Chen, J.3    Akk, G.4
  • 6
    • 0025828670 scopus 로고
    • Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor
    • Cooper E, Couturier S, and Ballivet M (1991) Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor. Nature (Lond) 350: 235-238.
    • (1991) Nature (Lond) , vol.350 , pp. 235-238
    • Cooper, E.1    Couturier, S.2    Ballivet, M.3
  • 9
    • 0029129899 scopus 로고
    • A single point mutation decreases picrotoxinin sensitivity of the human GABA receptor ρ1 subunit
    • Enz R and Bormann J (1995) A single point mutation decreases picrotoxinin sensitivity of the human GABA receptor ρ1 subunit. Neuroreport 6:1569-1572.
    • (1995) Neuroreport , vol.6 , pp. 1569-1572
    • Enz, R.1    Bormann, J.2
  • 10
    • 0029123899 scopus 로고
    • The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating
    • Filatov G and White M (1995) The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating. Mol Pharmacol 48:379-384.
    • (1995) Mol Pharmacol , vol.48 , pp. 379-384
    • Filatov, G.1    White, M.2
  • 13
    • 0010518490 scopus 로고
    • Spontaneous openings of the acetylcholine receptor channel
    • Jackson MB (1984) Spontaneous openings of the acetylcholine receptor channel. Proc Natl Acad Sci USA 81:3901-3904.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 3901-3904
    • Jackson, M.B.1
  • 14
    • 0002246124 scopus 로고    scopus 로고
    • A multiplicity of GABA receptors, in benzodiazepine/GABA receptors and chloride channels
    • (Olsen RW and Venter JC, eds) New York, Alan R Liss, 1986
    • Johnston GAR (1996) A multiplicity of GABA receptors, in benzodiazepine/GABA receptors and chloride channels, in Receptor Biochemistry and Methodology (Olsen RW and Venter JC, eds) pp 57-71, New York, Alan R Liss, 1986.
    • (1996) Receptor Biochemistry and Methodology , pp. 57-71
    • Johnston, G.A.R.1
  • 15
    • 0029593370 scopus 로고
    • Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins
    • Karlin A and Akabas MH (1995) Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins. Neuron 15:1231-1244.
    • (1995) Neuron , vol.15 , pp. 1231-1244
    • Karlin, A.1    Akabas, M.H.2
  • 16
    • 0030480913 scopus 로고    scopus 로고
    • Determinants of nicotinic receptor gating in natural and unnatural side chain structures at the M2 9′ position
    • Kearney PC, Zhang H, Zhong W, Dougherty DA, and Lester HA (1996) Determinants of nicotinic receptor gating in natural and unnatural side chain structures at the M2 9′ position. Neuron 17:1221-1229.
    • (1996) Neuron , vol.17 , pp. 1221-1229
    • Kearney, P.C.1    Zhang, H.2    Zhong, W.3    Dougherty, D.A.4    Lester, H.A.5
  • 18
    • 0027400866 scopus 로고
    • GABA ρ2 receptor pharmacological profile: GABA recognition site similarities to ρ1
    • Kusama T, Wang T, Guggino W, Cutting G, and Uhl G (1993) GABA ρ2 receptor pharmacological profile: GABA recognition site similarities to ρ1. Eur J Pharmacol 245:83-84.
    • (1993) Eur J Pharmacol , vol.245 , pp. 83-84
    • Kusama, T.1    Wang, T.2    Guggino, W.3    Cutting, G.4    Uhl, G.5
  • 19
    • 0029163027 scopus 로고
    • Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors
    • Labarca C, Nowak M, Zhang H, Tang L, Deshpande P, and Lester HA (1995) Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature (Lond) 376:514-516.
    • (1995) Nature (Lond) , vol.376 , pp. 514-516
    • Labarca, C.1    Nowak, M.2    Zhang, H.3    Tang, L.4    Deshpande, P.5    Lester, H.A.6
  • 20
    • 0001202076 scopus 로고
    • Conserved quaternary structure of ligand-gated ion channels: The postsynaptic glycine receptor is a pentamer
    • Langosch D, Thomas L, and Betz H (1988) Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer. Proc Natl Acad Sci USA 85:7394-7398.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 7394-7398
    • Langosch, D.1    Thomas, L.2    Betz, H.3
  • 21
    • 0024213680 scopus 로고
    • Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor
    • Leonard RJ, Labarca CG, Charnet P, Davidson N, and Lester HA (1988) Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor. Science (Washington DC) 242:1578-1581.
    • (1988) Science (Washington DC) , vol.242 , pp. 1578-1581
    • Leonard, R.J.1    Labarca, C.G.2    Charnet, P.3    Davidson, N.4    Lester, H.A.5
  • 25
    • 0026451639 scopus 로고
    • The atypical M2 segment of the β subunit confers picrotoxinin resistance to inhibitory glycine receptor channels
    • Pribilla I, Takagi T, Langosch D, Bormann J, and Betz H (1992) The atypical M2 segment of the β subunit confers picrotoxinin resistance to inhibitory glycine receptor channels. EMBO J 11:4305-4311.
    • (1992) EMBO J , vol.11 , pp. 4305-4311
    • Pribilla, I.1    Takagi, T.2    Langosch, D.3    Bormann, J.4    Betz, H.5
  • 26
    • 0029859986 scopus 로고    scopus 로고
    • Design and in vitro pharmacology of a selective γ-aminobutyric acid C receptor antagonist
    • Ragozzino D, Woodward RM, Murata Y, Eusebi F, Overman LE, and Miledi R (1996) Design and in vitro pharmacology of a selective γ-aminobutyric acid C receptor antagonist. Mol Pharmacol 50:1024-1030.
    • (1996) Mol Pharmacol , vol.50 , pp. 1024-1030
    • Ragozzino, D.1    Woodward, R.M.2    Murata, Y.3    Eusebi, F.4    Overman, L.E.5    Miledi, R.6
  • 30
    • 0024835104 scopus 로고
    • A receptor forms a picrotoxin-sensitive anion channel open in the absence of GABA
    • A receptor forms a picrotoxin-sensitive anion channel open in the absence of GABA. FEBS Lett 257:377-379.
    • (1989) FEBS Lett , vol.257 , pp. 377-379
    • Sigel, E.1    Baur, R.2    Malherbe, P.3    Mohler, H.4
  • 31
    • 0024321499 scopus 로고
    • Pharmacology of a novel effect of γ-aminobutyric acid on the frog optic tectum in vitro
    • Sivilotti L and Nistri A (1989) Pharmacology of a novel effect of γ-aminobutyric acid on the frog optic tectum in vitro. Eur J Pharmacol 164:205-212.
    • (1989) Eur J Pharmacol , vol.164 , pp. 205-212
    • Sivilotti, L.1    Nistri, A.2
  • 33
    • 0028921479 scopus 로고
    • Acetylcholine receptor channel imaged in the open state
    • Unwin N (1995) Acetylcholine receptor channel imaged in the open state. Nature (Lond) 373:37-43.
    • (1995) Nature (Lond) , vol.373 , pp. 37-43
    • Unwin, N.1
  • 35
    • 0026625673 scopus 로고
    • Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist
    • White B and Cohen J (1992) Agonist-induced changes in the structure of the acetylcholine receptor M2 regions revealed by photoincorporation of an uncharged nicotinic noncompetitive antagonist. J Biol Chem 267:15770-15783.
    • (1992) J Biol Chem , vol.267 , pp. 15770-15783
    • White, B.1    Cohen, J.2
  • 37
    • 0028970548 scopus 로고
    • A receptor channel-lining residues probed in cysteine mutants
    • A receptor channel-lining residues probed in cysteine mutants. Biophys J 69:1858-1867.
    • (1995) Biophys J , vol.69 , pp. 1858-1867
    • Xu, M.1    Covey, D.F.2    Akabas, M.H.3
  • 38
    • 0027194134 scopus 로고
    • Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes
    • Yakel JL, Lagrutta A, Adelman JP, and North RA (1993) Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes. Proc Natl Acad Sci USA 90:5030-5033.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5030-5033
    • Yakel, J.L.1    Lagrutta, A.2    Adelman, J.P.3    North, R.A.4
  • 39
    • 0029417199 scopus 로고
    • Cloning of a γ-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block
    • Zhang D, Pan Z-H, Brideau AD, and Lipton SA (1995) Cloning of a γ-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block. Proc Natl Acad Sci USA 92:11756-11760.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11756-11760
    • Zhang, D.1    Pan, Z.-H.2    Brideau, A.D.3    Lipton, S.A.4
  • 40
    • 0027956644 scopus 로고
    • A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms
    • 479.1
    • Zhang H-G, French-Constant RH, and Jackson MB (1994) A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms. J Physiol (Lond) 479.1:65-75.
    • (1994) J Physiol (Lond) , pp. 65-75
    • Zhang, H.-G.1    French-Constant, R.H.2    Jackson, M.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.