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Volumn 34, Issue 7, 2013, Pages 1420-1430

The Notch signaling pathway as a mediator of tumor survival

Author keywords

[No Author keywords available]

Indexed keywords

ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; BIM PROTEIN; CISPLATIN; CYCLIN D1; DOCETAXEL; GEFITINIB; I KAPPA B; JAGGED1; MK 0752; MYC PROTEIN; N2 [2 (3,5 DIFLUOROPHENYL) 2 HYDROXYACETYL] N1 (6,7 DIHYDRO 5 METHYL 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL)ALANINAMIDE; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; NOTCH4 RECEPTOR; OXALIPLATIN; PRESENILIN 2; PROTEIN P21; PROTEIN P53; SOMATOMEDIN C RECEPTOR; SONIC HEDGEHOG PROTEIN; SURVIVIN; TEMOZOLOMIDE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR HEY 1; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SLUG; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 84880306937     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt127     Document Type: Article
Times cited : (230)

References (140)
  • 1
    • 0001130046 scopus 로고
    • Character changes caused by mutation of an entire region of a chromosome in Drosophila
    • Mohr, O.L. (1919) Character changes caused by mutation of an entire region of a chromosome in Drosophila. Genetics, 4, 275-282.
    • (1919) Genetics , vol.4 , pp. 275-282
    • Mohr, O.L.1
  • 2
    • 0022780155 scopus 로고
    • Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors
    • Kidd, S. et al. (1986) Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors. Mol. Cell. Biol., 6, 3094-3108.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 3094-3108
    • Kidd, S.1
  • 3
    • 0022289842 scopus 로고
    • Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats
    • Wharton, K.A. et al. (1985) Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell, 43(3 Pt 2), 567-581.
    • (1985) Cell , vol.43 , Issue.3 PART 2 , pp. 567-581
    • Wharton, K.A.1
  • 4
    • 0032403190 scopus 로고    scopus 로고
    • Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region
    • Kurooka, H. et al. (1998) Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region. Nucleic Acids Res., 26, 5448-5455.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 5448-5455
    • Kurooka, H.1
  • 5
    • 0034671686 scopus 로고    scopus 로고
    • Notch signaling: from the outside in
    • Mumm, J.S. et al. (2000) Notch signaling: from the outside in. Dev. Biol., 228, 151-165.
    • (2000) Dev. Biol. , vol.228 , pp. 151-165
    • Mumm, J.S.1
  • 6
    • 65549121943 scopus 로고    scopus 로고
    • Notch signaling: the core pathway and its posttranslational regulation
    • Fortini, M.E. (2009) Notch signaling: the core pathway and its posttranslational regulation. Dev. Cell, 16, 633-647.
    • (2009) Dev. Cell , vol.16 , pp. 633-647
    • Fortini, M.E.1
  • 7
    • 0028943243 scopus 로고
    • Notch signaling
    • Artavanis-Tsakonas, S. et al. (1995) Notch signaling. Science, 268, 225-232.
    • (1995) Science , vol.268 , pp. 225-232
    • Artavanis-Tsakonas, S.1
  • 8
    • 33644752839 scopus 로고    scopus 로고
    • Notch signaling
    • Miele, L. (2006) Notch signaling. Clin. Cancer Res., 12, 1074-1079.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1074-1079
    • Miele, L.1
  • 9
    • 0032493302 scopus 로고    scopus 로고
    • The Notch1 receptor is cleaved constitutively by a furin-like convertase
    • Logeat, F. et al. (1998) The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc. Natl Acad. Sci. USA, 95, 8108-8112.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 8108-8112
    • Logeat, F.1
  • 10
    • 0030877659 scopus 로고    scopus 로고
    • Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
    • Blaumueller, C.M. et al. (1997) Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell, 90, 281-291.
    • (1997) Cell , vol.90 , pp. 281-291
    • Blaumueller, C.M.1
  • 11
    • 0033974972 scopus 로고    scopus 로고
    • Calcium depletion dissociates and activates heterodimeric notch receptors
    • Rand, M.D. et al. (2000) Calcium depletion dissociates and activates heterodimeric notch receptors. Mol. Cell. Biol., 20, 1825-1835.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1825-1835
    • Rand, M.D.1
  • 12
    • 34247189534 scopus 로고    scopus 로고
    • Structural basis for autoinhibition of Notch
    • Gordon, W.R. et al. (2007) Structural basis for autoinhibition of Notch. Nat. Struct. Mol. Biol., 14, 295-300.
    • (2007) Nat. Struct. Mol. Biol. , vol.14 , pp. 295-300
    • Gordon, W.R.1
  • 13
    • 0025971830 scopus 로고
    • The choice of cell fate in the epidermis of Drosophila
    • Heitzler, P. et al. (1991) The choice of cell fate in the epidermis of Drosophila. Cell, 64, 1083-1092.
    • (1991) Cell , vol.64 , pp. 1083-1092
    • Heitzler, P.1
  • 14
    • 84880307038 scopus 로고
    • Altered epidermal growth
    • Heitzler, P. et al. (1993) Altered epidermal growth
    • (1993)
    • Heitzler, P.1
  • 15
    • 0028991691 scopus 로고
    • The role of Notch in lateral inhibition and cell fate specification
    • Chitnis, A.B. (1995) The role of Notch in lateral inhibition and cell fate specification. Mol. Cell. Neurosci., 6, 311-321.
    • (1995) Mol. Cell. Neurosci. , vol.6 , pp. 311-321
    • Chitnis, A.B.1
  • 16
    • 84873728505 scopus 로고    scopus 로고
    • Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1
    • Lu, J. et al. (2013) Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell, 23, 171-185.
    • (2013) Cancer Cell , vol.23 , pp. 171-185
    • Lu, J.1
  • 17
    • 0033868818 scopus 로고    scopus 로고
    • A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE
    • Brou, C. et al. (2000) A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol. Cell, 5, 207-216.
    • (2000) Mol. Cell , vol.5 , pp. 207-216
    • Brou, C.1
  • 18
    • 0035479911 scopus 로고    scopus 로고
    • Notch and presenilin: a proteolytic mechanism emerges
    • Fortini, M.E. (2001) Notch and presenilin: a proteolytic mechanism emerges. Curr. Opin. Cell Biol., 13, 627-634.
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 627-634
    • Fortini, M.E.1
  • 19
    • 18444417998 scopus 로고    scopus 로고
    • Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
    • Francis, R. et al. (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev. Cell, 3, 85-97.
    • (2002) Dev. Cell , vol.3 , pp. 85-97
    • Francis, R.1
  • 20
    • 0037154158 scopus 로고    scopus 로고
    • APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
    • Goutte, C. et al. (2002) APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Natl Acad. Sci. USA, 99, 775-779.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 775-779
    • Goutte, C.1
  • 21
    • 0034618715 scopus 로고    scopus 로고
    • Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
    • Yu, G. et al. (2000) Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature, 407, 48-54.
    • (2000) Nature , vol.407 , pp. 48-54
    • Yu, G.1
  • 22
    • 0037431082 scopus 로고    scopus 로고
    • Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-secretase complex
    • De Strooper, B. (2003) Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-secretase complex. Neuron, 38, 9-12.
    • (2003) Neuron , vol.38 , pp. 9-12
    • De Strooper, B.1
  • 23
    • 67650660754 scopus 로고    scopus 로고
    • The Notch signaling pathway: transcriptional regulation at Notch target genes
    • Borggrefe, T. et al. (2009) The Notch signaling pathway: transcriptional regulation at Notch target genes. Cell. Mol. Life Sci., 66, 1631-1646.
    • (2009) Cell. Mol. Life Sci. , vol.66 , pp. 1631-1646
    • Borggrefe, T.1
  • 24
    • 0029085935 scopus 로고
    • Signalling downstream of activated mammalian Notch
    • Jarriault, S. et al. (1995) Signalling downstream of activated mammalian Notch. Nature, 377, 355-358.
    • (1995) Nature , vol.377 , pp. 355-358
    • Jarriault, S.1
  • 25
    • 0033198359 scopus 로고    scopus 로고
    • Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators
    • Nellesen, D.T. et al. (1999) Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators. Dev. Biol., 213, 33-53.
    • (1999) Dev. Biol. , vol.213 , pp. 33-53
    • Nellesen, D.T.1
  • 26
    • 0029583607 scopus 로고
    • Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)
    • Tamura, K. et al. (1995) Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr. Biol., 5, 1416-1423.
    • (1995) Curr. Biol. , vol.5 , pp. 1416-1423
    • Tamura, K.1
  • 27
    • 0028232358 scopus 로고
    • Recognition sequence of a highly conserved DNA binding protein RBP-J kappa
    • Tun, T. et al. (1994) Recognition sequence of a highly conserved DNA binding protein RBP-J kappa. Nucleic Acids Res., 22, 965-971.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 965-971
    • Tun, T.1
  • 28
    • 33746546368 scopus 로고    scopus 로고
    • C-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
    • Weng, A.P. et al. (2006) c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev., 20, 2096-2109.
    • (2006) Genes Dev. , vol.20 , pp. 2096-2109
    • Weng, A.P.1
  • 29
    • 0032145527 scopus 로고    scopus 로고
    • A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
    • Kao, H.Y. et al. (1998) A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev., 12, 2269-2277.
    • (1998) Genes Dev. , vol.12 , pp. 2269-2277
    • Kao, H.Y.1
  • 30
    • 0031785161 scopus 로고    scopus 로고
    • Delta-1 activation of notch-1 signaling results in HES-1 transactivation
    • Jarriault, S. et al. (1998) Delta-1 activation of notch-1 signaling results in HES-1 transactivation. Mol. Cell. Biol., 18, 7423-7431.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 7423-7431
    • Jarriault, S.1
  • 31
    • 0028973380 scopus 로고
    • Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity
    • Bailey, A.M. et al. (1995) Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev., 9, 2609-2622.
    • (1995) Genes Dev. , vol.9 , pp. 2609-2622
    • Bailey, A.M.1
  • 32
    • 0030010697 scopus 로고    scopus 로고
    • The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain
    • Fisher, A.L. et al. (1996) The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain. Mol. Cell. Biol., 16, 2670-2677.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2670-2677
    • Fisher, A.L.1
  • 33
    • 34547922380 scopus 로고    scopus 로고
    • Delta-Notch-and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors
    • Fischer, A. et al. (2007) Delta-Notch-and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res., 35, 4583-4596.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 4583-4596
    • Fischer, A.1
  • 34
    • 84862942273 scopus 로고    scopus 로고
    • Notch signaling is necessary to maintain quiescence in adult muscle stem cells
    • Bjornson, C.R. et al. (2012) Notch signaling is necessary to maintain quiescence in adult muscle stem cells. Stem Cells, 30, 232-242.
    • (2012) Stem Cells , vol.30 , pp. 232-242
    • Bjornson, C.R.1
  • 35
    • 84856118451 scopus 로고    scopus 로고
    • A critical requirement for notch signaling in maintenance of the quiescent skeletal muscle stem cell state
    • Mourikis, P. et al. (2012) A critical requirement for notch signaling in maintenance of the quiescent skeletal muscle stem cell state. Stem Cells, 30, 243-252.
    • (2012) Stem Cells , vol.30 , pp. 243-252
    • Mourikis, P.1
  • 36
    • 34248364852 scopus 로고    scopus 로고
    • RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells
    • Vasyutina, E. et al. (2007) RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells. Proc. Natl Acad. Sci. USA, 104, 4443-4448.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 4443-4448
    • Vasyutina, E.1
  • 37
    • 0036024023 scopus 로고    scopus 로고
    • Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma
    • Nickoloff, B.J. et al. (2002) Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ., 9, 842-855.
    • (2002) Cell Death Differ. , vol.9 , pp. 842-855
    • Nickoloff, B.J.1
  • 38
    • 77954215506 scopus 로고    scopus 로고
    • Notch signaling: emerging molecular targets for cancer therapy
    • Yin, L. et al. (2010) Notch signaling: emerging molecular targets for cancer therapy. Biochem. Pharmacol., 80, 690-701.
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 690-701
    • Yin, L.1
  • 39
    • 0034902568 scopus 로고    scopus 로고
    • Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic)
    • Ronchini, C. et al. (2001) Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol. Cell. Biol., 21, 5925-5934.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 5925-5934
    • Ronchini, C.1
  • 40
    • 0035425232 scopus 로고    scopus 로고
    • Nrarp is a novel intracellular component of the Notch signaling pathway
    • Lamar, E. et al. (2001) Nrarp is a novel intracellular component of the Notch signaling pathway. Genes Dev., 15, 1885-1899.
    • (2001) Genes Dev. , vol.15 , pp. 1885-1899
    • Lamar, E.1
  • 41
    • 33846048039 scopus 로고    scopus 로고
    • Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia
    • Vilimas, T. et al. (2007) Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat. Med., 13, 70-77.
    • (2007) Nat. Med. , vol.13 , pp. 70-77
    • Vilimas, T.1
  • 42
    • 17844384528 scopus 로고    scopus 로고
    • Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
    • Rangarajan, A. et al. (2001) Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J., 20, 3427-3436.
    • (2001) EMBO J. , vol.20 , pp. 3427-3436
    • Rangarajan, A.1
  • 43
    • 0036467663 scopus 로고    scopus 로고
    • Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway
    • Reizis, B. et al. (2002) Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev., 16, 295-300.
    • (2002) Genes Dev. , vol.16 , pp. 295-300
    • Reizis, B.1
  • 44
    • 33745131039 scopus 로고    scopus 로고
    • Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice
    • Klinakis, A. et al. (2006) Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc. Natl Acad. Sci. USA, 103, 9262-9267.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 9262-9267
    • Klinakis, A.1
  • 45
    • 33845306813 scopus 로고    scopus 로고
    • Notch1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
    • Palomero, T. et al. (2006) Notch1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc. Natl Acad. Sci. USA, 103, 18261-18266.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 18261-18266
    • Palomero, T.1
  • 46
    • 77951880179 scopus 로고    scopus 로고
    • Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway
    • Eliasz, S. et al. (2010) Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. Oncogene, 29, 2488-2498.
    • (2010) Oncogene , vol.29 , pp. 2488-2498
    • Eliasz, S.1
  • 47
    • 78751503434 scopus 로고    scopus 로고
    • Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells
    • Chen, Y. et al. (2011) Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells. Cancer Biol. Ther., 11, 14-21.
    • (2011) Cancer Biol. Ther. , vol.11 , pp. 14-21
    • Chen, Y.1
  • 48
    • 48249103470 scopus 로고    scopus 로고
    • Slug is a direct Notch target required for initiation of cardiac cushion cellularization
    • Niessen, K. et al. (2008) Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J. Cell Biol., 182, 315-325.
    • (2008) J. Cell Biol. , vol.182 , pp. 315-325
    • Niessen, K.1
  • 49
    • 0023636264 scopus 로고
    • Analysis of DNA surrounding the breakpoints of chromosomal translocations involving the beta T cell receptor gene in human lymphoblastic neoplasms
    • Reynolds, T.C. et al. (1987) Analysis of DNA surrounding the breakpoints of chromosomal translocations involving the beta T cell receptor gene in human lymphoblastic neoplasms. Cell, 50, 107-117.
    • (1987) Cell , vol.50 , pp. 107-117
    • Reynolds, T.C.1
  • 50
    • 0025856717 scopus 로고
    • TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    • Ellisen, L.W. et al. (1991) TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell, 66, 649-661.
    • (1991) Cell , vol.66 , pp. 649-661
    • Ellisen, L.W.1
  • 51
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    • Weng, A.P. et al. (2004) Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science, 306, 269-271.
    • (2004) Science , vol.306 , pp. 269-271
    • Weng, A.P.1
  • 52
    • 33644756556 scopus 로고    scopus 로고
    • Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma
    • Lin, Y.W. et al. (2006) Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma. Blood, 107, 2540-2543.
    • (2006) Blood , vol.107 , pp. 2540-2543
    • Lin, Y.W.1
  • 53
    • 84655175059 scopus 로고    scopus 로고
    • Activation of Notch signal pathway is associated with a poorer prognosis in acute myeloid leukemia
    • Xu, X. et al. (2011) Activation of Notch signal pathway is associated with a poorer prognosis in acute myeloid leukemia. Med. Oncol., 28 (suppl. 1), S483-S489.
    • (2011) Med. Oncol. , vol.28 , Issue.SUPPL. 1
    • Xu, X.1
  • 54
    • 84866462073 scopus 로고    scopus 로고
    • Prognostic impact of d-like ligand 4 and Notch1 in acute myeloid leukemia
    • Zhang, J. et al. (2012) Prognostic impact of d-like ligand 4 and Notch1 in acute myeloid leukemia. Oncol. Rep., 28, 1503-1511.
    • (2012) Oncol. Rep. , vol.28 , pp. 1503-1511
    • Zhang, J.1
  • 55
    • 0023226698 scopus 로고
    • A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17
    • Gallahan, D. et al. (1987) A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17. J. Virol., 61, 218-220.
    • (1987) J. Virol. , vol.61 , pp. 218-220
    • Gallahan, D.1
  • 56
    • 0030920376 scopus 로고    scopus 로고
    • The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)
    • Gallahan, D. et al. (1997) The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Oncogene, 14, 1883-1890.
    • (1997) Oncogene , vol.14 , pp. 1883-1890
    • Gallahan, D.1
  • 57
    • 0030054646 scopus 로고    scopus 로고
    • Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
    • Uyttendaele, H. et al. (1996) Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development, 122, 2251-2259.
    • (1996) Development , vol.122 , pp. 2251-2259
    • Uyttendaele, H.1
  • 58
    • 32944470488 scopus 로고    scopus 로고
    • Aberrant activation of notch signaling in human breast cancer
    • Stylianou, S. et al. (2006) Aberrant activation of notch signaling in human breast cancer. Cancer Res., 66, 1517-1525.
    • (2006) Cancer Res. , vol.66 , pp. 1517-1525
    • Stylianou, S.1
  • 59
    • 24944506696 scopus 로고    scopus 로고
    • High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
    • Reedijk, M. et al. (2005) High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res., 65, 8530-8537.
    • (2005) Cancer Res. , vol.65 , pp. 8530-8537
    • Reedijk, M.1
  • 60
    • 34249098132 scopus 로고    scopus 로고
    • High-level JAG1 mRNA and protein predict poor outcome in breast cancer
    • Dickson, B.C. et al. (2007) High-level JAG1 mRNA and protein predict poor outcome in breast cancer. Mod. Pathol., 20, 685-693.
    • (2007) Mod. Pathol. , vol.20 , pp. 685-693
    • Dickson, B.C.1
  • 61
    • 51649090695 scopus 로고    scopus 로고
    • JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer
    • Reedijk, M. et al. (2008) JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer. Breast Cancer Res. Treat., 111, 439-448.
    • (2008) Breast Cancer Res. Treat. , vol.111 , pp. 439-448
    • Reedijk, M.1
  • 62
    • 76049110053 scopus 로고    scopus 로고
    • Alterations of the Notch pathway in lung cancer
    • Westhoff, B. et al. (2009) Alterations of the Notch pathway in lung cancer. Proc. Natl Acad. Sci. USA, 106, 22293-22298.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 22293-22298
    • Westhoff, B.1
  • 63
    • 34249936877 scopus 로고    scopus 로고
    • Notch signaling inhibits growth of the human lung adenocarcinoma cell line A549
    • Zheng, Q. et al. (2007) Notch signaling inhibits growth of the human lung adenocarcinoma cell line A549. Oncol. Rep., 17, 847-852.
    • (2007) Oncol. Rep. , vol.17 , pp. 847-852
    • Zheng, Q.1
  • 64
    • 47849127670 scopus 로고    scopus 로고
    • Lung cancer stem cells
    • Pine, S.R. et al. (2008) Lung cancer stem cells. Dis. Markers, 24, 257-266.
    • (2008) Dis. Markers , vol.24 , pp. 257-266
    • Pine, S.R.1
  • 65
    • 34548599785 scopus 로고    scopus 로고
    • Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung
    • Chen, Y. et al. (2007) Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung. Cancer Res., 67, 7954-7959.
    • (2007) Cancer Res. , vol.67 , pp. 7954-7959
    • Chen, Y.1
  • 66
    • 80052795864 scopus 로고    scopus 로고
    • Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung adenocarcinoma
    • Allen, T.D. et al. (2011) Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung adenocarcinoma. Cancer Res., 71, 6010-6018.
    • (2011) Cancer Res. , vol.71 , pp. 6010-6018
    • Allen, T.D.1
  • 67
    • 0034674896 scopus 로고    scopus 로고
    • Chromosome 19 translocation, overexpression of Notch3, and human lung cancer
    • Dang, T.P. et al. (2000) Chromosome 19 translocation, overexpression of Notch3, and human lung cancer. J. Natl. Cancer Inst., 92, 1355-1357.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 1355-1357
    • Dang, T.P.1
  • 68
    • 18144426777 scopus 로고    scopus 로고
    • Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers
    • Haruki, N. et al. (2005) Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers. Cancer Res., 65, 3555-3561.
    • (2005) Cancer Res. , vol.65 , pp. 3555-3561
    • Haruki, N.1
  • 69
    • 34548572895 scopus 로고    scopus 로고
    • Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers
    • Konishi, J. et al. (2007) Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. Cancer Res., 67, 8051-8057.
    • (2007) Cancer Res. , vol.67 , pp. 8051-8057
    • Konishi, J.1
  • 70
    • 75749138443 scopus 로고    scopus 로고
    • Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim
    • Konishi, J. et al. (2010) Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim. Oncogene, 29, 589-596.
    • (2010) Oncogene , vol.29 , pp. 589-596
    • Konishi, J.1
  • 71
    • 76549124723 scopus 로고    scopus 로고
    • Targeting specific regions of the Notch3 ligand-binding domain induces apoptosis and inhibits tumor growth in lung cancer
    • Lin, L. et al. (2010) Targeting specific regions of the Notch3 ligand-binding domain induces apoptosis and inhibits tumor growth in lung cancer. Cancer Res., 70, 632-638.
    • (2010) Cancer Res. , vol.70 , pp. 632-638
    • Lin, L.1
  • 72
    • 78650082224 scopus 로고    scopus 로고
    • Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer: coexpression of Notch-1 and vascular endothelial growth factor-A predicts poor survival
    • Donnem, T. et al. (2010) Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer: coexpression of Notch-1 and vascular endothelial growth factor-A predicts poor survival. Cancer, 116, 5676-5685.
    • (2010) Cancer , vol.116 , pp. 5676-5685
    • Donnem, T.1
  • 73
    • 20144387679 scopus 로고    scopus 로고
    • Expression of Notch-1 and its ligands, Deltalike- 1 and Jagged-1, is critical for glioma cell survival and proliferation
    • Purow, B.W. et al. (2005) Expression of Notch-1 and its ligands, Deltalike- 1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res., 65, 2353-2363.
    • (2005) Cancer Res. , vol.65 , pp. 2353-2363
    • Purow, B.W.1
  • 74
    • 84868621391 scopus 로고    scopus 로고
    • The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma
    • Chen, L. et al. (2012) The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma. Carcinogenesis, 33, 2276-2282.
    • (2012) Carcinogenesis , vol.33 , pp. 2276-2282
    • Chen, L.1
  • 75
    • 79955688638 scopus 로고    scopus 로고
    • Notch1 is an independent prognostic factor for patients with glioma
    • Li, J. et al. (2011) Notch1 is an independent prognostic factor for patients with glioma. J. Surg. Oncol., 103, 813-817.
    • (2011) J. Surg. Oncol. , vol.103 , pp. 813-817
    • Li, J.1
  • 76
    • 38549148417 scopus 로고    scopus 로고
    • Notch and cancer: a double-edged sword
    • Koch, U. et al. (2007) Notch and cancer: a double-edged sword. Cell. Mol. Life Sci., 64, 2746-2762.
    • (2007) Cell. Mol. Life Sci. , vol.64 , pp. 2746-2762
    • Koch, U.1
  • 77
    • 0037370310 scopus 로고    scopus 로고
    • Notch1 functions as a tumor suppressor in mouse skin
    • Nicolas, M. et al. (2003) Notch1 functions as a tumor suppressor in mouse skin. Nat. Genet., 33, 416-421.
    • (2003) Nat. Genet. , vol.33 , pp. 416-421
    • Nicolas, M.1
  • 78
    • 60749099023 scopus 로고    scopus 로고
    • Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
    • Carlén, M. et al. (2009) Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nat. Neurosci., 12, 259-267.
    • (2009) Nat. Neurosci. , vol.12 , pp. 259-267
    • Carlén, M.1
  • 79
    • 79953204955 scopus 로고    scopus 로고
    • Dll1-and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells
    • Pellegrinet, L. et al. (2011) Dll1-and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology, 140, 1230-1240.e1.
    • (2011) Gastroenterology , vol.140 , pp. 1230-1240
    • Pellegrinet, L.1
  • 80
    • 33751216490 scopus 로고    scopus 로고
    • Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells
    • Gal, H. et al. (2006) Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells. Leukemia, 20, 2147-2154.
    • (2006) Leukemia , vol.20 , pp. 2147-2154
    • Gal, H.1
  • 81
    • 80051640151 scopus 로고    scopus 로고
    • Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL
    • Tatarek, J. et al. (2011) Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL. Blood, 118, 1579-1590.
    • (2011) Blood , vol.118 , pp. 1579-1590
    • Tatarek, J.1
  • 82
    • 18944375734 scopus 로고    scopus 로고
    • Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
    • Dontu, G. et al. (2004) Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res., 6, R605-R615.
    • (2004) Breast Cancer Res. , vol.6
    • Dontu, G.1
  • 83
    • 84871504759 scopus 로고    scopus 로고
    • NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitro
    • Simmons, M.J. et al. (2012) NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitro. Breast Cancer Res., 14, R126.
    • (2012) Breast Cancer Res , vol.14 , Issue.R126
    • Simmons, M.J.1
  • 84
    • 84870346423 scopus 로고    scopus 로고
    • Loss of Mel-18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway
    • Won, H.Y. et al. (2012) Loss of Mel-18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway. FASEB J., 26, 5002-5013.
    • (2012) FASEB J. , vol.26 , pp. 5002-5013
    • Won, H.Y.1
  • 85
    • 76549084826 scopus 로고    scopus 로고
    • Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor
    • Harrison, H. et al. (2010) Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res., 70, 709-718.
    • (2010) Cancer Res. , vol.70 , pp. 709-718
    • Harrison, H.1
  • 86
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh, S.K. et al. (2004) Identification of human brain tumour initiating cells. Nature, 432, 396-401.
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1
  • 87
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • Singh, S.K. et al. (2003) Identification of a cancer stem cell in human brain tumors. Cancer Res., 63, 5821-5828.
    • (2003) Cancer Res. , vol.63 , pp. 5821-5828
    • Singh, S.K.1
  • 88
    • 84861111256 scopus 로고    scopus 로고
    • The contribution of Notch signaling to glioblastoma via activation of cancer stem cell self-renewal: the role of the endothelial network
    • Gürsel, D.B. et al. (2012) The contribution of Notch signaling to glioblastoma via activation of cancer stem cell self-renewal: the role of the endothelial network. Neurosurgery, 70, N19-N21.
    • (2012) Neurosurgery , vol.70
    • Gürsel, D.B.1
  • 89
    • 0036737914 scopus 로고    scopus 로고
    • Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro
    • Ignatova, T.N. et al. (2002) Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia, 39, 193-206.
    • (2002) Glia , vol.39 , pp. 193-206
    • Ignatova, T.N.1
  • 90
    • 33646358694 scopus 로고    scopus 로고
    • Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
    • Lee, J. et al. (2006) Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell, 9, 391-403.
    • (2006) Cancer Cell , vol.9 , pp. 391-403
    • Lee, J.1
  • 91
    • 75349105363 scopus 로고    scopus 로고
    • NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts
    • Fan, X. et al. (2010) NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells, 28, 5-16.
    • (2010) Stem Cells , vol.28 , pp. 5-16
    • Fan, X.1
  • 92
    • 80052795862 scopus 로고    scopus 로고
    • Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells
    • Zhu, T.S. et al. (2011) Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells. Cancer Res., 71, 6061-6072.
    • (2011) Cancer Res. , vol.71 , pp. 6061-6072
    • Zhu, T.S.1
  • 93
    • 77956623598 scopus 로고    scopus 로고
    • Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate
    • Hovinga, K.E. et al. (2010) Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate. Stem Cells, 28, 1019-1029.
    • (2010) Stem Cells , vol.28 , pp. 1019-1029
    • Hovinga, K.E.1
  • 94
    • 33747874155 scopus 로고    scopus 로고
    • Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors
    • Fan, X. et al. (2006) Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res., 66, 7445-7452.
    • (2006) Cancer Res. , vol.66 , pp. 7445-7452
    • Fan, X.1
  • 95
    • 76749112922 scopus 로고    scopus 로고
    • NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer
    • Sikandar, S.S. et al. (2010) NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res., 70, 1469-1478.
    • (2010) Cancer Res. , vol.70 , pp. 1469-1478
    • Sikandar, S.S.1
  • 96
    • 77956522571 scopus 로고    scopus 로고
    • Notch3 overexpression is related to the recurrence of ovarian cancer and confers resistance to carboplatin
    • Park, J.T. et al. (2010) Notch3 overexpression is related to the recurrence of ovarian cancer and confers resistance to carboplatin. Am. J. Pathol., 177, 1087-1094.
    • (2010) Am. J. Pathol. , vol.177 , pp. 1087-1094
    • Park, J.T.1
  • 97
    • 39449088496 scopus 로고    scopus 로고
    • Identification and expansion of the tumorigenic lung cancer stem cell population
    • Eramo, A. et al. (2008) Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ., 15, 504-514.
    • (2008) Cell Death Differ. , vol.15 , pp. 504-514
    • Eramo, A.1
  • 98
    • 84872005140 scopus 로고    scopus 로고
    • Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling
    • Liu, Y.P. et al. (2013) Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling. Cancer Res., 73, 406-416.
    • (2013) Cancer Res. , vol.73 , pp. 406-416
    • Liu, Y.P.1
  • 99
    • 84877093512 scopus 로고    scopus 로고
    • Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma
    • Hassan, K.A. et al. (2013) Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res., 19, 1972-1980.
    • (2013) Clin Cancer Res. , vol.19 , pp. 1972-1980
    • Hassan, K.A.1
  • 100
    • 79960022317 scopus 로고    scopus 로고
    • Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling
    • Nishina, S. et al. (2011) Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling. Oncol. Rep., 26, 523-531.
    • (2011) Oncol. Rep. , vol.26 , pp. 523-531
    • Nishina, S.1
  • 101
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen, J. et al. (2012) A restricted cell population propagates glioblastoma growth after chemotherapy. Nature, 488, 522-526.
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1
  • 102
    • 84865222310 scopus 로고    scopus 로고
    • Defining the mode of tumour growth by clonal analysis
    • Driessens, G. et al. (2012) Defining the mode of tumour growth by clonal analysis. Nature, 488, 527-530.
    • (2012) Nature , vol.488 , pp. 527-530
    • Driessens, G.1
  • 103
    • 84864854371 scopus 로고    scopus 로고
    • Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas
    • Schepers, A.G. et al. (2012) Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science, 337, 730-735.
    • (2012) Science , vol.337 , pp. 730-735
    • Schepers, A.G.1
  • 104
    • 84858288644 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in tumor microenvironment
    • Jing, Y. et al. (2011) Epithelial-mesenchymal transition in tumor microenvironment. Cell Biosci., 1, 29.
    • (2011) Cell Biosci , vol.1 , Issue.29
    • Jing, Y.1
  • 105
    • 77953541796 scopus 로고    scopus 로고
    • Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor
    • Saad, S. et al. (2010) Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor. Int. J. Biochem. Cell Biol., 42, 1115-1122.
    • (2010) Int. J. Biochem. Cell Biol. , vol.42 , pp. 1115-1122
    • Saad, S.1
  • 106
    • 84860006878 scopus 로고    scopus 로고
    • Immunohistochemical study of the epithelial- mesenchymal transition phenotype in cancer of unknown primary: incidence, correlations and prognostic utility
    • Stoyianni, A. et al. (2012) Immunohistochemical study of the epithelial- mesenchymal transition phenotype in cancer of unknown primary: incidence, correlations and prognostic utility. Anticancer Res., 32, 1273-1281.
    • (2012) Anticancer Res. , vol.32 , pp. 1273-1281
    • Stoyianni, A.1
  • 107
    • 79957487931 scopus 로고    scopus 로고
    • Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
    • Bao, B. et al. (2011) Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Cancer Lett., 307, 26-36.
    • (2011) Cancer Lett. , vol.307 , pp. 26-36
    • Bao, B.1
  • 108
    • 84859095585 scopus 로고    scopus 로고
    • Activation of Notch-1 enhances epithelial-mesenchymal transition in gefitinib-acquired resistant lung cancer cells
    • Xie, M. et al. (2012) Activation of Notch-1 enhances epithelial-mesenchymal transition in gefitinib-acquired resistant lung cancer cells. J. Cell. Biochem., 113, 1501-1513.
    • (2012) J. Cell. Biochem. , vol.113 , pp. 1501-1513
    • Xie, M.1
  • 109
    • 84867919330 scopus 로고    scopus 로고
    • Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy
    • McAuliffe, S.M. et al. (2012) Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy. Proc. Natl Acad. Sci. USA, 109, E2939-E2948.
    • (2012) Proc. Natl Acad. Sci. USA , vol.109
    • McAuliffe, S.M.1
  • 110
    • 84872190576 scopus 로고    scopus 로고
    • SiRNA-mediated silencing of Notch-1 enhances docetaxel induced mitotic arrest and apoptosis in prostate cancer cells
    • Ye, Q.F. et al. (2012) siRNA-mediated silencing of Notch-1 enhances docetaxel induced mitotic arrest and apoptosis in prostate cancer cells. Asian Pac. J. Cancer Prev., 13, 2485-2489.
    • (2012) Asian Pac. J. Cancer Prev. , vol.13 , pp. 2485-2489
    • Ye, Q.F.1
  • 111
    • 58349091690 scopus 로고    scopus 로고
    • Gamma-Secretase inhibitors abrogate oxaliplatin- induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity
    • Meng, R.D. et al. (2009) gamma-Secretase inhibitors abrogate oxaliplatin- induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res., 69, 573-582.
    • (2009) Cancer Res. , vol.69 , pp. 573-582
    • Meng, R.D.1
  • 112
    • 77956294442 scopus 로고    scopus 로고
    • Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence
    • Gilbert, C.A. et al. (2010) Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence. Cancer Res., 70, 6870-6879.
    • (2010) Cancer Res. , vol.70 , pp. 6870-6879
    • Gilbert, C.A.1
  • 113
    • 75349108271 scopus 로고    scopus 로고
    • Notch promotes radioresistance of glioma stem cells
    • Wang, J. et al. (2010) Notch promotes radioresistance of glioma stem cells. Stem Cells, 28, 17-28.
    • (2010) Stem Cells , vol.28 , pp. 17-28
    • Wang, J.1
  • 114
    • 84866064437 scopus 로고    scopus 로고
    • The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models
    • Mizuma, M. et al. (2012) The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models. Mol. Cancer Ther., 11, 1999-2009.
    • (2012) Mol. Cancer Ther. , vol.11 , pp. 1999-2009
    • Mizuma, M.1
  • 115
    • 11144355129 scopus 로고    scopus 로고
    • Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation
    • Wong, G.T. et al. (2004) Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J. Biol. Chem., 279, 12876-12882.
    • (2004) J. Biol. Chem. , vol.279 , pp. 12876-12882
    • Wong, G.T.1
  • 116
    • 84880287852 scopus 로고    scopus 로고
    • Abcam, (29 April 2013, date last accessed)
    • Abcam. DAPT. http://www.abcam.com/DAPT-ab120633.html (29 April 2013, date last accessed).
    • DAPT
  • 117
    • 84880286531 scopus 로고    scopus 로고
    • Selleck, html (29 April 2013, date last accessed)
    • Selleck. Ro4929097. http://www.selleckchem.com/products/RO4929097. html (29 April 2013, date last accessed).
    • Ro4929097
  • 118
    • 84855344803 scopus 로고    scopus 로고
    • Gamma-secretase inhibitors target tumorinitiating cells in a mouse model of ERBB2 breast cancer
    • Kondratyev, M. et al. (2012) Gamma-secretase inhibitors target tumorinitiating cells in a mouse model of ERBB2 breast cancer. Oncogene, 31, 93-103.
    • (2012) Oncogene , vol.31 , pp. 93-103
    • Kondratyev, M.1
  • 119
    • 84865201590 scopus 로고    scopus 로고
    • Therapeutic effect of ?-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK
    • Maraver, A. et al. (2012) Therapeutic effect of ?-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK. Cancer Cell, 22, 222-234.
    • (2012) Cancer Cell , vol.22 , pp. 222-234
    • Maraver, A.1
  • 120
    • 54949110552 scopus 로고    scopus 로고
    • Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements
    • Hemming, M.L. et al. (2008) Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements. PLoS Biol., 6, e257.
    • (2008) PLoS Biol , vol.6
    • Hemming, M.L.1
  • 121
    • 43049163813 scopus 로고    scopus 로고
    • Substrate specificity of gamma-secretase and other intramembrane proteases
    • Beel, A.J. et al. (2008) Substrate specificity of gamma-secretase and other intramembrane proteases. Cell. Mol. Life Sci., 65, 1311-1334.
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 1311-1334
    • Beel, A.J.1
  • 122
    • 84880291713 scopus 로고    scopus 로고
    • NIH
    • NIH. (2012) Gamma secretase inhibitor. http://clinicaltrials.gov/ct2/results?term=gamma+secretase+inhibitor&Search=Search.
    • (2012) Gamma secretase inhibitor
  • 123
    • 84880262721 scopus 로고    scopus 로고
    • NIH
    • NIH. (2013) Notch inhibitor cancer. http://www.clinicaltrials.gov/ct2/res ults?term=notch+inhibitor+cancer&Search=Search.
    • (2013) Notch inhibitor cancer
  • 124
    • 84880273975 scopus 로고    scopus 로고
    • H. Lee Moffitt Cancer Center and Research Institute., An open-label study of RO4929097 in metastatic colorectal cancer (NCT01116687)
    • H. Lee Moffitt Cancer Center and Research Institute. (2012) An open-label study of RO4929097 in metastatic colorectal cancer (NCT01116687).
    • (2012)
  • 125
    • 84864005118 scopus 로고    scopus 로고
    • Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors
    • Krop, I. et al. (2012) Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors. J. Clin. Oncol., 30, 2307-2313.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2307-2313
    • Krop, I.1
  • 126
    • 84863786154 scopus 로고    scopus 로고
    • Preclinical analysis of the ?-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia
    • Samon, J.B. et al. (2012) Preclinical analysis of the ?-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia. Mol. Cancer Ther., 11, 1565-1575.
    • (2012) Mol. Cancer Ther. , vol.11 , pp. 1565-1575
    • Samon, J.B.1
  • 127
    • 84880293575 scopus 로고    scopus 로고
    • Children's Oncology Group, Gamma-secretase inhibitor RO4929097 in treating young patients with relapsed or refractory solid tumors, CNS tumors, lymphoma, or T-cell leukemia (NCT01088763)
    • Children's Oncology Group. (2012) Gamma-secretase inhibitor RO4929097 in treating young patients with relapsed or refractory solid tumors, CNS tumors, lymphoma, or T-cell leukemia (NCT01088763).
    • (2012)
  • 128
    • 77951139188 scopus 로고    scopus 로고
    • Therapeutic antibody targeting of individual Notch receptors
    • Wu, Y. et al. (2010) Therapeutic antibody targeting of individual Notch receptors. Nature, 464, 1052-1057.
    • (2010) Nature , vol.464 , pp. 1052-1057
    • Wu, Y.1
  • 129
    • 84868377211 scopus 로고    scopus 로고
    • Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells
    • Falk, R. et al. (2012) Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells. Methods, 58, 69-78.
    • (2012) Methods , vol.58 , pp. 69-78
    • Falk, R.1
  • 130
    • 34247539127 scopus 로고    scopus 로고
    • The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth
    • Thurston, G. et al. (2007) The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth. Nat. Rev. Cancer, 7, 327-331.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 327-331
    • Thurston, G.1
  • 131
    • 33845877157 scopus 로고    scopus 로고
    • Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    • Noguera-Troise, I. et al. (2006) Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature, 444, 1032-1037.
    • (2006) Nature , vol.444 , pp. 1032-1037
    • Noguera-Troise, I.1
  • 132
    • 84864877183 scopus 로고    scopus 로고
    • MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo
    • Jenkins, D.W. et al. (2012) MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo. Mol. Cancer Ther., 11, 1650-1660.
    • (2012) Mol. Cancer Ther. , vol.11 , pp. 1650-1660
    • Jenkins, D.W.1
  • 133
    • 84880272307 scopus 로고    scopus 로고
    • MedImmune, A phase 1 study to evaluate the safety, tolerability, and pharmacokinetics of MEDI0639 in advanced solid tumors (NCT01577745)
    • MedImmune (2010). A phase 1 study to evaluate the safety, tolerability, and pharmacokinetics of MEDI0639 in advanced solid tumors (NCT01577745).
    • (2010)
  • 134
    • 81855190019 scopus 로고    scopus 로고
    • Delta-like ligand 4-notch blockade and tumor radiation response
    • Liu, S.K. et al. (2011) Delta-like ligand 4-notch blockade and tumor radiation response. J. Natl Cancer Inst., 103, 1778-1798.
    • (2011) J. Natl Cancer Inst. , vol.103 , pp. 1778-1798
    • Liu, S.K.1
  • 135
    • 76749157186 scopus 로고    scopus 로고
    • Chronic DLL4 blockade induces vascular neoplasms
    • Yan, M. et al. (2010) Chronic DLL4 blockade induces vascular neoplasms. Nature, 463, E6-E7.
    • (2010) Nature , vol.463
    • Yan, M.1
  • 136
    • 78650480680 scopus 로고    scopus 로고
    • Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation
    • Poirault-Chassac, S. et al. (2010) Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation. Blood, 116, 5670-5678.
    • (2010) Blood , vol.116 , pp. 5670-5678
    • Poirault-Chassac, S.1
  • 137
    • 33646877856 scopus 로고    scopus 로고
    • Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells
    • Wang, Z. et al. (2006) Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. Cancer, 106, 2503-2513.
    • (2006) Cancer , vol.106 , pp. 2503-2513
    • Wang, Z.1
  • 138
    • 67349193226 scopus 로고    scopus 로고
    • Emerging role of Notch in stem cells and cancer
    • Wang, Z. et al. (2009) Emerging role of Notch in stem cells and cancer. Cancer Lett., 279, 8-12.
    • (2009) Cancer Lett. , vol.279 , pp. 8-12
    • Wang, Z.1
  • 139
    • 79961109379 scopus 로고    scopus 로고
    • Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo
    • Howells, L.M. et al. (2011) Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo. Int. J. Cancer, 129, 476-486.
    • (2011) Int. J. Cancer , vol.129 , pp. 476-486
    • Howells, L.M.1
  • 140
    • 84861910687 scopus 로고    scopus 로고
    • Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling
    • Li, Y. et al. (2012) Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling. FEBS J., 279, 2247-2259.
    • (2012) FEBS J. , vol.279 , pp. 2247-2259
    • Li, Y.1


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