-
1
-
-
0001130046
-
Character changes caused by mutation of an entire region of a chromosome in Drosophila
-
Mohr, O.L. (1919) Character changes caused by mutation of an entire region of a chromosome in Drosophila. Genetics, 4, 275-282.
-
(1919)
Genetics
, vol.4
, pp. 275-282
-
-
Mohr, O.L.1
-
2
-
-
0022780155
-
Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors
-
Kidd, S. et al. (1986) Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors. Mol. Cell. Biol., 6, 3094-3108.
-
(1986)
Mol. Cell. Biol.
, vol.6
, pp. 3094-3108
-
-
Kidd, S.1
-
3
-
-
0022289842
-
Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats
-
Wharton, K.A. et al. (1985) Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell, 43(3 Pt 2), 567-581.
-
(1985)
Cell
, vol.43
, Issue.3 PART 2
, pp. 567-581
-
-
Wharton, K.A.1
-
4
-
-
0032403190
-
Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region
-
Kurooka, H. et al. (1998) Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region. Nucleic Acids Res., 26, 5448-5455.
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 5448-5455
-
-
Kurooka, H.1
-
5
-
-
0034671686
-
Notch signaling: from the outside in
-
Mumm, J.S. et al. (2000) Notch signaling: from the outside in. Dev. Biol., 228, 151-165.
-
(2000)
Dev. Biol.
, vol.228
, pp. 151-165
-
-
Mumm, J.S.1
-
6
-
-
65549121943
-
Notch signaling: the core pathway and its posttranslational regulation
-
Fortini, M.E. (2009) Notch signaling: the core pathway and its posttranslational regulation. Dev. Cell, 16, 633-647.
-
(2009)
Dev. Cell
, vol.16
, pp. 633-647
-
-
Fortini, M.E.1
-
7
-
-
0028943243
-
Notch signaling
-
Artavanis-Tsakonas, S. et al. (1995) Notch signaling. Science, 268, 225-232.
-
(1995)
Science
, vol.268
, pp. 225-232
-
-
Artavanis-Tsakonas, S.1
-
8
-
-
33644752839
-
Notch signaling
-
Miele, L. (2006) Notch signaling. Clin. Cancer Res., 12, 1074-1079.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 1074-1079
-
-
Miele, L.1
-
9
-
-
0032493302
-
The Notch1 receptor is cleaved constitutively by a furin-like convertase
-
Logeat, F. et al. (1998) The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc. Natl Acad. Sci. USA, 95, 8108-8112.
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 8108-8112
-
-
Logeat, F.1
-
10
-
-
0030877659
-
Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
-
Blaumueller, C.M. et al. (1997) Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell, 90, 281-291.
-
(1997)
Cell
, vol.90
, pp. 281-291
-
-
Blaumueller, C.M.1
-
11
-
-
0033974972
-
Calcium depletion dissociates and activates heterodimeric notch receptors
-
Rand, M.D. et al. (2000) Calcium depletion dissociates and activates heterodimeric notch receptors. Mol. Cell. Biol., 20, 1825-1835.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 1825-1835
-
-
Rand, M.D.1
-
12
-
-
34247189534
-
Structural basis for autoinhibition of Notch
-
Gordon, W.R. et al. (2007) Structural basis for autoinhibition of Notch. Nat. Struct. Mol. Biol., 14, 295-300.
-
(2007)
Nat. Struct. Mol. Biol.
, vol.14
, pp. 295-300
-
-
Gordon, W.R.1
-
13
-
-
0025971830
-
The choice of cell fate in the epidermis of Drosophila
-
Heitzler, P. et al. (1991) The choice of cell fate in the epidermis of Drosophila. Cell, 64, 1083-1092.
-
(1991)
Cell
, vol.64
, pp. 1083-1092
-
-
Heitzler, P.1
-
14
-
-
84880307038
-
Altered epidermal growth
-
Heitzler, P. et al. (1993) Altered epidermal growth
-
(1993)
-
-
Heitzler, P.1
-
15
-
-
0028991691
-
The role of Notch in lateral inhibition and cell fate specification
-
Chitnis, A.B. (1995) The role of Notch in lateral inhibition and cell fate specification. Mol. Cell. Neurosci., 6, 311-321.
-
(1995)
Mol. Cell. Neurosci.
, vol.6
, pp. 311-321
-
-
Chitnis, A.B.1
-
16
-
-
84873728505
-
Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1
-
Lu, J. et al. (2013) Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell, 23, 171-185.
-
(2013)
Cancer Cell
, vol.23
, pp. 171-185
-
-
Lu, J.1
-
17
-
-
0033868818
-
A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE
-
Brou, C. et al. (2000) A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol. Cell, 5, 207-216.
-
(2000)
Mol. Cell
, vol.5
, pp. 207-216
-
-
Brou, C.1
-
18
-
-
0035479911
-
Notch and presenilin: a proteolytic mechanism emerges
-
Fortini, M.E. (2001) Notch and presenilin: a proteolytic mechanism emerges. Curr. Opin. Cell Biol., 13, 627-634.
-
(2001)
Curr. Opin. Cell Biol.
, vol.13
, pp. 627-634
-
-
Fortini, M.E.1
-
19
-
-
18444417998
-
Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
-
Francis, R. et al. (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev. Cell, 3, 85-97.
-
(2002)
Dev. Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
-
20
-
-
0037154158
-
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
-
Goutte, C. et al. (2002) APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Natl Acad. Sci. USA, 99, 775-779.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 775-779
-
-
Goutte, C.1
-
21
-
-
0034618715
-
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
-
Yu, G. et al. (2000) Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature, 407, 48-54.
-
(2000)
Nature
, vol.407
, pp. 48-54
-
-
Yu, G.1
-
22
-
-
0037431082
-
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-secretase complex
-
De Strooper, B. (2003) Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-secretase complex. Neuron, 38, 9-12.
-
(2003)
Neuron
, vol.38
, pp. 9-12
-
-
De Strooper, B.1
-
23
-
-
67650660754
-
The Notch signaling pathway: transcriptional regulation at Notch target genes
-
Borggrefe, T. et al. (2009) The Notch signaling pathway: transcriptional regulation at Notch target genes. Cell. Mol. Life Sci., 66, 1631-1646.
-
(2009)
Cell. Mol. Life Sci.
, vol.66
, pp. 1631-1646
-
-
Borggrefe, T.1
-
24
-
-
0029085935
-
Signalling downstream of activated mammalian Notch
-
Jarriault, S. et al. (1995) Signalling downstream of activated mammalian Notch. Nature, 377, 355-358.
-
(1995)
Nature
, vol.377
, pp. 355-358
-
-
Jarriault, S.1
-
25
-
-
0033198359
-
Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators
-
Nellesen, D.T. et al. (1999) Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators. Dev. Biol., 213, 33-53.
-
(1999)
Dev. Biol.
, vol.213
, pp. 33-53
-
-
Nellesen, D.T.1
-
26
-
-
0029583607
-
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)
-
Tamura, K. et al. (1995) Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr. Biol., 5, 1416-1423.
-
(1995)
Curr. Biol.
, vol.5
, pp. 1416-1423
-
-
Tamura, K.1
-
27
-
-
0028232358
-
Recognition sequence of a highly conserved DNA binding protein RBP-J kappa
-
Tun, T. et al. (1994) Recognition sequence of a highly conserved DNA binding protein RBP-J kappa. Nucleic Acids Res., 22, 965-971.
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 965-971
-
-
Tun, T.1
-
28
-
-
33746546368
-
C-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
-
Weng, A.P. et al. (2006) c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev., 20, 2096-2109.
-
(2006)
Genes Dev.
, vol.20
, pp. 2096-2109
-
-
Weng, A.P.1
-
29
-
-
0032145527
-
A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
-
Kao, H.Y. et al. (1998) A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev., 12, 2269-2277.
-
(1998)
Genes Dev.
, vol.12
, pp. 2269-2277
-
-
Kao, H.Y.1
-
30
-
-
0031785161
-
Delta-1 activation of notch-1 signaling results in HES-1 transactivation
-
Jarriault, S. et al. (1998) Delta-1 activation of notch-1 signaling results in HES-1 transactivation. Mol. Cell. Biol., 18, 7423-7431.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 7423-7431
-
-
Jarriault, S.1
-
31
-
-
0028973380
-
Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity
-
Bailey, A.M. et al. (1995) Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev., 9, 2609-2622.
-
(1995)
Genes Dev.
, vol.9
, pp. 2609-2622
-
-
Bailey, A.M.1
-
32
-
-
0030010697
-
The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain
-
Fisher, A.L. et al. (1996) The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain. Mol. Cell. Biol., 16, 2670-2677.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 2670-2677
-
-
Fisher, A.L.1
-
33
-
-
34547922380
-
Delta-Notch-and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors
-
Fischer, A. et al. (2007) Delta-Notch-and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res., 35, 4583-4596.
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 4583-4596
-
-
Fischer, A.1
-
34
-
-
84862942273
-
Notch signaling is necessary to maintain quiescence in adult muscle stem cells
-
Bjornson, C.R. et al. (2012) Notch signaling is necessary to maintain quiescence in adult muscle stem cells. Stem Cells, 30, 232-242.
-
(2012)
Stem Cells
, vol.30
, pp. 232-242
-
-
Bjornson, C.R.1
-
35
-
-
84856118451
-
A critical requirement for notch signaling in maintenance of the quiescent skeletal muscle stem cell state
-
Mourikis, P. et al. (2012) A critical requirement for notch signaling in maintenance of the quiescent skeletal muscle stem cell state. Stem Cells, 30, 243-252.
-
(2012)
Stem Cells
, vol.30
, pp. 243-252
-
-
Mourikis, P.1
-
36
-
-
34248364852
-
RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells
-
Vasyutina, E. et al. (2007) RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells. Proc. Natl Acad. Sci. USA, 104, 4443-4448.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 4443-4448
-
-
Vasyutina, E.1
-
37
-
-
0036024023
-
Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma
-
Nickoloff, B.J. et al. (2002) Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ., 9, 842-855.
-
(2002)
Cell Death Differ.
, vol.9
, pp. 842-855
-
-
Nickoloff, B.J.1
-
38
-
-
77954215506
-
Notch signaling: emerging molecular targets for cancer therapy
-
Yin, L. et al. (2010) Notch signaling: emerging molecular targets for cancer therapy. Biochem. Pharmacol., 80, 690-701.
-
(2010)
Biochem. Pharmacol.
, vol.80
, pp. 690-701
-
-
Yin, L.1
-
39
-
-
0034902568
-
Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic)
-
Ronchini, C. et al. (2001) Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol. Cell. Biol., 21, 5925-5934.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5925-5934
-
-
Ronchini, C.1
-
40
-
-
0035425232
-
Nrarp is a novel intracellular component of the Notch signaling pathway
-
Lamar, E. et al. (2001) Nrarp is a novel intracellular component of the Notch signaling pathway. Genes Dev., 15, 1885-1899.
-
(2001)
Genes Dev.
, vol.15
, pp. 1885-1899
-
-
Lamar, E.1
-
41
-
-
33846048039
-
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia
-
Vilimas, T. et al. (2007) Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat. Med., 13, 70-77.
-
(2007)
Nat. Med.
, vol.13
, pp. 70-77
-
-
Vilimas, T.1
-
42
-
-
17844384528
-
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
-
Rangarajan, A. et al. (2001) Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J., 20, 3427-3436.
-
(2001)
EMBO J.
, vol.20
, pp. 3427-3436
-
-
Rangarajan, A.1
-
43
-
-
0036467663
-
Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway
-
Reizis, B. et al. (2002) Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev., 16, 295-300.
-
(2002)
Genes Dev.
, vol.16
, pp. 295-300
-
-
Reizis, B.1
-
44
-
-
33745131039
-
Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice
-
Klinakis, A. et al. (2006) Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc. Natl Acad. Sci. USA, 103, 9262-9267.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 9262-9267
-
-
Klinakis, A.1
-
45
-
-
33845306813
-
Notch1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
-
Palomero, T. et al. (2006) Notch1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc. Natl Acad. Sci. USA, 103, 18261-18266.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 18261-18266
-
-
Palomero, T.1
-
46
-
-
77951880179
-
Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway
-
Eliasz, S. et al. (2010) Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. Oncogene, 29, 2488-2498.
-
(2010)
Oncogene
, vol.29
, pp. 2488-2498
-
-
Eliasz, S.1
-
47
-
-
78751503434
-
Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells
-
Chen, Y. et al. (2011) Notch-1 signaling facilitates survivin expression in human non-small cell lung cancer cells. Cancer Biol. Ther., 11, 14-21.
-
(2011)
Cancer Biol. Ther.
, vol.11
, pp. 14-21
-
-
Chen, Y.1
-
48
-
-
48249103470
-
Slug is a direct Notch target required for initiation of cardiac cushion cellularization
-
Niessen, K. et al. (2008) Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J. Cell Biol., 182, 315-325.
-
(2008)
J. Cell Biol.
, vol.182
, pp. 315-325
-
-
Niessen, K.1
-
49
-
-
0023636264
-
Analysis of DNA surrounding the breakpoints of chromosomal translocations involving the beta T cell receptor gene in human lymphoblastic neoplasms
-
Reynolds, T.C. et al. (1987) Analysis of DNA surrounding the breakpoints of chromosomal translocations involving the beta T cell receptor gene in human lymphoblastic neoplasms. Cell, 50, 107-117.
-
(1987)
Cell
, vol.50
, pp. 107-117
-
-
Reynolds, T.C.1
-
50
-
-
0025856717
-
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
-
Ellisen, L.W. et al. (1991) TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell, 66, 649-661.
-
(1991)
Cell
, vol.66
, pp. 649-661
-
-
Ellisen, L.W.1
-
51
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng, A.P. et al. (2004) Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science, 306, 269-271.
-
(2004)
Science
, vol.306
, pp. 269-271
-
-
Weng, A.P.1
-
52
-
-
33644756556
-
Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma
-
Lin, Y.W. et al. (2006) Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma. Blood, 107, 2540-2543.
-
(2006)
Blood
, vol.107
, pp. 2540-2543
-
-
Lin, Y.W.1
-
53
-
-
84655175059
-
Activation of Notch signal pathway is associated with a poorer prognosis in acute myeloid leukemia
-
Xu, X. et al. (2011) Activation of Notch signal pathway is associated with a poorer prognosis in acute myeloid leukemia. Med. Oncol., 28 (suppl. 1), S483-S489.
-
(2011)
Med. Oncol.
, vol.28
, Issue.SUPPL. 1
-
-
Xu, X.1
-
54
-
-
84866462073
-
Prognostic impact of d-like ligand 4 and Notch1 in acute myeloid leukemia
-
Zhang, J. et al. (2012) Prognostic impact of d-like ligand 4 and Notch1 in acute myeloid leukemia. Oncol. Rep., 28, 1503-1511.
-
(2012)
Oncol. Rep.
, vol.28
, pp. 1503-1511
-
-
Zhang, J.1
-
55
-
-
0023226698
-
A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17
-
Gallahan, D. et al. (1987) A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17. J. Virol., 61, 218-220.
-
(1987)
J. Virol.
, vol.61
, pp. 218-220
-
-
Gallahan, D.1
-
56
-
-
0030920376
-
The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)
-
Gallahan, D. et al. (1997) The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Oncogene, 14, 1883-1890.
-
(1997)
Oncogene
, vol.14
, pp. 1883-1890
-
-
Gallahan, D.1
-
57
-
-
0030054646
-
Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
-
Uyttendaele, H. et al. (1996) Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development, 122, 2251-2259.
-
(1996)
Development
, vol.122
, pp. 2251-2259
-
-
Uyttendaele, H.1
-
58
-
-
32944470488
-
Aberrant activation of notch signaling in human breast cancer
-
Stylianou, S. et al. (2006) Aberrant activation of notch signaling in human breast cancer. Cancer Res., 66, 1517-1525.
-
(2006)
Cancer Res.
, vol.66
, pp. 1517-1525
-
-
Stylianou, S.1
-
59
-
-
24944506696
-
High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
-
Reedijk, M. et al. (2005) High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res., 65, 8530-8537.
-
(2005)
Cancer Res.
, vol.65
, pp. 8530-8537
-
-
Reedijk, M.1
-
60
-
-
34249098132
-
High-level JAG1 mRNA and protein predict poor outcome in breast cancer
-
Dickson, B.C. et al. (2007) High-level JAG1 mRNA and protein predict poor outcome in breast cancer. Mod. Pathol., 20, 685-693.
-
(2007)
Mod. Pathol.
, vol.20
, pp. 685-693
-
-
Dickson, B.C.1
-
61
-
-
51649090695
-
JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer
-
Reedijk, M. et al. (2008) JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer. Breast Cancer Res. Treat., 111, 439-448.
-
(2008)
Breast Cancer Res. Treat.
, vol.111
, pp. 439-448
-
-
Reedijk, M.1
-
62
-
-
76049110053
-
Alterations of the Notch pathway in lung cancer
-
Westhoff, B. et al. (2009) Alterations of the Notch pathway in lung cancer. Proc. Natl Acad. Sci. USA, 106, 22293-22298.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 22293-22298
-
-
Westhoff, B.1
-
63
-
-
34249936877
-
Notch signaling inhibits growth of the human lung adenocarcinoma cell line A549
-
Zheng, Q. et al. (2007) Notch signaling inhibits growth of the human lung adenocarcinoma cell line A549. Oncol. Rep., 17, 847-852.
-
(2007)
Oncol. Rep.
, vol.17
, pp. 847-852
-
-
Zheng, Q.1
-
64
-
-
47849127670
-
Lung cancer stem cells
-
Pine, S.R. et al. (2008) Lung cancer stem cells. Dis. Markers, 24, 257-266.
-
(2008)
Dis. Markers
, vol.24
, pp. 257-266
-
-
Pine, S.R.1
-
65
-
-
34548599785
-
Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung
-
Chen, Y. et al. (2007) Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung. Cancer Res., 67, 7954-7959.
-
(2007)
Cancer Res.
, vol.67
, pp. 7954-7959
-
-
Chen, Y.1
-
66
-
-
80052795864
-
Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung adenocarcinoma
-
Allen, T.D. et al. (2011) Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung adenocarcinoma. Cancer Res., 71, 6010-6018.
-
(2011)
Cancer Res.
, vol.71
, pp. 6010-6018
-
-
Allen, T.D.1
-
67
-
-
0034674896
-
Chromosome 19 translocation, overexpression of Notch3, and human lung cancer
-
Dang, T.P. et al. (2000) Chromosome 19 translocation, overexpression of Notch3, and human lung cancer. J. Natl. Cancer Inst., 92, 1355-1357.
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, pp. 1355-1357
-
-
Dang, T.P.1
-
68
-
-
18144426777
-
Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers
-
Haruki, N. et al. (2005) Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers. Cancer Res., 65, 3555-3561.
-
(2005)
Cancer Res.
, vol.65
, pp. 3555-3561
-
-
Haruki, N.1
-
69
-
-
34548572895
-
Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers
-
Konishi, J. et al. (2007) Gamma-secretase inhibitor prevents Notch3 activation and reduces proliferation in human lung cancers. Cancer Res., 67, 8051-8057.
-
(2007)
Cancer Res.
, vol.67
, pp. 8051-8057
-
-
Konishi, J.1
-
70
-
-
75749138443
-
Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim
-
Konishi, J. et al. (2010) Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim. Oncogene, 29, 589-596.
-
(2010)
Oncogene
, vol.29
, pp. 589-596
-
-
Konishi, J.1
-
71
-
-
76549124723
-
Targeting specific regions of the Notch3 ligand-binding domain induces apoptosis and inhibits tumor growth in lung cancer
-
Lin, L. et al. (2010) Targeting specific regions of the Notch3 ligand-binding domain induces apoptosis and inhibits tumor growth in lung cancer. Cancer Res., 70, 632-638.
-
(2010)
Cancer Res.
, vol.70
, pp. 632-638
-
-
Lin, L.1
-
72
-
-
78650082224
-
Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer: coexpression of Notch-1 and vascular endothelial growth factor-A predicts poor survival
-
Donnem, T. et al. (2010) Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer: coexpression of Notch-1 and vascular endothelial growth factor-A predicts poor survival. Cancer, 116, 5676-5685.
-
(2010)
Cancer
, vol.116
, pp. 5676-5685
-
-
Donnem, T.1
-
73
-
-
20144387679
-
Expression of Notch-1 and its ligands, Deltalike- 1 and Jagged-1, is critical for glioma cell survival and proliferation
-
Purow, B.W. et al. (2005) Expression of Notch-1 and its ligands, Deltalike- 1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res., 65, 2353-2363.
-
(2005)
Cancer Res.
, vol.65
, pp. 2353-2363
-
-
Purow, B.W.1
-
74
-
-
84868621391
-
The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma
-
Chen, L. et al. (2012) The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma. Carcinogenesis, 33, 2276-2282.
-
(2012)
Carcinogenesis
, vol.33
, pp. 2276-2282
-
-
Chen, L.1
-
75
-
-
79955688638
-
Notch1 is an independent prognostic factor for patients with glioma
-
Li, J. et al. (2011) Notch1 is an independent prognostic factor for patients with glioma. J. Surg. Oncol., 103, 813-817.
-
(2011)
J. Surg. Oncol.
, vol.103
, pp. 813-817
-
-
Li, J.1
-
76
-
-
38549148417
-
Notch and cancer: a double-edged sword
-
Koch, U. et al. (2007) Notch and cancer: a double-edged sword. Cell. Mol. Life Sci., 64, 2746-2762.
-
(2007)
Cell. Mol. Life Sci.
, vol.64
, pp. 2746-2762
-
-
Koch, U.1
-
77
-
-
0037370310
-
Notch1 functions as a tumor suppressor in mouse skin
-
Nicolas, M. et al. (2003) Notch1 functions as a tumor suppressor in mouse skin. Nat. Genet., 33, 416-421.
-
(2003)
Nat. Genet.
, vol.33
, pp. 416-421
-
-
Nicolas, M.1
-
78
-
-
60749099023
-
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
-
Carlén, M. et al. (2009) Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nat. Neurosci., 12, 259-267.
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 259-267
-
-
Carlén, M.1
-
79
-
-
79953204955
-
Dll1-and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells
-
Pellegrinet, L. et al. (2011) Dll1-and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology, 140, 1230-1240.e1.
-
(2011)
Gastroenterology
, vol.140
, pp. 1230-1240
-
-
Pellegrinet, L.1
-
80
-
-
33751216490
-
Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells
-
Gal, H. et al. (2006) Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells. Leukemia, 20, 2147-2154.
-
(2006)
Leukemia
, vol.20
, pp. 2147-2154
-
-
Gal, H.1
-
81
-
-
80051640151
-
Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL
-
Tatarek, J. et al. (2011) Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL. Blood, 118, 1579-1590.
-
(2011)
Blood
, vol.118
, pp. 1579-1590
-
-
Tatarek, J.1
-
82
-
-
18944375734
-
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells
-
Dontu, G. et al. (2004) Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res., 6, R605-R615.
-
(2004)
Breast Cancer Res.
, vol.6
-
-
Dontu, G.1
-
83
-
-
84871504759
-
NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitro
-
Simmons, M.J. et al. (2012) NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitro. Breast Cancer Res., 14, R126.
-
(2012)
Breast Cancer Res
, vol.14
, Issue.R126
-
-
Simmons, M.J.1
-
84
-
-
84870346423
-
Loss of Mel-18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway
-
Won, H.Y. et al. (2012) Loss of Mel-18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway. FASEB J., 26, 5002-5013.
-
(2012)
FASEB J.
, vol.26
, pp. 5002-5013
-
-
Won, H.Y.1
-
85
-
-
76549084826
-
Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor
-
Harrison, H. et al. (2010) Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res., 70, 709-718.
-
(2010)
Cancer Res.
, vol.70
, pp. 709-718
-
-
Harrison, H.1
-
86
-
-
9244241576
-
Identification of human brain tumour initiating cells
-
Singh, S.K. et al. (2004) Identification of human brain tumour initiating cells. Nature, 432, 396-401.
-
(2004)
Nature
, vol.432
, pp. 396-401
-
-
Singh, S.K.1
-
87
-
-
0141842674
-
Identification of a cancer stem cell in human brain tumors
-
Singh, S.K. et al. (2003) Identification of a cancer stem cell in human brain tumors. Cancer Res., 63, 5821-5828.
-
(2003)
Cancer Res.
, vol.63
, pp. 5821-5828
-
-
Singh, S.K.1
-
88
-
-
84861111256
-
The contribution of Notch signaling to glioblastoma via activation of cancer stem cell self-renewal: the role of the endothelial network
-
Gürsel, D.B. et al. (2012) The contribution of Notch signaling to glioblastoma via activation of cancer stem cell self-renewal: the role of the endothelial network. Neurosurgery, 70, N19-N21.
-
(2012)
Neurosurgery
, vol.70
-
-
Gürsel, D.B.1
-
89
-
-
0036737914
-
Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro
-
Ignatova, T.N. et al. (2002) Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia, 39, 193-206.
-
(2002)
Glia
, vol.39
, pp. 193-206
-
-
Ignatova, T.N.1
-
90
-
-
33646358694
-
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
-
Lee, J. et al. (2006) Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell, 9, 391-403.
-
(2006)
Cancer Cell
, vol.9
, pp. 391-403
-
-
Lee, J.1
-
91
-
-
75349105363
-
NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts
-
Fan, X. et al. (2010) NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells, 28, 5-16.
-
(2010)
Stem Cells
, vol.28
, pp. 5-16
-
-
Fan, X.1
-
92
-
-
80052795862
-
Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells
-
Zhu, T.S. et al. (2011) Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells. Cancer Res., 71, 6061-6072.
-
(2011)
Cancer Res.
, vol.71
, pp. 6061-6072
-
-
Zhu, T.S.1
-
93
-
-
77956623598
-
Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate
-
Hovinga, K.E. et al. (2010) Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate. Stem Cells, 28, 1019-1029.
-
(2010)
Stem Cells
, vol.28
, pp. 1019-1029
-
-
Hovinga, K.E.1
-
94
-
-
33747874155
-
Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors
-
Fan, X. et al. (2006) Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res., 66, 7445-7452.
-
(2006)
Cancer Res.
, vol.66
, pp. 7445-7452
-
-
Fan, X.1
-
95
-
-
76749112922
-
NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer
-
Sikandar, S.S. et al. (2010) NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res., 70, 1469-1478.
-
(2010)
Cancer Res.
, vol.70
, pp. 1469-1478
-
-
Sikandar, S.S.1
-
96
-
-
77956522571
-
Notch3 overexpression is related to the recurrence of ovarian cancer and confers resistance to carboplatin
-
Park, J.T. et al. (2010) Notch3 overexpression is related to the recurrence of ovarian cancer and confers resistance to carboplatin. Am. J. Pathol., 177, 1087-1094.
-
(2010)
Am. J. Pathol.
, vol.177
, pp. 1087-1094
-
-
Park, J.T.1
-
97
-
-
39449088496
-
Identification and expansion of the tumorigenic lung cancer stem cell population
-
Eramo, A. et al. (2008) Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ., 15, 504-514.
-
(2008)
Cell Death Differ.
, vol.15
, pp. 504-514
-
-
Eramo, A.1
-
98
-
-
84872005140
-
Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling
-
Liu, Y.P. et al. (2013) Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating Notch signaling. Cancer Res., 73, 406-416.
-
(2013)
Cancer Res.
, vol.73
, pp. 406-416
-
-
Liu, Y.P.1
-
99
-
-
84877093512
-
Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma
-
Hassan, K.A. et al. (2013) Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res., 19, 1972-1980.
-
(2013)
Clin Cancer Res.
, vol.19
, pp. 1972-1980
-
-
Hassan, K.A.1
-
100
-
-
79960022317
-
Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling
-
Nishina, S. et al. (2011) Restored expression of the tumor suppressor gene RUNX3 reduces cancer stem cells in hepatocellular carcinoma by suppressing Jagged1-Notch signaling. Oncol. Rep., 26, 523-531.
-
(2011)
Oncol. Rep.
, vol.26
, pp. 523-531
-
-
Nishina, S.1
-
101
-
-
84865203983
-
A restricted cell population propagates glioblastoma growth after chemotherapy
-
Chen, J. et al. (2012) A restricted cell population propagates glioblastoma growth after chemotherapy. Nature, 488, 522-526.
-
(2012)
Nature
, vol.488
, pp. 522-526
-
-
Chen, J.1
-
102
-
-
84865222310
-
Defining the mode of tumour growth by clonal analysis
-
Driessens, G. et al. (2012) Defining the mode of tumour growth by clonal analysis. Nature, 488, 527-530.
-
(2012)
Nature
, vol.488
, pp. 527-530
-
-
Driessens, G.1
-
103
-
-
84864854371
-
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas
-
Schepers, A.G. et al. (2012) Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science, 337, 730-735.
-
(2012)
Science
, vol.337
, pp. 730-735
-
-
Schepers, A.G.1
-
104
-
-
84858288644
-
Epithelial-mesenchymal transition in tumor microenvironment
-
Jing, Y. et al. (2011) Epithelial-mesenchymal transition in tumor microenvironment. Cell Biosci., 1, 29.
-
(2011)
Cell Biosci
, vol.1
, Issue.29
-
-
Jing, Y.1
-
105
-
-
77953541796
-
Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor
-
Saad, S. et al. (2010) Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor. Int. J. Biochem. Cell Biol., 42, 1115-1122.
-
(2010)
Int. J. Biochem. Cell Biol.
, vol.42
, pp. 1115-1122
-
-
Saad, S.1
-
106
-
-
84860006878
-
Immunohistochemical study of the epithelial- mesenchymal transition phenotype in cancer of unknown primary: incidence, correlations and prognostic utility
-
Stoyianni, A. et al. (2012) Immunohistochemical study of the epithelial- mesenchymal transition phenotype in cancer of unknown primary: incidence, correlations and prognostic utility. Anticancer Res., 32, 1273-1281.
-
(2012)
Anticancer Res.
, vol.32
, pp. 1273-1281
-
-
Stoyianni, A.1
-
107
-
-
79957487931
-
Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
-
Bao, B. et al. (2011) Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Cancer Lett., 307, 26-36.
-
(2011)
Cancer Lett.
, vol.307
, pp. 26-36
-
-
Bao, B.1
-
108
-
-
84859095585
-
Activation of Notch-1 enhances epithelial-mesenchymal transition in gefitinib-acquired resistant lung cancer cells
-
Xie, M. et al. (2012) Activation of Notch-1 enhances epithelial-mesenchymal transition in gefitinib-acquired resistant lung cancer cells. J. Cell. Biochem., 113, 1501-1513.
-
(2012)
J. Cell. Biochem.
, vol.113
, pp. 1501-1513
-
-
Xie, M.1
-
109
-
-
84867919330
-
Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy
-
McAuliffe, S.M. et al. (2012) Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy. Proc. Natl Acad. Sci. USA, 109, E2939-E2948.
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
-
-
McAuliffe, S.M.1
-
110
-
-
84872190576
-
SiRNA-mediated silencing of Notch-1 enhances docetaxel induced mitotic arrest and apoptosis in prostate cancer cells
-
Ye, Q.F. et al. (2012) siRNA-mediated silencing of Notch-1 enhances docetaxel induced mitotic arrest and apoptosis in prostate cancer cells. Asian Pac. J. Cancer Prev., 13, 2485-2489.
-
(2012)
Asian Pac. J. Cancer Prev.
, vol.13
, pp. 2485-2489
-
-
Ye, Q.F.1
-
111
-
-
58349091690
-
Gamma-Secretase inhibitors abrogate oxaliplatin- induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity
-
Meng, R.D. et al. (2009) gamma-Secretase inhibitors abrogate oxaliplatin- induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res., 69, 573-582.
-
(2009)
Cancer Res.
, vol.69
, pp. 573-582
-
-
Meng, R.D.1
-
112
-
-
77956294442
-
Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence
-
Gilbert, C.A. et al. (2010) Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence. Cancer Res., 70, 6870-6879.
-
(2010)
Cancer Res.
, vol.70
, pp. 6870-6879
-
-
Gilbert, C.A.1
-
113
-
-
75349108271
-
Notch promotes radioresistance of glioma stem cells
-
Wang, J. et al. (2010) Notch promotes radioresistance of glioma stem cells. Stem Cells, 28, 17-28.
-
(2010)
Stem Cells
, vol.28
, pp. 17-28
-
-
Wang, J.1
-
114
-
-
84866064437
-
The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models
-
Mizuma, M. et al. (2012) The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models. Mol. Cancer Ther., 11, 1999-2009.
-
(2012)
Mol. Cancer Ther.
, vol.11
, pp. 1999-2009
-
-
Mizuma, M.1
-
115
-
-
11144355129
-
Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation
-
Wong, G.T. et al. (2004) Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J. Biol. Chem., 279, 12876-12882.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 12876-12882
-
-
Wong, G.T.1
-
116
-
-
84880287852
-
-
Abcam, (29 April 2013, date last accessed)
-
Abcam. DAPT. http://www.abcam.com/DAPT-ab120633.html (29 April 2013, date last accessed).
-
DAPT
-
-
-
117
-
-
84880286531
-
-
Selleck, html (29 April 2013, date last accessed)
-
Selleck. Ro4929097. http://www.selleckchem.com/products/RO4929097. html (29 April 2013, date last accessed).
-
Ro4929097
-
-
-
118
-
-
84855344803
-
Gamma-secretase inhibitors target tumorinitiating cells in a mouse model of ERBB2 breast cancer
-
Kondratyev, M. et al. (2012) Gamma-secretase inhibitors target tumorinitiating cells in a mouse model of ERBB2 breast cancer. Oncogene, 31, 93-103.
-
(2012)
Oncogene
, vol.31
, pp. 93-103
-
-
Kondratyev, M.1
-
119
-
-
84865201590
-
Therapeutic effect of ?-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK
-
Maraver, A. et al. (2012) Therapeutic effect of ?-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK. Cancer Cell, 22, 222-234.
-
(2012)
Cancer Cell
, vol.22
, pp. 222-234
-
-
Maraver, A.1
-
120
-
-
54949110552
-
Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements
-
Hemming, M.L. et al. (2008) Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements. PLoS Biol., 6, e257.
-
(2008)
PLoS Biol
, vol.6
-
-
Hemming, M.L.1
-
121
-
-
43049163813
-
Substrate specificity of gamma-secretase and other intramembrane proteases
-
Beel, A.J. et al. (2008) Substrate specificity of gamma-secretase and other intramembrane proteases. Cell. Mol. Life Sci., 65, 1311-1334.
-
(2008)
Cell. Mol. Life Sci.
, vol.65
, pp. 1311-1334
-
-
Beel, A.J.1
-
122
-
-
84880291713
-
-
NIH
-
NIH. (2012) Gamma secretase inhibitor. http://clinicaltrials.gov/ct2/results?term=gamma+secretase+inhibitor&Search=Search.
-
(2012) Gamma secretase inhibitor
-
-
-
123
-
-
84880262721
-
-
NIH
-
NIH. (2013) Notch inhibitor cancer. http://www.clinicaltrials.gov/ct2/res ults?term=notch+inhibitor+cancer&Search=Search.
-
(2013)
Notch inhibitor cancer
-
-
-
124
-
-
84880273975
-
-
H. Lee Moffitt Cancer Center and Research Institute., An open-label study of RO4929097 in metastatic colorectal cancer (NCT01116687)
-
H. Lee Moffitt Cancer Center and Research Institute. (2012) An open-label study of RO4929097 in metastatic colorectal cancer (NCT01116687).
-
(2012)
-
-
-
125
-
-
84864005118
-
Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors
-
Krop, I. et al. (2012) Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors. J. Clin. Oncol., 30, 2307-2313.
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 2307-2313
-
-
Krop, I.1
-
126
-
-
84863786154
-
Preclinical analysis of the ?-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia
-
Samon, J.B. et al. (2012) Preclinical analysis of the ?-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia. Mol. Cancer Ther., 11, 1565-1575.
-
(2012)
Mol. Cancer Ther.
, vol.11
, pp. 1565-1575
-
-
Samon, J.B.1
-
127
-
-
84880293575
-
-
Children's Oncology Group, Gamma-secretase inhibitor RO4929097 in treating young patients with relapsed or refractory solid tumors, CNS tumors, lymphoma, or T-cell leukemia (NCT01088763)
-
Children's Oncology Group. (2012) Gamma-secretase inhibitor RO4929097 in treating young patients with relapsed or refractory solid tumors, CNS tumors, lymphoma, or T-cell leukemia (NCT01088763).
-
(2012)
-
-
-
128
-
-
77951139188
-
Therapeutic antibody targeting of individual Notch receptors
-
Wu, Y. et al. (2010) Therapeutic antibody targeting of individual Notch receptors. Nature, 464, 1052-1057.
-
(2010)
Nature
, vol.464
, pp. 1052-1057
-
-
Wu, Y.1
-
129
-
-
84868377211
-
Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells
-
Falk, R. et al. (2012) Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells. Methods, 58, 69-78.
-
(2012)
Methods
, vol.58
, pp. 69-78
-
-
Falk, R.1
-
130
-
-
34247539127
-
The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth
-
Thurston, G. et al. (2007) The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth. Nat. Rev. Cancer, 7, 327-331.
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 327-331
-
-
Thurston, G.1
-
131
-
-
33845877157
-
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
-
Noguera-Troise, I. et al. (2006) Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature, 444, 1032-1037.
-
(2006)
Nature
, vol.444
, pp. 1032-1037
-
-
Noguera-Troise, I.1
-
132
-
-
84864877183
-
MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo
-
Jenkins, D.W. et al. (2012) MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo. Mol. Cancer Ther., 11, 1650-1660.
-
(2012)
Mol. Cancer Ther.
, vol.11
, pp. 1650-1660
-
-
Jenkins, D.W.1
-
133
-
-
84880272307
-
-
MedImmune, A phase 1 study to evaluate the safety, tolerability, and pharmacokinetics of MEDI0639 in advanced solid tumors (NCT01577745)
-
MedImmune (2010). A phase 1 study to evaluate the safety, tolerability, and pharmacokinetics of MEDI0639 in advanced solid tumors (NCT01577745).
-
(2010)
-
-
-
134
-
-
81855190019
-
Delta-like ligand 4-notch blockade and tumor radiation response
-
Liu, S.K. et al. (2011) Delta-like ligand 4-notch blockade and tumor radiation response. J. Natl Cancer Inst., 103, 1778-1798.
-
(2011)
J. Natl Cancer Inst.
, vol.103
, pp. 1778-1798
-
-
Liu, S.K.1
-
135
-
-
76749157186
-
Chronic DLL4 blockade induces vascular neoplasms
-
Yan, M. et al. (2010) Chronic DLL4 blockade induces vascular neoplasms. Nature, 463, E6-E7.
-
(2010)
Nature
, vol.463
-
-
Yan, M.1
-
136
-
-
78650480680
-
Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation
-
Poirault-Chassac, S. et al. (2010) Notch/Delta4 signaling inhibits human megakaryocytic terminal differentiation. Blood, 116, 5670-5678.
-
(2010)
Blood
, vol.116
, pp. 5670-5678
-
-
Poirault-Chassac, S.1
-
137
-
-
33646877856
-
Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells
-
Wang, Z. et al. (2006) Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. Cancer, 106, 2503-2513.
-
(2006)
Cancer
, vol.106
, pp. 2503-2513
-
-
Wang, Z.1
-
138
-
-
67349193226
-
Emerging role of Notch in stem cells and cancer
-
Wang, Z. et al. (2009) Emerging role of Notch in stem cells and cancer. Cancer Lett., 279, 8-12.
-
(2009)
Cancer Lett.
, vol.279
, pp. 8-12
-
-
Wang, Z.1
-
139
-
-
79961109379
-
Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo
-
Howells, L.M. et al. (2011) Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo. Int. J. Cancer, 129, 476-486.
-
(2011)
Int. J. Cancer
, vol.129
, pp. 476-486
-
-
Howells, L.M.1
-
140
-
-
84861910687
-
Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling
-
Li, Y. et al. (2012) Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling. FEBS J., 279, 2247-2259.
-
(2012)
FEBS J.
, vol.279
, pp. 2247-2259
-
-
Li, Y.1
|