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Volumn 1, Issue 1, 2011, Pages

Epithelial-Mesenchymal Transition in tumor microenvironment

Author keywords

Epithelial mesenchymal transition (EMT); Metastasis; Signaling pathway; Tumor microenvironment

Indexed keywords


EID: 84858288644     PISSN: None     EISSN: 20453701     Source Type: Journal    
DOI: 10.1186/2045-3701-1-29     Document Type: Review
Times cited : (240)

References (66)
  • 1
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • 10.1172/JCI39104, 2689101, 19487818
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009, 119:1420-8. 10.1172/JCI39104, 2689101, 19487818.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 2
    • 27844461512 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways
    • 10.1038/sj.onc.1209091, 16288291
    • Larue L, Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene 2005, 24:7443-54. 10.1038/sj.onc.1209091, 16288291.
    • (2005) Oncogene , vol.24 , pp. 7443-7454
    • Larue, L.1    Bellacosa, A.2
  • 4
    • 72949120827 scopus 로고    scopus 로고
    • Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma
    • 10.1002/hep.23221, 19821482
    • Yang MH, Chen CL, Chau GY, Chiou SH, Su CW, Chou TY, Peng WL, Wu JC. Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology 2009, 50:1464-74. 10.1002/hep.23221, 19821482.
    • (2009) Hepatology , vol.50 , pp. 1464-1474
    • Yang, M.H.1    Chen, C.L.2    Chau, G.Y.3    Chiou, S.H.4    Su, C.W.5    Chou, T.Y.6    Peng, W.L.7    Wu, J.C.8
  • 5
    • 75449104452 scopus 로고    scopus 로고
    • Expression and functional significance of Twist1 in hepatocellular carcinoma: its role in vasculogenic mimicry
    • Sun T, Zhao N, Zhao XL, Gu Q, Zhang SW, Che N, Wang XH, Du J, Liu YX, Sun BC. Expression and functional significance of Twist1 in hepatocellular carcinoma: its role in vasculogenic mimicry. Hepatology 2010, 51:545-56.
    • (2010) Hepatology , vol.51 , pp. 545-556
    • Sun, T.1    Zhao, N.2    Zhao, X.L.3    Gu, Q.4    Zhang, S.W.5    Che, N.6    Wang, X.H.7    Du, J.8    Liu, Y.X.9    Sun, B.C.10
  • 6
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    • 10.1038/nrc2131, 17508028
    • Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?. Nat Rev Cancer 2007, 7:415-28. 10.1038/nrc2131, 17508028.
    • (2007) Nat Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 7
    • 0035964349 scopus 로고    scopus 로고
    • Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
    • 10.1073/pnas.171610498, 56965, 11526241
    • Brabletz T, Jung A, Reu S, Porzner M, Hlubek F, Kunz-Schughart LA, Knuechel R, Kirchner T. Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci USA 2001, 98:10356-61. 10.1073/pnas.171610498, 56965, 11526241.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10356-10361
    • Brabletz, T.1    Jung, A.2    Reu, S.3    Porzner, M.4    Hlubek, F.5    Kunz-Schughart, L.A.6    Knuechel, R.7    Kirchner, T.8
  • 8
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • 10.1038/nature07205, 18650914
    • Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature 2008, 454:436-44. 10.1038/nature07205, 18650914.
    • (2008) Nature , vol.454 , pp. 436-444
    • Mantovani, A.1    Allavena, P.2    Sica, A.3    Balkwill, F.4
  • 9
    • 0033571403 scopus 로고    scopus 로고
    • At the crossroads of inflammation and tumorigenesis
    • 10.1084/jem.190.10.1367, 2195699, 10562311
    • Cordon-Cardo C, Prives C. At the crossroads of inflammation and tumorigenesis. J Exp Med 1999, 190:1367-70. 10.1084/jem.190.10.1367, 2195699, 10562311.
    • (1999) J Exp Med , vol.190 , pp. 1367-1370
    • Cordon-Cardo, C.1    Prives, C.2
  • 10
    • 77954565039 scopus 로고    scopus 로고
    • Inflammation-mediated promotion of invasion and metastasis
    • 10.1007/s10555-010-9227-2, 20414701
    • Solinas G, Marchesi F, Garlanda C, Mantovani A, Allavena P. Inflammation-mediated promotion of invasion and metastasis. Cancer Metastasis Rev 2010, 29:243-8. 10.1007/s10555-010-9227-2, 20414701.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 243-248
    • Solinas, G.1    Marchesi, F.2    Garlanda, C.3    Mantovani, A.4    Allavena, P.5
  • 12
    • 67349162130 scopus 로고    scopus 로고
    • Tumour necrosis factor and cancer
    • 10.1038/nrc2628, 19343034
    • Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer 2009, 9:361-71. 10.1038/nrc2628, 19343034.
    • (2009) Nat Rev Cancer , vol.9 , pp. 361-371
    • Balkwill, F.1
  • 13
    • 0345059766 scopus 로고    scopus 로고
    • Intravital imaging of cell movement in tumours
    • 10.1038/nrc1231, 14737122
    • Condeelis J, Segall JE. Intravital imaging of cell movement in tumours. Nat Rev Cancer 2003, 3:921-30. 10.1038/nrc1231, 14737122.
    • (2003) Nat Rev Cancer , vol.3 , pp. 921-930
    • Condeelis, J.1    Segall, J.E.2
  • 14
    • 34547798981 scopus 로고    scopus 로고
    • Role of nuclear factor kappa B and reactive oxygen species in the tumor necrosis factor-alpha-induced epithelial-mesenchymal transition of MCF-7 cells
    • 10.1590/S0100-879X2007000800007, 17665043
    • Dong R, Wang Q, He XL, Chu YK, Lu JG, Ma QJ. Role of nuclear factor kappa B and reactive oxygen species in the tumor necrosis factor-alpha-induced epithelial-mesenchymal transition of MCF-7 cells. Braz J Med Biol Res 2007, 40:1071-8. 10.1590/S0100-879X2007000800007, 17665043.
    • (2007) Braz J Med Biol Res , vol.40 , pp. 1071-1078
    • Dong, R.1    Wang, Q.2    He, X.L.3    Chu, Y.K.4    Lu, J.G.5    Ma, Q.J.6
  • 15
    • 67649966600 scopus 로고    scopus 로고
    • TNF-alpha induces TGF-beta1 expression in lung fibroblasts at the transcriptional level via AP-1 activation
    • 10.1111/j.1582-4934.2008.00647.x, 2855747, 20141610
    • Sullivan DE, Ferris M, Nguyen H, Abboud E, Brody AR. TNF-alpha induces TGF-beta1 expression in lung fibroblasts at the transcriptional level via AP-1 activation. J Cell Mol Med 2009, 13:1866-76. 10.1111/j.1582-4934.2008.00647.x, 2855747, 20141610.
    • (2009) J Cell Mol Med , vol.13 , pp. 1866-1876
    • Sullivan, D.E.1    Ferris, M.2    Nguyen, H.3    Abboud, E.4    Brody, A.R.5
  • 16
    • 0037572319 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids
    • 10.1091/mbc.E02-09-0583, 165077, 12802055
    • Bates RC, Mercurio AM. Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol Biol Cell 2003, 14:1790-800. 10.1091/mbc.E02-09-0583, 165077, 12802055.
    • (2003) Mol Biol Cell , vol.14 , pp. 1790-1800
    • Bates, R.C.1    Mercurio, A.M.2
  • 17
    • 0028603343 scopus 로고
    • TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors
    • 10.1083/jcb.127.6.2021, 2120317, 7806579
    • Miettinen PJ, Ebner R, Lopez AR, Derynck R. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol 1994, 127:2021-36. 10.1083/jcb.127.6.2021, 2120317, 7806579.
    • (1994) J Cell Biol , vol.127 , pp. 2021-2036
    • Miettinen, P.J.1    Ebner, R.2    Lopez, A.R.3    Derynck, R.4
  • 18
    • 0027528995 scopus 로고
    • Cholesterol, macrophages, and gene expression of TGF-beta 1 and fibronectin during nephrosis
    • Ding G, Pesek-Diamond I, Diamond JR. Cholesterol, macrophages, and gene expression of TGF-beta 1 and fibronectin during nephrosis. Am J Physiol 1993, 264:F577-84.
    • (1993) Am J Physiol , vol.264
    • Ding, G.1    Pesek-Diamond, I.2    Diamond, J.R.3
  • 19
    • 0031766270 scopus 로고    scopus 로고
    • Mechanisms of interstitial fibrosis in obstructive nephropathy
    • Diamond JR, Ricardo SD, Klahr S. Mechanisms of interstitial fibrosis in obstructive nephropathy. Semin Nephrol 1998, 18:594-602.
    • (1998) Semin Nephrol , vol.18 , pp. 594-602
    • Diamond, J.R.1    Ricardo, S.D.2    Klahr, S.3
  • 20
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    • 10.1038/nrc1208, 14557817
    • Siegel PM, Massague J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 2003, 3:807-21. 10.1038/nrc1208, 14557817.
    • (2003) Nat Rev Cancer , vol.3 , pp. 807-821
    • Siegel, P.M.1    Massague, J.2
  • 21
    • 33845524970 scopus 로고    scopus 로고
    • Transforming growth factor-beta in cancer and metastasis
    • 10.1007/s10555-006-9006-2, 16951986
    • Jakowlew SB. Transforming growth factor-beta in cancer and metastasis. Cancer Metastasis Rev 2006, 25:435-57. 10.1007/s10555-006-9006-2, 16951986.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 435-457
    • Jakowlew, S.B.1
  • 22
    • 47549090432 scopus 로고    scopus 로고
    • TGF-beta in Cancer
    • 10.1016/j.cell.2008.07.001, 18662538
    • Massague J. TGF-beta in Cancer. Cell 2008, 134:215-30. 10.1016/j.cell.2008.07.001, 18662538.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 23
    • 33845678877 scopus 로고    scopus 로고
    • Role of transforming growth factor-beta in cancer progression
    • 10.2217/14796694.2.6.743, 17155901
    • Galliher AJ, Neil JR, Schiemann WP. Role of transforming growth factor-beta in cancer progression. Future Oncol 2006, 2:743-63. 10.2217/14796694.2.6.743, 17155901.
    • (2006) Future Oncol , vol.2 , pp. 743-763
    • Galliher, A.J.1    Neil, J.R.2    Schiemann, W.P.3
  • 24
    • 1642334157 scopus 로고    scopus 로고
    • Tumour-derived TGF-beta1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells
    • 10.1038/sj.bjc.6601611, 2410183, 14970860
    • Lewis MP, Lygoe KA, Nystrom ML, Anderson WP, Speight PM, Marshall JF, Thomas GJ. Tumour-derived TGF-beta1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells. Br J Cancer 2004, 90:822-32. 10.1038/sj.bjc.6601611, 2410183, 14970860.
    • (2004) Br J Cancer , vol.90 , pp. 822-832
    • Lewis, M.P.1    Lygoe, K.A.2    Nystrom, M.L.3    Anderson, W.P.4    Speight, P.M.5    Marshall, J.F.6    Thomas, G.J.7
  • 25
    • 4043074287 scopus 로고    scopus 로고
    • TGF-beta1-promoted epithelial-to-mesenchymal transformation and cell adhesion contribute to TGF-beta1-enhanced cell migration in SMMC-7721 cells
    • 10.1038/sj.cr.7290179, 14672557
    • Xu Z, Shen MX, Ma DZ, Wang LY, Zha XL. TGF-beta1-promoted epithelial-to-mesenchymal transformation and cell adhesion contribute to TGF-beta1-enhanced cell migration in SMMC-7721 cells. Cell Res 2003, 13:343-50. 10.1038/sj.cr.7290179, 14672557.
    • (2003) Cell Res , vol.13 , pp. 343-350
    • Xu, Z.1    Shen, M.X.2    Ma, D.Z.3    Wang, L.Y.4    Zha, X.L.5
  • 26
    • 33751582928 scopus 로고    scopus 로고
    • Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney
    • 10.1038/sj.emboj.7601421, 1679761, 17093497
    • Boutet A, De Frutos CA, Maxwell PH, Mayol MJ, Romero J, Nieto MA. Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. Embo J 2006, 25:5603-13. 10.1038/sj.emboj.7601421, 1679761, 17093497.
    • (2006) Embo J , vol.25 , pp. 5603-5613
    • Boutet, A.1    De Frutos, C.A.2    Maxwell, P.H.3    Mayol, M.J.4    Romero, J.5    Nieto, M.A.6
  • 27
    • 49649124944 scopus 로고    scopus 로고
    • Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes
    • 10.1158/1078-0432.CCR-07-6735, 2631428, 18559496
    • Lyons JG, Patel V, Roue NC, Fok SY, Soon LL, Halliday GM, Gutkind JS. Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes. Cancer Res 2008, 68:4525-30. 10.1158/1078-0432.CCR-07-6735, 2631428, 18559496.
    • (2008) Cancer Res , vol.68 , pp. 4525-4530
    • Lyons, J.G.1    Patel, V.2    Roue, N.C.3    Fok, S.Y.4    Soon, L.L.5    Halliday, G.M.6    Gutkind, J.S.7
  • 29
    • 77954372059 scopus 로고    scopus 로고
    • Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms
    • 10.1111/j.1478-3231.2010.02205.x, 3111074, 20158611
    • Copple BL. Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms. Liver Int 2010, 30:669-82. 10.1111/j.1478-3231.2010.02205.x, 3111074, 20158611.
    • (2010) Liver Int , vol.30 , pp. 669-682
    • Copple, B.L.1
  • 30
    • 79951825517 scopus 로고    scopus 로고
    • Mouse Snail Is a Target Gene for Hif
    • 10.1158/1541-7786.MCR-10-0214, 21257819
    • Luo D, Wang J, Li J, Post M. Mouse Snail Is a Target Gene for Hif. Mol Cancer Res 2011, 9:234-45. 10.1158/1541-7786.MCR-10-0214, 21257819.
    • (2011) Mol Cancer Res , vol.9 , pp. 234-245
    • Luo, D.1    Wang, J.2    Li, J.3    Post, M.4
  • 31
    • 71949128382 scopus 로고    scopus 로고
    • Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1
    • 10.1152/ajplung.00007.2009, 2793183, 19801454
    • Zhou G, Dada LA, Wu M, Kelly A, Trejo H, Zhou Q, Varga J, Sznajder JI. Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1. Am J Physiol Lung Cell Mol Physiol 2009, 297:L1120-30. 10.1152/ajplung.00007.2009, 2793183, 19801454.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297
    • Zhou, G.1    Dada, L.A.2    Wu, M.3    Kelly, A.4    Trejo, H.5    Zhou, Q.6    Varga, J.7    Sznajder, J.I.8
  • 33
    • 20544437490 scopus 로고    scopus 로고
    • Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells
    • 10.1681/ASN.2004050425, 15677311
    • Rhyu DY, Yang Y, Ha H, Lee GT, Song JS, Uh ST, Lee HB. Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. J Am Soc Nephrol 2005, 16:667-75. 10.1681/ASN.2004050425, 15677311.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 667-675
    • Rhyu, D.Y.1    Yang, Y.2    Ha, H.3    Lee, G.T.4    Song, J.S.5    Uh, S.T.6    Lee, H.B.7
  • 34
    • 33846828787 scopus 로고    scopus 로고
    • NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2
    • 10.1038/sj.onc.1209808, 16862183
    • Chua HL, Bhat-Nakshatri P, Clare SE, Morimiya A, Badve S, Nakshatri H. NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2. Oncogene 2007, 26:711-24. 10.1038/sj.onc.1209808, 16862183.
    • (2007) Oncogene , vol.26 , pp. 711-724
    • Chua, H.L.1    Bhat-Nakshatri, P.2    Clare, S.E.3    Morimiya, A.4    Badve, S.5    Nakshatri, H.6
  • 35
    • 17144384376 scopus 로고    scopus 로고
    • NF-kappaB and JNK: an intricate affair
    • 10.4161/cc.3.12.1321, 15611622
    • Bubici C, Papa S, Pham CG, Zazzeroni F, Franzoso G. NF-kappaB and JNK: an intricate affair. Cell Cycle 2004, 3:1524-9. 10.4161/cc.3.12.1321, 15611622.
    • (2004) Cell Cycle , vol.3 , pp. 1524-1529
    • Bubici, C.1    Papa, S.2    Pham, C.G.3    Zazzeroni, F.4    Franzoso, G.5
  • 36
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • 10.1038/nrc822, 12189386
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002, 2:442-54. 10.1038/nrc822, 12189386.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 38
    • 0037388204 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic breast cancer cells
    • 10.1073/pnas.0530291100, 153034, 12629218
    • Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003, 100:3983-8. 10.1073/pnas.0530291100, 153034, 12629218.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3983-3988
    • Al-Hajj, M.1    Wicha, M.S.2    Benito-Hernandez, A.3    Morrison, S.J.4    Clarke, M.F.5
  • 39
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • 10.1038/nature05372, 17122772
    • O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007, 445:106-10. 10.1038/nature05372, 17122772.
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 41
    • 48949119473 scopus 로고    scopus 로고
    • Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
    • 10.1186/bcr1982, 2397524, 18366788
    • Fillmore CM, Kuperwasser C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res 2008, 10:R25. 10.1186/bcr1982, 2397524, 18366788.
    • (2008) Breast Cancer Res , vol.10
    • Fillmore, C.M.1    Kuperwasser, C.2
  • 42
    • 33845904383 scopus 로고    scopus 로고
    • The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation
    • 10.1093/jnci/djj495, 17179479
    • Phillips TM, McBride WH, Pajonk F. The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst 2006, 98:1777-85. 10.1093/jnci/djj495, 17179479.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1777-1785
    • Phillips, T.M.1    McBride, W.H.2    Pajonk, F.3
  • 43
    • 79952453864 scopus 로고    scopus 로고
    • Pancreatic Cancer Cells Resistant to Chemoradiotherapy Rich in "Stem-Cell-Like" Tumor Cells
    • 10.1007/s10620-010-1340-0, 20683663
    • Du Z, Qin R, Wei C, Wang M, Shi C, Tian R, Peng C. Pancreatic Cancer Cells Resistant to Chemoradiotherapy Rich in "Stem-Cell-Like" Tumor Cells. Dig Dis Sci 2011, 56:741-50. 10.1007/s10620-010-1340-0, 20683663.
    • (2011) Dig Dis Sci , vol.56 , pp. 741-750
    • Du, Z.1    Qin, R.2    Wei, C.3    Wang, M.4    Shi, C.5    Tian, R.6    Peng, C.7
  • 45
    • 78149243774 scopus 로고    scopus 로고
    • Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation
    • 10.1186/bcr2773, 3046435, 21067584
    • Louie E, Nik S, Chen JS, Schmidt M, Song B, Pacson C, Chen XF, Park S, Ju J, Chen EI. Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation. Breast Cancer Res 2010, 12:R94. 10.1186/bcr2773, 3046435, 21067584.
    • (2010) Breast Cancer Res , vol.12
    • Louie, E.1    Nik, S.2    Chen, J.S.3    Schmidt, M.4    Song, B.5    Pacson, C.6    Chen, X.F.7    Park, S.8    Ju, J.9    Chen, E.I.10
  • 47
    • 1542286220 scopus 로고    scopus 로고
    • Mesenchymal stem cells: clinical applications and biological characterization
    • 10.1016/j.biocel.2003.11.001, 15010324
    • Barry FP, Murphy JM. Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol 2004, 36:568-84. 10.1016/j.biocel.2003.11.001, 15010324.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 568-584
    • Barry, F.P.1    Murphy, J.M.2
  • 48
    • 34547567884 scopus 로고    scopus 로고
    • The participation of mesenchymal stem cells in tumor stroma formation and their application as targeted-gene delivery vehicles
    • Hall B, Andreeff M, Marini F. The participation of mesenchymal stem cells in tumor stroma formation and their application as targeted-gene delivery vehicles. Handb Exp Pharmacol 2007, 263-83.
    • (2007) Handb Exp Pharmacol , pp. 263-283
    • Hall, B.1    Andreeff, M.2    Marini, F.3
  • 49
    • 43049136909 scopus 로고    scopus 로고
    • Therapeutic potential of genetically modified mesenchymal stem cells
    • 10.1038/gt.2008.35, 18356815
    • Kumar S, Chanda D, Ponnazhagan S. Therapeutic potential of genetically modified mesenchymal stem cells. Gene Ther 2008, 15:711-5. 10.1038/gt.2008.35, 18356815.
    • (2008) Gene Ther , vol.15 , pp. 711-715
    • Kumar, S.1    Chanda, D.2    Ponnazhagan, S.3
  • 50
    • 77954674441 scopus 로고    scopus 로고
    • Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells
    • 10.1007/s00018-010-0338-2, 20238234
    • Ouyang G, Wang Z, Fang X, Liu J, Yang CJ. Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells. Cell Mol Life Sci 2010, 67:2605-18. 10.1007/s00018-010-0338-2, 20238234.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 2605-2618
    • Ouyang, G.1    Wang, Z.2    Fang, X.3    Liu, J.4    Yang, C.J.5
  • 51
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • 10.1038/ng1001-117, 11586292
    • Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 2001, 29:117-29. 10.1038/ng1001-117, 11586292.
    • (2001) Nat Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 52
    • 0034574298 scopus 로고    scopus 로고
    • How cells read TGF-beta signals
    • Massague J. How cells read TGF-beta signals. Nat Rev Mol Cell Biol 2000, 1:169-78.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 169-178
    • Massague, J.1
  • 53
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • 10.1038/nature02006, 14534577
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003, 425:577-84. 10.1038/nature02006, 14534577.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 54
    • 14844364701 scopus 로고    scopus 로고
    • Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
    • 10.1126/science.1105718, 15761148
    • Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science 2005, 307:1603-9. 10.1126/science.1105718, 15761148.
    • (2005) Science , vol.307 , pp. 1603-1609
    • Ozdamar, B.1    Bose, R.2    Barrios-Rodiles, M.3    Wang, H.R.4    Zhang, Y.5    Wrana, J.L.6
  • 55
    • 74949093198 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling in epithelial-mesenchymal transition and progression of cancer
    • 10.2183/pjab.85.314, 19838011
    • Miyazono K. Transforming growth factor-beta signaling in epithelial-mesenchymal transition and progression of cancer. Proc Jpn Acad Ser B Phys Biol Sci 2009, 85:314-23. 10.2183/pjab.85.314, 19838011.
    • (2009) Proc Jpn Acad Ser B Phys Biol Sci , vol.85 , pp. 314-323
    • Miyazono, K.1
  • 56
    • 63349088695 scopus 로고    scopus 로고
    • Targeting transforming growth factor (TGF)-betaRI inhibits activation of beta1 integrin and blocks vascular invasion in hepatocellular carcinoma
    • 10.1002/hep.22731, 19115199
    • Fransvea E, Mazzocca A, Antonaci S, Giannelli G. Targeting transforming growth factor (TGF)-betaRI inhibits activation of beta1 integrin and blocks vascular invasion in hepatocellular carcinoma. Hepatology 2009, 49:839-50. 10.1002/hep.22731, 19115199.
    • (2009) Hepatology , vol.49 , pp. 839-850
    • Fransvea, E.1    Mazzocca, A.2    Antonaci, S.3    Giannelli, G.4
  • 57
    • 43949140575 scopus 로고    scopus 로고
    • Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells
    • 10.1002/hep.22201, 18318443
    • Fransvea E, Angelotti U, Antonaci S, Giannelli G. Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology 2008, 47:1557-66. 10.1002/hep.22201, 18318443.
    • (2008) Hepatology , vol.47 , pp. 1557-1566
    • Fransvea, E.1    Angelotti, U.2    Antonaci, S.3    Giannelli, G.4
  • 58
    • 79952038728 scopus 로고    scopus 로고
    • The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targets
    • 10.1016/j.semcancer.2010.10.007, 20946957
    • Yang JD, Nakamura I, Roberts LR. The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targets. Semin Cancer Biol 2011, 21:35-43. 10.1016/j.semcancer.2010.10.007, 20946957.
    • (2011) Semin Cancer Biol , vol.21 , pp. 35-43
    • Yang, J.D.1    Nakamura, I.2    Roberts, L.R.3
  • 59
    • 45149092780 scopus 로고    scopus 로고
    • NF-kappaB and epithelial to mesenchymal transition of cancer
    • 10.1002/jcb.21695, 18253935
    • Min C, Eddy SF, Sherr DH, Sonenshein GE. NF-kappaB and epithelial to mesenchymal transition of cancer. J Cell Biochem 2008, 104:733-44. 10.1002/jcb.21695, 18253935.
    • (2008) J Cell Biochem , vol.104 , pp. 733-744
    • Min, C.1    Eddy, S.F.2    Sherr, D.H.3    Sonenshein, G.E.4
  • 61
    • 4344612243 scopus 로고    scopus 로고
    • NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
    • 503772, 15314694
    • Huber MA, Azoitei N, Baumann B, Grunert S, Sommer A, Pehamberger H, Kraut N, Beug H, Wirth T. NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 2004, 114:569-81. 503772, 15314694.
    • (2004) J Clin Invest , vol.114 , pp. 569-581
    • Huber, M.A.1    Azoitei, N.2    Baumann, B.3    Grunert, S.4    Sommer, A.5    Pehamberger, H.6    Kraut, N.7    Beug, H.8    Wirth, T.9
  • 62
    • 77954030498 scopus 로고    scopus 로고
    • NF-kappa B promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells
    • 10.1016/j.canlet.2010.03.003, 20350779
    • Maier HJ, Schmidt-Strassburger U, Huber MA, Wiedemann EM, Beug H, Wirth T. NF-kappa B promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. Cancer Lett 2010, 295:214-28. 10.1016/j.canlet.2010.03.003, 20350779.
    • (2010) Cancer Lett , vol.295 , pp. 214-228
    • Maier, H.J.1    Schmidt-Strassburger, U.2    Huber, M.A.3    Wiedemann, E.M.4    Beug, H.5    Wirth, T.6
  • 65
    • 48249103470 scopus 로고    scopus 로고
    • Slug is a direct Notch target required for initiation of cardiac cushion cellularization
    • 10.1083/jcb.200710067, 2483533, 18663143
    • Niessen K, Fu Y, Chang L, Hoodless PA, McFadden D, Karsan A. Slug is a direct Notch target required for initiation of cardiac cushion cellularization. J Cell Biol 2008, 182:315-25. 10.1083/jcb.200710067, 2483533, 18663143.
    • (2008) J Cell Biol , vol.182 , pp. 315-325
    • Niessen, K.1    Fu, Y.2    Chang, L.3    Hoodless, P.A.4    McFadden, D.5    Karsan, A.6
  • 66
    • 33747874155 scopus 로고    scopus 로고
    • Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors
    • 10.1158/0008-5472.CAN-06-0858, 16885340
    • Fan X, Matsui W, Khaki L, Stearns D, Chun J, Li YM, Eberhart CG. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res 2006, 66:7445-52. 10.1158/0008-5472.CAN-06-0858, 16885340.
    • (2006) Cancer Res , vol.66 , pp. 7445-7452
    • Fan, X.1    Matsui, W.2    Khaki, L.3    Stearns, D.4    Chun, J.5    Li, Y.M.6    Eberhart, C.G.7


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