Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer

Oncogene

Volumn 31, Issue 1, 2012, Pages 93-103

  Kondratyev, M ^a   Kreso, A ^a   Hallett, R M ^a   Girgis Gabardo, A ^a   Barcelon, M E ^a   Ilieva, D ^a   Ware, C ^b   Majumder, P K ^b   Hassell, J A ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

breast cancer; cancer stem cells; gamma secretase inhibitors; Notch signaling; transgenic mouse models; tumor initiating cells

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; GAMMA SECRETASE INHIBITOR; MRK 003; NOTCH RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER MODEL; CANCER STEM CELL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TREATMENT OUTCOME;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CYCLIC S-OXIDES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION PROFILING; GENES, ERBB-2; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, TRANSGENIC; NEOPLASTIC STEM CELLS; RECEPTORS, NOTCH; THIADIAZOLES;

MUS; MUS MUSCULUS;

EID: 84855344803     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.212     Document Type: Article

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