-
1
-
-
0033870071
-
Nonsteroidal anti-inflammatory drugs in patients with inflammatory bowel disease
-
O'Brien, J. Nonsteroidal anti-inflammatory drugs in patients with inflammatory bowel disease. Am. J. Gastroenterol., 2000, 95, 1859-1861.
-
(2000)
Am. J. Gastroenterol.
, vol.95
, pp. 1859-1861
-
-
O'Brien, J.1
-
2
-
-
0033729001
-
Aspirin and asthma
-
Babu, K. S.; Salvi, S. S. Aspirin and asthma. Chest, 2000, 118, 1470-1476.
-
(2000)
Chest
, vol.118
, pp. 1470-1476
-
-
Babu, K.S.1
Salvi, S.S.2
-
3
-
-
17144393290
-
Adverse cardiovascular effects of the coxibs
-
Dogne, J. M.; Supuran, C. T.; Pratico, D. Adverse cardiovascular effects of the coxibs. J. Med. Chem., 2005, 48, 2251-2257.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 2251-2257
-
-
Dogne, J.M.1
Supuran, C.T.2
Pratico, D.3
-
4
-
-
0019121064
-
2in patients with systemic mastocytosis
-
2in patients with systemic mastocytosis. N. Engl. J. Med., 1980, 303, 1400-1404.
-
(1980)
N. Engl. J. Med.
, vol.303
, pp. 1400-1404
-
-
Roberts, L.J.1
Sweetman, B.J.2
Lewis, R.A.3
Austen, K.F.4
Oates, J.A.5
-
5
-
-
0020001399
-
2generation after activation of rat and human mast cells with anti-IgE
-
2generation after activation of rat and human mast cells with anti-IgE. J. Immunol., 1982, 129, 1627-1631.
-
(1982)
J. Immunol.
, vol.129
, pp. 1627-1631
-
-
Lewis, R.A.1
Soter, N.A.2
Diamond, P.T.3
Austen, K.F.4
Oates, J.A.5
Roberts, L.J.6
-
6
-
-
0022557575
-
2into human airways during acute antigen challenge
-
2into human airways during acute antigen challenge. N. Engl. J. Med., 1986, 315, 800-804.
-
(1986)
N. Engl. J. Med.
, vol.315
, pp. 800-804
-
-
Murray, J.J.1
Tonnel, A.B.2
Brash, A.R.3
Roberts, L.J.4
Gosset, P.5
Workman, R.6
Capron, A.7
Oates, J.A.8
-
9
-
-
0023821185
-
2from human skin in vivo and in vitro during immediate allergic reactions
-
2from human skin in vivo and in vitro during immediate allergic reactions. Br. J. Pharmacol., 1988, 94, 773-780.
-
(1988)
Br. J. Pharmacol.
, vol.94
, pp. 773-780
-
-
Barr, R.M.1
Koro, O.2
Francis, D.M.3
Black, A.K.4
Numata, T.5
Greaves, M.W.6
-
10
-
-
4444262310
-
Pharmacology and signaling of prostaglandin receptors: Multiple roles in inflammation and immune modulation
-
Hata, A. N.; Breyer, R. M. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharmacol. Ther., 2004, 103, 147-166.
-
(2004)
Pharmacol. Ther.
, vol.103
, pp. 147-166
-
-
Hata, A.N.1
Breyer, R.M.2
-
11
-
-
0036135587
-
Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice
-
Fujitani, Y.; Kanaoka, Y.; Aritake, K.; Uodome, N.; Okazaki-Hatake, K.; Urade, Y. Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice. J. Immunol., 2002, 168, 443-449.
-
(2002)
J. Immunol.
, vol.168
, pp. 443-449
-
-
Fujitani, Y.1
Kanaoka, Y.2
Aritake, K.3
Uodome, N.4
Okazaki-Hatake, K.5
Urade, Y.6
-
12
-
-
0036118620
-
New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes
-
Noguchi, E.; Shibasaki, M.; Kamioka, M.; Yokouchi, Y.; Yamakawa-Kobayashi, K.; Hamaguchi, H.; Matsui, A.; Arinami, T. New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes. Clin. Exp. Allergy., 2002, 32, 93-96.
-
(2002)
Clin. Exp. Allergy.
, vol.32
, pp. 93-96
-
-
Noguchi, E.1
Shibasaki, M.2
Kamioka, M.3
Yokouchi, Y.4
Yamakawa-Kobayashi, K.5
Hamaguchi, H.6
Matsui, A.7
Arinami, T.8
-
13
-
-
6044229643
-
Identification of gene polymorphism in lipocalin-type prostaglandin D synthase and its association with carotid atherosclerosis in Japanese hypertensive patients
-
Miwa, Y.; Takiuchi, S.; Kamide, K.; Yoshii, M.; Horio, T.; Tanaka, C.; Banno, M.; Miyata, T.; Sasaguri, T.; Kawano, Y. Identification of gene polymorphism in lipocalin-type prostaglandin D synthase and its association with carotid atherosclerosis in Japanese hypertensive patients. Biochem. Biophys. Res. Commun., 2004, 322, 428-433.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.322
, pp. 428-433
-
-
Miwa, Y.1
Takiuchi, S.2
Kamide, K.3
Yoshii, M.4
Horio, T.5
Tanaka, C.6
Banno, M.7
Miyata, T.8
Sasaguri, T.9
Kawano, Y.10
-
14
-
-
33746589423
-
2receptors DP and CRTH2 for treatment of inflammation
-
2receptors DP and CRTH2 for treatment of inflammation. Curr. Top. Med. Chem., 2006, 6, 1427-1444.
-
(2006)
Curr. Top. Med. Chem.
, vol.6
, pp. 1427-1444
-
-
Ulven, T.1
Kostenis, E.2
-
15
-
-
33746644304
-
Eicosanoid antagonists
-
In Curtis-Prior, P., Ed.; John Wiley & Sons Ltd.: Chichester, UK
-
Yasui, K.; Arimura, A. Eicosanoid antagonists. In Eicosanoids; Curtis-Prior, P., Ed.; John Wiley & Sons Ltd.: Chichester, UK, 2004; pp 163-178.
-
(2004)
Eicosanoids
, pp. 163-178
-
-
Yasui, K.1
Arimura, A.2
-
16
-
-
5744239544
-
Recent progress in work on PGD(2) antagonists for drugs targeting allergic diseases
-
Mitsumori, S. Recent progress in work on PGD(2) antagonists for drugs targeting allergic diseases. Curr. Pharm. Des., 2004, 10, 3533-3538.
-
(2004)
Curr. Pharm. Des.
, vol.10
, pp. 3533-3538
-
-
Mitsumori, S.1
-
17
-
-
22744445889
-
Small-molecule CRTH2 antagonists for the treatment of allergic inflammation: An overview
-
Ly, T. W.; Bacon, K. B. Small-molecule CRTH2 antagonists for the treatment of allergic inflammation: an overview. Exp. Opin. Investig. Drugs, 2005, 14, 769-773.
-
(2005)
Exp. Opin. Investig. Drugs
, vol.14
, pp. 769-773
-
-
Ly, T.W.1
Bacon, K.B.2
-
19
-
-
44949095421
-
New drugs targeting Th2 lymphocytes in asthma
-
Caramori, G.; Groneberg, D.; Kazuhiro, I.; Casolari, P.; Adcock, I. M.; Papi, A. New drugs targeting Th2 lymphocytes in asthma. J. Occup. Med. Toxicol., 2008, 3, S6.
-
(2008)
J. Occup. Med. Toxicol.
, vol.3
-
-
Caramori, G.1
Groneberg, D.2
Kazuhiro, I.3
Casolari, P.4
Adcock, I.M.5
Papi, A.6
-
20
-
-
40349108550
-
1and CRTH2 in promoting allergic responses
-
1and CRTH2 in promoting allergic responses. Br. J. Pharmacol., 2008, 153, S191-S199.
-
(2008)
Br. J. Pharmacol.
, vol.153
-
-
Pettipher, R.1
-
21
-
-
0027974137
-
Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene
-
Hirata, M.; Kakizuka, A.; Aizawa, M.; Ushikubi, F.; Narumiya, S. Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. Proc. Natl. Acad. Sci. USA, 1994, 91, 11192-11196.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 11192-11196
-
-
Hirata, M.1
Kakizuka, A.2
Aizawa, M.3
Ushikubi, F.4
Narumiya, S.5
-
22
-
-
0029134144
-
Molecular cloning and characterization of the human prostanoid DP repector
-
Boie, Y.; Sawyer, N.; Slipetz, D. M.; Metters, K. M.; Abramovitz, M. Molecular cloning and characterization of the human prostanoid DP repector. J. Biol. Chem., 1995, 270, 18910-18916.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 18910-18916
-
-
Boie, Y.1
Sawyer, N.2
Slipetz, D.M.3
Metters, K.M.4
Abramovitz, M.5
-
24
-
-
0032934180
-
Prostanoid receptors involved in the relaxation of human pulmonary vessels
-
Walch, L.; Labat, C.; Gascard, J. P.; de Montpreville, V.; Brink, C.; Norel, X. Prostanoid receptors involved in the relaxation of human pulmonary vessels. Br. J. Pharmacol., 1999, 126, 859-866.
-
(1999)
Br. J. Pharmacol.
, vol.126
, pp. 859-866
-
-
Walch, L.1
Labat, C.2
Gascard, J.P.3
de Montpreville, V.4
Brink, C.5
Norel, X.6
-
25
-
-
0032909759
-
Prostanoid receptors involved in the relaxation of human bronchial preparations
-
Norel, X.; Walch, L.; Labat, C.; Gascard, J. P.; Dulmet, E.; Brink, C. Prostanoid receptors involved in the relaxation of human bronchial preparations. Br. J. Pharmacol., 1999, 126, 867-872.
-
(1999)
Br. J. Pharmacol.
, vol.126
, pp. 867-872
-
-
Norel, X.1
Walch, L.2
Labat, C.3
Gascard, J.P.4
Dulmet, E.5
Brink, C.6
-
26
-
-
0027510120
-
Further studies on ocular responses to DP receptor stimulation
-
Woodward, D. F.; Spada, C. S.; Hawley, S. B.; Williams, L. S.; Protzman, C. E.; Nieves, A. L. Further studies on ocular responses to DP receptor stimulation. Eur. J. Pharmacol., 1993, 230, 327-333.
-
(1993)
Eur. J. Pharmacol.
, vol.230
, pp. 327-333
-
-
Woodward, D.F.1
Spada, C.S.2
Hawley, S.B.3
Williams, L.S.4
Protzman, C.E.5
Nieves, A.L.6
-
27
-
-
0035949515
-
Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep
-
Mizoguchi, A.; Eguchi, N.; Kimura, K.; Kiyohara, Y.; Qu, W. M.; Huang, Z. L.; Mochizuki, T.; Lazarus, M.; Kobayashi, T.; Kaneko, T.; Narumiya, S.; Urade, Y.; Hayaishi, O. Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. Proc. Natl. Acad. Sci. USA, 2001, 98, 11674-11679.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 11674-11679
-
-
Mizoguchi, A.1
Eguchi, N.2
Kimura, K.3
Kiyohara, Y.4
Qu, W.M.5
Huang, Z.L.6
Mochizuki, T.7
Lazarus, M.8
Kobayashi, T.9
Kaneko, T.10
Narumiya, S.11
Urade, Y.12
Hayaishi, O.13
-
28
-
-
0034677595
-
2as a mediator of allergic asthma
-
2as a mediator of allergic asthma. Science, 2000, 287, 2013-2017.
-
(2000)
Science
, vol.287
, pp. 2013-2017
-
-
Matsuoka, T.1
Hirata, M.2
Tanaka, H.3
Takahashi, Y.4
Murata, T.5
Kabashima, K.6
Sugimoto, Y.7
Kobayashi, T.8
Ushikubi, F.9
Aze, Y.10
Eguchi, N.11
Urade, Y.12
Yoshida, N.13
Kimura, K.14
Mizoguchi, A.15
Honda, Y.16
Nagai, H.17
Narumiya, S.18
-
29
-
-
0034922462
-
Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751
-
Arimura, A.; Yasui, K.; Kishino, J.; Asanuma, F.; Hasegawa, H.; Kakudo, S.; Ohtani, M.; Arita, H. Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751. J. Pharmacol. Exp. Ther., 2001, 298, 411-419.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.298
, pp. 411-419
-
-
Arimura, A.1
Yasui, K.2
Kishino, J.3
Asanuma, F.4
Hasegawa, H.5
Kakudo, S.6
Ohtani, M.7
Arita, H.8
-
30
-
-
4444378913
-
2receptor antagonists
-
2receptor antagonists. Bioorg. Med. Chem. Lett., 2004, 14, 4891-4895.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 4891-4895
-
-
Torisu, K.1
Kobayashi, K.2
Iwahashi, M.3
Nakai, Y.4
Onoda, T.5
Nagase, T.6
Sugimoto, I.7
Okada, Y.8
Matsumoto, R.9
Nanbu, F.10
Ohuchida, S.11
Nakai, H.12
Toda, M.13
-
31
-
-
0141958256
-
2inhibits airway dentritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1
-
2inhibits airway dentritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1. J. Immunol., 2003, 171, 3936-3940.
-
(2003)
J. Immunol.
, vol.171
, pp. 3936-3940
-
-
Hammad, H.1
de Heer, H.J.2
Soullie, T.3
Hoogsteden, H.C.4
Trottein, F.5
Lambrecht, B.N.6
-
32
-
-
33847143728
-
Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells
-
Hammad, H.; Kool, M.; Soullie, T.; Narumiya, S.; Trottein, F.; Hoogsteden, H. C.; Lambrecht, B. N. Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. J. Exp. Med., 2007, 204, 357-367.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 357-367
-
-
Hammad, H.1
Kool, M.2
Soullie, T.3
Narumiya, S.4
Trottein, F.5
Hoogsteden, H.C.6
Lambrecht, B.N.7
-
33
-
-
12144290847
-
Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses
-
Angeli, W.; Staumont, D.; Charbonnier, A. S.; Hammad, H.; Gosset, P.; Pichavant, M.; Lambrecht, B. N.; Capron, M.; Dombrowicz, D.; Trottein, F. Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses. J. Immunol., 2004, 172, 3822-3829.
-
(2004)
J. Immunol.
, vol.172
, pp. 3822-3829
-
-
Angeli, W.1
Staumont, D.2
Charbonnier, A.S.3
Hammad, H.4
Gosset, P.5
Pichavant, M.6
Lambrecht, B.N.7
Capron, M.8
Dombrowicz, D.9
Trottein, F.10
-
34
-
-
14844346424
-
2receptor DP2/CRTH2 increases allergic inflammation in mouse
-
2receptor DP2/CRTH2 increases allergic inflammation in mouse. J. Immunol., 2005, 174, 3703-3708.
-
(2005)
J. Immunol.
, vol.174
, pp. 3703-3708
-
-
Spik, I.1
Brenuchon, C.2
Angeli, V.3
Staumont, D.4
Fleury, S.5
Capron, M.6
Trottein, F.7
Dombrowicz, D.8
-
35
-
-
8844254704
-
Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis
-
Arai, I.; Takano, N.; Hashimoto, Y.; Futaki, N.; Sugimoto, M.; Takahashi, N.; Inoue, T.; Nakaike, S. Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis. Eur. J. Pharmacol., 2004, 505, 229-235.
-
(2004)
Eur. J. Pharmacol.
, vol.505
, pp. 229-235
-
-
Arai, I.1
Takano, N.2
Hashimoto, Y.3
Futaki, N.4
Sugimoto, M.5
Takahashi, N.6
Inoue, T.7
Nakaike, S.8
-
36
-
-
6044248633
-
Role of prostanoid DP receptor variants in susceptibility to asthma
-
Oguma, T.; Palmer, L. J.; Birben, E.; Sonna, L. A.; Asano, K.; Lilly, C. M. Role of prostanoid DP receptor variants in susceptibility to asthma. N. Engl. J. Med., 2004, 351, 1752-1763.
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 1752-1763
-
-
Oguma, T.1
Palmer, L.J.2
Birben, E.3
Sonna, L.A.4
Asano, K.5
Lilly, C.M.6
-
37
-
-
0042623534
-
The DP receptor, allergic inflammation and asthma
-
Kabashima, K.; Narumiya, S. The DP receptor, allergic inflammation and asthma. Prostaglandins Leukot. Essent. Fatty Acids, 2003, 69, 187-194.
-
(2003)
Prostaglandins Leukot. Essent. Fatty Acids
, vol.69
, pp. 187-194
-
-
Kabashima, K.1
Narumiya, S.2
-
38
-
-
0035883174
-
2is a potent chemoattractant for human eosinophils that acts via a novel DP receptor
-
2is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood, 2001, 98, 1942-1948.
-
(2001)
Blood
, vol.98
, pp. 1942-1948
-
-
Monneret, G.1
Gravel, S.2
Diamond, M.3
Rokach, J.4
Powell, W.S.5
-
39
-
-
33646073728
-
Emerging roles of DP and CRTH2 in allergic inflammation
-
Kostenis, E.; Ulven, T. Emerging roles of DP and CRTH2 in allergic inflammation. Trends Mol. Med., 2006, 12, 148-158.
-
(2006)
Trends Mol. Med.
, vol.12
, pp. 148-158
-
-
Kostenis, E.1
Ulven, T.2
-
40
-
-
0029610569
-
Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW A868C) on the canine colonic epithelium-and argument for a different DP receptor
-
Rangachari, P. K.; Betti, P. A.; Prior, E. T.; Roberts, L. J. Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW A868C) on the canine colonic epithelium-and argument for a different DP receptor. J. Pharmacol. Exp. Ther., 1995, 275, 611-617.
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.275
, pp. 611-617
-
-
Rangachari, P.K.1
Betti, P.A.2
Prior, E.T.3
Roberts, L.J.4
-
42
-
-
0033557460
-
Discovery of three novel orphan G-protein-coupled receptors
-
Marchese, A.; Sawzdargo, M.; Nguyen, T.; Cheng, R.; Heng, H. H. Q.; Nowak, T.; Im, D. S.; Lynch, K. R.; George, S. R.; O'Dowd, B. F. Discovery of three novel orphan G-protein-coupled receptors. Genomics, 1999, 56, 12-21.
-
(1999)
Genomics
, vol.56
, pp. 12-21
-
-
Marchese, A.1
Sawzdargo, M.2
Nguyen, T.3
Cheng, R.4
Heng, H.H.Q.5
Nowak, T.6
Im, D.S.7
Lynch, K.R.8
George, S.R.9
O'Dowd, B.F.10
-
43
-
-
0033083112
-
Selective expression of a novel surface molecule by human Th2 cells in vivo
-
Nagata, K.; Tanaka, K.; Ogawa, K.; Kemmotsu, K.; Imai, T.; Yoshie, O.; Abe, H.; Tada, K.; Nakamura, M.; Sugamura, K.; Takano, S. Selective expression of a novel surface molecule by human Th2 cells in vivo. J. Immunol., 1999, 162, 1278-1286.
-
(1999)
J. Immunol.
, vol.162
, pp. 1278-1286
-
-
Nagata, K.1
Tanaka, K.2
Ogawa, K.3
Kemmotsu, K.4
Imai, T.5
Yoshie, O.6
Abe, H.7
Tada, K.8
Nakamura, M.9
Sugamura, K.10
Takano, S.11
-
44
-
-
0032829392
-
CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)
-
Nagata, K.; Hirai, H.; Tanaka, K.; Ogawa, K.; Aso, T.; Sugamura, K.; Nakamura, M.; Takano, S. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett., 1999, 459, 195-199.
-
(1999)
FEBS Lett.
, vol.459
, pp. 195-199
-
-
Nagata, K.1
Hirai, H.2
Tanaka, K.3
Ogawa, K.4
Aso, T.5
Sugamura, K.6
Nakamura, M.7
Takano, S.8
-
45
-
-
0035862329
-
2selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
-
2selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J. Exp. Med., 2001, 193, 255-261.
-
(2001)
J. Exp. Med.
, vol.193
, pp. 255-261
-
-
Hirai, H.1
Tanaka, K.2
Yoshie, O.3
Ogawa, K.4
Kenmotsu, K.5
Takamori, Y.6
Ichimasa, M.7
Sugamura, K.8
Nakamura, M.9
Takano, S.10
Nagata, K.11
-
46
-
-
0035216234
-
Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD(2) receptors CRTH2 and DP
-
Gervais, F. G.; Cruz, R. P. G.; Chateauneuf, A.; Gale, S.; Sawyer, N.; Nantel, F.; Metters, K. M.; O'Neill, G. P. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD(2) receptors CRTH2 and DP. J. Allergy Clin. Immunol., 2001, 108, 982-988.
-
(2001)
J. Allergy Clin. Immunol.
, vol.108
, pp. 982-988
-
-
Gervais, F.G.1
Cruz, R.P.G.2
Chateauneuf, A.3
Gale, S.4
Sawyer, N.5
Nantel, F.6
Metters, K.M.7
O'Neill, G.P.8
-
47
-
-
23444435395
-
Cutting edge: Chemoattractant receptorhomologous molecule expressed on TH2 cells plays a restricting role on IL-5 production and eosinophil recruitment
-
Chevalier, E.; Stock, J.; Fisher, T.; Dupont, M.; Fric, M.; Fargeau, H.; Leport, M.; Soler, S.; Fabien, S.; Pruniaux, M. P.; Fink, M.; Bertrand, C. P.; McNeish, J.; Li, B. Y. Cutting edge: chemoattractant receptorhomologous molecule expressed on TH2 cells plays a restricting role on IL-5 production and eosinophil recruitment. J. Immunol., 2005, 175, 2056-2060.
-
(2005)
J. Immunol.
, vol.175
, pp. 2056-2060
-
-
Chevalier, E.1
Stock, J.2
Fisher, T.3
Dupont, M.4
Fric, M.5
Fargeau, H.6
Leport, M.7
Soler, S.8
Fabien, S.9
Pruniaux, M.P.10
Fink, M.11
Bertrand, C.P.12
McNeish, J.13
Li, B.Y.14
-
48
-
-
0038387445
-
To respond or not to respond: T cells in allergic asthma
-
Herrick, C. A.; Bottomly, K. To respond or not to respond: T cells in allergic asthma. Nat. Rev. Immunol., 2003, 3, 405-412.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 405-412
-
-
Herrick, C.A.1
Bottomly, K.2
-
49
-
-
4544304222
-
Defining a link with asthma in mice congenitally deficient in eosinophils
-
Lee, J. J.; Dimina, D.; Macias, M. P.; Ochkur, S. I.; McGarry, M. P.; O'Neill, K. R.; Protheroe, C.; Pero, R.; Nguyen, T.; Cormier, S. A.; Lenkiewicz, E.; Colbert, D.; Rinaldi, L.; Ackerman, S. J.; Irvin, C. G.; Lee, N. A. Defining a link with asthma in mice congenitally deficient in eosinophils. Science, 2004, 305, 1773-1776.
-
(2004)
Science
, vol.305
, pp. 1773-1776
-
-
Lee, J.J.1
Dimina, D.2
McIas, M.P.3
Ochkur, S.I.4
McGarry, M.P.5
O'Neill, K.R.6
Protheroe, C.7
Pero, R.8
Nguyen, T.9
Cormier, S.A.10
Lenkiewicz, E.11
Colbert, D.12
Rinaldi, L.13
Ackerman, S.J.14
Irvin, C.G.15
Lee, N.A.16
-
50
-
-
4544274172
-
A critical role for eosinophils in allergic airways remodeling
-
Humbles, A. A.; Lloyd, C. M.; McMillan, S. J.; Friend, D. S.; Xanthou, G.; McKenna, E. E.; Ghiran, S.; Gerard, N. P.; Yu, C. N.; Orkin, S. H.; Gerard, C. A critical role for eosinophils in allergic airways remodeling. Science, 2004, 305, 1776-1779.
-
(2004)
Science
, vol.305
, pp. 1776-1779
-
-
Humbles, A.A.1
Lloyd, C.M.2
McMillan, S.J.3
Friend, D.S.4
Xanthou, G.5
McKenna, E.E.6
Ghiran, S.7
Gerard, N.P.8
Yu, C.N.9
Orkin, S.H.10
Gerard, C.11
-
51
-
-
60449083521
-
Basophils: Beyond effector cells of allergic inflammation
-
Schroeder, J. T. Basophils: beyond effector cells of allergic inflammation. Adv. Immunol., 2009; Vol. 101, 123-161.
-
(2009)
Adv. Immunol.
, vol.101
, pp. 123-161
-
-
Schroeder, J.T.1
-
52
-
-
4143121034
-
Differential modulation of human basophil functions through prostaglandin D-2 receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells/DP2
-
Yoshimura-Uchiyama, C.; Iikura, M.; Yamaguchi, M.; Nagase, H.; Ishii, A.; Matsushima, K.; Yamamoto, K.; Shichijo, M.; Bacon, K. B.; Hirai, K. Differential modulation of human basophil functions through prostaglandin D-2 receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells/DP2. Clin. Exp. Allergy., 2004, 34, 1283-1290.
-
(2004)
Clin. Exp. Allergy.
, vol.34
, pp. 1283-1290
-
-
Yoshimura-Uchiyama, C.1
Iikura, M.2
Yamaguchi, M.3
Nagase, H.4
Ishii, A.5
Matsushima, K.6
Yamamoto, K.7
Shichijo, M.8
Bacon, K.B.9
Hirai, K.10
-
53
-
-
8444225971
-
Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability
-
Huang, J. L.; Gao, P. S.; Mathias, R. A.; Yao, T. C.; Chen, L. C.; Kuo, M. L.; Hsu, S. C.; Plunkett, B.; Togias, A.; Barnes, K. C.; Stellato, C.; Beaty, T. H.; Huang, S. K. Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability. Hum. Mol. Genet., 2004, 13, 2691-2697.
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 2691-2697
-
-
Huang, J.L.1
Gao, P.S.2
Mathias, R.A.3
Yao, T.C.4
Chen, L.C.5
Kuo, M.L.6
Hsu, S.C.7
Plunkett, B.8
Togias, A.9
Barnes, K.C.10
Stellato, C.11
Beaty, T.H.12
Huang, S.K.13
-
54
-
-
67651098976
-
Genetic variations in chemoattractant receptor expressed on Th2 cells (CRTH2) is associated with asthma susceptibility in Chinese children
-
Wang, J. H.; Xu, Y. C.; Zhao, H.; Sui, H.; Liang, H. Y.; Jiang, X. F. Genetic variations in chemoattractant receptor expressed on Th2 cells (CRTH2) is associated with asthma susceptibility in Chinese children. Mol. Biol. Rep., 2009, 36, 1549-1553.
-
(2009)
Mol. Biol. Rep.
, vol.36
, pp. 1549-1553
-
-
Wang, J.H.1
Xu, Y.C.2
Zhao, H.3
Sui, H.4
Liang, H.Y.5
Jiang, X.F.6
-
55
-
-
70349194634
-
Genetic variation in CRTh2 influences development of allergic phenotypes
-
Cameron, L.; Depner, M.; Kormann, M.; Klopp, N.; Illig, T.; von Mutius, E.; Kabesch, M. Genetic variation in CRTh2 influences development of allergic phenotypes. Allergy, 2009, 64, 1478-1485.
-
(2009)
Allergy
, vol.64
, pp. 1478-1485
-
-
Cameron, L.1
Depner, M.2
Kormann, M.3
Klopp, N.4
Illig, T.5
von Mutius, E.6
Kabesch, M.7
-
56
-
-
1842430766
-
2receptors DP and CRTH2 in human nasal mucosa
-
2receptors DP and CRTH2 in human nasal mucosa. Prostaglandins Other Lipid Mediat., 2004, 73, 87-101.
-
(2004)
Prostaglandins Other Lipid Mediat.
, vol.73
, pp. 87-101
-
-
Nantel, F.1
Fong, C.2
Lamontagne, S.3
Wright, D.H.4
Giaid, A.5
Desrosiers, M.6
Metters, K.M.7
O'Neill, G.P.8
Gervais, F.G.9
-
57
-
-
0036380819
-
2receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis
-
2receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis. J. Invest. Dermatol., 2002, 119, 609-616.
-
(2002)
J. Invest. Dermatol.
, vol.119
, pp. 609-616
-
-
Iwasaki, M.1
Nagata, K.2
Takano, S.3
Takahashi, K.4
Ishii, N.5
Ikezawa, Z.6
-
58
-
-
7044272272
-
The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock
-
Venet, F.; Lepape, A.; Debard, A. L.; Bienvenu, J.; Bohe, J.; Monneret, G. The Th2 response as monitored by CRTH2 or CCR3 expression is severely decreased during septic shock. Clin. Immunol., 2004, 113, 278-284.
-
(2004)
Clin. Immunol.
, vol.113
, pp. 278-284
-
-
Venet, F.1
Lepape, A.2
Debard, A.L.3
Bienvenu, J.4
Bohe, J.5
Monneret, G.6
-
59
-
-
28044440325
-
2induces chemotaxis in eosinophils via its receptor CRTH2 and eosinophils may cause severe ocular inflammation in patients with allergic conjunctivitis
-
2induces chemotaxis in eosinophils via its receptor CRTH2 and eosinophils may cause severe ocular inflammation in patients with allergic conjunctivitis. Cornea, 2005, 24, S66-S70.
-
(2005)
Cornea
, vol.24
-
-
Fujishima, H.1
Fukagawa, K.2
Okada, N.3
Takano, Y.4
Tsubota, K.5
Hirai, H.6
Nagata, K.7
Matsumoto, K.8
Saito, H.9
-
60
-
-
15344348453
-
2by human osteoblasts and modulation of osteoprotegerin, RANKL, and cellular migration by DP and CRTH2 receptors
-
2by human osteoblasts and modulation of osteoprotegerin, RANKL, and cellular migration by DP and CRTH2 receptors. J. Bone Miner. Res., 2005, 20, 672-681.
-
(2005)
J. Bone Miner. Res.
, vol.20
, pp. 672-681
-
-
Gallant, M.A.1
Samadfam, R.2
Hackett, J.A.3
Antoniou, J.4
Parent, J.L.5
de Brum-Fernandes, A.J.6
-
61
-
-
0036944934
-
2receptor, CRTH2
-
2receptor, CRTH2. Br. J. Pharmacol., 2002, 137, 1163-1172.
-
(2002)
Br. J. Pharmacol.
, vol.137
, pp. 1163-1172
-
-
Sawyer, N.1
Cauchon, E.2
Chateauneuf, A.3
Cruz, R.P.G.4
Nicholson, D.W.5
Metters, K.M.6
O'Neill, G.P.7
Gervais, F.G.8
-
62
-
-
13844294096
-
2is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes
-
2is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes. Prostaglandins Other Lipid Mediat., 2005, 75, 153-167.
-
(2005)
Prostaglandins Other Lipid Mediat.
, vol.75
, pp. 153-167
-
-
Gazi, L.1
Gyles, S.2
Rose, J.3
Lees, S.4
Allan, C.5
Xue, L.Z.6
Jassal, R.7
Speight, G.8
Gamble, V.9
Pettipher, R.10
-
63
-
-
30644474849
-
2and its stereoisomer PGF2222are novel agonists of the chemoattractant receptor, CRTH2
-
2and its stereoisomer PGF2222are novel agonists of the chemoattractant receptor, CRTH2. FEBS Lett., 2006, 580, 373-379.
-
(2006)
FEBS Lett.
, vol.580
, pp. 373-379
-
-
Sandig, H.1
Andrew, D.2
Barnes, A.A.3
Sabroe, I.4
Pease, J.5
-
64
-
-
0037407693
-
2, from the bone marrow and primes eosinophils for chemotaxis
-
2, from the bone marrow and primes eosinophils for chemotaxis. J. Immunol., 2003, 170, 4752-4758.
-
(2003)
J. Immunol.
, vol.170
, pp. 4752-4758
-
-
Heinemann, A.1
Schuligoi, R.2
Sabroe, I.3
Hartnell, A.4
Peskar, B.A.5
-
65
-
-
27144494922
-
Physiological levels of 15-deoxy-CC12,14-prostaglandin J2 prime eotaxin-induced chemotaxis on human eosinophils through peroxisome proliferator-activated receptor-gamma lipation
-
Kobayashi, Y.; Ueki, S.; Mahemuti, G.; Chiba, T.; Oyamada, H.; Saito, N.; Kanda, A.; Kayaba, H.; Chihara, J. Physiological levels of 15-deoxy-CC12,14-prostaglandin J2 prime eotaxin-induced chemotaxis on human eosinophils through peroxisome proliferator-activated receptor-gamma lipation. J. Immunol., 2005, 175, 5744-5750.
-
(2005)
J. Immunol.
, vol.175
, pp. 5744-5750
-
-
Kobayashi, Y.1
Ueki, S.2
Mahemuti, G.3
Chiba, T.4
Oyamada, H.5
Saito, N.6
Kanda, A.7
Kayaba, H.8
Chihara, J.9
-
66
-
-
0031913845
-
Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist
-
Wright, D. H.; Metters, K. M.; Abramovitz, M.; Ford-Hutchinson, A. W. Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br. J. Pharmacol., 1998, 123, 1317-1324.
-
(1998)
Br. J. Pharmacol.
, vol.123
, pp. 1317-1324
-
-
Wright, D.H.1
Metters, K.M.2
Abramovitz, M.3
Ford-Hutchinson, A.W.4
-
67
-
-
10744227854
-
11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils
-
Bohm, E.; Sturm, G. J.; Weiglhofer, I.; Sandig, H.; Shichijo, M.; McNamee, A.; Pease, J. E.; Kollroser, M.; Peskar, B. A.; Heinemann, A. 11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils. J. Biol. Chem., 2004, 279, 7663-7670.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 7663-7670
-
-
Bohm, E.1
Sturm, G.J.2
Weiglhofer, I.3
Sandig, H.4
Shichijo, M.5
McNamee, A.6
Pease, J.E.7
Kollroser, M.8
Peskar, B.A.9
Heinemann, A.10
-
68
-
-
0001216272
-
Hydantoin prostaglandin analog, potent and selective inhibitors of platelet aggregation
-
Caldwell, A. G.; Harris, C. J.; Stepney, R.; Whittaker, N. Hydantoin prostaglandin analog, potent and selective inhibitors of platelet aggregation. J. Chem. Soc., Chem. Commun., 1979, 561-562.
-
(1979)
J. Chem. Soc., Chem. Commun.
, pp. 561-562
-
-
Caldwell, A.G.1
Harris, C.J.2
Stepney, R.3
Whittaker, N.4
-
69
-
-
33846089351
-
Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice
-
Arai, I.; Takaoka, A.; Hashimoto, Y.; Honma, Y.; Koizumi, C.; Futaki, N.; Sugimoto, M.; Takahashi, N.; Inoue, T.; Nakanishi, Y.; Sakurai, T.; Tanami, T.; Yagi, M.; Ono, N.; Nakaike, S. Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice. Eur. J. Pharmacol., 2007, 556, 207-214.
-
(2007)
Eur. J. Pharmacol.
, vol.556
, pp. 207-214
-
-
Arai, I.1
Takaoka, A.2
Hashimoto, Y.3
Honma, Y.4
Koizumi, C.5
Futaki, N.6
Sugimoto, M.7
Takahashi, N.8
Inoue, T.9
Nakanishi, Y.10
Sakurai, T.11
Tanami, T.12
Yagi, M.13
Ono, N.14
Nakaike, S.15
-
70
-
-
0037216649
-
2is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils
-
2is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils. J. Pharmacol. Exp. Ther., 2003, 304, 349-355.
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.304
, pp. 349-355
-
-
Monneret, G.1
Cossette, C.2
Gravel, S.3
Rokach, J.4
Powell, W.S.5
-
71
-
-
15044362172
-
2receptor agonist
-
2receptor agonist. Bioorg. Med. Chem. Lett., 2005, 15, 1873-1876.
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 1873-1876
-
-
Kim, S.1
Bellone, S.2
Maxey, K.M.3
Powell, W.S.4
Lee, G.J.5
Rokach, J.6
-
72
-
-
33845868015
-
2on human eosinophils and basophils
-
2on human eosinophils and basophils. J. Pharmacol. Exp. Ther., 2007, 320, 173-179.
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.320
, pp. 173-179
-
-
Cossette, C.1
Walsh, S.E.2
Kim, S.3
Lee, G.J.4
Lawson, J.A.5
Bellone, S.6
Rokach, J.7
Powell, W.S.8
-
73
-
-
15744402736
-
2receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats
-
2receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats. J. Pharmacol. Exp. Ther., 2005, 313, 64-69.
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.313
, pp. 64-69
-
-
Almishri, W.1
Cossette, C.2
Rokach, J.3
Martin, J.G.4
Hamid, Q.5
Powell, W.S.6
-
74
-
-
0036467346
-
2receptor, CRTH2
-
2receptor, CRTH2. J. Immunol., 2002, 168, 981-985.
-
(2002)
J. Immunol.
, vol.168
, pp. 981-985
-
-
Hirai, H.1
Tanaka, K.2
Takano, S.3
Ichimasa, M.4
Nakamura, M.5
Nagata, K.6
-
75
-
-
0037135567
-
Indomethacin causes prostaglandin D-2-like and eotaxin-like selective responses in eosinophils and basophils
-
Stubbs, V. E. L.; Schratl, P.; Hartnell, A.; Williams, T. J.; Peskar, B. A.; Heinemann, A.; Sabroe, I. Indomethacin causes prostaglandin D-2-like and eotaxin-like selective responses in eosinophils and basophils. J. Biol. Chem., 2002, 277, 26012-26020.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26012-26020
-
-
Stubbs, V.E.L.1
Schratl, P.2
Hartnell, A.3
Williams, T.J.4
Peskar, B.A.5
Heinemann, A.6
Sabroe, I.7
-
78
-
-
21744448211
-
Identification of a potent and selective synthetic agonist at the CRTH2 receptor
-
Gervais, F. G.; Morello, J. P.; Beaulieu, C.; Sawyer, N.; Denis, D.; Greig, G.; Malebranche, A. D.; O'Neill, G. P. Identification of a potent and selective synthetic agonist at the CRTH2 receptor. Mol. Pharmacol., 2005, 67, 1834-1839.
-
(2005)
Mol. Pharmacol.
, vol.67
, pp. 1834-1839
-
-
Gervais, F.G.1
Morello, J.P.2
Beaulieu, C.3
Sawyer, N.4
Denis, D.5
Greig, G.6
Malebranche, A.D.7
O'Neill, G.P.8
-
79
-
-
23044463582
-
2
-
2. J. Pharmacol. Exp. Ther., 2005, 314, 244-251.
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.314
, pp. 244-251
-
-
Mimura, H.1
Ikemura, T.2
Kotera, O.3
Sawada, M.4
Tashiro, S.5
Fuse, E.6
Ueno, K.7
Manabe, H.8
Ohshima, E.9
Karasawa, A.10
Miyaji, H.11
-
80
-
-
0024547972
-
The classification of prostaglandin DPreceptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist
-
Giles, H.; Leff, P.; Bolofo, M. L.; Kelly, M. G.; Robertson, A. D. The classification of prostaglandin DPreceptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. Br. J. Pharmacol., 1989, 96, 291-300.
-
(1989)
Br. J. Pharmacol.
, vol.96
, pp. 291-300
-
-
Giles, H.1
Leff, P.2
Bolofo, M.L.3
Kelly, M.G.4
Robertson, A.D.5
-
81
-
-
49749119253
-
2receptor, DP, in eosinophil trafficking
-
2receptor, DP, in eosinophil trafficking. J. Immunol., 2007, 179, 4792-4799.
-
(2007)
J. Immunol.
, vol.179
, pp. 4792-4799
-
-
Schratl, P.1
Royer, J.F.2
Kostenis, E.3
Ulven, T.4
Sturm, E.M.5
Waldhoer, M.6
Hoefler, G.7
Schuligoi, R.8
Lippe, I.T.9
Peskar, B.A.10
Heinemann, A.11
-
82
-
-
0023893829
-
AH6809, a prostaglandin DP-receptor blocking drug on human platelets
-
Keery, R. J.; Lumley, P. AH6809, a prostaglandin DP-receptor blocking drug on human platelets. Br. J. Pharmacol., 1988, 94, 745-754.
-
(1988)
Br. J. Pharmacol.
, vol.94
, pp. 745-754
-
-
Keery, R.J.1
Lumley, P.2
-
83
-
-
0030668052
-
Bicyclo 2.2.1 heptane and 6,6-dimethylbicyclo 3.1.1 heptane derivatives: Orally active, potent, and selective prostaglandin D-2 receptor antagonists
-
Tsuri, T.; Honma, T.; Hiramatsu, Y.; Okada, T.; Hashizume, H.; Mitsumori, S.; Inagaki, M.; Arimura, A.; Yasui, K.; Asanuma, F.; Kishino, J.; Ohtani, M. Bicyclo 2.2.1 heptane and 6,6-dimethylbicyclo 3.1.1 heptane derivatives: Orally active, potent, and selective prostaglandin D-2 receptor antagonists. J. Med. Chem., 1997, 40, 3504-3507.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 3504-3507
-
-
Tsuri, T.1
Honma, T.2
Hiramatsu, Y.3
Okada, T.4
Hashizume, H.5
Mitsumori, S.6
Inagaki, M.7
Arimura, A.8
Yasui, K.9
Asanuma, F.10
Kishino, J.11
Ohtani, M.12
-
84
-
-
12444339842
-
Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D-2 receptor antagonists. 1. Bicyclo 2.2.1 heptane derivatives
-
Mitsumori, S.; Tsuri, T.; Honma, T.; Hiramatsu, Y.; Okada, T.; Hashizume, H.; Inagaki, M.; Arimura, A.; Yasui, K.; Asanuma, F.; Kishino, J.; Ohtani, M. Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D-2 receptor antagonists. 1. Bicyclo 2.2.1 heptane derivatives. J. Med. Chem., 2003, 46, 2436-2445.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 2436-2445
-
-
Mitsumori, S.1
Tsuri, T.2
Honma, T.3
Hiramatsu, Y.4
Okada, T.5
Hashizume, H.6
Inagaki, M.7
Arimura, A.8
Yasui, K.9
Asanuma, F.10
Kishino, J.11
Ohtani, M.12
-
85
-
-
12444253023
-
Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D-2 receptor antagonists. 2. 6,6-dimethylbicyclo 3.1.1 heptane derivatives
-
Mitsumori, S.; Tsuri, T.; Honma, T.; Hiramatsu, Y.; Okada, T.; Hashizume, H.; Kida, S.; Inagaki, M.; Arimura, A.; Yasui, M.; Asanuma, F.; Kishino, J.; Ohtani, M. Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D-2 receptor antagonists. 2. 6,6-dimethylbicyclo 3.1.1 heptane derivatives. J. Med. Chem., 2003, 46, 2446-2455.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 2446-2455
-
-
Mitsumori, S.1
Tsuri, T.2
Honma, T.3
Hiramatsu, Y.4
Okada, T.5
Hashizume, H.6
Kida, S.7
Inagaki, M.8
Arimura, A.9
Yasui, M.10
Asanuma, F.11
Kishino, J.12
Ohtani, M.13
-
86
-
-
68349137905
-
2receptor antagonist modifies experimental asthma in sheep
-
2receptor antagonist modifies experimental asthma in sheep. Clin. Exp. Allergy., 2009, 39, 1404-1414.
-
(2009)
Clin. Exp. Allergy.
, vol.39
, pp. 1404-1414
-
-
Shichijo, M.1
Arimura, A.2
Hirano, Y.3
Yasui, K.4
Suzuki, N.5
Deguchi, M.6
Abraham, W.M.7
-
87
-
-
3843123328
-
2receptor antagonists
-
2receptor antagonists. Bioorg. Med. Chem. Lett., 2004, 14, 4557-4562.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 4557-4562
-
-
Torisu, K.1
Kobayashi, K.2
Iwahashi, M.3
Egashira, H.4
Nakai, Y.5
Okada, Y.6
Nanbu, F.7
Ohuchida, S.8
Nakai, H.9
Toda, M.10
-
88
-
-
3843125292
-
2receptor antagonist: Discovery of highly potent antagonists
-
2receptor antagonist: discovery of highly potent antagonists. Bioorg. Med. Chem., 2004, 12, 4685-4700.
-
(2004)
Bioorg. Med. Chem.
, vol.12
, pp. 4685-4700
-
-
Torisu, K.1
Kobayashi, K.2
Iwahashi, M.3
Nakai, Y.4
Onoda, T.5
Nagase, T.6
Sugimoto, I.7
Okada, Y.8
Matsumoto, R.9
Nanbu, F.10
Ohuchida, S.11
Nakai, H.12
Toda, M.13
-
89
-
-
4544266546
-
2receptor antagonists
-
2receptor antagonists. Bioorg. Med. Chem., 2004, 12, 5361-5378.
-
(2004)
Bioorg. Med. Chem.
, vol.12
, pp. 5361-5378
-
-
Torisu, K.1
Kobayashi, K.2
Iwahashi, M.3
Nakai, Y.4
Onoda, T.5
Nagase, T.6
Sugimoto, I.7
Okada, Y.8
Matsumoto, R.9
Nanbu, F.10
Ohuchida, S.11
Nakai, H.12
Toda, M.13
-
90
-
-
33746619778
-
-
WO 2004078719
-
Iwahashi, M.; Naganawa, A.; Nishiyama, T.; Nagase, T.; Kobayashi, K.; Nambu, F. Indole derivative compounds drugs containing the compounds as the active ingredient. WO 2004078719, 2004.
-
(2004)
Indole derivative compounds drugs containing the compounds as the active ingredient.
-
-
Iwahashi, M.1
Naganawa, A.2
Nishiyama, T.3
Nagase, T.4
Kobayashi, K.5
Nambu, F.6
-
91
-
-
2442541066
-
Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis
-
Beaulieu, C.; Wang, Z. Y.; Denis, D.; Greig, G.; Lamontagne, S.; O'Neill, G.; Slipetz, D.; Wang, J. Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis. Bioorg. Med. Chem. Lett., 2004, 14, 3195-3199.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 3195-3199
-
-
Beaulieu, C.1
Wang, Z.Y.2
Denis, D.3
Greig, G.4
Lamontagne, S.5
O'Neill, G.6
Slipetz, D.7
Wang, J.8
-
95
-
-
33746649247
-
-
US 2004229844
-
Cheng, K.; Waters, M. G.; Metters, K. M.; O'Neill, G. Method of treating atherosclerosis, dyslipidemias and related conditions. US 2004229844, 2004.
-
(2004)
Method of treating atherosclerosis, dyslipidemias and related conditions.
-
-
Cheng, K.1
Waters, M.G.2
Metters, K.M.3
O'Neill, G.4
-
96
-
-
33847345910
-
2receptor antagonist, [(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydroc yclopenta[b]indol-3-yl]-acetic acid (MK-0524)
-
2receptor antagonist, [(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydroc yclopenta[b]indol-3-yl]-acetic acid (MK-0524). J. Med. Chem., 2007, 50, 794-806.
-
(2007)
J. Med. Chem.
, vol.50
, pp. 794-806
-
-
Sturino, C.F.1
O'Neill, G.2
Lachance, N.3
Boyd, M.4
Berthelette, C.5
Labelle, M.6
Li, L.H.7
Roy, B.8
Scheigetz, J.9
Tsou, N.10
Aubin, Y.11
Bateman, K.P.12
Chauret, N.13
Day, S.H.14
Levesque, J.F.15
Seto, C.16
Silva, J.H.17
Trimble, L.A.18
Carriere, M.C.19
Denis, D.20
Greig, G.21
Kargman, S.22
Lamontagne, S.23
Mathieu, M.C.24
Sawyer, N.25
Slipetz, D.26
Abraham, W.M.27
Jones, T.28
McAuliffe, M.29
Piechuta, H.30
Nicoll-Griffith, D.A.31
Wang, Z.Y.32
Zamboni, R.33
Young, R.N.34
Metters, K.M.35
more..
-
97
-
-
34250713349
-
2receptor antagonist, in humans
-
2receptor antagonist, in humans. Drug. Metab. Dispos., 2007, 35, 1196-1202.
-
(2007)
Drug. Metab. Dispos.
, vol.35
, pp. 1196-1202
-
-
Karanam, B.1
Madeira, M.2
Bradley, S.3
Wenning, L.4
Desai, R.5
Soli, E.6
Schenk, D.7
Jones, A.8
Dean, B.9
Doss, G.10
Garrett, G.11
Crumley, T.12
Nirula, A.13
Lai, E.14
-
98
-
-
33646258753
-
2receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans
-
2receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc. Natl. Acad. Sci. USA, 2006, 103, 6682-6687.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 6682-6687
-
-
Cheng, K.1
Wu, T.J.2
Wu, K.K.3
Sturino, C.4
Metters, K.5
Gottesdiener, K.6
Wright, S.D.7
Wang, Z.Y.8
O'Neill, G.9
Lai, E.10
Waters, M.G.11
-
99
-
-
34249024864
-
Suppression of niacin-induced vasodilation with an antagonist to prostaglandin D-2 receptor subtype 1
-
Lai, E.; De Lepeleire, I.; Crumley, T. M.; Liu, F.; Wenning, L. A.; Michiels, N.; Vets, E.; O'Neill, G.; Wagner, J. A.; Gottesdiener, K. Suppression of niacin-induced vasodilation with an antagonist to prostaglandin D-2 receptor subtype 1. Clin. Pharmacol. Ther., 2007, 81, 849-857.
-
(2007)
Clin. Pharmacol. Ther.
, vol.81
, pp. 849-857
-
-
Lai, E.1
de Lepeleire, I.2
Crumley, T.M.3
Liu, F.4
Wenning, L.A.5
Michiels, N.6
Vets, E.7
O'Neill, G.8
Wagner, J.A.9
Gottesdiener, K.10
-
100
-
-
71749095907
-
Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis
-
Philip, G.; van Adelsberg, J.; Loeys, T.; Liu, N.; Wong, P.; Lai, E.; Dass, S. B.; Reiss, T. F. Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis. J. Allergy Clin. Immunol., 2009, 124, 942-948.
-
(2009)
J. Allergy Clin. Immunol.
, vol.124
, pp. 942-948
-
-
Philip, G.1
van Adelsberg, J.2
Loeys, T.3
Liu, N.4
Wong, P.5
Lai, E.6
Dass, S.B.7
Reiss, T.F.8
-
101
-
-
0030060019
-
BAY u3405, a thromboxane A2 antagonist, reduces bronchial hyperresponsiveness in asthmatics
-
Aizawa, H.; Shigyo, M.; Nogami, H.; Hirose, T.; Hara, N. BAY u3405, a thromboxane A2 antagonist, reduces bronchial hyperresponsiveness in asthmatics. Chest, 1996, 109, 338-342.
-
(1996)
Chest
, vol.109
, pp. 338-342
-
-
Aizawa, H.1
Shigyo, M.2
Nogami, H.3
Hirose, T.4
Hara, N.5
-
102
-
-
0141426811
-
Effect of ramatroban, a thromboxane A2 antagonist, in the treatment of perennial allergic rhinitis
-
Ohkubo, K.; Gotoh, M. Effect of ramatroban, a thromboxane A2 antagonist, in the treatment of perennial allergic rhinitis. Allergol. Int., 2003, 52, 131-138.
-
(2003)
Allergol. Int.
, vol.52
, pp. 131-138
-
-
Ohkubo, K.1
Gotoh, M.2
-
103
-
-
0024306565
-
Synthesis and absolute configuration of the new thromboxane antagonist (3R)-3-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9-carbazolepropanoic acid and comparison with its enantiomer
-
Rosentreter, U.; Boshagen, H.; Seuter, F.; Perzborn, E.; Fiedler, V. B. Synthesis and absolute configuration of the new thromboxane antagonist (3R)-3-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9-carbazolepropanoic acid and comparison with its enantiomer. Arzneim.-Forsch., 1989, 39-2, 1519-1521.
-
(1989)
Arzneim.-Forsch.
, vol.39
, Issue.2
, pp. 1519-1521
-
-
Rosentreter, U.1
Boshagen, H.2
Seuter, F.3
Perzborn, E.4
Fiedler, V.B.5
-
104
-
-
0026391524
-
2)-induced bronchoconstriction in the anaesthetised guinea pig
-
2)-induced bronchoconstriction in the anaesthetised guinea pig. Ann. N.Y. Acad. Sci., 1991, 629, 399-401.
-
(1991)
Ann. N.Y. Acad. Sci.
, vol.629
, pp. 399-401
-
-
Francis, H.P.1
Morris, T.G.2
Thompson, A.M.3
Patel, U.P.4
Gardiner, P.J.5
-
105
-
-
0025938173
-
2-induced bronchoconstriction in the guinea-pig
-
2-induced bronchoconstriction in the guinea-pig. Br. J. Pharmacol., 1991, 104, 596-602.
-
(1991)
Br. J. Pharmacol.
, vol.104
, pp. 596-602
-
-
Francis, H.P.1
Greenham, S.J.2
Patel, U.P.3
Thompson, A.M.4
Gardiner, P.J.5
-
106
-
-
0037382497
-
2-induced eosinophil migration in vitro
-
2-induced eosinophil migration in vitro. J. Pharmacol. Exp. Ther., 2003, 305, 347-352.
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.305
, pp. 347-352
-
-
Sugimoto, H.1
Shichijo, M.2
Iino, T.3
Manabe, Y.4
Watanabe, A.5
Shimazaki, M.6
Gantner, F.7
Bacon, K.B.8
-
107
-
-
0036166269
-
Therapeutic potential of thromboxane inhibitors in asthma
-
Dogne, J. M.; de Leval, X.; Benoit, P.; Rolin, S.; Pirotte, B.; Masereel, B. Therapeutic potential of thromboxane inhibitors in asthma. Exp. Opin. Investig. Drugs, 2002, 11, 275-281.
-
(2002)
Exp. Opin. Investig. Drugs
, vol.11
, pp. 275-281
-
-
Dogne, J.M.1
de Leval, X.2
Benoit, P.3
Rolin, S.4
Pirotte, B.5
Masereel, B.6
-
108
-
-
0012592619
-
2receptor antagonist ramatroban in animals-1st communication: Absorption, concentrations in plasma, metabolism, and excretion after single administration to rats and dogs
-
2receptor antagonist ramatroban in animals-1st communication: absorption, concentrations in plasma, metabolism, and excretion after single administration to rats and dogs. Arzneim.-Forsch., 1997, 47, 928-938.
-
(1997)
Arzneim.-Forsch.
, vol.47
, pp. 928-938
-
-
Boberg, M.1
Ahr, H.J.2
Beckermann, B.3
Buhner, K.4
Siefert, H.M.5
Steinke, W.6
Wunsche, C.7
Hirayama, M.8
-
109
-
-
0142179174
-
Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats
-
Shichijo, M.; Sugimoto, H.; Nagao, K.; Inbe, H.; Encinas, J. A.; Takeshita, K.; Bacon, K. B.; Gantner, F. Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats. J. Pharmacol. Exp. Ther., 2003, 307, 518-525.
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.307
, pp. 518-525
-
-
Shichijo, M.1
Sugimoto, H.2
Nagao, K.3
Inbe, H.4
Encinas, J.A.5
Takeshita, K.6
Bacon, K.B.7
Gantner, F.8
-
110
-
-
20044366174
-
2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor
-
2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor. J. Pharmacol. Exp. Ther., 2005, 312, 954-960.
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.312
, pp. 954-960
-
-
Shiraishi, Y.1
Asano, K.2
Nakajima, T.3
Oguma, T.4
Suzuki, Y.5
Shiomi, T.6
Sayama, K.7
Niimi, K.8
Wakaki, M.9
Kagyo, J.10
Ikeda, E.11
Hirai, H.12
Yamaguchi, K.13
Ishizaka, A.14
-
111
-
-
3242722422
-
CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation
-
Takeshita, K.; Yamasaki, T.; Nagao, K.; Sugimoto, H.; Shichijo, M.; Gantner, F.; Bacon, K. B. CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation. Int. Immunol., 2004, 16, 947-959.
-
(2004)
Int. Immunol.
, vol.16
, pp. 947-959
-
-
Takeshita, K.1
Yamasaki, T.2
Nagao, K.3
Sugimoto, H.4
Shichijo, M.5
Gantner, F.6
Bacon, K.B.7
-
112
-
-
33746923091
-
2plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor
-
2plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. J. Immunol., 2006, 177, 2621-2629.
-
(2006)
J. Immunol.
, vol.177
, pp. 2621-2629
-
-
Satoh, T.1
Moroi, R.2
Aritake, K.3
Urade, Y.4
Kanai, Y.5
Sumi, K.6
Yokozeki, H.7
Hirai, H.8
Nagata, K.9
Hara, T.10
Utsuyama, M.11
Hirokawa, K.12
Sugamura, K.13
Nshioka, K.14
Nakamura, M.15
-
113
-
-
13944263887
-
Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist
-
Ulven, T.; Kostenis, E. Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. J. Med. Chem., 2005, 48, 897-900.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 897-900
-
-
Ulven, T.1
Kostenis, E.2
-
114
-
-
33645106023
-
2receptor CRTH2
-
2receptor CRTH2. Mol. Pharmacol., 2006, 69, 1441-1453.
-
(2006)
Mol. Pharmacol.
, vol.69
, pp. 1441-1453
-
-
Mathiesen, J.M.1
Christopoulos, A.2
Ulven, T.3
Royer, J.F.4
Campillo, M.5
Heinemann, A.6
Pardo, L.7
Kostenis, E.8
-
115
-
-
35748943481
-
A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst
-
Royer, J. F.; Schratl, P.; Lorenz, S.; Kostenis, E.; Ulven, T.; Schuligoi, R.; Peskar, B. A.; Heinemann, A. A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst. Allergy, 2007, 62, 1401-1409.
-
(2007)
Allergy
, vol.62
, pp. 1401-1409
-
-
Royer, J.F.1
Schratl, P.2
Lorenz, S.3
Kostenis, E.4
Ulven, T.5
Schuligoi, R.6
Peskar, B.A.7
Heinemann, A.8
-
116
-
-
69249240524
-
2receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation
-
2receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation. Respir. Res., 2007, 8, 16.
-
(2007)
Respir. Res.
, vol.8
, pp. 16
-
-
Uller, L.1
Mathiesen, J.M.2
Alenmyr, L.3
Korsgren, M.4
Ulven, T.5
Hogberg, T.6
Andersson, G.7
Persson, C.G.A.8
Kostenis, E.9
-
118
-
-
67651120073
-
2receptor DP2 with efficacy in a murine model of allergic rhinitis
-
2receptor DP2 with efficacy in a murine model of allergic rhinitis. Bioorg. Med. Chem. Lett., 2009, 19, 4647-4651.
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 4647-4651
-
-
Stearns, B.A.1
Baccei, C.2
Bain, G.3
Broadhead, A.4
Clark, R.C.5
Coate, H.6
Evans, J.F.7
Fagan, P.8
Hutchinson, J.H.9
King, C.10
Lee, C.11
Lorrain, D.S.12
Prasit, P.13
Prodanovich, P.14
Santini, A.15
Scott, J.M.16
Stock, N.S.17
Truong, Y.P.18
-
119
-
-
20044385221
-
Isosteric ramatroban analogs: Selective and potent CRTH-2 antagonists
-
Robarge, M. J.; Bom, D. C.; Tumey, L. N.; Varga, N.; Gleason, E.; Silver, D.; Song, J. P.; Murphy, S. M.; Ekema, G.; Doucette, C.; Hanniford, D.; Palmer, M.; Pawlowski, G.; Danzig, J.; Loftus, M.; Hunady, K.; Sherf, B. A.; Mays, R. W.; Stricker-Krongrad, A.; Brunden, K. R.; Harrington, J. J.; Bennani, Y. L. Isosteric ramatroban analogs: selective and potent CRTH-2 antagonists. Bioorg. Med. Chem. Lett., 2005, 15, 1749-1753.
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 1749-1753
-
-
Robarge, M.J.1
Bom, D.C.2
Tumey, L.N.3
Varga, N.4
Gleason, E.5
Silver, D.6
Song, J.P.7
Murphy, S.M.8
Ekema, G.9
Doucette, C.10
Hanniford, D.11
Palmer, M.12
Pawlowski, G.13
Danzig, J.14
Loftus, M.15
Hunady, K.16
Sherf, B.A.17
Mays, R.W.18
Stricker-Krongrad, A.19
Brunden, K.R.20
Harrington, J.J.21
Bennani, Y.L.22
more..
-
122
-
-
34548830702
-
2receptor CRTH2
-
2receptor CRTH2. Bioorg. Med. Chem. Lett., 2007, 17, 5924-5927.
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 5924-5927
-
-
Ulven, T.1
Gallen, M.J.2
Nielsen, M.C.3
Merten, N.4
Schmidt, C.5
Mohr, K.6
Trankle, C.7
Kostenis, E.8
-
125
-
-
33746659573
-
-
WO 2003101981
-
Birkinshaw, T.; Bonnert, R.; Cook, A.; Rasul, R.; Sanganee, H.; Teague, S. Novel substituted indols. WO 2003101981, 2003.
-
(2003)
Novel substituted indols.
-
-
Birkinshaw, T.1
Bonnert, R.2
Cook, A.3
Rasul, R.4
Sanganee, H.5
Teague, S.6
-
126
-
-
33746659573
-
-
WO 2003101961
-
Bonnert, R.; Brough, S.; Cook, T.; Dickinson, M.; Rasul, R.; Sanganee, H.; Teague, S. Novel substituted indoles. WO 2003101961, 2003.
-
(2003)
Novel substituted indoles.
-
-
Bonnert, R.1
Brough, S.2
Cook, T.3
Dickinson, M.4
Rasul, R.5
Sanganee, H.6
Teague, S.7
-
127
-
-
33746585853
-
-
WO 2004007451
-
Bonnert, R.; Dickinson, M.; Rasul, R.; Sanganee, H.; Teague, S. Indole-3-sulphur derivatives and their use in the treatment of respiratory disorders. WO 2004007451, 2004.
-
(2004)
Indole-3-sulphur derivatives and their use in the treatment of respiratory disorders.
-
-
Bonnert, R.1
Dickinson, M.2
Rasul, R.3
Sanganee, H.4
Teague, S.5
-
128
-
-
33746586290
-
-
WO 2005019171
-
Bonnert, R. V.; Cook, A. R.; Luker, T. J.; Mohammed, R. T.; Thom, S. Substituted indoleacetic acids as CRTh2 receptor ligands for treating respiratory diseases. WO 2005019171, 2005.
-
(2005)
Substituted indoleacetic acids as CRTh2 receptor ligands for treating respiratory diseases.
-
-
Bonnert, R.V.1
Cook, A.R.2
Luker, T.J.3
Mohammed, R.T.4
Thom, S.5
-
130
-
-
33745813184
-
2) receptor antagonists
-
2) receptor antagonists. Bioorg. Med. Chem. Lett., 2006, 16, 4287-4290.
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 4287-4290
-
-
Birkinshaw, T.N.1
Teague, S.J.2
Beech, C.3
Bonnert, R.V.4
Hill, S.5
Patel, A.6
Reakes, S.7
Sanganee, H.8
Dougall, I.G.9
Phillips, T.T.10
Salter, S.11
Schmidt, J.12
Arrowsmith, E.C.13
Carrillo, J.J.14
Bell, F.M.15
Paine, S.W.16
Weaver, R.17
-
131
-
-
49749143696
-
2blocks the locomotion of eosinophils and basophils
-
2blocks the locomotion of eosinophils and basophils. Eur. J. Clin. Invest., 2008, 38, 663-671.
-
(2008)
Eur. J. Clin. Invest.
, vol.38
, pp. 663-671
-
-
Royer, J.F.1
Schratl, P.2
Carrillo, J.J.3
Jupp, R.4
Barker, J.5
Weyman-Jones, C.6
Beri, R.7
Sargent, C.8
Schmidt, J.A.9
Lang-Loidolt, D.10
Heinemann, A.11
-
132
-
-
33746582083
-
-
WO 2005054232
-
Bonnert, R. V.; Mohammed, R. T.; Teague, S. 1-Acetic acid-indole,-indazole, and-benzimidazole derivatives for the treatment of respiratory disorders. WO 2005054232, 2005.
-
(2005)
1-Acetic acid-indole,-indazole, and-benzimidazole derivatives for the treatment of respiratory disorders.
-
-
Bonnert, R.V.1
Mohammed, R.T.2
Teague, S.3
-
133
-
-
26444568206
-
2receptor CRTH2
-
2receptor CRTH2. J. Med. Chem., 2005, 48, 6174-6177.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 6174-6177
-
-
Armer, R.E.1
Ashton, M.R.2
Boyd, E.A.3
Brennan, C.J.4
Brookfield, F.A.5
Gazi, L.6
Gyles, S.L.7
Hay, P.A.8
Hunter, M.G.9
Middlemiss, D.10
Whittaker, M.11
Xue, L.Z.12
Pettipher, R.13
-
134
-
-
33746617053
-
-
WO 2005040114
-
Middlemiss, D.; Ashton, M. R.; Boyd, E. A.; Brookfield, F. A.; Armer, R. E. Compounds having CRTH2 antagonist activity. WO 2005040114, 2005.
-
(2005)
Compounds having CRTH2 antagonist activity.
-
-
Middlemiss, D.1
Ashton, M.R.2
Boyd, E.A.3
Brookfield, F.A.4
Armer, R.E.5
-
135
-
-
33746617053
-
-
WO 2005040112
-
Middlemiss, D.; Ashton, M. R.; Boyd, E. A.; Brookfield, F. A.; Armer, R. E. Compounds with PGD2 antagonist activity. WO 2005040112, 2005.
-
(2005)
Compounds with PGD2 antagonist activity.
-
-
Middlemiss, D.1
Ashton, M.R.2
Boyd, E.A.3
Brookfield, F.A.4
Armer, R.E.5
-
136
-
-
33746657361
-
-
WO 2005123731
-
Bala, K.; Leblanc, C.; Sandham, D. A.; Turner, K. L.; Watson, S. J.; Brown, L. N.; Cox, B. Pyrrolopyridines as CRTh2 receptor antagonists, their preparation, pharmaceutical compositions, and use in therapy. WO 2005123731, 2005.
-
(2005)
Pyrrolopyridines as CRTh2 receptor antagonists, their preparation, pharmaceutical compositions, and use in therapy.
-
-
Bala, K.1
Leblanc, C.2
Sandham, D.A.3
Turner, K.L.4
Watson, S.J.5
Brown, L.N.6
Cox, B.7
-
137
-
-
67651094080
-
7-Azaindole-3-acetic acid derivatives: Potent and selective CRTh2 receptor antagonists
-
Sandham, D. A.; Adcock, C.; Bala, K.; Barker, L.; Brown, Z.; Dubois, G.; Budd, D.; Cox, B.; Fairhurst, R. A.; Furegati, M.; Leblanc, C.; Manini, J.; Profit, R.; Reilly, J.; Stringer, R.; Schmidt, A.; Turner, K. L.; Watson, S. J.; Willis, J.; Williams, G.; Wilson, C. 7-Azaindole-3-acetic acid derivatives: Potent and selective CRTh2 receptor antagonists. Bioorg. Med. Chem. Lett., 2009, 19, 4794-4798.
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 4794-4798
-
-
Sandham, D.A.1
Adcock, C.2
Bala, K.3
Barker, L.4
Brown, Z.5
Dubois, G.6
Budd, D.7
Cox, B.8
Fairhurst, R.A.9
Furegati, M.10
Leblanc, C.11
Manini, J.12
Profit, R.13
Reilly, J.14
Stringer, R.15
Schmidt, A.16
Turner, K.L.17
Watson, S.J.18
Willis, J.19
Williams, G.20
Wilson, C.21
more..
-
140
-
-
30344468096
-
Indole-based CRTH2 antagonists
-
Norman, P. Indole-based CRTH2 antagonists. Expert Opin. Ther. Pat., 2005, 15, 1817-1823.
-
(2005)
Expert Opin. Ther. Pat.
, vol.15
, pp. 1817-1823
-
-
Norman, P.1
-
142
-
-
41849141562
-
Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases
-
Crosignani, S.; Page, P.; Missotten, M.; Colovray, V.; Cleva, C.; Arrighi, J. F.; Atherall, J.; Macritchie, J.; Martin, T.; Humbert, Y.; Gaudet, M.; Pupowicz, D.; Maio, M.; Pittet, P. A.; Golzio, L.; Giachetti, C.; Rocha, C.; Bernardinelli, G.; Filinchuk, Y.; Scheer, A.; Schwarz, M. K.; Chollet, A. Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. J. Med. Chem., 2008, 51, 2227-2243.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 2227-2243
-
-
Crosignani, S.1
Page, P.2
Missotten, M.3
Colovray, V.4
Cleva, C.5
Arrighi, J.F.6
Atherall, J.7
McRitchie, J.8
Martin, T.9
Humbert, Y.10
Gaudet, M.11
Pupowicz, D.12
Maio, M.13
Pittet, P.A.14
Golzio, L.15
Giachetti, C.16
Rocha, C.17
Bernardinelli, G.18
Filinchuk, Y.19
Scheer, A.20
Schwarz, M.K.21
Chollet, A.22
more..
-
143
-
-
23044460265
-
2receptor CRTH2
-
2receptor CRTH2. Mol. Pharmacol., 2005, 68, 393-402.
-
(2005)
Mol. Pharmacol.
, vol.68
, pp. 393-402
-
-
Mathiesen, J.M.1
Ulven, T.2
Martini, L.3
Gerlach, L.O.4
Heinemann, A.5
Kostenis, E.6
-
144
-
-
33746614894
-
-
WO 2004032848
-
Ghosh, S.; Elder, A. M.; Carson, K. G.; Sprott, K.; Harrison, S. PGD2 receptor antagonists for the treatment of inflammatory diseases. WO 2004032848, 2004.
-
(2004)
PGD2 receptor antagonists for the treatment of inflammatory diseases.
-
-
Ghosh, S.1
Elder, A.M.2
Carson, K.G.3
Sprott, K.4
Harrison, S.5
-
146
-
-
33746612129
-
-
EP 1413306
-
Kuhn, C.; Feru, F.; Bazin, M.; Awad, M.; Goldstein, S. W. A preparation of tetrahydroquinoline derivatives as CRTH2 antagonists. EP 1413306, 2004.
-
(2004)
A preparation of tetrahydroquinoline derivatives as CRTH2 antagonists.
-
-
Kuhn, C.1
Feru, F.2
Bazin, M.3
Awad, M.4
Goldstein, S.W.5
-
147
-
-
33746612129
-
-
EP 1435356
-
Kuhn, C.; Feru, F.; Bazin, M.; Awad, M.; Goldstein, S. W. Quinoline derivatives as CRTH2 antagonists. EP 1435356, 2004.
-
(2004)
Quinoline derivatives as CRTH2 antagonists.
-
-
Kuhn, C.1
Feru, F.2
Bazin, M.3
Awad, M.4
Goldstein, S.W.5
-
148
-
-
33746639320
-
-
WO 2004035543
-
Awad, M. M. A.; Bazin, M.; Feru, F.; Goldstein, S. W.; Kuhn, C. F. Tetrahydroquinoline derivatives as CRTh2 antagonists. WO 2004035543, 2004.
-
(2004)
Tetrahydroquinoline derivatives as CRTh2 antagonists.
-
-
Awad, M.M.A.1
Bazin, M.2
Feru, F.3
Goldstein, S.W.4
Kuhn, C.F.5
-
149
-
-
33746657780
-
-
WO 2005007094
-
Inman, W. D.; Liu, J.; Medina, J. C.; Miao, S.; Tang, H. L. Asthma and allergic inflammation modulators. WO 2005007094, 2005.
-
(2005)
Asthma and allergic inflammation modulators.
-
-
Inman, W.D.1
Liu, J.2
Medina, J.C.3
Miao, S.4
Tang, H.L.5
-
150
-
-
71849102580
-
Tetrahydroquinoline derivatives as CRTH2 antagonists
-
Liu, J. W.; Wang, Y. C.; Sun, Y.; Marshall, D.; Miao, S. C.; Tonn, G.; Anders, P.; Tocker, J.; Tang, H. L.; Medina, J. Tetrahydroquinoline derivatives as CRTH2 antagonists. Bioorg. Med. Chem. Lett., 2009, 19, 6840-6844.
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 6840-6844
-
-
Liu, J.W.1
Wang, Y.C.2
Sun, Y.3
Marshall, D.4
Miao, S.C.5
Tonn, G.6
Anders, P.7
Tocker, J.8
Tang, H.L.9
Medina, J.10
-
151
-
-
22944479010
-
A physicogenetic method to assign ligand-binding relationships between 7TM receptors
-
Frimurer, T. M.; Ulven, T.; Elling, C. E.; Gerlach, L. O.; Kostenis, E.; Hogberg, T. A physicogenetic method to assign ligand-binding relationships between 7TM receptors. Bioorg. Med. Chem. Lett., 2005, 15, 3707-3712.
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 3707-3712
-
-
Frimurer, T.M.1
Ulven, T.2
Elling, C.E.3
Gerlach, L.O.4
Kostenis, E.5
Hogberg, T.6
-
152
-
-
33746646520
-
-
WO 2004058164
-
Fu, Z.; Huang, X. A.; Liu, J.; Medina, J. C.; Schmitt, M. J.; Tang, L. H.; Wang, Y.; Xu, Q. Asthma and allergic inflammation modulators. WO 2004058164, 2004.
-
(2004)
Asthma and allergic inflammation modulators.
-
-
Fu, Z.1
Huang, X.A.2
Liu, J.3
Medina, J.C.4
Schmitt, M.J.5
Tang, L.H.6
Wang, Y.7
Xu, Q.8
-
153
-
-
71049187691
-
Discovery and optimization of CRTH2 and DP dual antagonists
-
Liu, J. W.; Fu, Z.; Wang, Y. C.; Schmitt, M.; Huang, A.; Marshall, D.; Tonn, G.; Seitz, L.; Sullivan, T.; Tang, H. L.; Collins, T.; Medina, J. Discovery and optimization of CRTH2 and DP dual antagonists. Bioorg. Med. Chem. Lett., 2009, 19, 6419-6423.
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 6419-6423
-
-
Liu, J.W.1
Fu, Z.2
Wang, Y.C.3
Schmitt, M.4
Huang, A.5
Marshall, D.6
Tonn, G.7
Seitz, L.8
Sullivan, T.9
Tang, H.L.10
Collins, T.11
Medina, J.12
-
154
-
-
33746643522
-
-
EP 1471057
-
Wie, L. T.; Koriyama, Y.; Yoshino, T.; Sato, H.; Tanaka, K.; Sugimoto, H.; Manabe, Y.; Bacon, K.; Urbahns, K. Pyrimidinylacetic acid derivatives, useful as CRTH2 antagonists. EP 1471057, 2004.
-
(2004)
Pyrimidinylacetic acid derivatives, useful as CRTH2 antagonists.
-
-
Wie, L.T.1
Koriyama, Y.2
Yoshino, T.3
Sato, H.4
Tanaka, K.5
Sugimoto, H.6
Manabe, Y.7
Bacon, K.8
Urbahns, K.9
-
155
-
-
33746651243
-
-
WO 2005073234
-
Ly, T.-W.; Yoshino, T.; Takekawa, Y.; Shintani, T.; Sugimoto, H.; Bacon, K. B.; Urbahns, K. Imidazo[1,2-c]pyrimidinylacetic acid derivatives. WO 2005073234, 2005.
-
(2005)
Imidazo[1,2-c]pyrimidinylacetic acid derivatives.
-
-
Ly, T.-W.1
Yoshino, T.2
Takekawa, Y.3
Shintani, T.4
Sugimoto, H.5
Bacon, K.B.6
Urbahns, K.7
-
156
-
-
57049141701
-
CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation
-
Lukacs, N. W.; Berlin, A. A.; Franz-Bacon, K.; Sasik, R.; Sprague, L. J.; Ly, T. W.; Hardiman, G.; Boehme, S. A.; Bacon, K. B. CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation. Am. J. Physiol. Lung Cell. Mol. Physiol., 2008, 295, L767-L779.
-
(2008)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.295
-
-
Lukacs, N.W.1
Berlin, A.A.2
Franz-Bacon, K.3
Sasik, R.4
Sprague, L.J.5
Ly, T.W.6
Hardiman, G.7
Boehme, S.A.8
Bacon, K.B.9
-
157
-
-
77955839741
-
-
WO 2004089885
-
Bonnert, R.; Brough, S.; Davies, A.; Luker, T.; McInally, T.; Millichip, I.; Pairaudeau, G.; Patel, A.; Rasul, R.; Thom, S. Novel compounds. WO 2004089885, 2004.
-
(2004)
Novel compounds.
-
-
Bonnert, R.1
Brough, S.2
Davies, A.3
Luker, T.4
McInally, T.5
Millichip, I.6
Pairaudeau, G.7
Patel, A.8
Rasul, R.9
Thom, S.10
-
160
-
-
34347371424
-
2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists
-
Sandham, D. A.; Aldcroft, C.; Baettig, U.; Barker, L.; Beer, D.; Bhalay, G.; Brown, Z.; Dubois, G.; Budd, D.; Bidlake, L.; Campbell, E.; Cox, B.; Everatt, B.; Harrison, D.; Leblanc, C. J.; Manini, J.; Profit, R.; Stringer, R.; Thompson, K. S.; Turner, K. L.; Tweed, M. F.; Walker, C.; Watson, S. J.; Whitebread, S.; Willis, J.; Williams, G.; Wilson, C. 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorg. Med. Chem. Lett., 2007, 17, 4347-4350.
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 4347-4350
-
-
Sandham, D.A.1
Aldcroft, C.2
Baettig, U.3
Barker, L.4
Beer, D.5
Bhalay, G.6
Brown, Z.7
Dubois, G.8
Budd, D.9
Bidlake, L.10
Campbell, E.11
Cox, B.12
Everatt, B.13
Harrison, D.14
Leblanc, C.J.15
Manini, J.16
Profit, R.17
Stringer, R.18
Thompson, K.S.19
Turner, K.L.20
Tweed, M.F.21
Walker, C.22
Watson, S.J.23
Whitebread, S.24
Willis, J.25
Williams, G.26
Wilson, C.27
more..
-
161
-
-
33746659572
-
-
WO 2005115382
-
Ulven, T.; Frimurer, T.; Rist, O.; Kostenis, E.; Hoegberg, T.; Receveur, J.-M.; Grimstrup, M. CRTH2 receptor ligands for therapeutic use. WO 2005115382, 2005.
-
(2005)
CRTH2 receptor ligands for therapeutic use.
-
-
Ulven, T.1
Frimurer, T.2
Rist, O.3
Kostenis, E.4
Hoegberg, T.5
Receveur, J.-M.6
Grimstrup, M.7
-
162
-
-
33750978443
-
Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits
-
Ulven, T.; Receveur, J. M.; Grimstrup, M.; Rist, O.; Frimurer, T. M.; Gerlach, L. O.; Mathiesen, J. M.; Kostenis, E.; Uller, L.; Hogberg, T. Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits. J. Med. Chem., 2006, 49, 6638-6641.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 6638-6641
-
-
Ulven, T.1
Receveur, J.M.2
Grimstrup, M.3
Rist, O.4
Frimurer, T.M.5
Gerlach, L.O.6
Mathiesen, J.M.7
Kostenis, E.8
Uller, L.9
Hogberg, T.10
-
163
-
-
33746627779
-
-
WO 2005116001
-
Ulven, T.; Frimurer, T.; Rist, O.; Kostenis, E.; Hoegberg, T.; Receveur, J.-M.; Grimstrup, M. Substituted thiazoleacetic acids as CRTH2 receptor ligands. WO 2005116001, 2005.
-
(2005)
Substituted thiazoleacetic acids as CRTH2 receptor ligands.
-
-
Ulven, T.1
Frimurer, T.2
Rist, O.3
Kostenis, E.4
Hoegberg, T.5
Receveur, J.-M.6
Grimstrup, M.7
-
164
-
-
74049135437
-
Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1
-
Rist, Ø.; Grimstrup, M.; Receveur, J.-M.; Frimurer, T. M.; Ulven, T.; Kostenis, E.; Högberg, T. Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1. Bioorg. Med. Chem. Lett., 2010, 20, 1177-1180.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 1177-1180
-
-
Rist, O.1
Grimstrup, M.2
Receveur, J.-M.3
Frimurer, T.M.4
Ulven, T.5
Kostenis, E.6
Högberg, T.7
-
165
-
-
74049135437
-
Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2
-
Grimstrup, M.; Rist, Ø.; Receveur, J.-M.; Frimurer, T. M.; Ulven, T.; Mathiesen, J. M.; Kostenis, E.; Högberg, T. Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2. Bioorg. Med. Chem. Lett., 2010, 20, 1181-1185.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 1181-1185
-
-
Grimstrup, M.1
Rist, O.2
Receveur, J.-M.3
Frimurer, T.M.4
Ulven, T.5
Mathiesen, J.M.6
Kostenis, E.7
Högberg, T.8
-
166
-
-
84880161395
-
-
WO 2007062677
-
Ulven, T.; Frimurer, T.; Rist, O.; Kostenis, E.; Hoegberg, T.; Receveur, J.-M.; Grimstrup, M. Thiazoleand pyrimidineacetic acid derivatives as CRTH2 receptor ligands, their preparation, pharmaceutical compositions, and use in therapy. WO 2007062677, 2007.
-
(2007)
Thiazoleand pyrimidineacetic acid derivatives as CRTH2 receptor ligands, their preparation, pharmaceutical compositions, and use in therapy.
-
-
Ulven, T.1
Frimurer, T.2
Rist, O.3
Kostenis, E.4
Hoegberg, T.5
Receveur, J.-M.6
Grimstrup, M.7
-
167
-
-
76649106066
-
Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists
-
Grimstrup, M.; Receveur, J.-M.; Rist, Ø.; Frimurer, T. M.; Nielsen, P. A.; Mathiesen, J. M.; Högberg, T. Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists. Bioorg. Med. Chem. Lett., 2010, 20(5), 1638-1641.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, Issue.5
, pp. 1638-1641
-
-
Grimstrup, M.1
Receveur, J.-M.2
Rist, O.3
Frimurer, T.M.4
Nielsen, P.A.5
Mathiesen, J.M.6
Högberg, T.7
-
168
-
-
33746659572
-
-
WO 2005115374
-
Ulven, T.; Frimurer, T.; Rist, O.; Kostenis, E.; Hoegberg, T. CRTH2 receptor ligands for therapeutic use. WO 2005115374, 2005.
-
(2005)
CRTH2 receptor ligands for therapeutic use.
-
-
Ulven, T.1
Frimurer, T.2
Rist, O.3
Kostenis, E.4
Hoegberg, T.5
|