Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Activation in Vivo Increases Blood Leukocyte Counts and Its Blockade Abrogates 13,14-Dihydro-15-ketoprostaglandin D2-Induced Eosinophilia in Rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 2, 2003, Pages 518-525

  Shichijo, Michitaka ^a   Sugimoto, Hiromi ^a   Nagao, Koichi ^a   Inbe, Hisayo ^a   Encinas, Jeffrey A ^a   Takeshita, Keisuke ^a   Bacon, Kevin B ^a   Gantner, Florian ^a  

^a BAYER YAKUHIN LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

13,14 DIHYDRO 15 OXOPROSTAGLANDIN D2; 3 BENZYL 5 (6 CARBOXYHEXYL) 1 (2 CYCLOHEXYL 2 HYDROXYETHYLAMINO)HYDANTOIN; 5 (6 CARBOXYHEXYL) 1 (3 CYCLOHEXYL 3 HYDROXYPROPYL)HYDANTOIN; CHEMOATTRACTANT; CHEMOATTRACTANT RECEPTOR; CHEMOATTRACTANT RECEPTOR HOMOLOGOUS MOLECULE EXPRESSED ON TH2 CELLS; COMPLEMENTARY DNA; G PROTEIN COUPLED RECEPTOR; INDOMETACIN; PERTUSSIS TOXIN; PROSTAGLANDIN D2; PROSTAGLANDIN D2 DERIVATIVE; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; RAMATROBAN; RIDOGREL; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CALCIUM MOBILIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; EOSINOPHIL; EOSINOPHILIA; GENE EXPRESSION; ISOTOPE LABELING; LEUKOCYTE ACTIVATION; LEUKOCYTE COUNT; LEUKOCYTE MIGRATION; LYMPHOCYTE; MOLECULAR CLONING; MOUSE; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH2 CELL;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BONE MARROW; CARBAZOLES; CLONING, MOLECULAR; EOSINOPHILIA; HUMANS; LEUKOCYTE COUNT; LEUKOCYTES; MICE; MOLECULAR SEQUENCE DATA; PROSTAGLANDIN D2; RATS; RATS, WISTAR; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; SEQUENCE HOMOLOGY, AMINO ACID; SULFONAMIDES; TH2 CELLS;

EID: 0142179174     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.055442     Document Type: Article

References (22)

1. Abe H, Takeshita T, Nagata K, Arita T, Endo Y, Fujita T, Takayama H, Kubo M, and Sugamura K (1999) Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family. Gene 227:71-77.
2. Boie Y, Sawyer N, Slipetz DM, Metters KM, and Abramovitz M (1995) Molecular cloning and characterization of the human prostanoid DP receptor. J Biol Chem 270:18910-18916.
3. Fujitani Y, Kanaoka Y, Aritake K, Uodome N, Okazaki-Hatake K, and Urade Y (2002) Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice. J Immunol 168:443-449.
4. Gallatin WM, Weissman IL, and Butcher EC (1983) A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature (Lond) 304:30-34.
5. Giles H and Leff P (1988) The biology and pharmacology of PGD2. Prostaglandins 35:277-300.
6. Gosset P, Bureau F, Angeli V, Pichavant M, Faveeuw C, Tonnel AB, and Trottein F (2003) Prostaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cells. J Immunol 170:4943-4952.
7. Hata AN, Zent R, Breyer MD, and Breyer RM (2003) Expression and molecular pharmacology of the mouse CRTH2 receptor. J Pharmacol Exp Ther 306:463-470.
8. Heinemann A, Schuligoi R, Sabroe I, Hartnell A, and Peskar BA (2003) delta12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis. J Immunol 170:4752-4758.
9. Hirai H, Tanaka K, Yoshie O, Ogawa K, Kenmotsu K, Takamori Y, Ichimasa M, Sugamura K, Nakamura M, Takano S, et al. (2001) Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils and basophils via seven-transmembrane receptor CRTH2. J Exp Med 193:255-261.
10. Hirata M, Kakizuka A, Aizawa M, Ushikubi F, and Narumiya S (1994) Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene. Proc Natl Acad Sci USA 91:11192-11196.
11. Larsen P, Schleihauf E, Yu H, Prior T, and Rangachari PK (2002) Calcium-stimulated short-circuit currents in the canine proximal colonic epithelium: effects ofDK-PGD2, a metabolite of prostaglandin D2. Can J Physiol Pharmacol 80:1085-1094.
12. Lewis RA and Austen KF (1981) Mediation of local homeostasis and inflammation by leukotrienes and other mast cell-dependent compounds. Nature (Lond) 293:103-108.
13. Matsuoka T, Hirata M, Tanaka H, Takahashi Y, Murata T, Kabashima K, Sugimoto Y, Kobayashi T, Ushikubi F, Aze Y, et al. (2000) Prostaglandin D2 as a mediator of allergic asthma. Science (Wash DC) 287:2013-2017.
14. Monneret G, Gravel S, Diamond M, Rokach J, and Powell WS (2001) Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood 98:1942-1948.
15. Murray JJ, Tonnel AB, Brash AR, Roberts LJ 2nd, Gosset P, Workman R, Capron A, and Oates JA (1985) Prostaglandin D2 is released during acute allergic bronchospasm in man. Trans Assoc Am Physicians 98:275-280.
16. Murray JJ, Tonnel AB, Brash AR, Roberts LJ 2nd, Gosset P, Workman R, Capron A, and Oates JA (1986) Release of prostaglandin D2 into human airways during acute antigen challenge. N Engl J Med 315:800-804.
17. Nagata K, Hirai H, Tanaka K, Ogawa K, Aso T, Sugamura K, Nakamura M, and Takano S (1999a) CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett 459:195-199.
18. Nagata K, Tanaka K, Ogawa K, Kemmotsu K, Imai T, Yoshie O, Abe H, Tada K, Nakamura M, Sugamura K, et al. (1999b) Selective expression of a novel surface molecule by human Th2 cells in vivo. J Immunol 162:1278-1286.
19. Sawyer N, Cauchon E, Chateauneuf A, Cruz RP, Nicholson DW, Metters KM, O'Neill GP, and Gervais FG (2002) Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol 137:1163-1172.
20. Sugimoto H, Shichijo M, Iino T, Manabe Y, Watanabe A, Shimazaki M, Gantner F, and Bacon KB (2003) An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. J Pharmacol Exp Ther 305:347-352.
21. Wenzel SE, Westcott JY, and Larsen GL (1991) Bronchoalveolar lavage fluid mediator levels 5 minutes after allergen challenge in atopic subjects with asthma: relationship to the development of late asthmatic responses. J Allergy Clin Immunol 87:540-548.
22. Yoshida T, Imai T, Kakizaki M, Nishimura M, Takagi S, and Yoshie O (1998) Identification of single C motif-1/lymphotactin receptor XCR1. J Biol Chem 273:16551-16554.