Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1

Journal of Immunology

Volumn 171, Issue 8, 2003, Pages 3936-3940

  Hammad, Hamida ^a   De Heer, Hendrik Jan ^a   Soullie, Thomas ^a   Hoogsteden, Henk C ^a   Trottein, Francois ^b   Lambrecht, Bart N ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b INSTITUT PASTEUR DE LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

5 (6 CARBOXYHEXYL) 1 (3 CYCLOHEXYL 3 HYDROXYPROPYL)HYDANTOIN; D PROSTANOID RECEPTOR 1; D PROSTANOID RECEPTOR 2; FLUORESCEIN ISOTHIOCYANATE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; OVALBUMIN; PROSTAGLANDIN D2; PROSTANOID RECEPTOR; UNCLASSIFIED DRUG; CYTOKINE; EPITOPE; HYDANTOIN DERIVATIVE; IMMUNOGLOBULIN RECEPTOR; PROSTAGLANDIN D2 RECEPTOR; PROSTAGLANDIN RECEPTOR;

ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HOMEOSTASIS; IMMUNE RESPONSE; LANGERHANS CELL; LUNG PARENCHYMA; LYMPH NODE; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN; SKIN INFLAMMATION; STEADY STATE; T LYMPHOCYTE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL MOTION; CYTOLOGY; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENDOTRACHEAL INTUBATION; IMMUNOLOGY; LEUKOCYTE MIGRATION INHIBITION TEST; LUNG; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION; THORAX; TRANSGENIC MOUSE;

ANIMALS; CELL MIGRATION INHIBITION; CELL MOVEMENT; CYTOKINES; DENDRITIC CELLS; DOWN-REGULATION; EPITOPES, T-LYMPHOCYTE; HYDANTOINS; INTUBATION, INTRATRACHEAL; LUNG; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; OVALBUMIN; PROSTAGLANDIN D2; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; T-LYMPHOCYTE SUBSETS; THORAX;

EID: 0141958256     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.8.3936     Document Type: Article

References (28)

1. Harris, S. G., J. Padilla, L. Koumas, D. Ray, and R. P. Phipps. 2002. Prostaglandins as modulators of immunity. Trends Immunol. 23:144.
2. Boie, Y., N. Sawyer, D. M. Slipetz, K. M. Metters, and M. Abramovitz. 1995. Molecular cloning and characterization of the human prostanoid DP receptor. J. Biol. Chem. 270:18910.
3. Nagata, K., H. Hirai, K. Tanaka, K. Ogawa, T. Aso, K. Sugamura, M. Nakamura, and S. Takano. 1999. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett. 459:195.
4. Kay, A. B., L. Barata, Q. Meng, S. R. Durham, and S. Ying. 1997. Eosinophils and eosinophil-associated cytokines in allergic inflammation. Int. Arch. Allergy Immunol. 113:196.
5. 2, and bronchial responsiveness to methacholine. Thorax 53:1041.
6. 2 by human helper T cell subsets. J. Immunol. 164:2277.
7. 2 production is likely antigen-presenting cells: localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues. J. Immunol. 143:2982.
8. 4 transporter MRP1 regulates CCL19 (MIP-3β, ELC)-dependent mobilization of dendritic cells to lymph nodes. Cell 103:757.
9. 2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. Blood 100:1354.
10. 2 in the inhibition of epidermal Langerhans cell migration during schistosomiasis infection. J. Exp. Med. 193:1135.
11. Eisenbarth, S. C., D. A. Piggott, J. W. Huleatt, I. Visintin, C. A. Herrick, and K. Bottomly. 2002. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196:1645.
12. Lambrecht, B. N., R. A. Pauwels, and B. Fazekas De St. Groth. 2000. Induction of rapid T cell activation, division, and recirculation by intratracheal injection of dendritic cells in a TCR transgenic model. J. Immunol. 164:2937.
13. Vremec, D., and K. Shortman. 1997. Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes. J. Immunol. 159:565.
14. Lambrecht, B. N., M. De Veerman, A. J. Coyle, J. C. Gutierrez-Ramos, K. Thielemans, and R. A. Pauwels. 2000. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J. Clin. Invest. 106:551.
15. Steinman, R. M., S. Turley, I. Mellman, and K. Inaba. 2000. The induction of tolerance by dendritic cells that have captured apoptotic cells. J. Exp. Med. 191:411.
16. + T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 193:1285.
17. Holt, P. G., S. Haining, D. J. Nelson, and J. D. Sedgwick. 1994. Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways. J. Immunol. 153:256.
18. Schwarzenberger, K., and M. C. Udey. 1996. Contact allergens and epidermal proinflammatory cytokines modulate Langerhans cell. E-cadherin expression in situ. J. Invest. Dermatol. 106:553.
19. 2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells. Nat. Med. 9:744.
20. Vermaelen, K. Y., I. Carro-Muino, B. N. Lambrecht. and R. A. Pauwels. 2001. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J. Exp. Med. 193:51.
21. Crowley, M., K. Inaba, and R. M. Steinman. 1990. Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins. J. Exp. Med. 172:383.
22. Cyster, J. G. 1999. Chemokines and cell migration in secondary lymphoid organs. Science 286:2098.
23. Mori, S., H. Nakano, K. Aritomi, C. R. Wang, M. D. Gunn, and T. Kakiuchi. 2001. Mice lacking expression of the chemokines CCL21-ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses. J. Exp. Med. 193:207.
24. Forster, R., A. Schubel, D. Breitfeld, E. Kremmer, I. Renner-Muller, E. Wolf, and M. Lipp. 1999. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99:23.
25. Bilyk, N., and P. G. Holt. 1995. Cytokine modulation of the immunosuppressive phenotype of pulmonary alveolar macrophage populations. Immunology 86:231.
26. Gilroy, D. W., P. R. Colville-Nash, D. Willis, J. Chivers, M. J. Paul-Clark, and D. A. Willoughby. 1999. Inducible cyclooxygenase may have anti-inflammatory properties. Nat. Med. 5:698.
27. Hammad, H., B. N. Lambrecht, P. Pochard, P. Gosset, P. Marquillies, A. B. Tonnel, and J. Pestel. 2002. Monocyte-derived dendritic cells induce a house dust mite-specific Th2 allergic inflammation in the lung of humanized SCID mice: involvement of CCR7. J. Immunol. 169:1524.
28. neg bone marrow precursors in a mouse model of asthma. Blood 100:3663.