Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4647-4651

  Stearns, Brian A ^a   Baccei, Christopher ^a   Bain, Gretchen ^a   Broadhead, Alex ^a   Clark, Ryan C ^a   Coate, Heather ^a   Evans, Jilly F ^a   Fagan, Patrick ^a   Hutchinson, John H ^a   King, Christopher ^a   Lee, Catherine ^a   Lorrain, Daniel S ^a   Prasit, Peppi ^a   Prodanovich, Pat ^a   Santini, Angelina ^a   Scott, Jill M ^a   Stock, Nicholas S ^a   Truong, Yen P ^a  

^a Amira Pharmaceuticals   (United States)

Author keywords

Allergic rhinitis; Antagonist; Azaindole; Binding; CRTH2; DP2; Eosinophil; Mouse sneeze; Prostaglandin D2; Shape change

Indexed keywords

AZAINDOLE; CYTOCHROME P450; INDOLE DERIVATIVE; PROSTAGLANDIN D2 RECEPTOR BLOCKING AGENT; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ALLERGIC RHINITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CELL SHAPE; CHEMICAL REACTION; CONTROLLED STUDY; CYCLIZATION; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EOSINOPHIL; FEMALE; HUMAN; IN VITRO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; POLYMERIZATION; SUBSTITUTION REACTION;

ANIMALS; ANTI-ALLERGIC AGENTS; ANTI-INFLAMMATORY AGENTS; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; FEMALE; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MICE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; RHINITIS, ALLERGIC, PERENNIAL;

MURINAE;

EID: 67651120073     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.085     Document Type: Article

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