Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 1. Bicyclo[2.2.1]heptane derivatives

Journal of Medicinal Chemistry

Volumn 46, Issue 12, 2003, Pages 2436-2445

  Mitsumori, Susumu ^a   Honma, Tsunetoshi ^a   Tsuri, Tatsuo ^a   Hiramatsu, Yoshiharu ^a   Okada, Toshihiko ^a   Hashizume, Hiroshi ^a   Inagaki, Masanao ^a   Arimura, Akinori ^a   Yasui, Kiyoshi ^a   Asanuma, Fujio ^a   Kishino, Junji ^a   Ohtani, Mitsuaki ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 BENZYL 5 (6 CARBOXYHEXYL) 1 (2 CYCLOHEXYL 2 HYDROXYETHYLAMINO)HYDANTOIN; ANTIALLERGIC AGENT; CYCLIC AMP; NORBORNANE DERIVATIVE; PROSTACYCLIN RECEPTOR; PROSTAGLANDIN D2 RECEPTOR BLOCKING AGENT; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; RADIOLIGAND; SULFONAMIDE; THROMBOXANE A2; UNCLASSIFIED DRUG;

ALLERGIC RHINITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CONJUNCTIVITIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; GUINEA PIG; LIGAND BINDING; NONHUMAN;

ADMINISTRATION, ORAL; AIRWAY OBSTRUCTION; ANIMALS; ANTI-ALLERGIC AGENTS; BICYCLO COMPOUNDS; BLOOD PLATELETS; CAPILLARY PERMEABILITY; CONJUNCTIVA; CYCLIC AMP; GUINEA PIGS; HEXANES; HUMANS; PROSTAGLANDIN D2; RADIOLIGAND ASSAY; RECEPTORS, EPOPROSTENOL; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; RECEPTORS, THROMBOXANE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 12444339842     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020517g     Document Type: Article

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