Bicyclo[2.2.1]heptane and 6,6-dimethylbicyclo[3.1.1]heptane derivatives: Orally active, potent, and selective prostaglandin D2 receptor antagonists

Journal of Medicinal Chemistry

Volumn 40, Issue 22, 1997, Pages 3504-3507

  Tsuri, T ^a   Honma, T ^a   Hiramatsu, Y ^a   Okada, T ^a   Hashizume, H ^a   Mitsumori, S ^a   Inagaki, M ^a   Arimura, A ^a   Yasui, K ^a   Asanuma, F ^a   Kishino, J ^a   Ohtani, M ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 6,6 DIMETHYLBICYCLO[3.1.1]HEPTANE DERIVATIVE; 7 [3 [(BIPHENYL 4 YLSULFONYL)AMINO]BICYCLO[2.2.1]HEPT 2 YL]HEPT 5 ENOIC ACID; NORBORNANE DERIVATIVE; PROSTAGLANDIN D2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; THROMBOXANE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ALLERGY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BRONCHODILATATION; CONJUNCTIVITIS; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG EFFICACY; DRUG FORMULATION; DRUG POTENCY; DRUG RECEPTOR BINDING; ENANTIOMER; GUINEA PIG; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BICYCLO COMPOUNDS; BLOOD PLATELETS; GUINEA PIGS; HUMANS; NORBORNANES; PROSTAGLANDIN D2; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030668052     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970343g     Document Type: Article

References (18)