Indole-3-acetic acid antagonists of the prostaglandin D2 Receptor CRTH2

Journal of Medicinal Chemistry

Volumn 48, Issue 20, 2005, Pages 6174-6177

  Armer, Richard E ^a   Ashton, Mark R ^b   Boyd, Edward A ^b   Brennan, Chris J ^b   Brookfield, Frederick A ^b   Gazi, Lucien ^a   Gyles, Shan L ^a   Hay, Philip A ^b   Hunter, Michael G ^a   Middlemiss, David ^c   Whittaker, Mark ^b   Xue, Luzheng ^a   Pettipher, Roy ^a  

^a Oxagen Ltd   (United Kingdom)

^b EVOTEC UK LTD   (United Kingdom)

^c XaviaPharm   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT RECEPTOR HOMOLOGOUS MOLECULE EXPRESSED ON TH2 CELL RECEPTOR; ETHOXYRESORUFIN; INDOLEACETIC ACID DERIVATIVE; INDOMETACIN; KETOCONAZOLE; L 888 607; MIDAZOLAM; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN D2 DERIVATIVE; PROSTAGLANDIN D2 RECEPTOR; QUINIDINE; RECEPTOR PROTEIN; SULFAPHENAZOLE; SULINDAC SULFIDE; TOLBUTAMIDE; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

ALLERGIC DISEASE; ALLERGIC RHINITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTHMA; ATOPIC DERMATITIS; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; INFLAMMATION; NONHUMAN; RAT; TH2 CELL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL AVAILABILITY; CALCIUM; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; INDOLEACETIC ACIDS; PROSTAGLANDIN D2; RATS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 26444568206     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050519b     Document Type: Article

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