Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 3, 2010, Pages 1181-1185

  Grimstrup, Marie ^a   Rist, Øystein ^a   Receveur, Jean Marie ^a   Frimurer, Thomas M ^a   Ulven, Trond ^a   Mathiesen, Jesper M ^a   Kostenis, Evi ^a   Högberg, Thomas ^a  

^a 7TM Pharma A S   (Denmark)

Author keywords

Chemical libraries; Chemoattractant receptor homologous molecule expressed on Th2 cells; CRTH2 antagonists; Hit to lead; Molecular modeling; PGD2; Structure activity relationships

Indexed keywords

3 FLUOROPHENYL COMPOUND; 4 FLUOROPHENYL COMPOUND; BENZENE DERIVATIVE; CHEMOATTRACTANT RECEPTOR HOMOLOGOUS PROTEIN 2; CHEMOATTRACTANT RECEPTOR HOMOLOGOUS PROTEIN 2 ANTAGONIST; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR ANTAGONIST; PYRIDINE; THIAZOLE; THIAZOLE DERIVATIVE; THIAZOLEACETIC ACID; UNCLASSIFIED DRUG; ACETIC ACID; IMMUNOGLOBULIN RECEPTOR; PEPTIDE LIBRARY; PROSTAGLANDIN D2 RECEPTOR; PROSTAGLANDIN RECEPTOR;

ARTICLE; BINDING AFFINITY; COMPUTER MODEL; CONTROLLED STUDY; DERIVATIZATION; DRUG ANTAGONISM; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG EFFICACY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; TH2 CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; COMPARATIVE STUDY; METABOLISM; PEPTIDE LIBRARY; RAT;

ACETIC ACID; ANIMALS; CELL LINE; HUMANS; PEPTIDE LIBRARY; RATS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; TH2 CELLS; THIAZOLES;

EID: 74049135437     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.12.015     Document Type: Article

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