Discovery of a new class of potent, selective, and orally active prostaglandin D 2 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 20, 2004, Pages 5361-5378

  Torisu, Kazuhiko ^a   Kobayashi, Kaoru ^a   Iwahashi, Maki ^a   Nakai, Yoshihiko ^a   Onoda, Takahiro ^a   Nagase, Toshihiko ^a   Sugimoto, Isamu ^a   Okada, Yutaka ^a   Matsumoto, Ryoji ^a   Nanbu, Fumio ^a   Ohuchida, Shuichi ^a   Nakai, Hisao ^a   Toda, Masaaki ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Antagonist; DP receptor; Prostaglandin

Indexed keywords

[2 METHYL 1 [4 [(4,6 DIMETHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL] 1H INDOL 4 YL]ACETIC ACID; [2 METHYL 1 [4 [(7 FLUORO 4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL] 1H INDOL 4 YL]ACETIC ACID; ACETIC ACID DERIVATIVE; INDOLE DERIVATIVE; PROSTAGLANDIN D2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ALLERGY; ARTICLE; BIOASSAY; BLOOD VESSEL PERMEABILITY; COLUMN CHROMATOGRAPHY; CONFORMATION; DRUG SELECTIVITY; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; INFLAMMATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; ANTI-ALLERGIC AGENTS; GUINEA PIGS; HUMANS; INDOLEACETIC ACIDS; RATS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN;

EID: 4544266546     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.07.048     Document Type: Article

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