Interleukin 10 (IL-10) gene variants and susceptibility for paediatric onset Crohn's disease

Alimentary Pharmacology and Therapeutics

Volumn 29, Issue 9, 2009, Pages 1025-1031

  Amre, D K ^a,b   MacK, D R ^c   Morgan, K ^d   Israel, D ^e   Lambrette, P ^a   Costea, I ^a,b   Krupoves, A ^a,b   Fegury, H ^a   Dong, J ^a   Grimard, G ^b   Deslandres, C ^a,b   Levy, E ^a,f   Seidman, E G ^g  

^a UNIVERSITY OF MONTREAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^d RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^e BC CHILDREN S HOSPITAL   (Canada)

^f UNIVERSITY OF MONTREAL   (Canada)

^g MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10;

ARTICLE; CHILD; CONTROLLED STUDY; CROHN DISEASE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; AGE OF ONSET; CANADA; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CROHN DISEASE; FEMALE; GENE FREQUENCY; HAPLOTYPES; HUMANS; INTERLEUKIN-10; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRODUCIBILITY OF RESULTS; RISK FACTORS; YOUNG ADULT;

EID: 63849311502     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2009.03953.x     Document Type: Article

References (32)

1. Bernstein CN, Blanchard JF, Rawsthorne P, et al. Epidemiology of Crohn's disease and Ulcerative Colitis in a central Canadian province: A population-based study. Am J Epidemiol 1999 149 : 916 24.
2. Hyams JS, Markowitz JF. Can we alter the natural history of Crohn disease in children? JPGN 2005 40 : 262 72.
3. Kim SC, Ferry GD. Inflammatory bowel disease in pediatric and adolescent patients: clinical, therapeutic, and psychosocial considerations. Gastroenterology 2004 126 : 1550 60.
4. Barrett JC, Hansoul S, Nicolae DL, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008 40 : 955 62.
5. Hibi T, Ogata H, Sakuraba A. Animal models of inflammatory bowel disease. J Gastroenterol 2002 37 : 409 17.
6. Lazarus R, Klimecki WT, Palmer LJ, et al. Single-nucleotide polymorphisms in the interleukin-10 gene: differences in frequencies, linkage disequilibrium patterns, and haplotypes in three United States Ethnic groups. Genomics 2002 80 : 223 8.
7. Warlé MC, Farhan A, Metselaar HJ, et al. Are cytokine gene polymorphisms related to in vitro cytokine production profiles? Liver Transpl 2003 9 : 170 81.
8. Klein W, Tromm A, Griga T, et al. The IL-10 gene is not involved in the predisposition of inflammatory bowel disease. Electrophoresis 2000 21 : 3578 82.
9. Parkes M, Satsangi J, Jewell D. Contribution of the IL-2 and IL-10 genes to inflammatory bowel disease (IBD) susceptibility. Clin Exp Immunol 1998 113 : 28 32.
10. Koss K, Satsangi J, Fanning GC, et al. Cytokine (TNFα, LTα and IL-10) polymorphisms in the inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies. Genes Immun 2000 1 : 185 90.
11. Aithal GP, Craggs A, Day CP, et al. Role of polymorphisms in the interleukin-10 gene in determining disease susceptibility and phenotype in inflammatory bowel disease. Dig Dis Sci 2001 46 : 1520 5.
12. Tagore A, Gonsalkorale WM, Pravica V, et al. Interleukin-10 (IL-10) genotypes in inflammatory bowel disease. Tissue Antigens 1999 54 : 386 90.
13. Cantor MJ, Nickerson P, Bernstein CN. The role of cytokine gene polymorphisms in determining disease susceptibility and phenotype in inflammatory bowel disease. Am J Gastroenterol 2005 100 : 1134 42.
14. Fowler EV, Eri R, Hume G, et al. TNF-α and IL10 SNPs act together to predict disease behavior in Crohn's disease. J Med Genet 2005 42 : 523 8.
15. Fernandez L, Martinez A, Mendoza JL, et al. Interleukin-10 polymorphisms in Spanish patients with IBD. Inflamm Bowel Dis 2005 11 : 739 43.
16. Franke A, Balschun T, Karlsen TH, et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 2008 40 : 1319 23.
17. Kugathasan S, Baldassano RN, Bradfield JP, et al. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat Genet 2008 40 : 1211 5.
18. Lennard-Jones JE. Classification of inflammatory bowel disease. Scand J Gastroenterol 1989 24 (suppl 170 2 6.
19. Sands B. From symptom to diagnosis: clinical distinctions among various forms of intestinal inflammation. Gastroenterology 2004 126 : 1518 32.
20. Krupoves A, Seidman EG, Mack D, et al. Associations between ABCB1/MDR1 gene polymorphisms and Crohn's disease: A gene-wide study in a pediatric population. Inflamm Bowel Dis 2008. [Epub ahead of print]
21. Amre DK, Mack DR, Morgan K, et al. Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children. Inflamm Bowel Dis 2008. [Epub ahead of print].
22. Amre DK, Mack DR, Israel D, et al. Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn's disease in Canadian children using a gene-wide haplotype-based approach. Inflamm Bowel Dis 2008 14 : 1214 8.
23. Amre DK, Mack D, Israel D, et al. Association between genetic variants in the IL-23R gene and early-onset Crohn's disease: results from a case-control and family-based study among Canadian children. Am J Gastroenterol 2008 103 : 615 20.
24. Satsangi J, Silverberg MS, Vermiere S, Colombel J-F. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 2006 55 : 749 53.
25. Carlson CS, Eberle MA, Rieder MJ, et al. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet 2004 74 : 106 20.
26. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a toolset for whole-genome association and population-based linkage analysis. Am J Hum Genet 2006 81 : 559 75.
27. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005 21 : 263 5.
28. Grütz G. New insights into the molecular mechanism of interleukin-10-mediated immunosuppression. J Leukoc Biol 2005 77 : 3 15.
29. Levings MK, Bacchetta R, Schulz U, et al. The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. Int Arch Allergy Immunol 2002 129 : 263 76.
30. Turner DM, Williams DM, Sankaran D, et al. An investigation of polymorphisms in the interleukin-10 gene promoter. Eur J Immunogenet 1997 24 : 1 8.
31. Mendoza JL, Urcelay E, Lana R, et al. Polymorphisms in interleukin-10 gene according to mutations of NOD2/CARD15 gene and relation to phenotype in Spanish patients with Crohn's disease. World J Gastroenterol 2006 21 : 443 8.
32. Colpaert S, Vanstraelen K, Liu Z, et al. Decreased lamina propria effector cell responsiveness to interleukin-10 in ileal Crohn's disease. Clin Immunol 2002 102 : 68 76.