-
1
-
-
0023947826
-
Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger
-
10.1161/01.STR.19.4.480 1:CAS:528:DyaL1cXks1Kksr0%3D
-
Abe K, Yuki S, Kogure K (1988) Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 19(4):480-485
-
(1988)
Stroke
, vol.19
, Issue.4
, pp. 480-485
-
-
Abe, K.1
Yuki, S.2
Kogure, K.3
-
2
-
-
33645463320
-
Edaravone inhibits the disease activity in rheumatoid arthritis
-
10.1111/j.1365-2710.2006.00722.x 16635056 10.1111/j.1365-2710.2006.00722. x 1:CAS:528:DC%2BD2sXitVCqtbY%3D
-
Arii K, Kumon Y, Ikeda Y, Suehiro T, Hashimoto K (2006) Edaravone inhibits the disease activity in rheumatoid arthritis. J Clin Pharm Ther 31(2):197-199. doi: 10.1111/j.1365-2710.2006.00722.x
-
(2006)
J Clin Pharm Ther
, vol.31
, Issue.2
, pp. 197-199
-
-
Arii, K.1
Kumon, Y.2
Ikeda, Y.3
Suehiro, T.4
Hashimoto, K.5
-
3
-
-
78650712733
-
Endothelial nitric oxide modulates expression and processing of amyloid precursor protein
-
10.1161/CIRCRESAHA.110.233080 21127294 10.1161/CIRCRESAHA.110.233080 1:CAS:528:DC%2BC3cXhsFChsb%2FI
-
Austin SA, Santhanam AV, Katusic ZS (2010) Endothelial nitric oxide modulates expression and processing of amyloid precursor protein. Circ Res 107(12):1498-1502. doi: 10.1161/CIRCRESAHA.110.233080
-
(2010)
Circ Res
, vol.107
, Issue.12
, pp. 1498-1502
-
-
Austin, S.A.1
Santhanam, A.V.2
Katusic, Z.S.3
-
4
-
-
45749089694
-
Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease
-
10.1124/jpet.108.137455 18417733 10.1124/jpet.108.137455 1:CAS:528:DC%2BD1cXotlyltr8%3D
-
Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA (2008) Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. J Pharmacol Exp Ther 326(1):196-208. doi: 10.1124/jpet.108.137455
-
(2008)
J Pharmacol Exp Ther
, vol.326
, Issue.1
, pp. 196-208
-
-
Begum, A.N.1
Jones, M.R.2
Lim, G.P.3
Morihara, T.4
Kim, P.5
Heath, D.D.6
Rock, C.L.7
Pruitt, M.A.8
Yang, F.9
Hudspeth, B.10
Hu, S.11
Faull, K.F.12
Teter, B.13
Cole, G.M.14
Frautschy, S.A.15
-
5
-
-
0348111546
-
Cytochrome c oxidase is decreased in Alzheimer's disease platelets
-
14675736 10.1016/S0197-4580(03)00033-2 1:CAS:528:DC%2BD3sXpvVaitL0%3D
-
Cardoso SM, Proenca MT, Santos S, Santana I, Oliveira CR (2004) Cytochrome c oxidase is decreased in Alzheimer's disease platelets. Neurobiol Aging 25(1):105-110
-
(2004)
Neurobiol Aging
, vol.25
, Issue.1
, pp. 105-110
-
-
Cardoso, S.M.1
Proenca, M.T.2
Santos, S.3
Santana, I.4
Oliveira, C.R.5
-
6
-
-
34447498539
-
Amelioration of early cognitive deficits by aged garlic extract in Alzheimer's transgenic mice
-
17380553 10.1002/ptr.2122 1:CAS:528:DC%2BD2sXovFWrt7Y%3D
-
Chauhan NB, Sandoval J (2007) Amelioration of early cognitive deficits by aged garlic extract in Alzheimer's transgenic mice. Phytother Res 21(7):629-640
-
(2007)
Phytother Res
, vol.21
, Issue.7
, pp. 629-640
-
-
Chauhan, N.B.1
Sandoval, J.2
-
7
-
-
0026745610
-
Mutation of the β-amyloid precursor protein in familial Alzheimer' disease increases β-protein production
-
1465129 10.1038/360672a0 1:CAS:528:DyaK3sXnvVGnuw%3D%3D
-
Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P et al (1992) Mutation of the β-amyloid precursor protein in familial Alzheimer' disease increases β-protein production. Nature 360(6405):672-674
-
(1992)
Nature
, vol.360
, Issue.6405
, pp. 672-674
-
-
Citron, M.1
Oltersdorf, T.2
Haass, C.3
McConlogue, L.4
Hung, A.Y.5
Seubert, P.6
-
8
-
-
69249212441
-
Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition
-
10.1016/j.freeradbiomed.2009.07.008 10.1016/j.freeradbiomed.2009.07.008 1:CAS:528:DC%2BD1MXhtVOisLrF
-
Dumont M, Ho DJ, Calingasan NY, Xu H, Gibson G, Beal MF (2009) Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition. Free Radic Biol Med 47(7):1019-1027. doi: 10.1016/j.freeradbiomed.2009.07.008
-
(2009)
Free Radic Biol Med
, vol.47
, Issue.7
, pp. 1019-1027
-
-
Dumont, M.1
Ho, D.J.2
Calingasan, N.Y.3
Xu, H.4
Gibson, G.5
Beal, M.F.6
-
9
-
-
34547451145
-
Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model
-
10.1111/j.1471-4159.2007.04613.x 17472706 10.1111/j.1471-4159.2007.04613. x 1:CAS:528:DC%2BD2sXhtVOqtL%2FF
-
Garcia-Alloza M, Borrelli LA, Rozkalne A, Hyman BT, Bacskai BJ (2007) Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem 102(4):1095-1104. doi: 10.1111/j.1471-4159.2007.04613.x
-
(2007)
J Neurochem
, vol.102
, Issue.4
, pp. 1095-1104
-
-
Garcia-Alloza, M.1
Borrelli, L.A.2
Rozkalne, A.3
Hyman, B.T.4
Bacskai, B.J.5
-
10
-
-
23244435445
-
The alpha-ketoglutarate-dehydrogenase complex: A mediator between mitochondria and oxidative stress in neurodegeneration
-
10.1385/MN:31:1-3:043 15953811 10.1385/MN:31:1-3:043 1:CAS:528: DC%2BD2MXmtFKltb4%3D
-
Gibson GE, Blass JP, Beal MF, Bunik V (2005) The alpha-ketoglutarate- dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration. Mol Neurobiol 31(1-3):43-63. doi: 10.1385/MN:31:1-3:043
-
(2005)
Mol Neurobiol
, vol.31
, Issue.1-3
, pp. 43-63
-
-
Gibson, G.E.1
Blass, J.P.2
Beal, M.F.3
Bunik, V.4
-
11
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
10.1126/science.1072994 12130773 10.1126/science.1072994 1:CAS:528:DC%2BD38Xls1Cju7s%3D
-
Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297(5580):353-356. doi: 10.1126/science.1072994
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
12
-
-
3042559829
-
Potent inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity
-
15212458 10.1021/jf049953x 1:CAS:528:DC%2BD2cXksFeks7g%3D
-
Heo HJ, Kim DO, Choi SJ, Shin DH, Lee CY (2004) Potent inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity. J Agric Food Chem 52(13):4128-4132
-
(2004)
J Agric Food Chem
, vol.52
, Issue.13
, pp. 4128-4132
-
-
Heo, H.J.1
Kim, D.O.2
Choi, S.J.3
Shin, D.H.4
Lee, C.Y.5
-
13
-
-
0000342402
-
Neuroprotective effect of the free radical scavenger MCI-186 in patients with cerebral infarction: Clinical evaluation using magnetic resonance imaging and spectroscopy
-
17895107 10.1016/S1052-3057(98)80049-9 1:STN:280:DC%2BD2srntlGktw%3D%3D
-
Houkin K, Nakayama N, Kamada K, Noujou T, Abe H, Kashiwaba T (1998) Neuroprotective effect of the free radical scavenger MCI-186 in patients with cerebral infarction: clinical evaluation using magnetic resonance imaging and spectroscopy. J Stroke Cerebrovasc Dis 7(5):315-322
-
(1998)
J Stroke Cerebrovasc Dis
, vol.7
, Issue.5
, pp. 315-322
-
-
Houkin, K.1
Nakayama, N.2
Kamada, K.3
Noujou, T.4
Abe, H.5
Kashiwaba, T.6
-
14
-
-
65649147852
-
Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo
-
19201991 10.1124/jpet.108.148676 1:CAS:528:DC%2BD1MXlt1Ols7s%3D
-
Inokuchi Y, Imai S, Nakajima Y, Shimazawa M, Aihara M, Araie M, Hara H (2009) Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo. J Pharmacol Exp Ther 329(2):687-698
-
(2009)
J Pharmacol Exp Ther
, vol.329
, Issue.2
, pp. 687-698
-
-
Inokuchi, Y.1
Imai, S.2
Nakajima, Y.3
Shimazawa, M.4
Aihara, M.5
Araie, M.6
Hara, H.7
-
15
-
-
84856507252
-
Effects of edaravone, a free radical scavenger, on serum levels of inflammatory biomarkers in acute brain infarction
-
21215657 10.1016/j.jstrokecerebrovasdis.2010.05.009
-
Isahaya K, Yamada K, Yamatoku M, Sakurai K, Takaishi S, Kato B, Hirayama T, Hasegawa Y (2012) Effects of edaravone, a free radical scavenger, on serum levels of inflammatory biomarkers in acute brain infarction. J Stroke Cerebrovasc Dis 21(2):102-107
-
(2012)
J Stroke Cerebrovasc Dis
, vol.21
, Issue.2
, pp. 102-107
-
-
Isahaya, K.1
Yamada, K.2
Yamatoku, M.3
Sakurai, K.4
Takaishi, S.5
Kato, B.6
Hirayama, T.7
Hasegawa, Y.8
-
16
-
-
35549012820
-
Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia
-
10.1016/j.neures.2007.08.008 17889387 10.1016/j.neures.2007.08.008 1:CAS:528:DC%2BD2sXht1Kgsb3F
-
Ishikawa A, Yoshida H, Metoki N, Toki T, Imaizumi T, Matsumiya T, Yamashita K, Taima K, Satoh K (2007) Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia. Neurosci Res 59(4):406-412. doi: 10.1016/j.neures.2007.08.008
-
(2007)
Neurosci Res
, vol.59
, Issue.4
, pp. 406-412
-
-
Ishikawa, A.1
Yoshida, H.2
Metoki, N.3
Toki, T.4
Imaizumi, T.5
Matsumiya, T.6
Yamashita, K.7
Taima, K.8
Satoh, K.9
-
17
-
-
84857404716
-
BACE-1 inhibition prevents the gamma-secretase inhibitor evoked Abeta rise in human neuroblastoma SH-SY5Y cells
-
10.1186/1423-0127-18-76 22018341 10.1186/1423-0127-18-76
-
Jamsa A, Belda O, Edlund M, Lindstrom E (2011) BACE-1 inhibition prevents the gamma-secretase inhibitor evoked Abeta rise in human neuroblastoma SH-SY5Y cells. J Biomed Sci 18:76. doi: 10.1186/1423-0127-18-76
-
(2011)
J Biomed Sci
, vol.18
, pp. 76
-
-
Jamsa, A.1
Belda, O.2
Edlund, M.3
Lindstrom, E.4
-
18
-
-
57549104901
-
Neuroprotective effects of edaravone, a free radical scavenger, on the rat hippocampus after pilocarpine-induced status epilepticus
-
10.1016/j.seizure.2008.06.012 18672383 10.1016/j.seizure.2008.06.012 1:STN:280:DC%2BD1M%2FhsFKrsQ%3D%3D
-
Kamida T, Fujiki M, Ooba H, Anan M, Abe T, Kobayashi H (2009) Neuroprotective effects of edaravone, a free radical scavenger, on the rat hippocampus after pilocarpine-induced status epilepticus. Seizure 18(1):71-75. doi: 10.1016/j.seizure.2008.06.012
-
(2009)
Seizure
, vol.18
, Issue.1
, pp. 71-75
-
-
Kamida, T.1
Fujiki, M.2
Ooba, H.3
Anan, M.4
Abe, T.5
Kobayashi, H.6
-
19
-
-
60749097825
-
Antioxidants and neuroprotection in the adult and developing central nervous system
-
19075654 10.2174/092986708786848640 1:CAS:528:DC%2BD1MXptV2huw%3D%3D
-
Kaur C, Ling EA (2008) Antioxidants and neuroprotection in the adult and developing central nervous system. Curr Med Chem 15(29):3068-3080
-
(2008)
Curr Med Chem
, vol.15
, Issue.29
, pp. 3068-3080
-
-
Kaur, C.1
Ling, E.A.2
-
20
-
-
77349084360
-
Naturally occurring phytochemicals for the prevention of Alzheimer's disease
-
10.1111/j.1471-4159.2009.06562.x 20050972 10.1111/j.1471-4159.2009.06562. x 1:CAS:528:DC%2BC3cXjsFaku74%3D
-
Kim J, Lee HJ, Lee KW (2010) Naturally occurring phytochemicals for the prevention of Alzheimer's disease. J Neurochem 112(6):1415-1430. doi: 10.1111/j.1471-4159.2009.06562.x
-
(2010)
J Neurochem
, vol.112
, Issue.6
, pp. 1415-1430
-
-
Kim, J.1
Lee, H.J.2
Lee, K.W.3
-
21
-
-
33750088980
-
The therapeutic efficacy of edaravone in extensively burned rats
-
10.1001/archsurg.141.10.992 17043277 10.1001/archsurg.141.10.992 1:CAS:528:DC%2BD28XhtFCrtrnP
-
Koizumi T, Tanaka H, Sakaki S, Shimazaki S (2006) The therapeutic efficacy of edaravone in extensively burned rats. Arch Surg 141(10):992-995. doi: 10.1001/archsurg.141.10.992
-
(2006)
Arch Surg
, vol.141
, Issue.10
, pp. 992-995
-
-
Koizumi, T.1
Tanaka, H.2
Sakaki, S.3
Shimazaki, S.4
-
22
-
-
0035826909
-
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10
-
10.1073/pnas.081612998
-
Kojru E, Gimpl G, Lammich S, März W, Fahrenholz F (2001) Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10. PNAS USA 98(10):5815-5820
-
(2001)
PNAS USA
, vol.98
, Issue.10
, pp. 5815-5820
-
-
Kojru, E.1
Gimpl, G.2
Lammich, S.3
März, W.4
Fahrenholz, F.5
-
23
-
-
33846633336
-
Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
-
10.1523/JNEUROSCI.3501-06.2007 17251419 10.1523/JNEUROSCI.3501-06.2007 1:CAS:528:DC%2BD2sXhs1Wrsbc%3D
-
Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL, Klein WL (2007) Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci 27(4):796-807. doi: 10.1523/JNEUROSCI.3501-06. 2007
-
(2007)
J Neurosci
, vol.27
, Issue.4
, pp. 796-807
-
-
Lacor, P.N.1
Buniel, M.C.2
Furlow, P.W.3
Clemente, A.S.4
Velasco, P.T.5
Wood, M.6
Viola, K.L.7
Klein, W.L.8
-
24
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
-
9600986 10.1073/pnas.95.11.6448 1:STN:280:DyaK1c3mtlektQ%3D%3D
-
Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, Klein WL (1998) Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A 95(11):6448-6453
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, Issue.11
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
Morgan, T.E.7
Rozovsky, I.8
Trommer, B.9
Viola, K.L.10
Wals, P.11
Zhang, C.12
Finch, C.E.13
Krafft, G.A.14
Klein, W.L.15
-
25
-
-
33644875726
-
Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42
-
10.1111/j.1471-4159.2005.03553.x 16300630 10.1111/j.1471-4159.2005.03553. x 1:CAS:528:DC%2BD28XntVSjtw%3D%3D
-
Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R, Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S (2006) Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. J Neurochem 96(2):355-365. doi: 10.1111/j.1471-4159.2005.03553.x
-
(2006)
J Neurochem
, vol.96
, Issue.2
, pp. 355-365
-
-
Leuchtenberger, S.1
Kummer, M.P.2
Kukar, T.3
Czirr, E.4
Teusch, N.5
Sagi, S.A.6
Berdeaux, R.7
Pietrzik, C.U.8
Ladd, T.B.9
Golde, T.E.10
Koo, E.H.11
Weggen, S.12
-
26
-
-
0035503597
-
The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
-
11606625 1:CAS:528:DC%2BD3MXnvVeqs7g%3D
-
Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM (2001) The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 21(21):8370-8377
-
(2001)
J Neurosci
, vol.21
, Issue.21
, pp. 8370-8377
-
-
Lim, G.P.1
Chu, T.2
Yang, F.3
Beech, W.4
Frautschy, S.A.5
Cole, G.M.6
-
27
-
-
31844439888
-
Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro
-
10.1002/jnr.20734 16385556 10.1002/jnr.20734 1:CAS:528: DC%2BD28XitFCjs7k%3D
-
Ma QL, Lim GP, Harris-White ME, Yang F, Ambegaokar SS, Ubeda OJ, Glabe CG, Teter B, Frautschy SA, Cole GM (2006) Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro. J Neurosci Res 83(3):374-384. doi: 10.1002/jnr.20734
-
(2006)
J Neurosci Res
, vol.83
, Issue.3
, pp. 374-384
-
-
Ma, Q.L.1
Lim, G.P.2
Harris-White, M.E.3
Yang, F.4
Ambegaokar, S.S.5
Ubeda, O.J.6
Glabe, C.G.7
Teter, B.8
Frautschy, S.A.9
Cole, G.M.10
-
28
-
-
33745253950
-
Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway
-
10.1016/j.nbd.2006.02.010 16626961 10.1016/j.nbd.2006.02.010 1:CAS:528:DC%2BD28XlvFyqtro%3D
-
Malaplate-Armand C, Florent-Bechard S, Youssef I, Koziel V, Sponne I, Kriem B, Leininger-Muller B, Olivier JL, Oster T, Pillot T (2006) Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway. Neurobiol Dis 23(1):178-189. doi: 10.1016/j.nbd.2006.02.010
-
(2006)
Neurobiol Dis
, vol.23
, Issue.1
, pp. 178-189
-
-
Malaplate-Armand, C.1
Florent-Bechard, S.2
Youssef, I.3
Koziel, V.4
Sponne, I.5
Kriem, B.6
Leininger-Muller, B.7
Olivier, J.L.8
Oster, T.9
Pillot, T.10
-
29
-
-
57649170951
-
Edaravone, a free radical scavenger, is effective on neuropathic pain in rats
-
10.1016/j.brainres.2008.10.073 19028459 10.1016/j.brainres.2008.10.073 1:CAS:528:DC%2BD1cXhsFansrjF
-
Mao YF, Yan N, Xu H, Sun JH, Xiong YC, Deng XM (2009) Edaravone, a free radical scavenger, is effective on neuropathic pain in rats. Brain Res 1248:68-75. doi: 10.1016/j.brainres.2008.10.073
-
(2009)
Brain Res
, vol.1248
, pp. 68-75
-
-
Mao, Y.F.1
Yan, N.2
Xu, H.3
Sun, J.H.4
Xiong, Y.C.5
Deng, X.M.6
-
30
-
-
15944426135
-
Effects of edaravone on human neutrophil function
-
10.1111/j.1399-6576.2005.00610.x 15752406 10.1111/j.1399-6576.2005.00610. x 1:CAS:528:DC%2BD2MXjtFansrg%3D
-
Mikawa K, Akamatsu H, Nishina K, Obara H, Niwa Y (2005) Effects of edaravone on human neutrophil function. Acta Anaesthesiol Scand 49(3):385-389. doi: 10.1111/j.1399-6576.2005.00610.x
-
(2005)
Acta Anaesthesiol Scand
, vol.49
, Issue.3
, pp. 385-389
-
-
Mikawa, K.1
Akamatsu, H.2
Nishina, K.3
Obara, H.4
Niwa, Y.5
-
31
-
-
23844517474
-
Efficacy of edaravone, a free radical scavenger, for the treatment of acute lacunar infarction
-
(Tokyo) discussion 348
-
Mishina M, Komaba Y, Kobayashi S, Tanaka N, Kominami S, Fukuchi T, Mizunari T, Hamamoto M, Teramoto A, Katayama Y (2005) Efficacy of edaravone, a free radical scavenger, for the treatment of acute lacunar infarction. Neurol Med Chir (Tokyo) 45(7):344-348; discussion 348
-
(2005)
Neurol Med Chir
, vol.45
, Issue.7
, pp. 344-348
-
-
Mishina, M.1
Komaba, Y.2
Kobayashi, S.3
Tanaka, N.4
Kominami, S.5
Fukuchi, T.6
Mizunari, T.7
Hamamoto, M.8
Teramoto, A.9
Katayama, Y.10
-
32
-
-
84655160768
-
Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?
-
22122230 10.1111/j.1471-4159.2011.07510.x 1:CAS:528:DC%2BC38XhsFyns7c%3D
-
Nalivaeva NN, Beckett C, Belyaev ND, Turner AJ (2012) Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease? J Neurochem 120(Suppl. 1):167-185
-
(2012)
J Neurochem
, vol.120
, Issue.SUPPL. 1
, pp. 167-185
-
-
Nalivaeva, N.N.1
Beckett, C.2
Belyaev, N.D.3
Turner, A.J.4
-
33
-
-
0024414674
-
Effect of MCI-186 on brain edema in rats
-
2505409 10.1161/01.STR.20.9.1236 1:CAS:528:DyaL1MXls1OjtbY%3D
-
Nishi H, Watanabe T, Sakurai H, Yuki S, Ishibashi A (1989) Effect of MCI-186 on brain edema in rats. Stroke 20(9):1236-1240
-
(1989)
Stroke
, vol.20
, Issue.9
, pp. 1236-1240
-
-
Nishi, H.1
Watanabe, T.2
Sakurai, H.3
Yuki, S.4
Ishibashi, A.5
-
34
-
-
77952670768
-
Edaravone directly reacts with singlet oxygen and protects cells from attack
-
20350554 10.1016/j.lfs.2010.03.017 1:CAS:528:DC%2BC3cXlvVenuro%3D
-
Nishinaka Y, Mori H, Endo N, Miyoshi T, Yamashita K, Adachi S, Arai T (2010) Edaravone directly reacts with singlet oxygen and protects cells from attack. Life Sci 86(21-22):808-813
-
(2010)
Life Sci
, vol.86
, Issue.21-22
, pp. 808-813
-
-
Nishinaka, Y.1
Mori, H.2
Endo, N.3
Miyoshi, T.4
Yamashita, K.5
Adachi, S.6
Arai, T.7
-
35
-
-
17444362654
-
Temporal effects of edaravone, a free radical scavenger, on transient ischemia-induced neuronal dysfunction in the rat hippocampus
-
10.1016/j.ejphar.2005.01.050 15840397 10.1016/j.ejphar.2005.01.050 1:CAS:528:DC%2BD2MXjsVGksL8%3D
-
Otani H, Togashi H, Jesmin S, Sakuma I, Yamaguchi T, Matsumoto M, Kakehata H, Yoshioka M (2005) Temporal effects of edaravone, a free radical scavenger, on transient ischemia-induced neuronal dysfunction in the rat hippocampus. Eur J Pharmacol 512(2-3):129-137. doi: 10.1016/j.ejphar.2005.01.050
-
(2005)
Eur J Pharmacol
, vol.512
, Issue.2-3
, pp. 129-137
-
-
Otani, H.1
Togashi, H.2
Jesmin, S.3
Sakuma, I.4
Yamaguchi, T.5
Matsumoto, M.6
Kakehata, H.7
Yoshioka, M.8
-
36
-
-
70449433157
-
The role of cytochrome c oxidase deficiency in ROS and amyloid plaque formation
-
10.1007/s10863-009-9245-3 19795195 10.1007/s10863-009-9245-3 1:CAS:528:DC%2BD1MXhtlCnu7zE
-
Pickrell AM, Fukui H, Moraes CT (2009) The role of cytochrome c oxidase deficiency in ROS and amyloid plaque formation. J Bioenerg Biomembr 41(5):453-456. doi: 10.1007/s10863-009-9245-3
-
(2009)
J Bioenerg Biomembr
, vol.41
, Issue.5
, pp. 453-456
-
-
Pickrell, A.M.1
Fukui, H.2
Moraes, C.T.3
-
37
-
-
78249284625
-
A free radical-generating system regulates APP metabolism/processing
-
10.1016/j.febslet.2010.10.028 20965178 10.1016/j.febslet.2010.10.028 1:CAS:528:DC%2BC3cXhsVans7%2FL
-
Recuero M, Munoz T, Aldudo J, Subias M, Bullido MJ, Valdivieso F (2010) A free radical-generating system regulates APP metabolism/processing. FEBS Lett 584(22):4611-4618. doi: 10.1016/j.febslet.2010.10.028
-
(2010)
FEBS Lett
, vol.584
, Issue.22
, pp. 4611-4618
-
-
Recuero, M.1
Munoz, T.2
Aldudo, J.3
Subias, M.4
Bullido, M.J.5
Valdivieso, F.6
-
38
-
-
34347219785
-
Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy
-
10.1016/j.ejphar.2007.04.016 17521626 10.1016/j.ejphar.2007.04.016 1:CAS:528:DC%2BD2sXntFKgt7k%3D
-
Saini AK, Kumar HSA, Sharma SS (2007) Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy. Eur J Pharmacol 568(1-3):164-172. doi: 10.1016/j.ejphar.2007.04.016
-
(2007)
Eur J Pharmacol
, vol.568
, Issue.1-3
, pp. 164-172
-
-
Saini, A.K.1
Kumar, H.S.A.2
Sharma, S.S.3
-
39
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
11274343 1:CAS:528:DC%2BD3MXislCrsLc%3D
-
Selkoe DJ (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81(2):741-766
-
(2001)
Physiol Rev
, vol.81
, Issue.2
, pp. 741-766
-
-
Selkoe, D.J.1
-
40
-
-
77955283395
-
Animal and human studies with the mitochondria-targeted antioxidant MitoQ
-
10.1111/j.1749-6632.2010.05627.x 20649545 10.1111/j.1749-6632.2010.05627. x 1:CAS:528:DC%2BC3cXhtFegsLrF
-
Smith RA, Murphy MP (2010) Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Ann N Y Acad Sci 1201:96-103. doi: 10.1111/j.1749-6632.2010.05627.x
-
(2010)
Ann N y Acad Sci
, vol.1201
, pp. 96-103
-
-
Smith, R.A.1
Murphy, M.P.2
-
41
-
-
46449119069
-
Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models
-
10.1016/j.freeradbiomed.2008.04.022 18482592 10.1016/j.freeradbiomed. 2008.04.022 1:CAS:528:DC%2BD1cXntlSku7s%3D
-
Sonnen JA, Breitner JC, Lovell MA, Markesbery WR, Quinn JF, Montine TJ (2008) Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models. Free Radic Biol Med 45(3):219-230. doi: 10.1016/j.freeradbiomed.2008.04.022
-
(2008)
Free Radic Biol Med
, vol.45
, Issue.3
, pp. 219-230
-
-
Sonnen, J.A.1
Breitner, J.C.2
Lovell, M.A.3
Markesbery, W.R.4
Quinn, J.F.5
Montine, T.J.6
-
42
-
-
0020685951
-
Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain
-
10.1002/ana.410130116 6219611 10.1002/ana.410130116 1:STN:280: DyaL3s7ltFentA%3D%3D
-
Sorbi S, Bird ED, Blass JP (1983) Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain. Ann Neurol 13(1):72-78. doi: 10.1002/ana.410130116
-
(1983)
Ann Neurol
, vol.13
, Issue.1
, pp. 72-78
-
-
Sorbi, S.1
Bird, E.D.2
Blass, J.P.3
-
43
-
-
70449714158
-
Coenzyme Q10 effects in neurodegenerative disease
-
19966907 1:CAS:528:DC%2BD1MXhsFSmtb3E
-
Spindler M, Beal MF, Henchcliffe C (2009) Coenzyme Q10 effects in neurodegenerative disease. Neuropsychiatr Dis Treat 5:597-610
-
(2009)
Neuropsychiatr Dis Treat
, vol.5
, pp. 597-610
-
-
Spindler, M.1
Beal, M.F.2
Henchcliffe, C.3
-
44
-
-
27944485677
-
Experimental study on the protective effects of edaravone against ischemic spinal cord injury
-
10.1016/j.jtcvs.2005.08.049 16308003 10.1016/j.jtcvs.2005.08.049 1:CAS:528:DC%2BD28Xjs1SlsA%3D%3D
-
Suzuki K, Kazui T, Terada H, Umemura K, Ikeda Y, Bashar AH, Yamashita K, Washiyama N, Suzuki T, Ohkura K, Yasuike J (2005) Experimental study on the protective effects of edaravone against ischemic spinal cord injury. J Thorac Cardiovasc Surg 130(6):1586-1592. doi: 10.1016/j.jtcvs.2005.08.049
-
(2005)
J Thorac Cardiovasc Surg
, vol.130
, Issue.6
, pp. 1586-1592
-
-
Suzuki, K.1
Kazui, T.2
Terada, H.3
Umemura, K.4
Ikeda, Y.5
Bashar, A.H.6
Yamashita, K.7
Washiyama, N.8
Suzuki, T.9
Ohkura, K.10
Yasuike, J.11
-
45
-
-
67349169168
-
Edaravone in ALS
-
10.1016/j.expneurol.2009.03.001 19285071 10.1016/j.expneurol.2009.03.001
-
Takahashi R (2009) Edaravone in ALS. Exp Neurol 217(2):235-236. doi: 10.1016/j.expneurol.2009.03.001
-
(2009)
Exp Neurol
, vol.217
, Issue.2
, pp. 235-236
-
-
Takahashi, R.1
-
46
-
-
77951101600
-
A dual activity of ROS and oxidative stress on adult neurogenesis and Alzheimer's disease
-
20236039 10.2174/187152410790780172 1:CAS:528:DC%2BC3cXjslegs7s%3D
-
Taupin P (2010) A dual activity of ROS and oxidative stress on adult neurogenesis and Alzheimer's disease. Cent Nerv Syst Agents Med Chem 10(1):16-21
-
(2010)
Cent Nerv Syst Agents Med Chem
, vol.10
, Issue.1
, pp. 16-21
-
-
Taupin, P.1
-
47
-
-
34250664327
-
MitoQ-a mitochondria-targeted antioxidant
-
17642004 1:CAS:528:DC%2BD2sXotFyks78%3D
-
Tauskela JS (2007) MitoQ-a mitochondria-targeted antioxidant. IDrugs 10(6):399-412
-
(2007)
IDrugs
, vol.10
, Issue.6
, pp. 399-412
-
-
Tauskela, J.S.1
-
48
-
-
78649983748
-
Alzheimer's disease: Effects of beta-amyloid on mitochondria
-
10.1016/j.mito.2010.08.009 20817045 10.1016/j.mito.2010.08.009 1:CAS:528:DC%2BC3cXhsFGhtrvK
-
Tillement L, Lecanu L, Papadopoulos V (2011) Alzheimer's disease: effects of beta-amyloid on mitochondria. Mitochondrion 11(1):13-21. doi: 10.1016/j.mito.2010.08.009
-
(2011)
Mitochondrion
, vol.11
, Issue.1
, pp. 13-21
-
-
Tillement, L.1
Lecanu, L.2
Papadopoulos, V.3
-
49
-
-
47849101646
-
Evaluation of coenzyme Q as an antioxidant strategy for Alzheimer's disease
-
18560133 1:CAS:528:DC%2BD1cXmvFGltro%3D
-
Wadsworth TL, Bishop JA, Pappu AS, Woltjer RL, Quinn JF (2008) Evaluation of coenzyme Q as an antioxidant strategy for Alzheimer's disease. J Alzheimers Dis 14(2):225-234
-
(2008)
J Alzheimers Dis
, vol.14
, Issue.2
, pp. 225-234
-
-
Wadsworth, T.L.1
Bishop, J.A.2
Pappu, A.S.3
Woltjer, R.L.4
Quinn, J.F.5
-
50
-
-
33748753481
-
Clearance of amyloid-beta in Alzheimer's disease: Progress, problems and perspectives
-
10.1016/j.drudis.2006.08.004 16997144 10.1016/j.drudis.2006.08.004 1:CAS:528:DC%2BD28XpvFSis7w%3D
-
Wang YJ, Zhou HD, Zhou XF (2006) Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives. Drug Discov Today 11(19-20):931-938. doi: 10.1016/j.drudis.2006.08.004
-
(2006)
Drug Discov Today
, vol.11
, Issue.19-20
, pp. 931-938
-
-
Wang, Y.J.1
Zhou, H.D.2
Zhou, X.F.3
-
51
-
-
77956583512
-
Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain
-
10.1111/j.1471-4159.2010.06899.x 20663017 10.1111/j.1471-4159.2010.06899. x 1:CAS:528:DC%2BC3cXht1ejurrL
-
Wang S, Wang R, Chen L, Bennett DA, Dickson DW, Wang DS (2010a) Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain. J Neurochem 115(1):47-57. doi: 10.1111/j.1471-4159.2010.06899.x
-
(2010)
J Neurochem
, vol.115
, Issue.1
, pp. 47-57
-
-
Wang, S.1
Wang, R.2
Chen, L.3
Bennett, D.A.4
Dickson, D.W.5
Wang, D.S.6
-
52
-
-
77958592688
-
Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model
-
10.1186/1750-1326-5-46 21044348 10.1186/1750-1326-5-46
-
Wang X, Zheng W, Xie JW, Wang T, Wang SL, Teng WP, Wang ZY (2010b) Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model. Mol Neurodegener 5:46. doi: 10.1186/1750-1326-5-46
-
(2010)
Mol Neurodegener
, vol.5
, pp. 46
-
-
Wang, X.1
Zheng, W.2
Xie, J.W.3
Wang, T.4
Wang, S.L.5
Teng, W.P.6
Wang, Z.Y.7
-
53
-
-
0028292964
-
Protective effects of MCI-186 on cerebral ischemia: Possible involvement of free radical scavenging and antioxidant actions
-
8138971 1:CAS:528:DyaK2cXis1Sqtrk%3D
-
Watanabe T, Yuki S, Egawa M, Nishi H (1994) Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 268(3):1597-1604
-
(1994)
J Pharmacol Exp Ther
, vol.268
, Issue.3
, pp. 1597-1604
-
-
Watanabe, T.1
Yuki, S.2
Egawa, M.3
Nishi, H.4
-
54
-
-
0038785815
-
Structure-activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone)
-
10.1179/135100003225001520 12935312 10.1179/135100003225001520 1:CAS:528:DC%2BD3sXntVCht74%3D
-
Watanabe K, Morinaka Y, Iseki K, Watanabe T, Yuki S, Nishi H (2003) Structure-activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone). Redox Rep 8(3):151-155. doi: 10.1179/135100003225001520
-
(2003)
Redox Rep
, vol.8
, Issue.3
, pp. 151-155
-
-
Watanabe, K.1
Morinaka, Y.2
Iseki, K.3
Watanabe, T.4
Yuki, S.5
Nishi, H.6
-
55
-
-
46849106962
-
The novel antioxidant edaravone: From bench to bedside
-
10.1111/j.1527-3466.2008.00041.x 18485133 10.1111/j.1527-3466.2008.00041. x 1:CAS:528:DC%2BD1cXosFGnsbs%3D
-
Watanabe T, Tahara M, Todo S (2008) The novel antioxidant edaravone: from bench to bedside. Cardiovasc Ther 26(2):101-114. doi: 10.1111/j.1527-3466.2008. 00041.x
-
(2008)
Cardiovasc Ther
, vol.26
, Issue.2
, pp. 101-114
-
-
Watanabe, T.1
Tahara, M.2
Todo, S.3
-
56
-
-
33846301100
-
Effects of chemical chaperones on oxidative stress and detergent-insoluble species formation following conditional expression of amyloid precursor protein carboxy-terminal fragment
-
10.1016/j.nbd.2006.10.003 17141508 10.1016/j.nbd.2006.10.003 1:CAS:528:DC%2BD2sXpvVKktw%3D%3D
-
Woltjer RL, McMahan W, Milatovic D, Kjerulf JD, Shie FS, Rung LG, Montine KS, Montine TJ (2007) Effects of chemical chaperones on oxidative stress and detergent-insoluble species formation following conditional expression of amyloid precursor protein carboxy-terminal fragment. Neurobiol Dis 25(2):427-437. doi: 10.1016/j.nbd.2006.10.003
-
(2007)
Neurobiol Dis
, vol.25
, Issue.2
, pp. 427-437
-
-
Woltjer, R.L.1
McMahan, W.2
Milatovic, D.3
Kjerulf, J.D.4
Shie, F.S.5
Rung, L.G.6
Montine, K.S.7
Montine, T.J.8
-
57
-
-
79954590730
-
Decrease in brain soluble amyloid precursor protein beta (sAPPbeta) in Alzheimer's disease cortex
-
10.1002/jnr.22618 21433051 10.1002/jnr.22618 1:CAS:528: DC%2BC3MXks1Wrtr4%3D
-
Wu G, Sankaranarayanan S, Hsieh SH, Simon AJ, Savage MJ (2011) Decrease in brain soluble amyloid precursor protein beta (sAPPbeta) in Alzheimer's disease cortex. J Neurosci Res 89(6):822-832. doi: 10.1002/jnr.22618
-
(2011)
J Neurosci Res
, vol.89
, Issue.6
, pp. 822-832
-
-
Wu, G.1
Sankaranarayanan, S.2
Hsieh, S.H.3
Simon, A.J.4
Savage, M.J.5
-
58
-
-
39749173050
-
Edaravone neuroprotection effected by suppressing the gene expression of the Fas signal pathway following transient focal ischemia in rats
-
17967739 10.1007/BF03033912 1:CAS:528:DC%2BD1cXnvFeqsA%3D%3D
-
Xiao B, Bi FF, Hu YQ, Tian FF, Wu ZG, Mujlli HM, Ding L, Zhou XF (2007) Edaravone neuroprotection effected by suppressing the gene expression of the Fas signal pathway following transient focal ischemia in rats. Neurotox Res 12(3):155-162
-
(2007)
Neurotox Res
, vol.12
, Issue.3
, pp. 155-162
-
-
Xiao, B.1
Bi, F.F.2
Hu, Y.Q.3
Tian, F.F.4
Wu, Z.G.5
Mujlli, H.M.6
Ding, L.7
Zhou, X.F.8
-
59
-
-
20044370990
-
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
-
10.1074/jbc.M404751200 15590663 10.1074/jbc.M404751200 1:CAS:528:DC%2BD2MXhtlClt7w%3D
-
Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM (2005) Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem 280(7):5892-5901. doi: 10.1074/jbc.M404751200
-
(2005)
J Biol Chem
, vol.280
, Issue.7
, pp. 5892-5901
-
-
Yang, F.1
Lim, G.P.2
Begum, A.N.3
Ubeda, O.J.4
Simmons, M.R.5
Ambegaokar, S.S.6
Chen, P.P.7
Kayed, R.8
Glabe, C.G.9
Frautschy, S.A.10
Cole, G.M.11
-
60
-
-
33746549327
-
Neuroprotective effects of edaravone: A novel free radical scavenger in cerebrovascular injury
-
10.1111/j.1527-3458.2006.00009.x 16834755 10.1111/j.1527-3458.2006.00009. x 1:CAS:528:DC%2BD28Xos1yksL4%3D
-
Yoshida H, Yanai H, Namiki Y, Fukatsu-Sasaki K, Furutani N, Tada N (2006) Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. CNS Drug Rev 12(1):9-20. doi: 10.1111/j.1527-3458.2006. 00009.x
-
(2006)
CNS Drug Rev
, vol.12
, Issue.1
, pp. 9-20
-
-
Yoshida, H.1
Yanai, H.2
Namiki, Y.3
Fukatsu-Sasaki, K.4
Furutani, N.5
Tada, N.6
-
61
-
-
33748748708
-
Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients
-
16988474
-
Zhang L, Fiala M, Cashman J, Sayre J, Espinosa A, Mahanian M, Zaghi J, Badmaev V, Graves MC, Bernard G, Rosenthal M (2006) Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. J Alzheimers Dis 10(1):1-7 Heilongjiang Province Bureau
-
(2006)
J Alzheimers Dis
, vol.10
, Issue.1
, pp. 1-7
-
-
Zhang, L.1
Fiala, M.2
Cashman, J.3
Sayre, J.4
Espinosa, A.5
Mahanian, M.6
Zaghi, J.7
Badmaev, V.8
Graves, M.C.9
Bernard, G.10
Rosenthal, M.11
|