Effects of edaravone, a free radical scavenger, on serum levels of inflammatory biomarkers in acute brain infarction

Journal of Stroke and Cerebrovascular Diseases

Volumn 21, Issue 2, 2012, Pages 102-107

  Isahaya, Kenji ^a   Yamada, Koji ^a   Yamatoku, Masato ^a   Sakurai, Kenzo ^a   Takaishi, Satoshi ^a   Kato, Bunta ^a   Hirayama, Toshikazu ^a   Hasegawa, Yasuhiro ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

biomarker; Brain infarction; inflammation; interleukin; metalloproteinase; tumor necrosis factor

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; GELATINASE A; GELATINASE B; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 6; NORPHENAZONE; SCAVENGER; TUMOR NECROSIS FACTOR ALPHA;

ACUTE DISEASE; AGED; ANALYSIS OF VARIANCE; ARTICLE; BLOOD SAMPLING; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SAMPLE SIZE; SENSITIVITY ANALYSIS; STATISTICAL MODEL; VENOUS BLOOD;

ACUTE DISEASE; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ANTIPYRINE; BIOLOGICAL MARKERS; BRAIN INFARCTION; C-REACTIVE PROTEIN; CHI-SQUARE DISTRIBUTION; FEMALE; FREE RADICAL SCAVENGERS; HUMANS; INFLAMMATION MEDIATORS; INFUSIONS, INTRAVENOUS; INTERLEUKINS; JAPAN; LINEAR MODELS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; PROSPECTIVE STUDIES; TIME FACTORS; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84856507252     PISSN: 10523057     EISSN: 15328511     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2010.05.009     Document Type: Article

References (35)

1. P.H. Chan Reactive oxygen radicals in signaling and damage in the ischemic brain J Cereb Blood Flow Metab 21 2001 2 14 (Pubitemid 32036708)
2. R.G. Sitrin, P.M. Pan, and H.A. Harper Clustering of urokinase receptor (uPAR; CD87) induces proinflammatory signaling in human polymorphonuclear neutrophils J Immunol 165 2000 3341 3349
3. M. Marikovsky, V. Ziv, and N. Nevo Cu/Zn superoxide dismutase plays important role in immune response J Immunol 170 2003 2993 3001 (Pubitemid 36302172)
4. T. Watanabe, I. Morita, and H. Nishi Preventive effect of MCI-186 on 15-HPETE-induced vascular endothelial cell injury in vitro Prostaglandins Leukot Essent Fatty Acids 33 1988 81 87
5. T. Yamamoto, S. Yuki, and T. Watanabe Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia Brain Res 762 1997 240 242 (Pubitemid 27315958)
6. K. Abe, S. Yuki, and K. Kogure Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger Stroke 19 1988 480 485
7. H. Nishi, T. Watanabe, and H. Sakurai Effect of MCI-186 on brain edema in rats Stroke 20 1989 1236 1240 (Pubitemid 19226920)
8. K. Yagi, K.T. Kitazato, and M. Uno Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator Stroke 40 2009 626 631
9. K. Toyoda, K. Fujii, and M. Kamouchi Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion J Neurol Sci 221 2004 11 17 (Pubitemid 38721285)
10. N. Zhang, M. Komine-Kobayashi, and R. Tanaka Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain Stroke 36 2005 2220 2225 (Pubitemid 41429250)
11. S. Amemiya, T. Kamiya, and C. Nito Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats Eur J Pharmacol 516 2005 125 130 (Pubitemid 40799348)
12. S.W. Greenhouse, and S. Geisser On methods in the analysis of profile data Psychometrika 24 1959 95 112
13. B.Q. Zhao, E. Tejima, and E.H. Lo Neurovascular proteases in brain injury, hemorrhage and remodeling after stroke Stroke 38 2007 748 752 (Pubitemid 46188254)
14. A.M. Romanic, R.F. White, and A.J. Arleth Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: Inhibition of matrix metalloproteinase-9 reduces infarct size Stroke 29 1998 1020 1030 (Pubitemid 28228167)
15. G.A. Rosenberg, E.Y. Estrada, and J.E. Dencoff Matrix metalloproteinases and TIMPS are associated with blood-brain barrier opening after reperfusion in rat brain Stroke 29 1998 2189 2195 (Pubitemid 28443538)
16. J.H. Heo, J. Lucero, and T. Abumiya Matrix metalloproteinases increase very early during experimental focal cerebral ischemia J Cereb Blood Flow Metab 19 1999 624 633 (Pubitemid 30161214)
17. K.P. Park, A. Rosell, and C. Foerch Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats Stroke 40 2009 2836 2842
18. H. Nagase, and J. Woessner Jr. Matrix metalloproteinases J Biol Chem 274 1999 21491 21494
19. A. Gummesson, D. Hagg, and F.J. Olson Adipose tissue is not an important source for matrix metalloproteinase-9 in the circulation Scand J Clin Lab Invest 69 2009 636 642
20. H. Birkedal-Hansen, W.G. Moore, and M.K. Bodden Matrix metalloproteinases: A review Crit Rev Oral Biol Med 4 1993 197 250 (Pubitemid 23103292)
21. M.A. Lee, J. Palace, and G. Stabler Serum gelatinase B, TIMP-1 and TIMP-2 levels in multiple sclerosis: A longitudinal clinical and MRI study Brain 122 1999 191 197 (Pubitemid 29067202)
22. A. Creange, T. Sharshar, and T. Planchenault Matrix metalloproteinase-9 is increased and correlates with severity in Guillain-Barre syndrome Neurology 53 1999 1683 1691 (Pubitemid 29530340)
23. T. Sharshar, M.C. Durand, and J.P. Lefaucheur MMP-9 correlates with electrophysiologic abnormalities in Guillain-Barre syndrome Neurology 59 2002 1649 1651 (Pubitemid 35387081)
24. K. Arii, Y. Kumon, and K. Sugahara Edaravone inhibits collagen-induced arthritis possibly through suppression of nuclear factor-kappa B Mol Immunol 45 2008 463 469 (Pubitemid 47332633)
25. The Edaravone Acute Brain Infarction Study Group Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction: Randomized, placebo-controlled, double-blind study at multicenters Cerebrovasc Dis 15 2003 222 229
26. K. Tsuji, T. Aoki, and E. Tejima Tissue plasminogen activator promotes matrix metalloproteinase-9 up-regulation after transient focal cerebral ischemia Stroke 36 2005 1954 1959 (Pubitemid 41266533)
27. P.J. Kelly, J.D. Morrow, and M.M. Ning Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: The Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) Study Stroke 39 2008 100 104
28. J. Montaner, J. Alvarez-Sabin, and C. Molina Matrix metalloproteinase expression after human cardioembolic stroke: Temporal profile and relation to neurological impairment Stroke 32 2001 1759 1766 (Pubitemid 32772204)
29. J. Montaner, J. Alvarez-Sabin, and C.A. Molina Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke Stroke 32 2001 2762 2767 (Pubitemid 33134461)
30. M. Castellanos, R. Leira, and J. Serena Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke Stroke 34 2003 40 46
31. Y.S. Kim, K.Y. Lee, and S.H. Koh The role of matrix metalloproteinase 9 in early neurological worsening of acute lacunar infarction Eur Neurol 55 2006 11 15 (Pubitemid 43325882)
32. H. Yoshida, H. Yanai, and Y. Namiki Neuroprotective effect of edaravone: A novel free radical scavenger in cerebrovascular injury CNS Drugs 12 2006 9 20 (Pubitemid 44133577)
33. L.L. Latour, D.W. Kang, and M.A. Ezzeddine Early blood-brain barrier disruption in human focal brain ischemia Ann Neurol 56 2004 468 477 (Pubitemid 39319336)
34. T.L. Barr, L.L. Latour, and K.Y. Lee Blood-brain barrier disruption in humans is independently associated with increased matrix metalloproteinase-9 Stroke 41 2010 e123 e128
35. A. Batra, L.L. Latour, and C.A. Ruetzler Increased plasma and tissue MMP levels are associated with BCSFB and BBB disruption evident on post-contrast FLAIR after experimental stroke J Cereb Blood Flow Metab 30 2010 1188 1199