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Volumn 21, Issue 7, 2007, Pages 629-640

Amelioration of early cognitive deficits by aged garlic extract in Alzheimer's transgenic mice

Author keywords

A ; Alzheimer's disease; ELISA; Hippocampus; Morris water maze; Tg2576; TgCRND8; Y maze

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; GARLIC EXTRACT;

EID: 34447498539     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2122     Document Type: Article
Times cited : (80)

References (67)
  • 1
    • 0030029823 scopus 로고    scopus 로고
    • Therapeutic actions of garlic constituents
    • Agarwal KC. 1996. Therapeutic actions of garlic constituents. Med Res Rev 16: 111-124.
    • (1996) Med Res Rev , vol.16 , pp. 111-124
    • Agarwal, K.C.1
  • 2
    • 0034678024 scopus 로고    scopus 로고
    • Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNF alpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism
    • Akama KT, Van Eldik LJ. 2000. Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNF alpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism. J Biol Chem 275: 7918-7924.
    • (2000) J Biol Chem , vol.275 , pp. 7918-7924
    • Akama, K.T.1    Van Eldik, L.J.2
  • 3
    • 0035689651 scopus 로고    scopus 로고
    • Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: Task specificity and correlations between Abeta deposition and spatial memory
    • Arendash GW, Gordon MN, Diamond DM et al. 2001. Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory. DNA Cell Biol 20: 737-744.
    • (2001) DNA Cell Biol , vol.20 , pp. 737-744
    • Arendash, G.W.1    Gordon, M.N.2    Diamond, D.M.3
  • 4
    • 0036810329 scopus 로고    scopus 로고
    • Alzheimer's disease and the basal forebrain cholinergic system: Relations to beta-amyloid peptides, cognition, and treatment strategies
    • Auld DS, Kornecook TJ, Bastianetto S, Quirion R. 2002. Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies. Prog Neurobiol 68: 209-245.
    • (2002) Prog Neurobiol , vol.68 , pp. 209-245
    • Auld, D.S.1    Kornecook, T.J.2    Bastianetto, S.3    Quirion, R.4
  • 5
    • 0037705997 scopus 로고    scopus 로고
    • Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory?
    • Balschun D, Wolfer DP, Gass P et al. 2003. Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory? J Neurosci 23: 6304-6314.
    • (2003) J Neurosci , vol.23 , pp. 6304-6314
    • Balschun, D.1    Wolfer, D.P.2    Gass, P.3
  • 6
    • 0037276195 scopus 로고    scopus 로고
    • Anti-amyloidogenic effect of Allium sativum in Alzheimer's transgenic model Tg2576
    • Chauhan NB. 2003. Anti-amyloidogenic effect of Allium sativum in Alzheimer's transgenic model Tg2576. J Herb Pharmacother 3: 95-107.
    • (2003) J Herb Pharmacother , vol.3 , pp. 95-107
    • Chauhan, N.B.1
  • 7
    • 29144463219 scopus 로고    scopus 로고
    • Effect of aged garlic extract on amyloidogenesis and tau phosphorylation in Tg2576 mouse model of AD
    • Program No. 674.17
    • Chauhan NB. 2004. Effect of aged garlic extract on amyloidogenesis and tau phosphorylation in Tg2576 mouse model of AD. Soc Neurosci Abstr, Program No. 674.17.
    • (2004) Soc Neurosci Abstr
    • Chauhan, N.B.1
  • 8
    • 29144508430 scopus 로고    scopus 로고
    • Multiplicity of garlic health effects and Alzheimer's disease
    • Chauhan NB. 2005. Multiplicity of garlic health effects and Alzheimer's disease. J Nutr Health Aging 9: 421-432.
    • (2005) J Nutr Health Aging , vol.9 , pp. 421-432
    • Chauhan, N.B.1
  • 9
    • 0037411794 scopus 로고    scopus 로고
    • Effect of PPF and ALCAR on the induction of NGF- and p75-mRNA and on APP processing in Tg2576 brain
    • Chauhan NB, Siegel GJ. 2003. Effect of PPF and ALCAR on the induction of NGF- and p75-mRNA and on APP processing in Tg2576 brain. Neurochem Int 43: 225-233.
    • (2003) Neurochem Int , vol.43 , pp. 225-233
    • Chauhan, N.B.1    Siegel, G.J.2
  • 10
    • 11144284662 scopus 로고    scopus 로고
    • Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576
    • Chauhan NB, Siegel GJ, Feinstein DL. 2005. Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576. Neuropharmacology 48: 93-104.
    • (2005) Neuropharmacology , vol.48 , pp. 93-104
    • Chauhan, N.B.1    Siegel, G.J.2    Feinstein, D.L.3
  • 11
    • 0035877756 scopus 로고    scopus 로고
    • Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695
    • Chishti MA, Yang DS, Janus C et al. 2001. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem 276: 21562-21570.
    • (2001) J Biol Chem , vol.276 , pp. 21562-21570
    • Chishti, M.A.1    Yang, D.S.2    Janus, C.3
  • 12
    • 3342903288 scopus 로고    scopus 로고
    • Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury
    • Conte V, Uryu K, Fujimoto S et al. 2004. Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury. J Neurochem 90: 758-764.
    • (2004) J Neurochem , vol.90 , pp. 758-764
    • Conte, V.1    Uryu, K.2    Fujimoto, S.3
  • 13
    • 0034746897 scopus 로고    scopus 로고
    • Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition
    • Das P, Murphy MP, Younkin LH, Younkin SG, Golde TE. 2001. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiol Aging 22: 721-727.
    • (2001) Neurobiol Aging , vol.22 , pp. 721-727
    • Das, P.1    Murphy, M.P.2    Younkin, L.H.3    Younkin, S.G.4    Golde, T.E.5
  • 14
    • 0026065020 scopus 로고
    • Subtypes and differential laminar distributions of beta A4 deposits in Alzheimer's disease: Relationship with the intellectual status of 26 cases
    • Delaere P, Duyckaerts C, He Y, Piette F, Hauw JJ. 1991. Subtypes and differential laminar distributions of beta A4 deposits in Alzheimer's disease: relationship with the intellectual status of 26 cases. Acta Neuropathol (Berl) 81: 328-335.
    • (1991) Acta Neuropathol (Berl) , vol.81 , pp. 328-335
    • Delaere, P.1    Duyckaerts, C.2    He, Y.3    Piette, F.4    Hauw, J.J.5
  • 15
    • 0037151046 scopus 로고    scopus 로고
    • Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
    • Dineley KT, Xia X, Bui D, Sweatt JD, Zheng H. 2002. Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J Biol Chem 277: 22768-22780.
    • (2002) J Biol Chem , vol.277 , pp. 22768-22780
    • Dineley, K.T.1    Xia, X.2    Bui, D.3    Sweatt, J.D.4    Zheng, H.5
  • 16
    • 4143069007 scopus 로고    scopus 로고
    • Hippocampal CA3-region is crucial for acquisition and memory consolidation in Morris water maze task in mice
    • Florian C, Roullet P. 2004. Hippocampal CA3-region is crucial for acquisition and memory consolidation in Morris water maze task in mice. Behav Brain Res 154: 365-374.
    • (2004) Behav Brain Res , vol.154 , pp. 365-374
    • Florian, C.1    Roullet, P.2
  • 17
    • 0030924820 scopus 로고    scopus 로고
    • S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells
    • Geng Z, Rong Y, Lau BH. 1997. S-allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Free Radic Biol Med 23: 345-350.
    • (1997) Free Radic Biol Med , vol.23 , pp. 345-350
    • Geng, Z.1    Rong, Y.2    Lau, B.H.3
  • 18
    • 0034988318 scopus 로고    scopus 로고
    • Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice
    • Gordon MN, King DL, Diamond DM et al. 2001. Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice. Neurobiol Aging 22: 377-385.
    • (2001) Neurobiol Aging , vol.22 , pp. 377-385
    • Gordon, M.N.1    King, D.L.2    Diamond, D.M.3
  • 19
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J, Allsop D. 1991. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 12: 383-388.
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 20
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy JA, Higgins GA. 1992. Alzheimer's disease: the amyloid cascade hypothesis. Science 256(5054): 184-185.
    • (1992) Science , vol.256 , Issue.5054 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 21
    • 0032756213 scopus 로고    scopus 로고
    • Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: Lack of association with amyloid deposits
    • Holcomb LA, Gordon MN, Jantzen P, Hsiao K, Duff K, Morgan D. 1999. Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behav Genet 29: 177-185.
    • (1999) Behav Genet , vol.29 , pp. 177-185
    • Holcomb, L.A.1    Gordon, M.N.2    Jantzen, P.3    Hsiao, K.4    Duff, K.5    Morgan, D.6
  • 22
    • 0031914718 scopus 로고    scopus 로고
    • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
    • Holcomb L, Gordon MN, McGowan E et al. 1998. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 4: 97-100.
    • (1998) Nat Med , vol.4 , pp. 97-100
    • Holcomb, L.1    Gordon, M.N.2    McGowan, E.3
  • 23
    • 0032417251 scopus 로고    scopus 로고
    • Transgenic mice expressing Alzheimer amyloid precursor proteins
    • Hsiao K. 1998. Transgenic mice expressing Alzheimer amyloid precursor proteins. Exp Gerontol 33(7-8): 883-889.
    • (1998) Exp Gerontol , vol.33 , Issue.7-8 , pp. 883-889
    • Hsiao, K.1
  • 24
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • Hsiao K, Chapman P, Nilsen S et al. 1996. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274(5284): 99-102.
    • (1996) Science , vol.274 , Issue.5284 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3
  • 25
    • 18044378759 scopus 로고    scopus 로고
    • Hyde LA, Kazdoba TM, Grilli M et al. 2005. Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice. Behav Brain Res 160: 344-355. Erratum in: Behav Brain Res 163: 277.
    • Hyde LA, Kazdoba TM, Grilli M et al. 2005. Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice. Behav Brain Res 160: 344-355. Erratum in: Behav Brain Res 163: 277.
  • 26
    • 0028169925 scopus 로고
    • Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43)
    • Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. 1994. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron 13: 45-53.
    • (1994) Neuron , vol.13 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, N.5    Ihara, Y.6
  • 28
    • 0034622244 scopus 로고    scopus 로고
    • Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes
    • Janus C, D'Amelio S, Amitay O et al. 2000a. Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes. Neurobiol Aging 21: 541-549.
    • (2000) Neurobiol Aging , vol.21 , pp. 541-549
    • Janus, C.1    D'Amelio, S.2    Amitay, O.3
  • 29
    • 0034700471 scopus 로고    scopus 로고
    • A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
    • Janus C, Pearson J, McLaurin J et al. 2000b. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 408(6815): 979-982.
    • (2000) Nature , vol.408 , Issue.6815 , pp. 979-982
    • Janus, C.1    Pearson, J.2    McLaurin, J.3
  • 30
    • 0034837627 scopus 로고    scopus 로고
    • Transgenic mouse models of Alzheimer's disease
    • Janus C, Westaway D. 2001. Transgenic mouse models of Alzheimer's disease. Physiol Behav 73: 873-886.
    • (2001) Physiol Behav , vol.73 , pp. 873-886
    • Janus, C.1    Westaway, D.2
  • 31
    • 10044297055 scopus 로고    scopus 로고
    • Lifelong immunization with human beta-amyloid (1-42) protects Alzheimer's transgenic mice against cognitive impairment throughout aging
    • Jensen MT, Mottin MD, Cracchiolo JR, Leighty RE, Arendash GW. 2005. Lifelong immunization with human beta-amyloid (1-42) protects Alzheimer's transgenic mice against cognitive impairment throughout aging. Neuroscience 130: 667-684.
    • (2005) Neuroscience , vol.130 , pp. 667-684
    • Jensen, M.T.1    Mottin, M.D.2    Cracchiolo, J.R.3    Leighty, R.E.4    Arendash, G.W.5
  • 32
    • 0031020909 scopus 로고    scopus 로고
    • Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease
    • Johnson-Wood K, Lee M, Motter R et al. 1997. Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease. Proc Natl Acad Sci USA 94: 1550-1555.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1550-1555
    • Johnson-Wood, K.1    Lee, M.2    Motter, R.3
  • 33
    • 0035313202 scopus 로고    scopus 로고
    • Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine
    • Kim KM, Chun SB, Koo MS et al. 2001. Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine. Free Radic Biol Med 30: 747-756.
    • (2001) Free Radic Biol Med , vol.30 , pp. 747-756
    • Kim, K.M.1    Chun, S.B.2    Koo, M.S.3
  • 34
    • 27144447811 scopus 로고    scopus 로고
    • Sequence determinants of enhanced amyloidogenicity of Alzheimer A{beta}42 peptide relative to A{beta}40
    • Kim W, Hecht MH. 2005. Sequence determinants of enhanced amyloidogenicity of Alzheimer A{beta}42 peptide relative to A{beta}40. J Biol Chem 280: 35069-35076.
    • (2005) J Biol Chem , vol.280 , pp. 35069-35076
    • Kim, W.1    Hecht, M.H.2
  • 35
    • 0033199822 scopus 로고    scopus 로고
    • Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease
    • King DL, Arendash GW, Crawford F, Sterk T, Menendez J, Mullan MJ. 1999. Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease. Behav Brain Res 103: 145-162.
    • (1999) Behav Brain Res , vol.103 , pp. 145-162
    • King, D.L.1    Arendash, G.W.2    Crawford, F.3    Sterk, T.4    Menendez, J.5    Mullan, M.J.6
  • 36
    • 17644370721 scopus 로고    scopus 로고
    • Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease
    • Kobayashi DT, Chen KS. 2005. Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease. Genes Brain Behav 4: 173-196.
    • (2005) Genes Brain Behav , vol.4 , pp. 173-196
    • Kobayashi, D.T.1    Chen, K.S.2
  • 37
    • 0035807829 scopus 로고    scopus 로고
    • Specific spatial learning deficits become severe with age in beta-amyloid precursor protein transgenic mice that harbor diffuse beta-amyloid deposits but do not form plaques
    • Koistinaho M, Ort M, Cimadevilla JM et al. 2001. Specific spatial learning deficits become severe with age in beta-amyloid precursor protein transgenic mice that harbor diffuse beta-amyloid deposits but do not form plaques. Proc Natl Acad Sci USA 98: 14675-14680.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 14675-14680
    • Koistinaho, M.1    Ort, M.2    Cimadevilla, J.M.3
  • 38
    • 0036703483 scopus 로고    scopus 로고
    • Reversible memory loss in a mouse transgenic model of Alzheimer's disease
    • Kotilinek LA, Bacskai B, Westerman M et al. 2002. Reversible memory loss in a mouse transgenic model of Alzheimer's disease. J Neurosci 22: 6331-6335.
    • (2002) J Neurosci , vol.22 , pp. 6331-6335
    • Kotilinek, L.A.1    Bacskai, B.2    Westerman, M.3
  • 39
    • 14844321855 scopus 로고    scopus 로고
    • Cholesterol homeostasis failure as a unifying cause of synaptic degeneration
    • Koudinov AR, Koudinova NV. 2005. Cholesterol homeostasis failure as a unifying cause of synaptic degeneration. J Neurol Sci 229-230: 233-240.
    • (2005) J Neurol Sci , vol.229-230 , pp. 233-240
    • Koudinov, A.R.1    Koudinova, N.V.2
  • 40
    • 12344284943 scopus 로고    scopus 로고
    • Genetic aspects of amyloid beta-protein fibrillogenesis in Alzheimer's disease
    • Kowalska A. 2004. Genetic aspects of amyloid beta-protein fibrillogenesis in Alzheimer's disease. Folia Neuropathol 42: 235-237.
    • (2004) Folia Neuropathol , vol.42 , pp. 235-237
    • Kowalska, A.1
  • 41
    • 0028172886 scopus 로고
    • Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red
    • Lorenzo A, Yankner BA. 1994. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci USA 91: 12243-12247.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12243-12247
    • Lorenzo, A.1    Yankner, B.A.2
  • 42
    • 16644378019 scopus 로고    scopus 로고
    • Effects of pre-germinated brown rice on beta-amyloid protein-induced learning and memory deficits in mice
    • Mamiya T, Asanuma T, Kise M et al. 2004. Effects of pre-germinated brown rice on beta-amyloid protein-induced learning and memory deficits in mice. Biol Pharm Bull 27: 1041-1045.
    • (2004) Biol Pharm Bull , vol.27 , pp. 1041-1045
    • Mamiya, T.1    Asanuma, T.2    Kise, M.3
  • 43
    • 0027297138 scopus 로고
    • Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF
    • Mattson MP, Tomaselli KJ, Rydel RE. 1993. Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF. Brain Res 621: 35-49.
    • (1993) Brain Res , vol.621 , pp. 35-49
    • Mattson, M.P.1    Tomaselli, K.J.2    Rydel, R.E.3
  • 44
    • 2542511697 scopus 로고    scopus 로고
    • Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum
    • Mesulam M, Shaw P, Mash D, Weintraub S. 2004. Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum. Ann Neurol 55: 815-828.
    • (2004) Ann Neurol , vol.55 , pp. 815-828
    • Mesulam, M.1    Shaw, P.2    Mash, D.3    Weintraub, S.4
  • 45
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D et al. 1991. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41: 479-486.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3
  • 46
    • 84984755327 scopus 로고    scopus 로고
    • A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • Morgan D, Diamond DM, Gottschall PE et al. 2000. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408(6815): 982-985.
    • (2000) Nature , vol.408 , Issue.6815 , pp. 982-985
    • Morgan, D.1    Diamond, D.M.2    Gottschall, P.E.3
  • 47
    • 0030770254 scopus 로고    scopus 로고
    • Allixin, a phytoalexin produced by garlic, and its analogues as novel exogenous substances with neurotrophic activity
    • Moriguchi T, Matsuura H, Itakura Y, Katsuki H, Saito H, Nishiyama N. 1997a. Allixin, a phytoalexin produced by garlic, and its analogues as novel exogenous substances with neurotrophic activity. Life Sci 61: 1413-1420.
    • (1997) Life Sci , vol.61 , pp. 1413-1420
    • Moriguchi, T.1    Matsuura, H.2    Itakura, Y.3    Katsuki, H.4    Saito, H.5    Nishiyama, N.6
  • 48
    • 0030830265 scopus 로고    scopus 로고
    • Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons
    • Moriguchi T, Matsuura H, Kodera Y et al. 1997b. Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons. Neurochem Res 22: 1449-1452.
    • (1997) Neurochem Res , vol.22 , pp. 1449-1452
    • Moriguchi, T.1    Matsuura, H.2    Kodera, Y.3
  • 49
    • 0029932180 scopus 로고    scopus 로고
    • Aged garlic extract prolongs longevity and improves spatial memory deficit in senescence-accelerated mouse
    • Moriguchi T, Saito H, Nishiyama N. 1996. Aged garlic extract prolongs longevity and improves spatial memory deficit in senescence-accelerated mouse. Biol Pharm Bull 19: 305-307.
    • (1996) Biol Pharm Bull , vol.19 , pp. 305-307
    • Moriguchi, T.1    Saito, H.2    Nishiyama, N.3
  • 50
    • 0030902690 scopus 로고    scopus 로고
    • Anti-ageing effect of aged garlic extract in the inbred brain atrophy mouse model
    • Moriguchi T, Saito H, Nishiyama N. 1997c. Anti-ageing effect of aged garlic extract in the inbred brain atrophy mouse model. Clin Exp Pharmacol Physiol 24: 235-242.
    • (1997) Clin Exp Pharmacol Physiol , vol.24 , pp. 235-242
    • Moriguchi, T.1    Saito, H.2    Nishiyama, N.3
  • 51
    • 0019957779 scopus 로고
    • Place navigation impaired in rats with hippocampal lesions
    • Morris RG, Garrud P, Rawlins JN, O'Keefe J. 1982. Place navigation impaired in rats with hippocampal lesions. Nature 297(5868): 681-683.
    • (1982) Nature , vol.297 , Issue.5868 , pp. 681-683
    • Morris, R.G.1    Garrud, P.2    Rawlins, J.N.3    O'Keefe, J.4
  • 52
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
    • Naslund J, Haroutunian V, Mohs R et al. 2000. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA 283: 1571-1577.
    • (2000) JAMA , vol.283 , pp. 1571-1577
    • Naslund, J.1    Haroutunian, V.2    Mohs, R.3
  • 53
    • 0035126248 scopus 로고    scopus 로고
    • Ameliorative effect of S-allylcysteine, a major thioallyl constituent in aged garlic extract, on learning deficits in senescence-accelerated mice
    • Nishiyama N, Moriguchi T, Morihara N, Saito H. 2001. Ameliorative effect of S-allylcysteine, a major thioallyl constituent in aged garlic extract, on learning deficits in senescence-accelerated mice. J Nutr 131(3s): 1093S-1095S.
    • (2001) J Nutr , vol.131 , Issue.3 S
    • Nishiyama, N.1    Moriguchi, T.2    Morihara, N.3    Saito, H.4
  • 54
    • 0035123594 scopus 로고    scopus 로고
    • S-allylcysteine inhibits free radical production, lipid peroxidation and neuronal damage in rat brain ischemia
    • Numagami Y, Ohnishi ST. 2001. S-allylcysteine inhibits free radical production, lipid peroxidation and neuronal damage in rat brain ischemia. J Nutr 131(3s): 1100S-1105S.
    • (2001) J Nutr , vol.131 , Issue.3 S
    • Numagami, Y.1    Ohnishi, S.T.2
  • 55
    • 9644254315 scopus 로고    scopus 로고
    • Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer's disease
    • Ognibene E, Middei S, Daniele S et al. 2005. Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer's disease. Behav Brain Res 156: 225-232.
    • (2005) Behav Brain Res , vol.156 , pp. 225-232
    • Ognibene, E.1    Middei, S.2    Daniele, S.3
  • 56
    • 33644851439 scopus 로고    scopus 로고
    • The solvent protection of Alzheimer amyloid-beta (1-42) fibrils as determined by solution NMR spectroscopy
    • Olofsson A, Sauer-Eriksson AE, Ohman A. 2006. The solvent protection of Alzheimer amyloid-beta (1-42) fibrils as determined by solution NMR spectroscopy. J Biol Chem 281: 477-483.
    • (2006) J Biol Chem , vol.281 , pp. 477-483
    • Olofsson, A.1    Sauer-Eriksson, A.E.2    Ohman, A.3
  • 57
    • 0036687490 scopus 로고    scopus 로고
    • Neuroprotective effect of garlic compounds in amyloid-beta peptide-induced apoptosis in vitro
    • Peng Q, Buz'Zard AR, Lau BH. 2002. Neuroprotective effect of garlic compounds in amyloid-beta peptide-induced apoptosis in vitro. Med Sci Monit 8: BR328-BR337.
    • (2002) Med Sci Monit , vol.8
    • Peng, Q.1    Buz'Zard, A.R.2    Lau, B.H.3
  • 58
    • 0032491494 scopus 로고    scopus 로고
    • Genetic neurodegenerative diseases: The human illness and transgenic models
    • Price DL, Sisodia SS, Borchelt DR. 1998. Genetic neurodegenerative diseases: the human illness and transgenic models. Science 282: 1079-1083.
    • (1998) Science , vol.282 , pp. 1079-1083
    • Price, D.L.1    Sisodia, S.S.2    Borchelt, D.R.3
  • 59
    • 0022550027 scopus 로고
    • Purification, ultrastructure, and chemical analysis of Alzheimer disease amyloid plaque core protein
    • Roher A, Wolfe D, Palutke M, KuKuruga D. 1986. Purification, ultrastructure, and chemical analysis of Alzheimer disease amyloid plaque core protein. Proc Natl Acad Sci USA 83: 2662-2666.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 2662-2666
    • Roher, A.1    Wolfe, D.2    Palutke, M.3    KuKuruga, D.4
  • 60
    • 0034516988 scopus 로고    scopus 로고
    • Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein
    • Selkoe DJ. 2000. Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann N Y Acad Sci 924: 17-25.
    • (2000) Ann N Y Acad Sci , vol.924 , pp. 17-25
    • Selkoe, D.J.1
  • 61
    • 7944233158 scopus 로고    scopus 로고
    • Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases
    • Selkoe DJ. 2004. Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nat Cell Biol 6: 1054-1061.
    • (2004) Nat Cell Biol , vol.6 , pp. 1054-1061
    • Selkoe, D.J.1
  • 62
    • 0344826082 scopus 로고    scopus 로고
    • Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment
    • Stackman RW, Eckenstein F, Frei B, Kulhanek D, Nowlin J, Quinn JF. 2003. Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment. Exp Neurol 184: 510-520.
    • (2003) Exp Neurol , vol.184 , pp. 510-520
    • Stackman, R.W.1    Eckenstein, F.2    Frei, B.3    Kulhanek, D.4    Nowlin, J.5    Quinn, J.F.6
  • 63
    • 0036792096 scopus 로고    scopus 로고
    • Amyloid beta-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling
    • Vitolo OV, Sant'Angelo A, Costanzo V, Battaglia F, Arancio O, Shelanski M. 2002. Amyloid beta-peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proc Natl Acad Sci USA 99: 13217-13221.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13217-13221
    • Vitolo, O.V.1    Sant'Angelo, A.2    Costanzo, V.3    Battaglia, F.4    Arancio, O.5    Shelanski, M.6
  • 64
    • 0032837741 scopus 로고    scopus 로고
    • The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging
    • Wang J, Dickson DW, Trojanowski JQ, Lee VM. 1999. The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging. Exp Neurol 158: 328-337.
    • (1999) Exp Neurol , vol.158 , pp. 328-337
    • Wang, J.1    Dickson, D.W.2    Trojanowski, J.Q.3    Lee, V.M.4
  • 65
    • 0036489445 scopus 로고    scopus 로고
    • The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease
    • Westerman MA, Cooper-Blacketer D, Mariash A et al. 2002. The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci 22: 1858-1867.
    • (2002) J Neurosci , vol.22 , pp. 1858-1867
    • Westerman, M.A.1    Cooper-Blacketer, D.2    Mariash, A.3
  • 67
    • 0032458593 scopus 로고    scopus 로고
    • Functional relationship between age-related immunodeficiency and learning deterioration
    • Zhang Y, Moriguchi T, Saito H, Nishiyama N. 1998. Functional relationship between age-related immunodeficiency and learning deterioration. Eur J Neurosci 10: 3869-3875.
    • (1998) Eur J Neurosci , vol.10 , pp. 3869-3875
    • Zhang, Y.1    Moriguchi, T.2    Saito, H.3    Nishiyama, N.4


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