Edaravone, a free radical scavenger, is effective on neuropathic pain in rats

Brain Research

Volumn 1248, Issue , 2009, Pages 68-75

  Mao, Yan Fei ^a,c   Yan, Ni ^b   Xu, Hua ^a   Sun, Ji Hu ^b   Xiong, Yuan Chang ^a   Deng, Xiao Ming ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Edaravone; Free radical scavenger; Neuropathic pain; Spinal nerve ligation

Indexed keywords

HYDROGEN PEROXIDE; NORPHENAZONE; SCAVENGER; STRESS ACTIVATED PROTEIN KINASE;

ALLODYNIA; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; DISEASE COURSE; DRUG EFFICACY; ENZYME ACTIVATION; MOTOR DYSFUNCTION; NERVE CELL EXCITABILITY; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SPINAL GANGLION; SPINAL NERVE;

ANALGESICS; ANIMALS; ANTIPYRINE; BLOTTING, WESTERN; CELLS, CULTURED; CHRONIC DISEASE; FREE RADICAL SCAVENGERS; GANGLIA, SPINAL; JANUS KINASES; NEURALGIA; PAIN MEASUREMENT; PAIN THRESHOLD; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SPINAL NERVES;

RATTUS;

EID: 57649170951     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.10.073     Document Type: Article

References (42)

1. Chandra J., Samali A., and Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic. Biol. Med. 29 (2000) 323-333
2. Chen J., Luo C., Li H.L., and Chen H.S. Primary hyperalgesia to mechanical and heat stimuli following subcutaneous bee venom injection into the plantar surface of hind paw in the conscious rat: a comparative study with the formalin test. Pain 83 (1999) 67-76
3. Chung J.M., and Chung K. Importance of hyperexcitability of DRG neurons in neuropathic pain. Pain Pract. 2 (2002) 87-97
4. Craig P., and Jeffrey M. Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress. Neuroscience 28 (2008) 4861-4871
5. Crisp T., Minus T.O., Coleman M.L., Giles J.R., Cibula C., and Finnerty E.P. Aging,peripheral nerve injury and nociception: effects of the antioxidant 16-desmethyltirilazad. Behav. Brain Res. 166 (2006) 159-165
6. Edaravone Acute Infarction Study Group. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc. Dis. 15 (2003) 222-229
7. Emerit J., Edeas M., and Bricaire F. Neurodegenerative diseases and oxidative stress. Biomed. Pharmacother. 58 (2004) 39-46
8. 2-.), superoxide dismutases, and related matters. J. Biol. Chem. 272 (1997) 18515-18517
9. Fujisawa T., Takeda K., and Ichijo H. ASK family proteins in stress response and disease. Mol. Biotechnol. 37 (2007) 13-18
10. Gao X., Kim H.K., Chung J.M., and Chung K. Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain. Pain 131 (2007) 262-271
11. Jin S.X., Zhuang Z.Y., Woolf C.J., and Ji R.R. p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J. Neurosci. 23 (2003) 4017-4022
12. Ji R.R., and Woolf C.J. Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. Neurobiol. Dis. 8 (2001) 1-10
13. Khalil Z., Liu T., and Helme R.D. Free radicals contribute to the reduction in peripheral vascular responses and the maintenance of thermal hyperalgesia in rats with chronic constriction injury. Pain 79 (1999) 31-37
14. Kim S.H., and Chung J.M. An experimental model for peripheral neuropathyproduced by segmental spinal nerve ligation in the rat. Pain 50 (1992) 355-363
15. Kim H.K., Park S.K., Zhou J.L., Taglialatela G., Chung K., Coggeshall R.E., and Chung J.M. Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain. Pain 111 (2004) 116-124
16. Kim H.K., Kim J.H., Gao X., Zhou J.L., Lee I., Chung K., and Chung J.M. Analgesic effect of vitamin E is mediated by reducing central sensitization in neuropathic pain. Pain 122 (2006) 53-62
17. Lai B., Zhang L., Dong L.Y., Zhu Y.H., Sun F.Y., and Zheng P. Inhibition of Qi site of mitochondrial complex III with antimycin A decreases persistent and transient sodium currents via reactive oxygen species and protein kinase C in rat hippocampal CA1 cells. Exp. Neurol. 194 (2005) 484-494
18. Lin Q., Peng Y.B., Wu J., and Willis W.D. Involvement of cGMP in nociceptive processing by and sensitization of spinothalamic neurons in primates. J. Neurosci. 17 (1997) 3293-3302
19. Liu D., Liu J., Sun D., and Wen J. The time course of hydroxyl radical formation following spinal cord injury: the possible role of the iron-catalyzed Haber-Weiss reaction. J. Neurotrauma 21 (2004) 805-816
20. Loh K.P., Huang S.H., De Silva R., Tan B.K., and Zhu Y.Z. Oxidative stress: apoptosis in neuronal injury. Curr. Alzheimer Res. 3 (2006) 327-337
21. Lu, X., Kambe, F., Cao, X., Kozaki, Y., Kaji, T., Ishii, T., Seo, H., 2008. DHCR24 is a hydrogen peroxide scavenger, protecting cells from oxidative-stress-induced apoptosis. Endocrinology [Electronic publication ahead of print].
22. Ma C., and LaMotte R.H. Enhanced excitability of dissociated primary sensory neurons after chronic compression of the dorsal root ganglion in the rat. Pain 113 (2005) 106-112
23. Nishiyama T., and Ogawa M. Intrathecal edaravone, a free radical scavenger, is effective on inflammatory-induced pain in rats. Acta Anaesthesiol. Scand. 49 (2005) 147-151
24. Obata K., Yamanaka H., Kobayashi K., Dai Y., Mizushima T., Katsura H., Fukuoka T., Tokunaga A., and Noguchi K. Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. J. Neurosci. 24 (2004) 10211-10222
25. Park E.S., Gao X., Chung J.M., and Chung K. Levels of mitochondrial reactive oxygen species increase in rat neuropathic spinal dorsal horn neurons. Neurosci. Lett. 391 (2006) 108-111
26. Reiter R.J., Tan D.X., and Burkhardt S. Reactive oxygen and nitrogen species and cellular and organismal decline: amelioration with melatonin. Mech. Ageing Dev. 123 (2002) 1007-1019
27. Russell J.W., Berent-Spillson A., Vincent A.M., Freimann C.L., Sullivan K.A., and Feldman E.L. Oxidative injury and neuropathy in diabetes and impaired glucose tolerance. Neurobiol. Dis. 30 (2008) 420-429
28. Salvemini D., Wang Z.Q., Zweier J.L., Samouilov A., Macarthur H., Misko T.P., Currie M.G., Cuzzocrea S., Sikorski J.A., and Riley D.P. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats. Science 286 (1999) 304-306
29. Scott B., and Lew J. Effect of chronic hydrogen peroxide exposure on neuronal electric membrane properties. Neurotoxicology 9 (1988) 189-196
30. Sun J.H., Yang B., Donnelly D.F., Ma C., and Lamotte R.H. MCP-1 enhances excitability of nociceptive neurons in chronically compressed dorsal root ganglia. J. Neurophysiol. 96 (2006) 2189-2199
31. Sun G.Y., Horrocks L.A., and Farooqui A.A. The roles of NADPH oxidase and phospholipases A2 in oxidative and inflammatory responses in neurodegenerative diseases. J. Neurochem. 103 (2007) 1-16
32. Takeda, T., Takeda, S., Takumida, M., Okada, T., Kakigi, A., Nakatani, H., Hamada, M., Yamakawa, K., 2007. Protective effects of edaravone against ischemia-induced facial palsy. Auris. Nasus. Larynx. [Electronic publication ahead of print].
33. Tal M. A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy. NeuroReport 7 (1996) 1382-1384
34. Tanaka M. Pharmacological and clinical profile of the free radical scavenger edaravone as a neuroprotective agent. Nippon Yakurigaku Zasshi 119 (2002) 301-308
35. Taniguchi M., Uchinami M., Doi K., Yoshida M., Sasaki H., Tamagawa K., Horiuchi T., and Tanaka K. Edaravone reduces ischemia-reperfusion injury mediators in rat liver. J. Surg. Res. 137 (2007) 69-74
36. Traystman R.J., Kirsch J.R., and Koehler R.C. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J. Appl. Physiol. 71 (1991) 1185-1195
37. Wang Z.Q., Porreca F., Cuzzocrea S., Galen K., Lightfoot R., Masini E., Muscoli C., Mollace V., Ndengele M., Ischiropoulos H., and Salvemini D. A newly identified role for superoxide in inflammatory pain. J. Pharmacol. Exp. Ther. 309 (2004) 869-878
38. Watanabe K., Ma M., Wen J., Kodama M., and Aizawa Y. Effects of edaravone in heart of aged rats after cerebral ischemia-reperfusion injury. Biol. Pharm. Bull. 30 (2007) 460-464
39. Woolf C.J., and Mannion R.J. Neuropathic pain: etiology, symptoms, mechanisms, and management. Lancet 353 (1999) 1959-1964
40. Yoshida H., Yanai H., Namiki Y., Fukatsu-Sasaki K., Furutani N., and Tada N. Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. CNS Drug Rev. 12 (2006) 9-20
41. Zhuang Z.Y., Wen Y.R., Zhang D.R., Borsello T., Bonny C., Strichartz G.R., Decosterd I., and Ji R.R. A peptide c-Jun N-Terminal Kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. J. Neurosci. 26 (2006) 3551-3560
42. Zhu X., Su B., Wang X., Smith M.A., and Perry G. Causes of oxidative stress in Alzheimer disease. Cell. Mol. Life Sci. 64 (2007) 2202-2210