Curcuminoids enhance amyloid-β uptake by macrophages of Alzheimer's disease patients

Journal of Alzheimer's Disease

Volumn 10, Issue 1, 2006, Pages 1-7

  Zhang, Laura ^a   Fiala, Milan ^a,f   Cashman, John ^b   Sayre, James ^c   Espinosa, Araceli ^a   Mahanian, Michelle ^a   Zaghi, Justin ^a   Badmaev, Vladimir ^d   Graves, Michael C ^a   Bernard, George ^a,e   Rosenthal, Mark ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Human BioMolecular Institute   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SABINSA CORPORATION   (United States)

^e UCLA SCHOOL OF DENTISTRY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; Amyloid ; Curcuminoids; Immunomodulation; Phagocytosis

Indexed keywords

AMYLOID BETA PROTEIN; CURCUMIN; CURCUMINOID DERIVATIVE; PHALLOIDIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; INNATE IMMUNITY; MACROPHAGE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

EID: 33748748708     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2006-10101     Document Type: Article

References (25)

1. S. Antony, R. Kuttan and G. Kuttan, Immunomodulatory activity of curcumin, Immunol Invest 28 (1999), 291-303.
2. F. Bard, C. Cannon, R. Barbour, R.L. Burke, D. Games, H. Grajeda, T. Guido, K. Hu, J. Huang, K. Johnson-Wood, K. Khan, D. Kholodenko, M. Lee, I. Lieberburg, R. Motter, M. Nguyen, F. Soriano, N. Vasquez, K. Weiss, B. Welch, P. Seubert, D. Schenk and T. Yednock, Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease, Nat Med 6 (2000), 916-919.
3. E. Carro and I. Torres-Aleman, Alzheimer's The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of disease, Eur J Pharmacol 490 (2004), 127-133.
4. M. Fiala, J. Lin, J. Ringman, V. Kermani-Arab, G. Tsao, A. Patel, A. Lossinsky, M.C. Graves, A. Gustavson, J. Sayre, E. Sofroni, T. Suarez, F. Chiappelli and G. Bernard, Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients, Journal of Alzheimer's Disease 7 (2005), 221-232.
5. M. Fiala, J. Lin, J. Ringman, V. Kermani-Arab, G. Tsao, A. Patel, A.S. Lossinsky, M.C. Graves, A. Gustavson, J. Sayre, E. Sofroni, T. Suarez, F. Chiappelli and G. Bernard, Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients, J Alzheimers Dis 7 (2005), 221-232; discussion 255-262.
6. M. Fiala, Q.N. Liu, J. Sayre, V. Pop, V. Brahmandam, M.C. Graves and H.V. Vinters, Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier, Eur J Clin Invest 32 (2002), 360-371.
7. M. Fiala, L. Zhang, X.-H. Gan, M. Graves, S. Hama, B. Sherry, D. Taub, D. Way, M. Weinand, M. Witte, D. Lorton, Y.-M. Kuo and A. Roher, Amyloid-beta induces chemokine secretion and monocyte migration across a human blood-brain barrier model, Molecular Medicine 4 (1998), 480-489.
8. M.S. Forman, J.Q. Trojanowski and V.M. Lee, Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs, Nat Med 10 (2004), 1055-1063.
9. D. Games, F. Bard, H. Grajeda, T. Guido, K. Khan, F. Soriano, N. Vasquez, N. Wehner, K. Johnson-Wood, T. Yednock, P. Seubert and D. Schenk, Prevention and reduction of AD-type pathology in PDAPP mice immunized with A beta 1-42, Ann N Y Acad Sci 920 (2000), 274-284.
10. E. Jaruga, S. Salvioli, J. Dobrucki, S. Chrul, J. Bandorowicz-Pikula, E. Sikora, C. Franceschi, A. Cossarizza and G. Bartosz, Apoptosis-like, reversible changes in plasma membrane asymmetry and permeability, and transient modifications in mitochondrial membrane potential induced by curcumin in rat thymocytes, FEBS Lett 433 (1998), 287-293.
11. G.P. Lim, T. Chu, F. Yang, W. Beech, S.A. Frautschy and G.M. Cole, The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse, J Neurosci 21 (2001), 8370-8377.
12. L.F. Lue, D.G. Walker and J. Rogers, Modeling microglial activation in Alzheimer's disease with human postmortem microglial cultures, Neurobiol Aging 22 (2001), 945-956.
13. E. Masliah, L. Hansen, A. Adame, L. Crews, F. Bard, C. Lee, P. Seubert, D. Games, L. Kirby and D. Schenk, Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease, Neurology 64 (2005), 129-131.
14. G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price and E.M. Stadlan, Clinical diagnosis of Alzheimer's disease: report of the MNCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease, Neurology 34 (1984), 939-944.
15. A. Monsonego and H.L. Weiner, Immunotherapeutic approaches to Alzheimer's disease, Science 302 (2003), 834-838.
16. A. Monsonego, V. Zota, A. Karni, J.I. Krieger, A. Bar-Or, G. Bitan, A.E. Budson, R. Sperling, D.J. Selkoe and H.L. Weiner, Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease, J Clin Invest 112 (2003), 415-122.
17. J.A. Nicoll, D. Wilkinson, C. Holmes, P. Steart, H. Markham and R.O. Weller, Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report, Nat Med 9 (2003), 448-452.
18. E. Richartz, E. Stransky, A. Batra, P. Simon, P. Lewczuk, G. Buchkremer, M. Bartels and K. Schott, Decline of immune responsiveness: A pathogenetic factor in Alzheimer's disease? J Psychiatr Res 39 (2005), 535-543.
19. R.R. Satoskar, S.J. Shah and S.G. Shenoy, Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation, Int J Clin Pharmacol Ther Toxicol 24 (1986), 651-654.
20. D.J. Selkoe, Alzheimer disease: mechanistic understanding predicts novel therapies, Ann Intern Med 140 (2004), 627-638.
21. K.P. Townsend, T. Town, T. Mori, L.F. Lue, D. Shytle, P.R. Sanberg, D. Morgan, F. Fernandez, R.A. Flavell and J. Tan, CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide, Eur J Immunol 35 (2005), 901-910.
22. S.D. Webster, A.J. Yang, L. Margol, W. Garzon-Rodriguez, C.G. Glabe and A.J. Tenner, Complement component C1q modulates the phagocytosis of Abeta by microglia, Exp Neurol 161 (2000), 127-138.
23. H.L. Weiner and D.J. Selkoe, Inflammation and therapeutic vaccination in CNS diseases, Nature 420 (2002), 879-884.
24. T. Wyss-Coray and L. Mucke, Inflammation in neurodegenerative disease - a double-edged sword, Neuron 35 (2002), 419-432.
25. F. Yang, G.P. Lim, A.N. Begum, O.J. Ubeda, M.R. Simmons, S.S. Ambegaokar, P.P. Chen, R. Kayed, C.G. Glabe, S.A. Frautschy and G.M. Cole, Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo, J Biol Chem 280 (2005), 5892-5901.