Edaravone in ALS

Experimental Neurology

Volumn 217, Issue 2, 2009, Pages 235-236

  Takahashi, Ryosuke ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ACETYLCYSTEINE; ALPHA TOCOPHEROL; COPPER ZINC SUPEROXIDE DISMUTASE; NORPHENAZONE; TRANSCRIPTION FACTOR NRF2;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; DISEASE COURSE; DRUG EFFICACY; DRUG MEGADOSE; ENZYME ACTIVITY; FAMILIAL DISEASE; GENE MUTATION; HUMAN; LIFESPAN; MOTOR PERFORMANCE; NERVE CELL; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; QUALITY OF LIFE; RESPIRATORY FAILURE; SEX DIFFERENCE;

EID: 67349169168     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2009.03.001     Document Type: Note

References (21)

1. Barber S.C., Mead R.J., and Shaw P.J. Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target. Biochim. Biophys. Acta 1762 (2006) 1051-1067
2. Beckman J.S., Carson M., Smith C.D., and Koppenol W.H. ALS, SOD and peroxynitrite. Nature 364 (1993) 584
3. Benatar M. Lost in translation: treatment trials in the SOD1 mouse and in human ALS. Neurobiol. Dis. 26 (2007) 1-13
4. Boillee S., Yamanaka K., Lobsiger C.S., Copeland N.G., Jenkins N.A., Kassiotis G., Kollias G., and Cleveland D.W. Onset and progression in inherited ALS determined by motor neurons and microglia. Science 312 (2006) 1389-1392
5. Borchelt D.R., Lee M.K., Slunt H.S., Guarnieri M., Xu Z.S., Wong P.C., Brown Jr. R.H., Price D.L., Sisodia S.S., and Cleveland D.W. Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 8292-8296
6. Deng H.X., Hentati A., Tainer J.A., Iqbal Z., Cayabyab A., Hung W.Y., Getzoff E.D., Hu P., Herzfeldt B., Roos R.P., et al. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science 261 (1993) 1047-1051
7. Gurney M.E., Pu H., Chiu A.Y., Dal Canto M.C., Polchow C.Y., Alexander D.D., Caliendo J., Hentati A., Kwon Y.W., Deng H.X., et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264 (1994) 1772-1775
8. Ito H., Wate R., Zhang J., Ohnishi S., Kaneko S., Ito H., Nakano S., and Kusaka H. Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice. Exp. Neurol. 213 (2008) 448-455
9. Kabashi E., and Durham H.D. Failure of protein quality control in amyotrophic lateral sclerosis. Biochim. Biophys. Acta 1762 (2006) 1038-1050
10. Kirby J., Halligan E., Baptista M.J., Allen S., Heath P.R., Holden H., Barber S.C., Loynes C.A., Wood-Allum C.A., Lunec J., and Shaw P.J. Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS. Brain 128 (2005) 1686-1706
11. Mitchell J.D., and Borasio G.D. Amyotrophic lateral sclerosis. Lancet 369 (2007) 2031-2041
12. Neumann M., Kwong L.K., Sampathu D.M., Trojanowski J.Q., and Lee V.M. TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: protein misfolding diseases without amyloidosis. Arch. Neurol. 64 (2007) 1388-1394
13. Orrell R.W., Lane R.J., and Ross M. A systematic review of antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease. Amyotroph. Lateral Scler. 9 (2008) 195-211
14. Robberecht W., Sapp P., Viaene M.K., Rosen D., McKenna-Yasek D., Haines J., Horvitz R., Theys P., and Brown Jr. R. Cu/Zn superoxide dismutase activity in familial and sporadic amyotrophic lateral sclerosis. J. Neurochem. 62 (1994) 384-387
15. Rosen D.R., Siddique T., Patterson D., Figlewicz D.A., Sapp P., Hentati A., Donaldson D., Goto J., O'Regan J.P., Deng H.X., et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362 (1993) 59-62
16. Valentine J.S., and Hart P.J. Misfolded CuZnSOD and amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 3617-3622
17. Valentine J.S., Doucette P.A., and Zittin Potter S. Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis. Annu. Rev. Biochem. 74 (2005) 563-593
18. Wang J., Slunt H., Gonzales V., Fromholt D., Coonfield M., Copeland N.G., Jenkins N.A., and Borchelt D.R. Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature. Hum. Mol. Genet. 12 (2003) 2753-2764
19. Yamanaka K., Chun S.J., Boillee S., Fujimori-Tonou N., Yamashita H., Gutmann D.H., Takahashi R., Misawa H., and Cleveland D.W. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat. Neurosci. 11 (2008) 251-253
20. Yoshida H., Yanai H., Namiki Y., Fukatsu-Sasaki K., Furutani N., and Tada N. Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury. CNS Drug Rev. 12 (2006) 9-20
21. Yoshino H., and Kimura A. Investigation of the therapeutic effects of edaravone, a free radical scavenger, on amyotrophic lateral sclerosis (Phase II study). Amyotroph. Lateral. Scler. 7 (2006) 241-245