The therapeutic efficacy of edaravone in extensively burned rats

Archives of Surgery

Volumn 141, Issue 10, 2006, Pages 992-995

  Koizumi, Takeo ^a   Tanaka, Hideharu ^b   Sakaki, Seiki ^a   Shimazaki, Shuji ^a  

^a KYORIN UNIVERSITY   (Japan)

^b KOKUSHIKAN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MALONALDEHYDE; NORPHENAZONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; XANTHINE OXIDASE;

ARTICLE; BLOOD LEVEL; BRAIN INFARCTION; BURN; CELL INFILTRATION; CONTROLLED STUDY; DRUG EFFICACY; LEUKOCYTE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RISK FACTOR;

ANIMALS; ANTIPYRINE; BURNS; DISEASE MODELS, ANIMAL; FREE RADICAL SCAVENGERS; FREE RADICALS; LUNG; MALE; MALONDIALDEHYDE; PROSPECTIVE STUDIES; RANDOM ALLOCATION; RATS; RATS, WISTAR; XANTHINE OXIDASE;

EID: 33750088980     PISSN: 00040010     EISSN: 15383644     Source Type: Journal    
DOI: 10.1001/archsurg.141.10.992     Document Type: Article

References (31)

1. Daryani R, LaLonde C, Zhu D, Weidner M, Knox J, Demling RH. Effect of endotoxin and a body burn on lung and liver lipid peroxidation and catalase activity. J Trauma. 1990;30:1330-1334.
2. Demling RH, LaLonde C. Systemic lipid peroxidation and inflammation induced by thermal injury persists into the post-resuscitation period. J Trauma. 1990;30:69-74.
3. Watanabe T, Yuki S, Egawa M, Nishi H. Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther. 1994;268:1597-1604.
4. Kawai H, Nakai H, Suga M, Yuki S, Watanabe T, Saito K. Effects of a novel free radical scavenger, MCI-186, on ischemic brain damage in the rat distal middle cerebral artery occlusion model. J Pharmacol Exp Ther. 1997;281:921-927.
5. Edaravone Acute Brain Infarction Study Group. Effect of novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Cerebrovasc Dis. 2003;15:222-229.
6. Otomo E, Tohgi H, Kogure K, et al. Clinical efficacy of a free radical scavenger, MCI-186, on acute cerebral infarction: early phase II clinical trial. Ther Res. 1998;185:841-863.
7. Houkin K, Nakayama N, Kamada K, Noujou T, Abe H, Kashiwaba T. Neuroprotective effect of the free radical scavenger MCI-186 in patients with cerebral infarction: clinical evaluation using magnetic resonance imaging and spectroscopy. J Stroke Cerebrovasc Dis. 1998;7:1-9.
8. Walker HL, Mason AD. A standard animal burn. J Trauma. 1968;8:1049-1051.
9. Yalcin O, Soybir G, Koksoy F, Kose H, Ozturk R, Cokneseli B. Effects of granulocyte colony-stimulating factor on bacterial translocation due to burn wound sepsis. Surg Today. 1997;27:154-158.
10. Nada MS, Ljiljana B, Vesna K, Zorana J, Slavica S. Spectrophotometric assay of xanthine oxidase with 2,2′-azino-di (3-ethylbenzthiazoline-6- sulphonate) (ABTS) as chromogen. Clin Chim Acta. 1987;162:29-36.
11. Dinauer MC. The respiratory burst oxidase and the molecular genetics of chronic granulomatous disease. Crit Rev Clin Lab Sci. 1993;30:329-369.
12. Kono H, Asakawa M, Fujii H, et al. Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. J Pharmacol Exp Ther. 2003;307:74-82.
13. Saibara T, Toda K, Wakatsuki A, Ogawa Y, Ono M, Onishi S. Protective effect of 3-methyl-1-phenyl-2-pyrazolin-5-one, a free radical scavenger, on acute toxicity of paraquat in mice. Toxicol Lett. 2003;143:51-54.
14. Tomatsuri N, Yoshida N, Takagi T, et al. Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats. Int J Mol Med. 2004;13:105-109.
15. Koh T, Shinozawa Y, Koike K, Ymazaki M, Endoh T, Nomura R. Effects of free radical scavengers in the acute phase of burn [abstract]. J Jpn Assoc Acute Med. 2002;13:578.
16. Matsuda T, Tanaka H, Williams S, Hanumadass M, Abcarian E, Reyes H. Reduced fluid volume requirement for resuscitation of third-degree burns with high-dose vitamin C. J Burn Care Rehabil. 1991;12:525-532.
17. Matsuda T, Tanaka H, Hanumadass M, et al. Effects of high-dose vitamin C administration on postburn microvascular fluid and protein flux. J Burn Care Rehabil. 1992;13:560-566.
18. Matsuda T, Tanaka H, Yuasa H, et al. The effects of high-dose vitamin C therapy on postburn lipid peroxidation. J Burn Care Rehabi. 1993;14:624-629.
19. Tanaka H, Broaderick P, Shimazaki S. How long do we need to give antioxidant therapy during resuscitation when its administration is delayed for two hours? J Burn Care Rehabil. 1992;13:567-572.
20. Nishikimi M. Oxidation of ascorbic acid with superoxide anion generated by the xanthine oxidase system. Biochem Biophys Res Commun. 1975;63:463-468.
21. Bielski BHJ, Richter HW, Chan PC. Some properties of the ascorbate free radical. Ann N Y Acad Sci. 1975;258:231-237.
22. Bodannes RS, Chan PC. Ascorbic acid as a scavenger of singlet oxygen. FEBS Lett. 1979;105:195.
23. LaLonde C, Nayak U, Hennigan J, Demling RH. Excessive liver oxidant stress causes mortality in response to burn injury combined with endotoxin and is prevented with antioxidants. J Burn Care Rehabil. 1997;18:187-192.
24. LaLonde C, Nayak U, Hennigan J, Demling RH. Plasma catalase and glutathione levels are decreased in response to inhalation injury. J Burn Care Rehabil. 1997;18:515-519.
25. Parks DA, Bulkley G, Granger W, Hamilton S, McCord J. Ischemic injury in the cat small intestine: role of superoxide radicals. Gastroenterology. 1982;82:9-15.
26. Cetinkale O, Senelo O, Bulen R. The effect of antioxidant therapy on cell-mediated immunity following burn injury in an animal model. Burns. 1999;25:113-118.
27. Zhang MJ, Qifang W, Lanxing G, Hong J, Zongyin W. Comparative observation of the changes in serum lipid peroxides influenced by the supplementation of vitamin E in burn patients and healthy controls. Burns. 1992;18:19-21.
28. Willmore LJ, Rubin J. The effect of tocopherol and dimethyl sulfoxide on local edema and lipid peroxidation induced by isocortical injection of ferrous chloride. Brain Res. 1984;296:389-392.
29. Bekyarova G, Yankova T, Gakunska B. Increased antioxidant capacity, suppression of free radical damage and erythrocyte aggreability after combined application of alpha tocopherol and FC-43 perfluorocarbon emulsion in early postburn period in rast. Artif Cells Blood Substit Immobil Biotechnol. 1996;24:629-641.
30. Thomson PD, Till G, Woonlliscroft J, Smith J, Prasad J. Supreoxide dismutase prevents lipid peroxidation in burned patients. Burns. 1990;16:406-413.
31. Dupont GP, Huecksteadt TP, Marshall BC. Regulation of xanthine dehydrogenases and xanthine oxidase activity and gene expression in cultured rat pulmonary endothelial cells. J Clin Invest. 1992;89:197-202.