Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition

Free Radical Biology and Medicine

Volumn 47, Issue 7, 2009, Pages 1019-1027

  Dumont, Magali ^a   Ho, Daniel J ^a   Calingasan, Noel Y ^a   Xu, Hui ^a,b   Gibson, Gary ^a,b   Beal, M Flint ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b BURKE MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

Ketoglutarate dehydrogenase enzyme complex; A oligomers; Alzheimer disease; Amyloid plaques; Free radicals; Mitochondria; Oxidative stress; Spatial learning and memory

Indexed keywords

3 NITROTYROSINE; AMYLOID; DIHYDROLIPOAMIDE SUCCINYLTRANSFERASE; HYDROGEN PEROXIDE; OXOGLUTARATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE;

AGE DETERMINATION; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE DELETION; GENE MUTATION; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; SPATIAL MEMORY; TRANSGENIC MOUSE;

ACYLTRANSFERASES; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOIDOSIS; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; MALE; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; MITOCHONDRIA; OXIDATIVE STRESS; PEPTIDE FRAGMENTS;

MUS; MUS MUSCULUS;

EID: 69249212441     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.07.008     Document Type: Article

References (37)

1. Canevari L., Abramov A.Y., and Duchen M.R. Toxicity of amyloid beta peptide: tales of calcium, mitochondria, and oxidative stress. Neurochem. Res. 29 (2004) 637-650
2. Smith M.A., Hirai K., Hsiao K., Pappolla M.A., Harris P.L., Siedlak S.L., Tabaton M., and Perry G. Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. J. Neurochem. 70 (1998) 2212-2215
3. Butterfield D.A., Drake J., Pocernich C., and Castegna A. Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. Trends Mol. Med. 7 (2001) 548-554
4. Butterfield D.A., and Lauderback C.M. Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress. Free Radic. Biol. Med. 32 (2002) 1050-1060
5. Smith M.A., Richey Harris P.L., Sayre L.M., Beckman J.S., and Perry G. Widespread peroxynitrite-mediated damage in Alzheimer's disease. J. Neurosci. 17 (1997) 2653-2657
6. Butterfield D.A., Reed T.T., Perluigi M., De Marco C., Coccia R., Keller J.N., Markesbery W.R., and Sultana R. Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease. Brain Res. 1148 (2007) 243-248
7. Sayre L.M., Zelasko D.A., Harris P.L., Perry G., Salomon R.G., and Smith M.A. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J. Neurochem. 68 (1997) 2092-2097
8. Ando Y., Brannstrom T., Uchida K., Nyhlin N., Nasman B., Suhr O., Yamashita T., Olsson T., El Salhy M., Uchino M., and Ando M. Histochemical detection of 4-hydroxynonenal protein in Alzheimer amyloid. J. Neurol. Sci. 156 (1998) 172-176
9. Nunomura A., Perry G., Aliev G., Hirai K., Takeda A., Balraj E.K., Jones P.K., Ghanbari H., Wataya T., Shimohama S., Chiba S., Atwood C.S., Petersen R.B., and Smith M.A. Oxidative damage is the earliest event in Alzheimer disease. J. Neuropathol. Exp. Neurol. 60 (2001) 759-767
10. Pratico D., Uryu K., Leight S., Trojanoswki J.Q., and Lee V.M. Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J. Neurosci. 21 (2001) 4183-4187
11. Abdul H.M., Sultana R., St Clair D.K., Markesbery W.R., and Butterfield D.A. Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age. Free Radic. Biol. Med. 45 (2008) 1420-1425
12. Li F., Calingasan N.Y., Yu F., Mauck W.M., Toidze M., Almeida C.G., Takahashi R.H., Carlson G.A., Flint Beal M., Lin M.T., and Gouras G.K. Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice. J. Neurochem. 89 (2004) 1308-1312
13. Melov S., Adlard P.A., Morten K., Johnson F., Golden T.R., Hinerfeld D., Schilling B., Mavros C., Masters C.L., Volitakis I., Li Q.X., Laughton K., Hubbard A., Cherny R.A., Gibson B., and Bush A.I. Mitochondrial oxidative stress causes hyperphosphorylation of tau. PLoS ONE 2 (2007) e536
14. Esposito L., Raber J., Kekonius L., Yan F., Yu G.Q., Bien-Ly N., Puolivali J., Scearce-Levie K., Masliah E., and Mucke L. Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice. J. Neurosci. 26 (2006) 5167-5179
15. M. Dumont; E. Wille; C. Stack; N.Y. Calingasan; M.F. Beal; M.T. Lin, Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease. FASEB J. 2009 (April 3, Electronic publication ahead of print).
16. Gibson G.E., Blass J.P., Beal M.F., and Bunik V. The alpha-ketoglutarate-dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration. Mol. Neurobiol. 31 (2005) 43-63
17. Gibson G.E., Sheu K.F., Blass J.P., Baker A., Carlson K.C., Harding B., and Perrino P. Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease. Arch. Neurol. 45 (1988) 836-840
18. Butterworth R.F., and Besnard A.M. Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease. Metab. Brain Dis. 5 (1990) 179-184
19. Mastrogiacomo F., Bergeron C., and Kish S.J. Brain alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. J. Neurochem. 61 (1993) 2007-2014
20. Gibson G.E., Zhang H., Sheu K.F., Bogdanovich N., Lindsay J.G., Lannfelt L., Vestling M., and Cowburn R.F. Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation. Ann. Neurol. 44 (1998) 676-681
21. S.S Karuppagounder; H. Xu; Q. Shi; L.H. Chen; S. Pedrini; D. Pechman; H. Baker; M.F. Beal; S.E Gandy; G.E. Gibson, Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiol. Aging 2008 (April 9, Electronic publication ahead of print).
22. Dumont M., Wille E., Calingasan N.Y., Tampellini D., Williams C., Gouras G.K., Liby K., Sporn M., Nathan C., Flint Beal M., and Lin M.T. Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease. J. Neurochem. 109 (2009) 502-512
23. Chishti M.A., Yang D.S., Janus C., Phinney A.L., Horne P., Pearson J., Strome R., Zuker N., Loukides J., French J., Turner S., Lozza G., Grilli M., Kunicki S., Morissette C., Paquette J., Gervais F., Bergeron C., Fraser P.E., Carlson G.A., George-Hyslop P.S., and Westaway D. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J. Biol. Chem. 276 (2001) 21562-21570
24. Hirata-Fukae C., Li H.F., Hoe H.S., Gray A.J., Minami S.S., Hamada K., Niikura T., Hua F., Tsukagoshi-Nagai H., Horikoshi-Sakuraba Y., Mughal M., Rebeck G.W., LaFerla F.M., Mattson M.P., Iwata N., Saido T.C., Klein W.L., Duff K.E., Aisen P.S., and Matsuoka Y. Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Res. 1216 (2008) 92-103
25. Wang J., Tanila H., Puolivali J., Kadish I., and van Groen T. Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice. Neurobiol. Dis. 14 (2003) 318-327
26. Kayed R., Head E., Thompson J.L., McIntire T.M., Milton S.C., Cotman C.W., and Glabe C.G. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300 (2003) 486-489
27. Hyde L.A., Kazdoba T.M., Grilli M., Lozza G., Brusa R., Zhang Q., Wong G.T., McCool M.F., Zhang L., Parker E.M., and Higgins G.A. Age-progressing cognitive impairments and neuropathology in transgenic CRND8 mice. Behav. Brain Res. 160 (2005) 344-355
28. Yoshiike Y., Minai R., Matsuo Y., Chen Y.R., Kimura T., and Takashima A. Amyloid oligomer conformation in a group of natively folded proteins. PLoS ONE 3 (2008) e3235
29. Placanica L., Zhu L., and Li Y.M. Gender-and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease. PLoS ONE 4 (2009) e5088
30. Huang X., Atwood C.S., Hartshorn M.A., Multhaup G., Goldstein L.E., Scarpa R.C., Cuajungco M.P., Gray D.N., Lim J., Moir R.D., Tanzi R.E., and Bush A.I. The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry 38 (1999) 7609-7616
31. Varadarajan S., Yatin S., Kanski J., Jahanshahi F., and Butterfield D.A. Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress. Brain Res. Bull. 50 (1999) 133-141
32. De Felice F.G., Velasco P.T., Lambert M.P., Viola K., Fernandez S.J., Ferreira S.T., and Klein W.L. Abeta oligomers induce neuronal oxidative stress through an N-methyl-d-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J. Biol. Chem. 282 (2007) 11590-11601
33. Keller J.N., Kindy M.S., Holtsberg F.W., St Clair D.K., Yen H.C., Germeyer A., Steiner S.M., Bruce-Keller A.J., Hutchins J.B., and Mattson M.P. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J. Neurosci. 18 (1998) 687-697
34. Shi Q., Chen H.L., Xu H., and Gibson G.E. Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity. J. Biol. Chem. 280 (2005) 10888-10896
35. Ali S.S., Xiong C., Lucero J., Behrens M.M., Dugan L.L., and Quick K.L. Gender differences in free radical homeostasis during aging: shorter-lived female C57BL6 mice have increased oxidative stress. Aging Cell 5 (2006) 565-574
36. Liu L., Komatsu H., Murray I.V., and Axelsen P.H. Promotion of amyloid beta protein misfolding and fibrillogenesis by a lipid oxidation product. J. Mol. Biol. 377 (2008) 1236-1250
37. Bieschke J., Zhang Q., Powers E.T., Lerner R.A., and Kelly J.W. Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation. Biochemistry 44 (2005) 4977-4983