A plausible explanation for enhanced bioavailability of P-gp substrates in presence of piperine: Simulation for next generation of P-gp inhibitors

Journal of Molecular Modeling

Volumn 19, Issue 1, 2013, Pages 227-238

  Singh, Durg Vijay ^a   Godbole, Madan M ^b   Misra, Krishna ^c  

^a INDIAN INSTITUTE OF INFORMATION TECHNOLOGY   (India)

^b SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

^c Center of Biomedical Magnetic Resonance   (India)

Author keywords

Docking; E pharmacophores; Homology modeling; Immunofluorscence; P glycoprotein (P gp); P gp inhibitors; Piperine

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLYLIMIDODIPHOSPHATE; MULTIDRUG RESISTANCE PROTEIN; PIPERINE; RHODAMINE;

ARTICLE; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG BINDING; DRUG BIOAVAILABILITY; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MOLECULAR DOCKING; PRIORITY JOURNAL; SIMULATION;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENYLYL IMIDODIPHOSPHATE; ALKALOIDS; AMINO ACIDS; ANIMALS; BENZODIOXOLES; BINDING SITES; BIOLOGICAL AVAILABILITY; CELL SURVIVAL; COMPUTER SIMULATION; DOGS; FLOW CYTOMETRY; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; MODELS, MOLECULAR; P-GLYCOPROTEIN; PIPERIDINES; POLYUNSATURATED ALKAMIDES; PROTEIN STRUCTURE, TERTIARY; RHODAMINES; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY;

RUMEX;

EID: 84872287149     PISSN: 16102940     EISSN: 09485023     Source Type: Journal    
DOI: 10.1007/s00894-012-1535-8     Document Type: Article

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