Investigating the putative glycine hinge in Shaker potassium channel

Journal of General Physiology

Volumn 126, Issue 3, 2005, Pages 213-226

  Ding, Shinghua ^a,b   Ingleby, Lindsey ^a   Ahern, Christopher A ^a   Horn, Richard ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; GLYCINE; MUTANT PROTEIN; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BIOGENESIS; BIOTINYLATION; CELL MEMBRANE; CHANNEL GATING; COMPARATIVE STUDY; CONTROLLED STUDY; EMBRYO; GLYCOSYLATION; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MOLECULAR SIZE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; STRUCTURE ANALYSIS; WILD TYPE;

ANIMALS; BINDING SITES; CELL LINE; EPITOPES; GLYCINE; GLYCOSYLATION; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MUTATION; OOCYTES; PEPTIDES; POINT MUTATION; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PROTEIN STRUCTURE, SECONDARY; QUATERNARY AMMONIUM COMPOUNDS; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; TRANSFECTION; XENOPUS LAEVIS;

EID: 24344432708     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.200509287     Document Type: Article

References (72)

1. Abramson, J., I. Smirnova, V. Kasho, G. Verner, H.R. Kaback, and S. Iwata. 2003. Structure and mechanism of the lactose permease of Escherichia coli. Science. 301:610-615.
2. Armstrong, C.M. 1971. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J. Gen. Physiol. 58:413-437.
3. Barlow, D.J., and J.M. Thornton. 1988. Helix geometry in proteins. J. Mol. Biol. 201:601-619.
4. + channel. Science. 271:653-656.
5. Bezanilla, F. 2000. The voltage sensor in voltage dependent ion channels. Physiol. Rev. 80:555-592.
6. Bright, J.N., and M.S.P. Sansom. 2003. The flexing/twirling helix: exploring the flexibility about molecular hinges formed by proline and glycine motifs in transmembrane helices. J. Phys. Chem. B. 107:627-636.
7. Bright, J.N., I.H. Shrivastava, F.S. Cordes, and M.S.P. Sansom. 2002. Conformational dynamics of helix S6 from Shaker potassium channel: simulation studies. Biopolymers. 64:303-313.
8. Chakrabartty, A., J.A. Schellman, and R.L. Baldwin. 1991. Large differences in the helix propensities of alanine and glycine. Nature. 351:586-588.
9. Chou, P.Y., and G.D. Fasman. 1974. Prediction of protein conformation. Biochemistry. 13:222-245.
10. Cordes, F.S., J.N. Bright, and M.S. Sansom. 2002. Proline-induced distortions of transmembrane helices. J. Mol. Biol. 323:951-960.
11. De Souza, N.F., and S.M. Simon. 2002. Glycosylation affects the rate of traffic of the Shaker potassium channel through the secretory pathway. Biochemistry. 41:11351-11361.
12. Deber, C.M., and A.G. Therien. 2002. Putting the beta-breaks on membrane protein misfolding. Nat. Struct. Biol. 9:318-319.
13. + channel and its structural implications. Nature. 403:321-325.
14. + channel. Neuron. 32:649-656.
15. Ding, S., and R. Horn. 2002. Tail end of the S6 segment: role in permeation in Shaker potassium channels. J. Gen. Physiol. 120:87-97.
16. Ding, S., and R. Horn. 2003. Effect of S6 tail mutations on charge movement in Shaker potassium channels. Biophys. J. 84:295-305.
17. Domene, C., D. A. Doyle, and C. Venien-Bryan. 2005. Modeling of an ion channel in its open conformation. Biophys. J. 89:L01-L03.
18. + conduction and selectivity. Science. 280:69-77.
19. 2 terminal addition or deletion. Consequences of missing a residue at the join in a channel. J. Mol. Biol. 231:1102-1121.
20. Falcon, C.M., and K.S. Matthews. 1999. Glycine insertion in the hinge region of lactose repressor protein alters DNA binding. J. Biol. Chem. 274:30849-30857.
21. Falke, J.J., S.K. Drake, A.L. Hazard, and O.B. Peersen. 1994. Molecular tuning of ion binding to calcium signaling proteins. Q. Rev. Biophys. 27:219-290.
22. Flynn, G.E., and W.N. Zagotta. 2001. Conformational changes in S6 coupled to the opening of cyclic-nucleotide gated channels. Neuron. 30:689-698.
23. Grummt, M., G. Woehlke, U. Henningsen, S. Fuchs, M. Schleicher, and M. Schliwa. 1998. Importance of a flexible hinge near the motor domain in kinesin-driven motility. EMBO J. 17:5536-5542.
24. + channel. J. Gen. Physiol. 119:521-531.
25. + channel by 1-alkanols is linked to a key residue in the activation gate. Am. J. Physiol. Cell Physiol. 285:C788-C796.
26. + channel can be trapped in the open state by an intersubunit metal bridge. Neuron. 21:617-621.
27. Hoshi, T., W.N. Zagotta, and R.W. Aldrich. 1990. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science. 250:533-538.
28. Javadpour, M.M., M. Eilers, M. Groesbeek, and S.O. Smith. 1999. Helix packing in polytopic membrane proteins: role of glycine in transmembrane helix association. Biophys. J. 77:1609-1618.
29. Jiang, Y., A. Lee, J.Y. Chen, M. Cadene, B.T. Chait, and R. MacKinnon. 2002a. Crystal structure and mechanism of a calcium-gated potassium channel. Nature. 417:515-522.
30. Jiang, Y., A. Lee, J.Y. Chen, M. Cadene, B.T. Chait, and R. MacKinnon. 2002b. The open pore conformation of potassium channels. Nature. 417:523-526.
31. + channel. Nature. 423:33-41.
32. + channel by pivoted bending of a transmembrane segment. Mol. Cell. 10:469-481.
33. Johnson, J.P., Jr., and W.N. Zagotta. 2001. Rotational movement during cyclic nucleotide-gated channel opening. Nature. 412:917-921.
34. Kelly, B.L., and A. Gross. 2003. Potassium channel gating observed with site-directed mass tagging. Nat. Struct. Biol. 10:280-284.
35. + at the potassium channel selectivity filter. Biophys. J. 74:1840-1849.
36. Kiss, L., J. LoTurco, and S.J. Korn. 1999. Contribution of the selectivity filter to inactivation in potassium channels. Biophys. J. 76:253-263.
37. v channel through modification of a hydrophobic seal. J. Gen. Physiol. 124:319-332.
38. Kuo, A., J.M. Gulbis, J.F. Antcliff, T. Rahman, E.D. Lowe, J. Zimmer, J. Cuthbertson, F.M. Ashcroft, T. Ezaki, and D.A. Doyle. 2003. Crystal structure of the potassium channel KirBac1.1 in the closed state. Science. 300:1922-1926.
39. Labro, A.J., A.L. Raes, I. Bellens, N. Ottschytsch, and D.J. Snyders. 2003. Gating of Shaker-type channels requires the flexibility of S6 caused by prolines. J. Biol. Chem. 278:50724-50731.
40. Lemmon, M.A., and D.M. Engelman. 1994. Specificty and promiscuity in membrane helix interactions. Q. Rev. Biophys. 27:157-218.
41. Li-Smerin, Y., and K.J. Swartz. 2001. Helical structure of the COOH terminus of S3 and its contribution to the gating modifier toxin receptor in voltage-gated ion channels. J. Gen. Physiol. 117:205-217.
42. Li, S.C., and C.M. Deber. 1992. Glycine and beta-branched residues support and modulate peptide helicity in membrane environon-ments. FEBS Lett. 311:217-220.
43. Liu, Y.S.A., P. Sompornpisut, and E. Perozo. 2001. Structure of the KcsA channel intracellular gate in the open state. Nat. Struct. Biol. 8:883-887.
44. MacArthur, M.W., and J.M. Thornton. 1991. Influence of proline residues on protein conformation. J. Mol. Biol. 218:397-412.
45. + channels. Biochemistry. 43:13242-13247.
46. Neher, E., and C.F. Stevens. 1977. Conductance fluctuations and ionic pores in membranes. Annu. Rev. Biophys. Bioeng. 6:345-381.
47. O'Neil, K.T., and W.F. DeGrado. 1990. A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids. Science. 250:646-651.
48. Palczewski, K., T. Kumasaka, T. Hori, C.A. Behnke, H. Motoshima, B.A. Fox, I. Le Trong, D.C. Teller, T. Okada, R.E. Stenkamp, et al. 2000. Crystal structure of rhodopsin: a G protein-coupled receptor. Science. 289:739-745.
49. + channel. Neuron. 14:1293-1301.
50. +-channel activation gating. Science. 285:73-78.
51. Russ, W.P., and D.M. Engelman. 2000. The GxxxG motif: a framework for transmembrane helix-helix association. J. Mol. Biol. 296:911-919.
52. Santacruz-Toloza, L., Y. Huang, S.A. John, and D.M. Papazian. 1994. Glycosylation of Shaker potassium channel protein in insect cell culture and in Xenopus oocytes. Biochemistry. 33:5607-5613.
53. Schuller, D.J., A. Wilks, P.R. Ortiz de Montellano, and T.L. Poulos. 1999. Crystal structure of human heme oxygenase-1. Nat. Struct. Biol. 6:860-867.
54. Serrano, L., J.-L. Neira, J. Sancho, and A.R. Fersht. 1992. Effect of alanine versus glycine in α-helices on protein stability. Nature. 356:453-455.
55. +-selective family of ion channels using a comprehensive alignment and the KcsA structure. Biophys. J. 84:2929-2942.
56. + channel. Neuron. 38:61-67.
57. + channel. J. Gen. Physiol. 112:211-221.
58. Starkus, J.G., L. Kuschel, M.D. Rayner, and S.H. Heinemann. 1997. Ion conduction through C-type inactivated Shaker channels. J. Gen. Physiol. 110:539-550.
59. Sukhareva, M., D.H. Hackos, and K. Swartz. 2003. Constitutive activation of the Shaker Kv channel. J. Gen. Physiol. 122:541-556.
60. Tieleman, D.P., I.H. Shrivastava, M.R. Ulmschneider, and M.S. Sansom. 2001. Proline-induced hinges in transmembrane helices: possible roles in ion channel gating. Proteins. 44:63-72.
61. + channel by lateral forces applied to the C-termini of inner helices. Biophys. J. 87:1526-1536.
62. Von Heijne, G. 1991. Proline kinks in transmembrane α-helices. J. Mol. Biol. 218:499-503.
63. + channels defined by high-affinity metal bridges. Nature. 428:864-868.
64. + channel α subunit in voltage-dependent gating and drug block. J. Biol. Chem. 277:35393-35401.
65. Yellen, G. 1998. The moving parts of voltage-gated ion channels. Q. Rev. Biophys. 31:239-295.
66. Yellen, G. 2002. The voltage-gated potassium channels and their relatives. Nature. 419:35-42.
67. + channel. Cell. 111:231-239.
68. Yun, R.H., A. Anderson, and J. Hermans. 1991. Proline in α-helix: stability and conformation studied by dynamics simulation. Proteins Struct. Funct. Genet. 10:219-228.
69. Zagotta, W.N., T. Hoshi, and R.W. Aldrich. 1990. Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science. 250:568-571.
70. + channels: a molecular switch for electrical signalling. Neuron. 41:859-865.
71. Zhou, M., J.H. Morais-Cabral, S. Mann, and R. MacKinnon. 2001a. Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature. 411:657-661.
72. + channel-Fab complex at 2.0 Å resolution. Nature. 414:43-48.