Properties of P-glycoprotein with mutations in the "catalytic carboxylate" glutamate residues

Journal of Biological Chemistry

Volumn 279, Issue 45, 2004, Pages 46518-46526

  Tombline, Gregory ^a   Bartholomew, Lori A ^a   Tyndall, Grace A ^a   Gimi, Khursheed ^a   Urbatsch, Ina L ^a,b   Senior, Alan E ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CHEMICAL BONDS; DIMERS; GLUCOSE; HYDROLYSIS;

MUTATIONS; NUCLEOTIDE BINDING DOMAIN 1 (NBD1); P-GLYCOPROTEINS (PGP);

PROTEINS;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; AMINO ACID; CARBOXYLIC ACID; GLUTAMIC ACID; GLYCOPROTEIN P; LIGAND; NUCLEOTIDE BINDING PROTEIN; ORTHOVANADIC ACID;

AMINO ACID COMPOSITION; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; DIMERIZATION; ENZYME METABOLISM; HYDROLYSIS; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; STRUCTURE ANALYSIS; TURNOVER TIME;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ALANINE; ANIMALS; ASPARTIC ACID; BINDING, COMPETITIVE; CARBOXYLIC ACIDS; CATALYSIS; DIMERIZATION; DITHIOTHREITOL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; HYDROLYSIS; KINETICS; LIPID METABOLISM; LYSINE; MICE; MODELS, CHEMICAL; MUTATION; P-GLYCOPROTEIN; PICHIA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; TIME FACTORS; VANADATES;

EID: 8744266443     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M408052200     Document Type: Article

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