Dynamic ligand-induced conformational rearrangements in P-glycoprotein as probed by fluorescence resonance energy transfer spectroscopy

Journal of Biological Chemistry

Volumn 287, Issue 2, 2012, Pages 1112-1127

  Verhalen, Brandy ^a   Ernst, Stefan ^b   Börsch, Michael ^b   Wilkens, Stephan ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-CANCER CHEMOTHERAPY; ATP-BINDING CASSETTE TRANSPORTERS; CATALYTIC CYCLES; CATALYTIC MECHANISMS; CYCLOSPORIN; DWELL TIME; EFFLUX PUMPS; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT DYES; NUCLEOTIDE-BINDING DOMAIN; P-GLYCOPROTEIN; SINGLE-MOLECULE; STRUCTURAL REARRANGEMENT; TIME-SCALES; TOXIC ORGANIC COMPOUNDS;

AMINO ACIDS; BINDING ENERGY; CHEMOTHERAPY; ENERGY TRANSFER; ENZYME ACTIVITY; FLUORESCENCE; GLYCOPROTEINS; HYDROLYSIS; MOLECULES; QUANTUM CHEMISTRY;

CONFORMATIONS;

AMINO TERMINAL TELOPEPTIDE; CARBOXY TERMINAL TELOPEPTIDE; CYCLOSPORIN; GLYCOPROTEIN P; NUCLEOTIDE BINDING PROTEIN; VANADIC ACID; VERAPAMIL;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE RESONANCE ENERGY TRANSFER; MOLECULAR DYNAMICS; MOLECULAR PROBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIGANDS; MICE; MODELS, MOLECULAR; P-GLYCOPROTEINS; PROTEIN CONFORMATION; VANADATES;

EID: 84855476209     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.301192     Document Type: Article

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