Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes

Molecular and Cellular Endocrinology

Volumn 307, Issue 1-2, 2009, Pages 89-98

  Wang, Nian ^a   Zhang, DeLing ^a   Mao, XianQing ^a   Zou, Feng ^a   Jin, Huan ^a   Ouyang, JingPing ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Astragalus polysaccharide; ATF6; ER stress; PTP1B; Type 2 diabetes

Indexed keywords

4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; ACTIVATING TRANSCRIPTION FACTOR 6; ASTRAGALUS EXTRACT; GLUCOSE; INSULIN; PROTEIN TYROSINE PHOSPHATASE 1B; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTRAGALUS PLANT; CONTROLLED STUDY; CYTOSOL; DISEASE MODEL; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; GENE OVEREXPRESSION; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN SENSITIVITY; LIPID DIET; LIVER CELL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES;

ACTIVATING TRANSCRIPTION FACTOR 6; ANIMALS; ASTRAGALUS PLANT; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; GLUCOSE; HOMEOSTASIS; HUMANS; INSULIN; LIVER; PLASMIDS; POLYSACCHARIDES; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RATS; RATS, SPRAGUE-DAWLEY; STRESS, PHYSIOLOGICAL; SULFONES; TRANSFECTION;

EID: 67349167991     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2009.03.001     Document Type: Article

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